VOLUME OF FLUIDNCT07787455
Goal Directed Fluid Therapy in Craniotomy Operations Guided By Pulse Pressure Variability (PPV) Versus Central Venous Pressure (CVP)
An observational study of VOLUME OF FLUID, run by Ain Shams University at 1 site in Egypt.
Trial summary
the aim from the study is goal directed fluid therapy in carniotomy operations guided by ppv versus cvp Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- VOLUME OF FLUID
- How many people
- 50 participants
- Where
- 1 siteEgypt
- Study dates
- 11 Jan 2026to 1 Aug 2026
- How long will I take part?
- 6 Months
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- Adult, Older adult
Study population: PT WAS RANDOMLY ALLOACTED TO 2 GROUPS GROUP A : CVP BETWEEN 8-10 CMH2O GROUP B : PPV LESS THAN 13 %
Who may be able to join
- ASA I,II AGE 18-65
Who cannot join
- CHRONIC CARDIC ARRHYTHMIA FLASE HIGH CVP ALTERED MYOCARDIAL FUNCTION PERIPHRAL VASCULAR DISEASE SEVER RESPRITORY DISEASE PEREGANACY PATIENT REFUSAL EXCESSIVE BLOOD LOSS OPERATIONS
- -
Trial locations and contacts
1 site in 1 country.
About this study
the aim from the study is goal directed fluid therapy in carniotomy operations guided by ppv versus cvp
Read the detailed description
it is a study to compare the effectiveness of goal directed fluid therapy (GDTF) in patients undergoing craniotomy when gudied by cvp group (25 cases) versus group ppv (25 cases) .the primary outcome is the amout of fluid given to the patient gudied by cvp compared to amount given gudied by ppv . secondaary outcome include: incidence of hypotesion ,vasopressor use, serum lacatate ,pulmonary complications , PONV ,length of hospital stay
- Conditions
- VOLUME OF FLUID
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| CVP GROUP | SHOULD BE BETWWEN 8-10 CMH2O | |
| PPV GROUP | KEEP PPV LESS THAN 13% |
What is being measured
The primary outcome is the main question the study is designed to answer.
TOTAL VOLUME OF FLUIDS
COMPARE INRAOPRETIVE CRYSTELLOIDS VOLUMES BETWEEN CVP GUDIED AND PPV GUDIED GROUP IN CRANIOTOMY OPERATIONS
Measured: INTRAOPRETIVE TIME SNICE INDUCTION TILL END OF OPERATION
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Aug 2026
- Study start11 Jan 2026
- Primary completion11 May 2026
- Study completion1 Aug 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for VOLUME OF FLUIDStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 50 participants (actual)
- Target duration
- 6 Months
Sponsor and investigators
- Lead sponsor
- Ain Shams University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07787455
- Sponsor's protocol ID
- MS 900/2025
- Status last verified
- Aug 2026
- First submitted
- 23 Aug 2026
- Last updated
- 26 Aug 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: HAVE NO PLAN FOR NOW
Study at a glance
From the registry record, last updated by the sponsor on 26 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Goal Directed Fluid Therapy in Craniotomy Operations Guided By Pulse Pressure Variability (PPV) Versus Central Venous Pressure (CVP)
- ClinicalTrials.gov ID
- NCT07787455
- Acronym / sponsor ID
- MS 900/2025
- Conditions
- VOLUME OF FLUID
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- Ain Shams UniversityUniversity, hospital or other
- Study start
- 11 Jan 2026 (actual)
- Primary completion
- 11 May 2026 (actual)
- Study completion
- 1 Aug 2026 (actual)
- First posted
- 26 Aug 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
the aim from the study is goal directed fluid therapy in carniotomy operations guided by ppv versus cvp
Detailed description
it is a study to compare the effectiveness of goal directed fluid therapy (GDTF) in patients undergoing craniotomy when gudied by cvp group (25 cases) versus group ppv (25 cases) .the primary outcome is the amout of fluid given to the patient gudied by cvp compared to amount given gudied by ppv . secondaary outcome include: incidence of hypotesion ,vasopressor use, serum lacatate ,pulmonary complications , PONV ,length of hospital stay
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 6 Months
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| CVP GROUP | – | –SHOULD BE BETWWEN 8-10 CMH2O |
| PPV GROUP | – | –KEEP PPV LESS THAN 13% |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Age groups
- Adult, Older adult
- Study population
- PT WAS RANDOMLY ALLOACTED TO 2 GROUPS GROUP A : CVP BETWEEN 8-10 CMH2O GROUP B : PPV LESS THAN 13 %
Key inclusion criteria (1 listed)
- ASA I,II AGE 18-65
Key exclusion criteria (2 listed)
- CHRONIC CARDIC ARRHYTHMIA FLASE HIGH CVP ALTERED MYOCARDIAL FUNCTION PERIPHRAL VASCULAR DISEASE SEVER RESPRITORY DISEASE PEREGANACY PATIENT REFUSAL EXCESSIVE BLOOD LOSS OPERATIONS
- -
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
TOTAL VOLUME OF FLUIDS
Time frame: INTRAOPRETIVE TIME SNICE INDUCTION TILL END OF OPERATION
COMPARE INRAOPRETIVE CRYSTELLOIDS VOLUMES BETWEEN CVP GUDIED AND PPV GUDIED GROUP IN CRANIOTOMY OPERATIONS
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Aug 2026.
- Individual participant dataSharing planned: Undecided. HAVE NO PLAN FOR NOW
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of VOLUME OF FLUID, run by Ain Shams University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 26 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
TOTAL VOLUME OF FLUIDS (time frame: INTRAOPRETIVE TIME SNICE INDUCTION TILL END OF OPERATION). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Aug 2026.