Benign Paroxysmal Positional Vertigo (BPPV)NCT07787559
Epley Versus Semont-plus Maneuver for Benign Paroxysmal Positional Vertigo
A study testing Semont-plus and Epley in people with Benign Paroxysmal Positional Vertigo (BPPV), run by Military Hospital 175 at 1 site in Vietnam.
Trial summary
The goal of this clinical trial is to learn which of two head-movement treatments works better for benign paroxysmal positional vertigo (BPPV) of the posterior canal in adults. BPPV is a common cause of short spells of spinning dizziness. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Benign Paroxysmal Positional Vertigo (BPPV)
- What is being tested?
- Semont-plus and Epley
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 160 participants
- Where
- 1 siteVietnam
- Study dates
- 1 Sep 2026to 30 Nov 2027
- Phase
- Interventional
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age 18 years or older
- Posterior semicircular canal benign paroxysmal positional vertigo of the canalolithiasis type, diagnosed according to the Barany Society 2015 diagnostic criteria
- Unilateral involvement of a single semicircular canal
Who cannot join
- Involvement of more than one semicircular canal
- Any condition making the repositioning maneuver unsafe, including severe cervical spine disease with restricted range of motion or instability, previous cervical spine fracture, severe osteoporosis, unstable cardiovascular disease, or respiratory failure
- Unable to cooperate with the maneuver
- Any ocular or neurologic condition preventing technically adequate videonystagmography recording, such as inability to keep the eyes open, severe ptosis, or interfering spontaneous nystagmus from another cause
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Vietnam1 site
Military Hospital 175
Ho Chi Minh City
Chau Van Ha, (+84) 0963219277, hachau.ht89@gmail.com
About this study
Official title: Efficacy of the Epley Versus Semont-plus Maneuver in Patients With Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo: A Randomized Controlled Trial Using Quantitative Video-Nystagmography Measurement
The goal of this clinical trial is to learn which of two head-movement treatments works better for benign paroxysmal positional vertigo (BPPV) of the posterior canal in adults. BPPV is a common cause of short spells of spinning dizziness. It happens when tiny crystals come loose inside the balance organ of the inner ear and drift into one of its canals. Changing head position then brings on a spinning feeling, along with quick jerking movements of the eyes.
The main question it aims to answer is:
Read more
- Does one treatment reduce these jerking eye movements more than the other, measured before treatment, 30 minutes after treatment, and 3 days after treatment?
The study will also look at:
- How many participants become free of positional dizziness after treatment
- How many days pass before the dizziness stops
- Whether repeating the treatment at home more times a day shortens recovery
- How often unwanted effects, such as nausea or vomiting, happen with each treatment
Researchers will compare the Semont-plus maneuver to the Epley maneuver, the long-standing standard treatment, to see if it clears the crystals out of the canal faster and more completely.
Participants will:
- Be placed by chance, into the Epley group or the Semont-plus group
- Have the jerking movements of the eyes recorded with video goggles while the doctor moves their head into the position that brings on the dizziness
- Receive their assigned maneuver at the hospital, followed by a second recording about 30 minutes later
- Be taught to carry out the same maneuver on their own at home, as often as they feel able to
- Come back after 3 days for another recording of their eye movements
- Come back after 1 month to talk with the study team about how their dizziness changed over that time
- Keep a short daily diary of their dizziness and of how many times a day they did the maneuver at home
- Being tested
- Semont-plus, Epley
- Medical subject headings
- Benign Paroxysmal Positional Vertigo
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Semont-plusProcedure or surgery
Semont-plus liberatory maneuver for posterior canal BPPV, performed by a trained therapist at the enrolment visit. From the upright seated position the head is turned 45 degrees toward the nonaffected side. The body is then moved 150 degrees toward the affected side, so that the head comes to lie about 60 degrees below the earth horizontal and the otoconia are carried beyond the vertex of the canal. The body is next moved 240 degrees toward the nonaffected side, which drives the otoconia toward the vestibule, and the participant is finally brought 90 degrees back to the upright position. Each position is held for about one minute or until the induced nystagmus stops. The maneuver is repeated within the same session if positional nystagmus persists. Participants are then taught to perform it on their own at home, as often as they are able, and to record each home session in a diary.
EpleyProcedure or surgery
Epley maneuver for posterior canal BPPV, performed by a trained therapist at the enrolment visit. From the upright seated position the head is rotated 45 degrees toward the affected ear. The body is then moved backward so that the head hangs below the earth horizontal. The head is rotated 90 degrees toward the nonaffected ear, after which the whole body is rotated downward until the participant faces the floor with the affected ear pointing toward the ceiling. The participant returns to sitting with the head still rotated 45 degrees toward the nonaffected ear, and the head is turned back to neutral at the end. Each position is held until the induced nystagmus stops, and for at least 30 seconds. The maneuver is repeated within the same session if positional nystagmus persists. Participants are then taught to perform it on their own at home, as often as they are able, and to record each home session in a diary.
| Study group | Role | What they receive |
|---|---|---|
| Semont-Plus | Experimental | Not described Receives: Procedure: Semont-plus |
| Epley | Active comparator | Not described Receives: Procedure: Epley |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in average slow-phase velocity of positional nystagmus
Measured: Before the maneuver, 30 minutes after the maneuver, and 3 days after the maneuver
Secondary outcomes (4)
Proportion of participants with a successful repositioning maneuver
Measured: 30 minutes and 3 days after the first treatment maneuver
Number of days until resolution of positional vertigo
Measured: From the enrolment visit (day 0) to 1 month
Correlation between the number of self-administered maneuvers per day and time to resolution of positional vertigo
Measured: From the enrolment visit (day 0) to 1 month
Number of participants with adverse events during treatment
Measured: From the enrolment visit (day 0) to 1 month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Aug 2026
- Study start1 Sep 2026 (estimated)
- Primary completion30 Oct 2027 (estimated)
- Study completion30 Nov 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Benign Paroxysmal Positional Vertigo (BPPV)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Investigator, Outcomes assessor
- Enrolment
- 160 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Military Hospital 175
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Hoang Tien Trong Nghia, Military Hospital 175
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07787559
- Sponsor's protocol ID
- DTCSHY.24/26/175.A7
- Status last verified
- Jun 2026
- First submitted
- 22 Aug 2026
- Last updated
- 27 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided