Postoperative Nausea and VomitingNCT07796529
Menthol Chewing Gum After Laparoscopic Colorectal Surgery
A study testing Menthol Chewing Gum in people with Postoperative Nausea and Vomiting and Bowel Functions, run by Sennur Kula Şahin at 1 site in Turkey (Türkiye).
Trial summary
This randomized controlled trial was conducted to evaluate the effect of menthol chewing gum on postoperative nausea and vomiting, bowel function, and recovery in patients undergoing laparoscopic colorectal surgery. Read more about this study
- Who is it for?
- Ages 18 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Postoperative Nausea and Vomiting, Bowel Functions, Postoperative Recovery
- What is being tested?
- Menthol Chewing Gum
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Jan 2024to 25 Apr 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Aged 18-60 years
- Willing to participate in the study
- At least literate
- Able to communicate without cognitive, sensory, or verbal impairment
- No diagnosed psychiatric disorder
- No vertigo
Show all 12Show fewer
- Undergoing elective surgery
- Not using sedative, anxiolytic, or similar medications
- Able to speak Turkish
- Able to chew gum
- No allergy to menthol or mint
- No history of jaw or oral surgery
Who cannot join
- Absence of teeth
- Unwilling to chew gum
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Istinye University Medical Park Gaziosmanpasa Hospital
Istanbul, Istanbul, 34010
About this study
Official title: The Effect of Menthol Chewing Gum on Nausea and Vomiting, Bowel Function, and Recovery After Laparoscopic Colorectal Surgery: A Randomized Controlled Trial
This randomized controlled trial was conducted to evaluate the effect of menthol chewing gum on postoperative nausea and vomiting, bowel function, and recovery in patients undergoing laparoscopic colorectal surgery. A total of 50 patients were randomly assigned to an intervention group (n=25) or a control group (n=25). Participants in the intervention group received menthol chewing gum in addition to standard postoperative care, while participants in the control group received standard postoperative care only. Nausea, bowel function, and postoperative recovery were assessed during the first three postoperative days.
Read the detailed description
Postoperative nausea and vomiting and delayed return of bowel function are common concerns following laparoscopic colorectal surgery and may affect postoperative recovery. Chewing gum is a non-pharmacological intervention that may stimulate gastrointestinal activity.
This randomized controlled trial evaluated the effect of menthol chewing gum on postoperative nausea and vomiting, bowel function, and recovery in patients undergoing laparoscopic colorectal surgery. Participants were randomly allocated to an intervention group or a control group.
Both groups received routine postoperative treatment and nursing care. In the intervention group, participants chewed menthol gum for 30 minutes and repeated the intervention three hours later. The same procedure was applied on the first, second, and third postoperative days. Participants in the control group received routine postoperative treatment and care without menthol chewing gum.
Postoperative nausea, bowel function, and recovery status were evaluated during the first three postoperative days. Postoperative recovery was assessed using the Surgical Recovery Status Scale, and nausea intensity was assessed using a Visual Analog Scale.
- Being tested
- Menthol Chewing Gum
- Keywords
- Menthol Chewing Gum, Chewing Gum, Laparoscopic Colorectal Surgery, Postoperative Nausea and Vomiting, Bowel Function, Surgical Recovery, Nonpharmacological Intervention
- Medical subject headings
- Postoperative Nausea and Vomiting
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Menthol Chewing GumBehavioural
Participants chewed menthol gum for 30 minutes, followed by a second 30-minute chewing session three hours later. This intervention was repeated on postoperative days 1, 2, and 3 in addition to standard postoperative care.
| Study group | Role | What they receive |
|---|---|---|
| 1 | Experimental | Menthol Chewing Gum Group Receives: Behavioral: Menthol Chewing Gum |
| 2 | No intervention | Control Group |
What is being measured
The primary outcome is the main question the study is designed to answer.
Postoperative Nausea and Vomiting Frequency
The frequency of postoperative nausea and vomiting was recorded for each participant during the first three postoperative days. Higher values indicate a greater frequency of nausea and vomiting.
Measured: Postoperative days 1, 2, and 3
Secondary outcomes (1)
Postoperative Gas Passage Frequency
The frequency of defecation was recorded during the first three postoperative days as an indicator of postoperative bowel function.
Measured: Postoperative days 1, 2, and 3
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Sep 2026
- Study start15 Jan 2024
- Primary completion25 Apr 2024
- Study completion25 Apr 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Postoperative Nausea and VomitingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants were randomly assigned in a 1:1 ratio to either the menthol chewing gum group or the standard care control group.
- Masking
- Single blind
- Who is masked
- Care provider
- Enrolment
- 50 participants (actual)
Sponsor and investigators
- Lead sponsor
- Sennur Kula Şahin
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Sennur Kula Şahin, Istinye University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07796529
- Sponsor's protocol ID
- MCG-CRC-2024-01
- Status last verified
- Aug 2026
- First submitted
- 26 Aug 2026
- Last updated
- 1 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 1 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Menthol Chewing Gum on Nausea and Vomiting, Bowel Function, and Recovery After Laparoscopic Colorectal Surgery: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07796529
- Acronym / sponsor ID
- MCG-CRC-2024-01
- Keywords
- Menthol Chewing Gum, Chewing Gum, Laparoscopic Colorectal Surgery, Postoperative Nausea and Vomiting, Bowel Function, Surgical Recovery, Nonpharmacological Intervention
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- Sennur Kula ŞahinUniversity, hospital or other
- Study start
- 15 Jan 2024 (actual)
- Primary completion
- 25 Apr 2024 (actual)
- Study completion
- 25 Apr 2024 (actual)
- First posted
- 1 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial was conducted to evaluate the effect of menthol chewing gum on postoperative nausea and vomiting, bowel function, and recovery in patients undergoing laparoscopic colorectal surgery. A total of 50 patients were randomly assigned to an intervention group (n=25) or a control group (n=25). Participants in the intervention group received menthol chewing gum in addition to standard postoperative care, while participants in the control group received standard postoperative care only. Nausea, bowel function, and postoperative recovery were assessed during the first three postoperative days.
Detailed description
Postoperative nausea and vomiting and delayed return of bowel function are common concerns following laparoscopic colorectal surgery and may affect postoperative recovery. Chewing gum is a non-pharmacological intervention that may stimulate gastrointestinal activity.
This randomized controlled trial evaluated the effect of menthol chewing gum on postoperative nausea and vomiting, bowel function, and recovery in patients undergoing laparoscopic colorectal surgery. Participants were randomly allocated to an intervention group or a control group.
Both groups received routine postoperative treatment and nursing care. In the intervention group, participants chewed menthol gum for 30 minutes and repeated the intervention three hours later. The same procedure was applied on the first, second, and third postoperative days. Participants in the control group received routine postoperative treatment and care without menthol chewing gum.
Postoperative nausea, bowel function, and recovery status were evaluated during the first three postoperative days. Postoperative recovery was assessed using the Surgical Recovery Status Scale, and nausea intensity was assessed using a Visual Analog Scale.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (care provider)
- Number of arms
- 2
- Model description
- Participants were randomly assigned in a 1:1 ratio to either the menthol chewing gum group or the standard care control group.
| Arm | Type | Receives |
|---|---|---|
| 1 | Experimental | Behavioral: Menthol Chewing GumMenthol Chewing Gum Group |
| 2 | No intervention | –Control Group |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (12 listed)
- Aged 18-60 years
- Willing to participate in the study
- At least literate
- Able to communicate without cognitive, sensory, or verbal impairment
- No diagnosed psychiatric disorder
Key exclusion criteria (2 listed)
- Absence of teeth
- Unwilling to chew gum
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Menthol Chewing GumParticipants chewed menthol gum for 30 minutes, followed by a second 30-minute chewing session three hours later. This intervention was repeated on postoperative days 1, 2, and 3 in addition to standard postoperative care. | Behavioural | 1 |
Primary outcome
Postoperative Nausea and Vomiting Frequency
Time frame: Postoperative days 1, 2, and 3
The frequency of postoperative nausea and vomiting was recorded for each participant during the first three postoperative days. Higher values indicate a greater frequency of nausea and vomiting.
1 secondary outcome
Postoperative Gas Passage Frequency
Time frame: Postoperative days 1, 2, and 3
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Menthol Chewing Gum in people with Postoperative Nausea and Vomiting and Bowel Functions, run by Sennur Kula Şahin at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 12 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 1 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Postoperative Nausea and Vomiting Frequency (time frame: Postoperative days 1, 2, and 3). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Sep 2026.