Dentine Autograft in Extraction SocketNCT07798206
Comparison Between Dentine Autograft VS Platelet Rich Fibrin in Extraction Socket Bone Healing
A study testing DENTION AND PRF APPLICATION IN SOCKET and PLATETELT RICH FIBRIN IN EXTRACTION SOCKET in people with Dentine Autograft in Extraction Socket and Prf in Extraction Socket, run by Cairo University at 1 site in Egypt.
Trial summary
The present study will be performed to: evaluate alveolar bone healing using dentin autograft mixed with platelet-rich plasma in extraction socket vs graftless healing. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Dentine Autograft in Extraction Socket, Prf in Extraction Socket
- What is being tested?
- DENTION AND PRF APPLICATION IN SOCKET and PLATETELT RICH FIBRIN IN EXTRACTION SOCKET
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 45 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jan 2023to 1 Jul 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- 1. Patients with hopeless non molar teeth that need extraction. 2. Age above 18 years. 3. Generally good state of health. 4. Agreement to participate in the study and also have to be able to attend postoperative clinical and radiological follow-up 6. Acquisition of informed consent.
Who cannot join
- 1- Patients refuse to be enrolled in this study
- 2- Patients with uncontrolled systemic disease.
- 3- Previously diagnosed hematological and neurological conditions.
Trial locations and contacts
1 site in 1 country.
Egypt1 site
Faculty of Dentistry, Cairo University
Cairo, Cairo Governorate, 11553
About this study
Official title: Histomorphological Evaluation of Alveolar Bone Healing Using Dentin Autograft Mixed With Platelet-rich Fibrin in Extraction Socket vs Graftless Healing
The present study will be performed to:
evaluate alveolar bone healing using dentin autograft mixed with platelet-rich plasma in extraction socket vs graftless healing.
Read the detailed description
When teeth are extracted, a certain amount of bone loss or resorption occurs, usually about 30-60%. This loss is typically three-dimensional in nature, with width loss or horizontal deficiency developing to a greater extent than other types of deficiencies. An alveolar defect can be classified as the loss of labial or buccal cortical or medullary bone. In some cases, both exist. Although all alveolar defects present challenges when planning a dental implant procedure, if the defect is in the buccal cortex or cortical plate after tooth extraction, this can create significant difficulties in the reconstruction of a dental implant. Bone loss or bone augmentation techniques have been developed to counteract alveolar defects, such as guided bone regeneration, onlay block bone grafting, ridge/split bone grafting, and alveolar distraction osteogenesis. These procedures can help improve an alveolar defect and prepare the alveolar ridge for a successful dental implant.
- Being tested
- DENTION AND PRF APPLICATION IN SOCKET, PLATETELT RICH FIBRIN IN EXTRACTION SOCKET
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
DENTION AND PRF APPLICATION IN SOCKETProcedure or surgery
DENTION IS HARVESTED FROM NON RESTORABLE TOOTH TO BE GROUND AND MIXED WITH PRF TO BE APPLIED IN EXTRACTION SOCKETS < 1ST GROUP> PRF IS WITHDROWN FROM BLOOD AND CENTRIFUGED TO FORM A GRAFT TO BE APPLIED IN EXTRACTION SOCKETS <2ND GROUP> EXTRACTION SOCKETS ARE LEFT TO HEAL SPONTANUOUSLY
PLATETELT RICH FIBRIN IN EXTRACTION SOCKETProcedure or surgery
DENTION IS HARVESTED FROM NON RESTORABLE TOOTH TO BE GROUND AND MIXED WITH PRF TO BE APPLIED IN EXTRACTION SOCKETS < 1ST GROUP> PRF IS WITHDROWN FROM BLOOD AND CENTRIFUGED TO FORM A GRAFT TO BE APPLIED IN EXTRACTION SOCKETS <2ND GROUP> EXTRACTION SOCKETS ARE LEFT TO HEAL SPONTANUOUSLY
| Study group | Role | What they receive |
|---|---|---|
| Graftless Healing (Control) | No intervention | Participants undergo atraumatic extraction of a hopeless non-molar tooth. The extraction socket is left to heal spontaneously without placement of any grafting material. The socket is sutured with 3-0 Vicryl to allow primary wound closure. Clinical, radiographic, and histomorphometric evaluations are performed according to the study follow-up schedule. |
| Autogenous Dentin Graft Mixed with Platelet-Rich Plasma (PRP) | Experimental | Participants undergo atraumatic extraction of a hopeless non-molar tooth followed by immediate socket preservation using an autogenous dentin graft prepared from the extracted tooth. The dentin particles are processed using the Smart Dentin Grinder system, disinfected, rinsed with phosphate-buffered saline, and mixed with autologous platelet-rich plasma (PRP) to produce a sticky dentin graft. The graft is placed into the extraction socket, and the surgical site is sutured with 3-0 Vicryl. Clinical, radiographic, and histomorphometric outcomes are evaluated throughout the follow-up period. Receives: Procedure: DENTION AND PRF APPLICATION IN SOCKET |
| Platelets rich fibrin applied in the socket | Experimental | PRF from patient own blood is applied to the socket Receives: Procedure: PLATETELT RICH FIBRIN IN EXTRACTION SOCKET |
What is being measured
The primary outcome is the main question the study is designed to answer.
Histomorphometric bone formation (%)
a trephine bur is used to extract a sample from healed bone to be stained with H\&E and analyzed under microscope
Measured: 3-6 months
Secondary outcomes (1)
Bone density (radiographic) Healing index
type of bone is measerd on cbct scan after three months from healing of bone
Measured: 3-6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Sep 2026
- Study start1 Jan 2023
- Primary completion13 Jan 2026
- Study completion1 Jul 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Dentine Autograft in Extraction SocketStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 45 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Eman abdelbaki, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07798206
- Sponsor's protocol ID
- Dentine autograft vs PRF
- Status last verified
- Jul 2026
- First submitted
- 27 Aug 2026
- Last updated
- 1 Sep 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data (IPD) will not be shared because the study was not designed with participant-level data sharing. The collected data contain confidential information, and participants did not provide consent for public sharing of de-identified individual-level data. Only aggregate study results will be published.
Study at a glance
From the registry record, last updated by the sponsor on 1 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Histomorphological Evaluation of Alveolar Bone Healing Using Dentin Autograft Mixed With Platelet-rich Fibrin in Extraction Socket vs Graftless Healing
- ClinicalTrials.gov ID
- NCT07798206
- Acronym / sponsor ID
- Dentine autograft vs PRF
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 45 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 Jan 2023 (actual)
- Primary completion
- 13 Jan 2026 (actual)
- Study completion
- 1 Jul 2026 (actual)
- First posted
- 1 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The present study will be performed to:
evaluate alveolar bone healing using dentin autograft mixed with platelet-rich plasma in extraction socket vs graftless healing.
Detailed description
When teeth are extracted, a certain amount of bone loss or resorption occurs, usually about 30-60%. This loss is typically three-dimensional in nature, with width loss or horizontal deficiency developing to a greater extent than other types of deficiencies. An alveolar defect can be classified as the loss of labial or buccal cortical or medullary bone. In some cases, both exist. Although all alveolar defects present challenges when planning a dental implant procedure, if the defect is in the buccal cortex or cortical plate after tooth extraction, this can create significant difficulties in the reconstruction of a dental implant. Bone loss or bone augmentation techniques have been developed to counteract alveolar defects, such as guided bone regeneration, onlay block bone grafting, ridge/split bone grafting, and alveolar distraction osteogenesis. These procedures can help improve an alveolar defect and prepare the alveolar ridge for a successful dental implant.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Graftless Healing (Control) | No intervention | –Participants undergo atraumatic extraction of a hopeless non-molar tooth. The extraction socket is left to heal spontaneously without placement of any grafting material. The socket is sutured with 3-0 Vicryl to allow primary wound closure. Clinical, radiographic, and histomorphometric evaluations are performed according to the study follow-up schedule. |
| Autogenous Dentin Graft Mixed with Platelet-Rich Plasma (PRP) | Experimental | Procedure: DENTION AND PRF APPLICATION IN SOCKETParticipants undergo atraumatic extraction of a hopeless non-molar tooth followed by immediate socket preservation using an autogenous dentin graft prepared from the extracted tooth. The dentin particles are processed using the Smart Dentin Grinder system, disinfected, rinsed with phosphate-buffered saline, and mixed with autologous platelet-rich plasma (PRP) to produce a sticky dentin graft. The graft is placed into the extraction socket, and the surgical site is sutured with 3-0 Vicryl. Clinical, radiographic, and histomorphometric outcomes are evaluated throughout the follow-up period. |
| Platelets rich fibrin applied in the socket | Experimental | Procedure: PLATETELT RICH FIBRIN IN EXTRACTION SOCKETPRF from patient own blood is applied to the socket |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- 1. Patients with hopeless non molar teeth that need extraction. 2. Age above 18 years. 3. Generally good state of health. 4. Agreement to participate in the study and also have to be able to attend postoperative clinical and radiological follow-up 6. Acquisition of informed consent.
Key exclusion criteria (3 listed)
- 1- Patients refuse to be enrolled in this study
- 2- Patients with uncontrolled systemic disease.
- 3- Previously diagnosed hematological and neurological conditions.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| DENTION AND PRF APPLICATION IN SOCKETDENTION IS HARVESTED FROM NON RESTORABLE TOOTH TO BE GROUND AND MIXED WITH PRF TO BE APPLIED IN EXTRACTION SOCKETS < 1ST GROUP> PRF IS WITHDROWN FROM BLOOD AND CENTRIFUGED TO FORM A GRAFT TO BE APPLIED IN EXTRACTION SOCKETS <2ND GROUP> EXTRACTION SOCKETS ARE LEFT TO HEAL SPONTANUOUSLY | Procedure or surgery | Autogenous Dentin Graft Mixed with Platelet-Rich Plasma (PRP) |
| PLATETELT RICH FIBRIN IN EXTRACTION SOCKETDENTION IS HARVESTED FROM NON RESTORABLE TOOTH TO BE GROUND AND MIXED WITH PRF TO BE APPLIED IN EXTRACTION SOCKETS < 1ST GROUP> PRF IS WITHDROWN FROM BLOOD AND CENTRIFUGED TO FORM A GRAFT TO BE APPLIED IN EXTRACTION SOCKETS <2ND GROUP> EXTRACTION SOCKETS ARE LEFT TO HEAL SPONTANUOUSLY | Procedure or surgery | Platelets rich fibrin applied in the socket |
Primary outcome
Histomorphometric bone formation (%)
Time frame: 3-6 months
a trephine bur is used to extract a sample from healed bone to be stained with H\&E and analyzed under microscope
1 secondary outcome
Bone density (radiographic) Healing index
Time frame: 3-6 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Sep 2026.
- Individual participant dataSharing planned: No. Individual participant data (IPD) will not be shared because the study was not designed with participant-level data sharing. The collected data contain confidential information, and participants did not provide consent for public sharing of de-identified individual-level data. Only aggregate study results will be published.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing DENTION AND PRF APPLICATION IN SOCKET and PLATETELT RICH FIBRIN IN EXTRACTION SOCKET in people with Dentine Autograft in Extraction Socket and Prf in Extraction Socket, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 1 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Histomorphometric bone formation (%) (time frame: 3-6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Sep 2026.