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Shoulder PainNCT07798531

Anatomically-Guided Electroacupuncture Combined With Cupping for Shoulder Pain

A study testing Anatomically-guided electroacupuncture, Moving cupping therapy and Classical electroacupuncture in people with Shoulder Pain, run by University of Medicine and Pharmacy at Ho Chi Minh City at 1 site in Vietnam.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

This study compares two acupuncture-based treatments for shoulder pain. Adults with shoulder pain will be randomly assigned to one of two groups. One group will receive electroacupuncture at points chosen based on the anatomy of the painful muscle, combined with moving cupping therapy. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Shoulder Pain
What is being tested?
Anatomically-guided electroacupuncture, Moving cupping therapy and Classical electroacupuncture
Type of treatment
Surgery or procedure
Could I receive a placebo?
No, everyone receives an active treatment
How many people
70 participants
Where
1 siteVietnam
Study dates
22 Dec 2025to 31 Mar 2026
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Adults over 18 years of age
  • Diagnosed with shoulder pain according to ICD-10 codes M75.0-M75.9
  • No infectious or malignant disease of the shoulder
  • Willing to provide informed consent to participate

Who cannot join

  • Complete rotator cuff tear on imaging requiring surgical intervention
  • Currently receiving systemic corticosteroid therapy
  • Concurrently receiving acupuncture treatment at another facility
  • Contraindication to electroacupuncture or cupping therapy, including coagulation disorders, skin infection at the treatment site, or cardiac pacemaker

Trial locations and contacts

1 site in 1 country.

Vietnam1 site
  • Thong Nhat hospital

    Ho Chi Minh City, 70000

Other trials in Vietnam

About this study

Official title: "Anatomically-Guided Electroacupuncture Combined With Cupping for Pain Relief and Shoulder Function Recovery: A Randomized Controlled Trial"

This study compares two acupuncture-based treatments for shoulder pain. Adults with shoulder pain will be randomly assigned to one of two groups. One group will receive electroacupuncture at points chosen based on the anatomy of the painful muscle, combined with moving cupping therapy. The other group will receive electroacupuncture using a standard set of traditional acupuncture points. Both groups will receive daily treatment for 5 days. The main question is whether the combined treatment reduces pain and improves shoulder function more than standard electroacupuncture, measured using a shoulder pain and disability questionnaire completed before treatment and after each session.

Read the detailed description

This is a single-center, prospective, randomized controlled trial conducted at the Traditional Medicine Unit, Thong Nhat Hospital, Ho Chi Minh City, Vietnam, from December 2025 to March 2026. Seventy adults over 18 years of age diagnosed with mechanical shoulder pain (ICD-10 M75.0-M75.9) were assigned in a 1:1 ratio, using block randomization with sealed envelopes (block size of 10), to an intervention group (n=35) or a control group (n=35).

The intervention group received moving cupping therapy over the upper back and shoulder region for 10-15 minutes every other day (3 sessions total), followed by electroacupuncture at points selected according to the anatomical location of the affected muscle layer and the movement that provoked pain, applied at 60-100 Hz for 20 minutes once daily for 5 consecutive days. The control group received electroacupuncture using a standard set of classical acupuncture points at the same frequency, duration, and treatment schedule, without cupping.

The primary outcome is change in the Shoulder Pain and Disability Index (SPADI), which includes a pain subscale (5 items) and a disability subscale (8 items), assessed at baseline and after each of the 5 treatment sessions. Adverse events were monitored throughout the treatment period. Statistical analysis followed the intention-to-treat principle, using repeated-measures analysis of variance and linear mixed models to compare score trajectories between groups over time, adjusted for age, sex, and body mass index.

Conditions
Shoulder Pain
Being tested
Anatomically-guided electroacupuncture, Moving cupping therapy, Classical electroacupuncture
Keywords
electroacupuncture, cupping therapy, shoulder pain and disability index, myofascial trigger points, traditional medicine
Medical subject headings
Shoulder Pain

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Anatomically-guided electroacupunctureProcedure or surgery

    Electroacupuncture using filiform needles inserted at ashi points (tender points) selected according to the anatomical location of the affected shoulder muscle and the movement provoking pain (e.g., SI9, SI11, TE14, LI15, GB21, BL17). Needles were stimulated electrically at 60-100 Hz and retained for 20 minutes, once daily for 5 consecutive days.

  • Moving cupping therapyProcedure or surgery

    Moving cupping therapy applied over the upper back and shoulder region. Paraffin oil was applied to the skin, and a plastic cup (3-5 cm diameter) was moved along both sides of the thoracic spine, passing over the supraspinous and infraspinous fossae, using intermittent lifting to avoid localized bruising. Total duration 10-15 minutes per session, performed every other day for 3 sessions.

  • Classical electroacupunctureProcedure or surgery

    Electroacupuncture using filiform needles inserted at a standard set of classical acupuncture points following the protocol of the Vietnam Ministry of Health, including local points SI15, SI14, BL11, GB21, TE14, LI15, LI14, SI9, and SI11, plus distal points LI11, LI10, TE5, and LI4. Needles were stimulated electrically at 60-100 Hz, retained for 20 minutes, once daily for 5 consecutive days.

Study groups in NCT07798531
Study groupRoleWhat they receive
Anatomically-Guided Electroacupuncture Plus Moving CuppingExperimentalParticipants received moving cupping therapy over the upper back and shoulder for 10-15 minutes every other day (3 sessions), followed by electroacupuncture at points selected according to the anatomical location of the affected muscle and the movement provoking pain, at 60-100 Hz for 20 minutes once daily for 5 consecutive days.
Receives: Procedure: Anatomically-guided electroacupuncture; Procedure: Moving cupping therapy
Classical ElectroacupunctureActive comparatorParticipants received electroacupuncture using a standard set of classical acupuncture points (SI15, SI14, BL11, GB21, TE14, LI15, LI14, SI9, SI11, plus distal points LI11, LI10, TE5, LI4) at 60-100 Hz for 20 minutes once daily for 5 consecutive days.
Receives: Procedure: Classical electroacupuncture

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Change in Shoulder Pain and Disability Index (SPADI) Pain Subscale Score

    The SPADI pain subscale consists of 5 items, each scored 0-10, for a total raw score of 0-50, transformed to a 0-100 scale. Higher scores indicate greater pain severity. Assessed by patient self-report before treatment and after each of 5 daily treatment sessions.

    Measured: Baseline (T0), Day 1 (T1), Day 2 (T2), Day 3 (T3), Day 4 (T4), and Day 5 (T5)

  2. Change in Shoulder Pain and Disability Index (SPADI) Disability Subscale Score

    The SPADI disability subscale consists of 8 items assessing activities of daily living, each scored 0-10, for a total raw score of 0-80, transformed to a 0-100 scale. Higher scores indicate greater functional limitation. Assessed by patient self-report before treatment and after each of 5 daily treatment sessions.

    Measured: Baseline (T0), Day 1 (T1), Day 2 (T2), Day 3 (T3), Day 4 (T4), and Day 5 (T5)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted1 Sep 2026
  2. Study start22 Dec 2025
  3. Primary completion31 Mar 2026
  4. Study completion31 Mar 2026

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
70 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07798531
Sponsor's protocol ID
5365/ĐHYD- HĐĐĐ
Status last verified
Aug 2026
First submitted
27 Aug 2026
Last updated
1 Sep 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Yes: De-identified individual participant data underlying the results reported in this article, along with the study protocol, will be made available upon reasonable request to the corresponding author (Ly-Na T. Vu, vtlna@ump.edu.vn), for researchers who provide a methodologically sound proposal, beginning 9 months and ending 36 months after article publication. Data will be shared for the purpose of achieving the aims in the approved proposal, subject to a signed data access agreement.

Publications

  • Mohamed AA, Zhang X, Jan YK. Evidence-based and adverse-effects analyses of cupping therapy in musculoskeletal and sports rehabilitation: A systematic and evidence-based review. J Back Musculoskelet Rehabil. 2023;36(1):3-19. doi: 10.3233/BMR-210242.

    PubMed 35848010
  • Sun KO, Chan KC, Lo SL, Fong DY. Acupuncture for frozen shoulder. Hong Kong Med J. 2001 Dec;7(4):381-91.

    PubMed 11773673
  • Chen ZY, Wang MH, Ye Z. Effect of electroacupuncture combined with rehabilitation techniques on shoulder function in patients with rotator cuff injuries. World J Clin Cases. 2024 Jul 26;12(21):4582-4589. doi: 10.12998/wjcc.v12.i21.4582.

    PubMed 39070812
  • Sujithra TS, Mangayarkarasi N, Manavalan N, Prabu P. Efficacy of Cupping Therapy Compared to Acupuncture in Patients with Periarthritis of Shoulder: A Comparative Study. Alternative and Integrative Medicine. 2021;10(2).

  • Lauche R, Spitzer J, Schwahn B, Ostermann T, Bernardy K, Cramer H, Dobos G, Langhorst J. Efficacy of cupping therapy in patients with the fibromyalgia syndrome-a randomised placebo controlled trial. Sci Rep. 2016 Nov 17;6:37316. doi: 10.1038/srep37316.

    PubMed 27853272
  • Karamanlioglu DS, Kaysin MY, Begoglu FA, Akpinar P, Ozkan FU, Aktas I. Effects of acupuncture on pain and function in patients with subacromial impingement syndrome: A randomized sham-controlled trial. Integr Med Res. 2024 Jun;13(2):101049. doi: 10.1016/j.imr.2024.101049. Epub 2024 May 25.

    PubMed 38948487
  • Stör, J., Stör, W. Die Studienlage zur Akupunkturwirkung bei Schulter-Arm-Syndrom (beispielsweise Frozen Shoulder, Periarthritis humeroscapularis). Dtsch Z Akupunkt 60, 20-22 (2017). https://doi.org/10.1016/S0415-6412(17)30080-2

  • Guerra de Hoyos JA, Martin MDCA, Leon EBYB, Lopez MV, Lopez TM, Morilla FAV, Moreno MJG. Randomised trial of long term effect of acupuncture for shoulder pain. Pain. 2004 Dec;112(3):289-298. doi: 10.1016/j.pain.2004.08.030.

    PubMed 15561384
  • Dorsher, P.T., Schmid, O. & Fleckenstein, J. The "most common" myofascial trigger points and classical acupuncture points. Part 1. Dtsch Z Akupunkt 68, 58-70 (2025). https://doi.org/10.1007/s42212-025-00735-8

  • Molsberger AF, Schneider T, Gotthardt H, Drabik A. German Randomized Acupuncture Trial for chronic shoulder pain (GRASP) - a pragmatic, controlled, patient-blinded, multi-centre trial in an outpatient care environment. Pain. 2010 Oct;151(1):146-154. doi: 10.1016/j.pain.2010.06.036. Epub 2010 Jul 23.

    PubMed 20655660

Questions about this trial

What is this clinical trial studying?

A study testing Anatomically-guided electroacupuncture, Moving cupping therapy and Classical electroacupuncture in people with Shoulder Pain, run by University of Medicine and Pharmacy at Ho Chi Minh City at 1 site in Vietnam.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 1 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Vietnam. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Change in Shoulder Pain and Disability Index (SPADI) Pain Subscale Score (time frame: Baseline (T0), Day 1 (T1), Day 2 (T2), Day 3 (T3), Day 4 (T4), and Day 5 (T5)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07798531, which also lists 10 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Sep 2026.

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