MenopauseNCT07800793
Effects of a Mobile Game in Menopausal Women
A study testing Menopause Mobile Game in people with Menopause and Brain Fog, run by Medipol University at 1 site in Turkey (Türkiye).
Trial summary
The goal of this clinical trial is to evaluate the effect of a mobile game-based cognitive intervention on brain fog and psychological well-being in menopausal women aged 45-55 years. Read more about this study
- Who is it for?
- Ages 45 to 55 years, women only
- Conditions the study is for
- Menopause, Brain Fog, Psychological Well-being
- What is being tested?
- Menopause Mobile Game
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 82 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Oct 2026to 15 Dec 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 45 to 55 years
- Women only
- No healthy volunteers
- Adult
Who may be able to join
- Women aged 45-55 years
- Able to read and write in Turkish
- Able to use a smartphone (Android or iOS)
- Amenorrhea for at least 12 months
- Willing to participate and provide written informed consent
Who cannot join
- Diagnosis of serious neurological disorders such as dementia, Alzheimer's disease, epilepsy, or multiple sclerosis
- Diagnosis of severe psychiatric disorders such as major depression, bipolar disorder, or schizophrenia
- Regular use of medications that may significantly affect cognitive function, including antiepileptics, antiparkinsonian drugs, antipsychotics, or antidepressants
- Participation in cognitive training, memory training, or a similar digital intervention within the last 6 months
- Visual, auditory, or motor impairments that would prevent the use of the mobile application
- Participants scoring within the lowest 25% quartile (Q1) on the Brain Fog Scale
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site
İstanbul Medipol University Mega Hospital
Istanbul, Mrs
Nazire BAHAR, Lecturer, 905540070907, naziresel@gmail.com
Nazire BAHAR, Lecturer
About this study
Official title: The Effects of Mobile Gaming on Brain Fog and Psychological Well-Being Among Menopausal Women
The goal of this clinical trial is to evaluate the effect of a mobile game-based cognitive intervention on brain fog and psychological well-being in menopausal women aged 45-55 years. The main questions it aims to answer are:
Are Brain Fog Scale scores lower among women in the mobile game intervention group compared with women in the control group? Are Warwick-Edinburgh Mental Well-Being Scale scores higher among women in the mobile game intervention group compared with women in the control group? Do women participating in the mobile game intervention demonstrate greater reductions in Brain Fog Scale scores and greater improvements in Warwick-Edinburgh Mental Well-Being Scale scores after the intervention compared with their baseline measurements?
Read more
Researchers will compare participants receiving the mobile game-based cognitive intervention with participants receiving routine follow-up only to determine the effectiveness of the intervention on brain fog and psychological well-being.
Participants will:
Complete baseline assessments using the Brain Fog Scale and the Warwick-Edinburgh Mental Well-Being Scale.
Be randomly assigned to either the intervention group or the control group. Use the cognitive training mobile game for 15 minutes per day, 5 days per week, for 6 weeks if assigned to the intervention group.
Receive routine follow-up only if assigned to the control group. Complete post-intervention assessments at the end of the 6-week study period.
Read the detailed description
Menopause is a natural stage in a woman's life characterized by hormonal changes that may affect physical, psychological, and cognitive health. In addition to vasomotor symptoms, many women report cognitive difficulties during the menopausal transition, commonly referred to as "brain fog." Brain fog encompasses subjective experiences such as reduced concentration, forgetfulness, slower information processing, and difficulties in maintaining attention. These cognitive challenges may negatively influence daily functioning, work productivity, self-confidence, and overall quality of life.
Psychological well-being is another important aspect of women's health during menopause. Hormonal fluctuations, aging-related changes, and psychosocial factors may contribute to declines in well-being. Cognitive difficulties and psychological well-being are closely interrelated, as persistent cognitive concerns may increase emotional distress and negatively affect individuals' perceptions of their mental health and well-being.
Digital health interventions have gained increasing attention as accessible and scalable approaches for supporting health promotion and symptom management. Among these interventions, mobile games offer opportunities to engage users through interactive and motivating activities while facilitating learning and cognitive stimulation. Cognitive training exercises delivered through mobile games may support cognitive functions such as attention, working memory, cognitive flexibility, verbal fluency, and visual memory. However, evidence regarding the effectiveness of mobile game-based cognitive interventions specifically designed for menopausal women remains limited.
The mobile game used in this study was developed to provide cognitive training through gamified activities targeting multiple cognitive domains. The intervention incorporates structured exercises intended to support attention, memory, problem-solving, and cognitive flexibility while promoting sustained engagement through an interactive digital format.
This study will investigate whether participation in a mobile game-based cognitive intervention can improve cognitive functioning related to brain fog and enhance psychological well-being among menopausal women. The findings are expected to contribute to the growing evidence base on non-pharmacological digital interventions and may support the development of accessible, low-cost, and sustainable approaches for promoting cognitive and psychological health during menopause.
- Conditions
- Menopause, Brain Fog, Psychological Well-being
- Being tested
- Menopause Mobile Game
- Keywords
- menopause, brain fog, psychological well-being
- Medical subject headings
- Mental Fatigue, Psychological Well-Being
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Menopause Mobile GameBehavioural
Also called Menopause Education and Self-Management Mobile Game
Participants in the intervention group will use a mobile game specifically designed for menopausal women to support cognitive functioning. The game includes interactive exercises and activities targeting attention, memory, processing speed, and other cognitive skills. Participants will use the mobile game throughout the intervention period in addition to routine care.
| Study group | Role | What they receive |
|---|---|---|
| Menopause Mobile Game Intervention | Experimental | Participants will use a mobile game developed to address brain fog symptoms during menopause. Receives: Behavioral: Menopause Mobile Game |
| Routine Care Control | No intervention | Participants will receive routine care and will not use the mobile game during the study period. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Brain fog
Change in Brain Fog Scale total score from baseline to post-intervention. The Brain Fog Scale is a 30-item instrument assessing cognitive, physical, and psychological symptoms of brain fog. Total scores range from 30 to 150, with higher scores indicating greater brain fog severity (worse outcome).
Measured: Baseline and Week 6
Secondary outcomes (1)
Change in Warwick-Edinburgh Mental Well-Being
The effect of the mobile game intervention on psychological well-being among menopausal women will be assessed using the Warwick-Edinburgh Mental Well-Being Scale. Total scores range from 14 to 70, with higher scores indicating better mental well-being. Changes in total scores from baseline to Week 6 will be evaluated.
Measured: Baseline and Week 6
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Sep 2026
- Study start15 Oct 2026 (estimated)
- Primary completion15 Sep 2027 (estimated)
- Study completion15 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for MenopauseStudies of the same condition, open and under way.
- More trials run by Medipol UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 82 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Medipol University
- Sponsor type
- University, hospital or other
- Collaborators
- Istanbul University - Cerrahpasa
- Responsible party
- Principal investigator, Nazire Bahar, Medipol University
- Investigators
- Nazire BAHAR, Principal investigator, Istanbul Universitesi-Cerrahpasa
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07800793
- Sponsor's protocol ID
- E-10840098-50.04-5261
- Status last verified
- Aug 2026
- First submitted
- 30 Aug 2026
- Last updated
- 17 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data (IPD) will not be publicly shared because the study involves sensitive health-related information collected from participants. Data will be used solely for the purposes of this research and will be reported in aggregate form to protect participant confidentiality.
Study at a glance
From the registry record, last updated by the sponsor on 17 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effects of Mobile Gaming on Brain Fog and Psychological Well-Being Among Menopausal Women
- ClinicalTrials.gov ID
- NCT07800793
- Acronym / sponsor ID
- E-10840098-50.04-5261
- Conditions
- Menopause, Brain Fog, Psychological Well-being
- Keywords
- menopause, brain fog, psychological well-being
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 82 participants (estimated)
- Lead sponsor
- Medipol UniversityUniversity, hospital or other
- Collaborators
- Istanbul University - Cerrahpasa
- Study start
- 15 Oct 2026 (estimated)
- Primary completion
- 15 Sep 2027 (estimated)
- Study completion
- 15 Dec 2027 (estimated)
- First posted
- 2 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to evaluate the effect of a mobile game-based cognitive intervention on brain fog and psychological well-being in menopausal women aged 45-55 years. The main questions it aims to answer are:
Are Brain Fog Scale scores lower among women in the mobile game intervention group compared with women in the control group? Are Warwick-Edinburgh Mental Well-Being Scale scores higher among women in the mobile game intervention group compared with women in the control group? Do women participating in the mobile game intervention demonstrate greater reductions in Brain Fog Scale scores and greater improvements in Warwick-Edinburgh Mental Well-Being Scale scores after the intervention compared with their baseline measurements?
Researchers will compare participants receiving the mobile game-based cognitive intervention with participants receiving routine follow-up only to determine the effectiveness of the intervention on brain fog and psychological well-being.
Participants will:
Complete baseline assessments using the Brain Fog Scale and the Warwick-Edinburgh Mental Well-Being Scale.
Be randomly assigned to either the intervention group or the control group. Use the cognitive training mobile game for 15 minutes per day, 5 days per week, for 6 weeks if assigned to the intervention group.
Receive routine follow-up only if assigned to the control group. Complete post-intervention assessments at the end of the 6-week study period.
Detailed description
Menopause is a natural stage in a woman's life characterized by hormonal changes that may affect physical, psychological, and cognitive health. In addition to vasomotor symptoms, many women report cognitive difficulties during the menopausal transition, commonly referred to as "brain fog." Brain fog encompasses subjective experiences such as reduced concentration, forgetfulness, slower information processing, and difficulties in maintaining attention. These cognitive challenges may negatively influence daily functioning, work productivity, self-confidence, and overall quality of life.
Psychological well-being is another important aspect of women's health during menopause. Hormonal fluctuations, aging-related changes, and psychosocial factors may contribute to declines in well-being. Cognitive difficulties and psychological well-being are closely interrelated, as persistent cognitive concerns may increase emotional distress and negatively affect individuals' perceptions of their mental health and well-being.
Digital health interventions have gained increasing attention as accessible and scalable approaches for supporting health promotion and symptom management. Among these interventions, mobile games offer opportunities to engage users through interactive and motivating activities while facilitating learning and cognitive stimulation. Cognitive training exercises delivered through mobile games may support cognitive functions such as attention, working memory, cognitive flexibility, verbal fluency, and visual memory. However, evidence regarding the effectiveness of mobile game-based cognitive interventions specifically designed for menopausal women remains limited.
The mobile game used in this study was developed to provide cognitive training through gamified activities targeting multiple cognitive domains. The intervention incorporates structured exercises intended to support attention, memory, problem-solving, and cognitive flexibility while promoting sustained engagement through an interactive digital format.
This study will investigate whether participation in a mobile game-based cognitive intervention can improve cognitive functioning related to brain fog and enhance psychological well-being among menopausal women. The findings are expected to contribute to the growing evidence base on non-pharmacological digital interventions and may support the development of accessible, low-cost, and sustainable approaches for promoting cognitive and psychological health during menopause.
Study design
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Menopause Mobile Game Intervention | Experimental | Behavioral: Menopause Mobile GameParticipants will use a mobile game developed to address brain fog symptoms during menopause. |
| Routine Care Control | No intervention | –Participants will receive routine care and will not use the mobile game during the study period. |
Who may qualify
- Ages
- 45 to 55 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Women aged 45-55 years
- Able to read and write in Turkish
- Able to use a smartphone (Android or iOS)
- Amenorrhea for at least 12 months
- Willing to participate and provide written informed consent
Key exclusion criteria (6 listed)
- Diagnosis of serious neurological disorders such as dementia, Alzheimer's disease, epilepsy, or multiple sclerosis
- Diagnosis of severe psychiatric disorders such as major depression, bipolar disorder, or schizophrenia
- Regular use of medications that may significantly affect cognitive function, including antiepileptics, antiparkinsonian drugs, antipsychotics, or antidepressants
- Participation in cognitive training, memory training, or a similar digital intervention within the last 6 months
- Visual, auditory, or motor impairments that would prevent the use of the mobile application
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Menopause Mobile GameAlso: Menopause Education and Self-Management Mobile GameParticipants in the intervention group will use a mobile game specifically designed for menopausal women to support cognitive functioning. The game includes interactive exercises and activities targeting attention, memory, processing speed, and other cognitive skills. Participants will use the mobile game throughout the intervention period in addition to routine care. | Behavioural | Menopause Mobile Game Intervention |
Primary outcome
Brain fog
Time frame: Baseline and Week 6
Change in Brain Fog Scale total score from baseline to post-intervention. The Brain Fog Scale is a 30-item instrument assessing cognitive, physical, and psychological symptoms of brain fog. Total scores range from 30 to 150, with higher scores indicating greater brain fog severity (worse outcome).
1 secondary outcome
Change in Warwick-Edinburgh Mental Well-Being
Time frame: Baseline and Week 6
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Sep 2026.
- Individual participant dataSharing planned: No. Individual participant data (IPD) will not be publicly shared because the study involves sensitive health-related information collected from participants. Data will be used solely for the purposes of this research and will be reported in aggregate form to protect participant confidentiality.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Nazire BAHAR principal investigator
Istanbul Universitesi-Cerrahpasa
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Menopause Mobile Game in people with Menopause and Brain Fog, run by Medipol University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 17 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Nazire BAHAR (905540070907, naziresel@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Brain fog (time frame: Baseline and Week 6). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Sep 2026.