Prolonged SittingNCT07802574
Effects of Interrupting Prolonged Sitting With Different Standing Intervals on Vascular Health in Women
A study testing Short Standing Interval, Continuous Standing Interval and Intermittent Standing Interval in people with Prolonged Sitting and Vascular Health, run by King Saud University at 1 site in Saudi Arabia.
Trial summary
The goal of this clinical trial is to examine the effects of interrupting prolonged sitting with different standing intervals on vascular health in healthy women aged 18-45 years. Read more about this study
- Who is it for?
- Ages 18 to 45 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Prolonged Sitting, Vascular Health, Sedentary Behavior
- What is being tested?
- Short Standing Interval, Continuous Standing Interval and Intermittent Standing Interval
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 21 participants
- Where
- 1 siteSaudi Arabia
- Study dates
- 2 Apr 2026to 20 May 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- Women only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Female participants aged 18-45 years.
- Healthy individuals with normal blood pressure levels (systolic blood pressure <130 mmHg and diastolic blood pressure <80 mmHg).
- Body mass index (BMI) less than 30 kg/m².
- Ability to stand without support.
- No history of cardiovascular disease or chronic diseases that may affect study outcomes.
Who cannot join
- Pregnancy or breastfeeding.
- Back injuries preventing prolonged sitting.
- Use of medications that may affect cardiovascular responses, including antihypertensive, antidiabetic, antidepressant, or hormonal medications.
- Presence of chronic diseases or cardiovascular conditions affecting vascular health.
Trial locations and contacts
1 site in 1 country.
About this study
The goal of this clinical trial is to examine the effects of interrupting prolonged sitting with different standing intervals on vascular health in healthy women aged 18-45 years. The main questions it aims to answer are:
Does interrupting prolonged sitting with short standing intervals (10 minutes every hour) improve blood pressure and pulse wave velocity more than prolonged continuous standing intervals (30 minutes every hour)? Does interrupting prolonged sitting with prolonged intermittent standing intervals (30 minutes every hour divided into three 10-minute standing bouts) improve blood pressure and pulse wave velocity more than prolonged continuous standing intervals (30 minutes every hour)?
Read more
The researcher will compare three different sitting interruption conditions to evaluate their effects on vascular health outcomes:
Standing for 10 minutes every hour. Continuous standing for 30 minutes every hour. Intermittent standing for 30 minutes every hour divided into three 10-minute standing bouts.
Participants will:
Attend three experimental sessions in random order separated by at least 7 days.
Complete 3 hours of sitting with different standing interruption protocols. Undergo measurements of blood pressure, pulse wave velocity, and heart rate before sitting and after each hour of the experiment.
Undergo height, weight, and body mass index measurements.
- Conditions
- Prolonged Sitting, Vascular Health, Sedentary Behavior
- Being tested
- Short Standing Interval, Continuous Standing Interval, Intermittent Standing Interval
- Medical subject headings
- Sedentary Behavior
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Short Standing IntervalBehavioural
Participants will interrupt prolonged sitting with 10 minutes of standing every hour during 3 hours of sitting.
Continuous Standing IntervalBehavioural
Participants will interrupt prolonged sitting with 30 continuous minutes of standing every hour during 3 hours of sitting.
Intermittent Standing IntervalBehavioural
Participants will interrupt prolonged sitting with 30 minutes of standing every hour divided into three 10-minute standing bouts during 3 hours of sitting.
| Study group | Role | What they receive |
|---|---|---|
| Short Standing Interval | Experimental | Participants will complete 3 hours of sitting interrupted with 10 minutes of standing every hour. Receives: Behavioral: Short Standing Interval |
| Continuous Standing Interval | Experimental | Participants will complete 3 hours of sitting interrupted with 30 continuous minutes of standing every hour. Receives: Behavioral: Continuous Standing Interval |
| Intermittent Standing Interval | Experimental | Participants will complete 3 hours of sitting interrupted with 30 minutes of standing every hour divided into three 10-minute standing bouts. Receives: Behavioral: Intermittent Standing Interval |
What is being measured
The primary outcome is the main question the study is designed to answer.
Blood Pressure
Systolic and diastolic blood pressure will be measured before sitting and after each hour during the experimental sessions.
Measured: Baseline, 1 hour, 2 hours, and 3 hours
Pulse Wave Velocity
Measured: Baseline, 1 hour, 2 hours, and 3 hours
Heart Rate
Measured: Baseline, 1 hour, 2 hours, and 3 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Sep 2026
- Study start2 Apr 2026
- Primary completion20 May 2026
- Study completion20 May 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Prolonged SittingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- Participants will complete three experimental conditions in random order using a randomized crossover design. Each participant will undergo all three sitting interruption protocols with at least 7 days between sessions.
- Masking
- None (open label)
- Enrolment
- 21 participants (actual)
Sponsor and investigators
- Lead sponsor
- King Saud University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Bushra Khalid Alharbi, King Saud University
- Investigators
- Abdullah B Alansare, PhD, Study chair, King Saud University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07802574
- Sponsor's protocol ID
- E-25-10479
- Status last verified
- Oct 2026
- First submitted
- 31 Aug 2026
- Last updated
- 9 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 9 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Interrupting Prolonged Sitting With Different Standing Intervals on Vascular Health in Women
- ClinicalTrials.gov ID
- NCT07802574
- Acronym / sponsor ID
- E-25-10479
- Conditions
- Prolonged Sitting, Vascular Health, Sedentary Behavior
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 21 participants (actual)
- Lead sponsor
- King Saud UniversityUniversity, hospital or other
- Study start
- 2 Apr 2026 (actual)
- Primary completion
- 20 May 2026 (actual)
- Study completion
- 20 May 2026 (actual)
- First posted
- 3 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to examine the effects of interrupting prolonged sitting with different standing intervals on vascular health in healthy women aged 18-45 years. The main questions it aims to answer are:
Does interrupting prolonged sitting with short standing intervals (10 minutes every hour) improve blood pressure and pulse wave velocity more than prolonged continuous standing intervals (30 minutes every hour)? Does interrupting prolonged sitting with prolonged intermittent standing intervals (30 minutes every hour divided into three 10-minute standing bouts) improve blood pressure and pulse wave velocity more than prolonged continuous standing intervals (30 minutes every hour)?
The researcher will compare three different sitting interruption conditions to evaluate their effects on vascular health outcomes:
Standing for 10 minutes every hour. Continuous standing for 30 minutes every hour. Intermittent standing for 30 minutes every hour divided into three 10-minute standing bouts.
Participants will:
Attend three experimental sessions in random order separated by at least 7 days.
Complete 3 hours of sitting with different standing interruption protocols. Undergo measurements of blood pressure, pulse wave velocity, and heart rate before sitting and after each hour of the experiment.
Undergo height, weight, and body mass index measurements.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 3
- Model description
- Participants will complete three experimental conditions in random order using a randomized crossover design. Each participant will undergo all three sitting interruption protocols with at least 7 days between sessions.
| Arm | Type | Receives |
|---|---|---|
| Short Standing Interval | Experimental | Behavioral: Short Standing IntervalParticipants will complete 3 hours of sitting interrupted with 10 minutes of standing every hour. |
| Continuous Standing Interval | Experimental | Behavioral: Continuous Standing IntervalParticipants will complete 3 hours of sitting interrupted with 30 continuous minutes of standing every hour. |
| Intermittent Standing Interval | Experimental | Behavioral: Intermittent Standing IntervalParticipants will complete 3 hours of sitting interrupted with 30 minutes of standing every hour divided into three 10-minute standing bouts. |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Female participants aged 18-45 years.
- Healthy individuals with normal blood pressure levels (systolic blood pressure <130 mmHg and diastolic blood pressure <80 mmHg).
- Body mass index (BMI) less than 30 kg/m².
- Ability to stand without support.
- No history of cardiovascular disease or chronic diseases that may affect study outcomes.
Key exclusion criteria (4 listed)
- Pregnancy or breastfeeding.
- Back injuries preventing prolonged sitting.
- Use of medications that may affect cardiovascular responses, including antihypertensive, antidiabetic, antidepressant, or hormonal medications.
- Presence of chronic diseases or cardiovascular conditions affecting vascular health.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Short Standing IntervalParticipants will interrupt prolonged sitting with 10 minutes of standing every hour during 3 hours of sitting. | Behavioural | Short Standing Interval |
| Continuous Standing IntervalParticipants will interrupt prolonged sitting with 30 continuous minutes of standing every hour during 3 hours of sitting. | Behavioural | Continuous Standing Interval |
| Intermittent Standing IntervalParticipants will interrupt prolonged sitting with 30 minutes of standing every hour divided into three 10-minute standing bouts during 3 hours of sitting. | Behavioural | Intermittent Standing Interval |
Primary outcome
Blood Pressure
Time frame: Baseline, 1 hour, 2 hours, and 3 hours
Systolic and diastolic blood pressure will be measured before sitting and after each hour during the experimental sessions.
Pulse Wave Velocity
Time frame: Baseline, 1 hour, 2 hours, and 3 hours
Heart Rate
Time frame: Baseline, 1 hour, 2 hours, and 3 hours
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Oct 2026.
- Individual participant dataSharing planned: Undecided
Related trials for Prolonged Sitting
Recruiting
Effect of Chocolate Consumption Prior to Prolonged Sitting on Cardiovascular Health in Young Women
Cardiovascular Health During Prolonged Sitting
Recruiting
Frequency of Interrupting Sitting and Cognitive Function
Sedentary Behaviors, Breaking Prolonged Sitting With Physical Activity
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Abdullah B Alansare, PhD study chair
King Saud University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Short Standing Interval, Continuous Standing Interval and Intermittent Standing Interval in people with Prolonged Sitting and Vascular Health, run by King Saud University at 1 site in Saudi Arabia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 9 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Saudi Arabia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Blood Pressure (time frame: Baseline, 1 hour, 2 hours, and 3 hours). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Oct 2026; AzTrials last refreshed its copy on 1 Nov 2026.