Exercise PhysiologyILEXNCT07805772
Effects of Different Exercise Types on Irisin, Leptin, and Ghrelin Levels in Sedentary Women
A study testing Aerobic Exercise, Anaerobic Exercise and High-Intensity Interval Training (HIIT) in people with Exercise Physiology and Metabolic Hormones, run by Inonu University at 1 site in Turkey (Türkiye).
Trial summary
This interventional study aims to investigate the acute effects of three different exercise modalities-aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT)-on irisin, leptin, and ghrelin levels in sedentary women. A total of 20 sedentary women will participate in the study. Read more about this study
- Who is it for?
- Ages 18 to 24 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Exercise Physiology, Metabolic Hormones
- What is being tested?
- Aerobic Exercise, Anaerobic Exercise and High-Intensity Interval Training (HIIT)
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 5 Nov 2026to 30 Nov 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 24 years
- Women only
- Healthy volunteers accepted
- Adult
Inclusion Criteria: Female participants Sedentary individuals Voluntary participation in the study Ability and willingness to complete the planned exercise sessions
Exclusion Criteria: Inability to participate in the planned exercise sessions Withdrawal of consent or unwillingness to continue participation
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site
Exercise Physiology Laboratory, Faculty of Sport Sciences, Karabuk University
Karabük, Karabük Province
musa şahin, PhD, +905549755058, musasahin@karabuk.edu.tr
About this study
Official title: Investigation of the Effects of Different Types of Exercise on Irisin, Leptin, and Ghrelin Levels in Sedentary Women
This interventional study aims to investigate the acute effects of three different exercise modalities-aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT)-on irisin, leptin, and ghrelin levels in sedentary women. A total of 20 sedentary women will participate in the study. Hormonal responses will be evaluated in relation to the exercise sessions to determine exercise-induced changes in irisin, leptin, and ghrelin and to compare the responses associated with the three exercise modalities.
Read the detailed description
This interventional study is designed to investigate and compare the acute effects of aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT) on irisin, leptin, and ghrelin levels in sedentary women. A total of 20 sedentary women will participate in the study.
Participants will complete three different exercise conditions: aerobic exercise, anaerobic exercise, and HIIT. Irisin, leptin, and ghrelin levels will be evaluated in relation to each exercise condition to determine acute exercise-induced hormonal responses. The study will compare changes in these biomarkers across the three exercise modalities to determine whether the hormonal responses differ according to exercise type.
The study is intended to provide a better understanding of the acute endocrine and metabolic responses to exercise modalities with different physiological demands in sedentary women, with particular emphasis on irisin, leptin, and ghrelin.
- Conditions
- Exercise Physiology, Metabolic Hormones
- Being tested
- Aerobic Exercise, Anaerobic Exercise, High-Intensity Interval Training (HIIT)
- Keywords
- Irisin, Leptin, Ghrelin, Sedentary Women
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Aerobic ExerciseBehavioural
Participants will complete an aerobic exercise session as one of the three exercise conditions. Irisin, leptin, and ghrelin levels will be assessed in relation to the exercise session to determine the acute hormonal response to aerobic exercise.
Anaerobic ExerciseBehavioural
Participants will complete an anaerobic exercise session as one of the three exercise conditions. Irisin, leptin, and ghrelin levels will be assessed in relation to the exercise session to determine the acute hormonal response to anaerobic exercise.
High-Intensity Interval Training (HIIT)Behavioural
Participants will complete a high-intensity interval training (HIIT) session as one of the three exercise conditions. Irisin, leptin, and ghrelin levels will be assessed in relation to the exercise session to determine the acute hormonal response to HIIT.
| Study group | Role | What they receive |
|---|---|---|
| Multiple Exercise Modalities | Experimental | Participants in this arm will complete three different exercise conditions in separate sessions: aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT). Irisin, leptin, and ghrelin levels will be assessed in relation to each exercise condition to evaluate and compare acute hormonal responses across the three exercise modalities. Receives: Behavioral: Aerobic Exercise; Behavioral: Anaerobic Exercise; Behavioral: High-Intensity Interval Training (HIIT) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Irisin Level
Irisin levels will be assessed in relation to each exercise condition to determine the change in circulating irisin levels associated with aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT)
Measured: Pre-exercise and immediately post-exercise during each exercise session
Change in Leptin Level
Leptin levels will be assessed in relation to each exercise condition to determine the change in circulating leptin levels associated with aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT).
Measured: Pre-exercise and immediately post-exercise during each exercise session
Change in Ghrelin Level
Ghrelin levels will be assessed in relation to each exercise condition to determine the change in circulating ghrelin levels associated with aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT).
Measured: Pre-exercise and immediately post-exercise during each exercise session
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Sep 2026
- Study start5 Nov 2026 (estimated)
- Primary completion25 Nov 2026 (estimated)
- Study completion30 Nov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Exercise PhysiologyStudies of the same condition, open and under way.
- More trials run by Inonu UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- All participants will complete three exercise conditions-aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT)-in separate sessions. Each participant will therefore serve as her own control, allowing within-participant comparisons of irisin, leptin, and ghrelin responses across the three exercise modalities.
- Masking
- None (open label)
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Inonu University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Assoc. Prof. Dr. Özgür EKEN, Inonu University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07805772
- Sponsor's protocol ID
- IRISIN-LEPTIN-2026-248
- Acronym
- ILEX
- Status last verified
- Oct 2026
- First submitted
- 1 Sep 2026
- Last updated
- 27 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: There is no plan to make individual participant data (IPD) available to other researchers.
Study at a glance
From the registry record, last updated by the sponsor on 27 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigation of the Effects of Different Types of Exercise on Irisin, Leptin, and Ghrelin Levels in Sedentary Women
- ClinicalTrials.gov ID
- NCT07805772
- Acronym / sponsor ID
- ILEX / IRISIN-LEPTIN-2026-248
- Conditions
- Exercise Physiology, Metabolic Hormones
- Keywords
- Irisin, Leptin, Ghrelin, Sedentary Women
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- Inonu UniversityUniversity, hospital or other
- Study start
- 5 Nov 2026 (estimated)
- Primary completion
- 25 Nov 2026 (estimated)
- Study completion
- 30 Nov 2026 (estimated)
- First posted
- 4 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This interventional study aims to investigate the acute effects of three different exercise modalities-aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT)-on irisin, leptin, and ghrelin levels in sedentary women. A total of 20 sedentary women will participate in the study. Hormonal responses will be evaluated in relation to the exercise sessions to determine exercise-induced changes in irisin, leptin, and ghrelin and to compare the responses associated with the three exercise modalities.
Detailed description
This interventional study is designed to investigate and compare the acute effects of aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT) on irisin, leptin, and ghrelin levels in sedentary women. A total of 20 sedentary women will participate in the study.
Participants will complete three different exercise conditions: aerobic exercise, anaerobic exercise, and HIIT. Irisin, leptin, and ghrelin levels will be evaluated in relation to each exercise condition to determine acute exercise-induced hormonal responses. The study will compare changes in these biomarkers across the three exercise modalities to determine whether the hormonal responses differ according to exercise type.
The study is intended to provide a better understanding of the acute endocrine and metabolic responses to exercise modalities with different physiological demands in sedentary women, with particular emphasis on irisin, leptin, and ghrelin.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- All participants will complete three exercise conditions-aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT)-in separate sessions. Each participant will therefore serve as her own control, allowing within-participant comparisons of irisin, leptin, and ghrelin responses across the three exercise modalities.
| Arm | Type | Receives |
|---|---|---|
| Multiple Exercise Modalities | Experimental | Behavioral: Aerobic Exercise, Behavioral: Anaerobic Exercise, Behavioral: High-Intensity Interval Training (HIIT)Participants in this arm will complete three different exercise conditions in separate sessions: aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT). Irisin, leptin, and ghrelin levels will be assessed in relation to each exercise condition to evaluate and compare acute hormonal responses across the three exercise modalities. |
Who may qualify
- Ages
- 18 to 24 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Aerobic ExerciseParticipants will complete an aerobic exercise session as one of the three exercise conditions. Irisin, leptin, and ghrelin levels will be assessed in relation to the exercise session to determine the acute hormonal response to aerobic exercise. | Behavioural | Multiple Exercise Modalities |
| Anaerobic ExerciseParticipants will complete an anaerobic exercise session as one of the three exercise conditions. Irisin, leptin, and ghrelin levels will be assessed in relation to the exercise session to determine the acute hormonal response to anaerobic exercise. | Behavioural | Multiple Exercise Modalities |
| High-Intensity Interval Training (HIIT)Participants will complete a high-intensity interval training (HIIT) session as one of the three exercise conditions. Irisin, leptin, and ghrelin levels will be assessed in relation to the exercise session to determine the acute hormonal response to HIIT. | Behavioural | Multiple Exercise Modalities |
Primary outcome
Change in Irisin Level
Time frame: Pre-exercise and immediately post-exercise during each exercise session
Irisin levels will be assessed in relation to each exercise condition to determine the change in circulating irisin levels associated with aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT)
Change in Leptin Level
Time frame: Pre-exercise and immediately post-exercise during each exercise session
Leptin levels will be assessed in relation to each exercise condition to determine the change in circulating leptin levels associated with aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT).
Change in Ghrelin Level
Time frame: Pre-exercise and immediately post-exercise during each exercise session
Ghrelin levels will be assessed in relation to each exercise condition to determine the change in circulating ghrelin levels associated with aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT).
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Oct 2026.
- Individual participant dataSharing planned: No. There is no plan to make individual participant data (IPD) available to other researchers.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Aerobic Exercise, Anaerobic Exercise and High-Intensity Interval Training (HIIT) in people with Exercise Physiology and Metabolic Hormones, run by Inonu University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 27 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Özgür EKEN, PhD (+905532132795, ozgur.eken@inonu.edu.tr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Irisin Level (time frame: Pre-exercise and immediately post-exercise during each exercise session). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Oct 2026.