Lower Extremity AnatomyNCT07805902
Anatomical Probability Model for Tibial and Peroneal Motor Entry Points
An observational study of Lower Extremity Anatomy and Peripheral Nerve Anatomy, run by Research Inc at 1 site in Colombia.
Trial summary
This completed descriptive cadaveric study mapped the motor entry points of lower-leg muscles supplied by the tibial, superficial peroneal, and deep peroneal nerves. Twenty fresh-frozen adult lower-limb specimens without prior trauma or surgery were examined. One extremity from each cadaver was selected by coin toss. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Lower Extremity Anatomy, Peripheral Nerve Anatomy, Surgical Anatomy
- What is being tested?
- Standardized Cadaveric Lower-Limb Dissection
- How many people
- 20 participants
- Where
- 1 siteColombia
- Study dates
- 1 Oct 2026to 2 Oct 2026
- How long will I take part?
- 1 Day
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Fresh-frozen adult cadaveric lower-limb specimens available through the institutional cadaveric program at CLEMI in Cundinamarca, Colombia. Specimens were selected according to institutional procurement standards and were required to have no prior trauma or surgical intervention involving the lower limbs. One extremity per cadaver was selected by coin toss for dissection.
Who may be able to join
- Adult cadaveric specimen (age at death 18 years or older)
- Fresh-frozen lower-limb specimen made available under institutional standards for cadaveric research
- No prior trauma involving the selected lower limb
- No prior surgical intervention involving the selected lower limb
Who cannot join
- Cadaveric specimen from an individual younger than 18 years at death
- Prior trauma involving the lower limb
- Prior surgical intervention involving the lower limb
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Colombia1 site
entro Latinoamericano de Investigación y Entrenamiento en Cirugía Mínimamente Invasiva (CLEMI)
Bogotá
MARIA F GARCIA RUEDA, MD, Orthopedist, +573208541343, m-garciar@javeriana.edu.co
About this study
This completed descriptive cadaveric study mapped the motor entry points of lower-leg muscles supplied by the tibial, superficial peroneal, and deep peroneal nerves. Twenty fresh-frozen adult lower-limb specimens without prior trauma or surgery were examined. One extremity from each cadaver was selected by coin toss. Investigators performed standardized posterior, lateral, and anterior compartment dissections, followed each terminal motor branch to the point where it entered the target muscle, and measured its location relative to total leg length. For each muscle, motor entry point location was expressed as a proportion of leg length and summarized using the mean, standard deviation, and probability intervals corresponding to mean plus or minus one and two standard deviations. The study was designed to provide quantitative anatomical reference zones that may support surgical planning for hyperselective neurectomy and related lower-leg procedures.
Read the detailed description
Hyperselective neurectomy requires accurate localization of terminal motor branches and their neuromuscular entry points in the lower leg. This descriptive cadaveric study was designed to establish proportional anatomical reference zones for motor branches of the tibial, superficial peroneal, and deep peroneal nerves.
Fresh-frozen adult lower-limb specimens without prior trauma or prior surgical intervention were examined. One extremity per cadaver was selected by coin toss. Standardized posterior, lateral, and anterior compartment dissections were performed to identify the tibial nerve and the common peroneal nerve, trace the superficial and deep peroneal divisions, and follow terminal motor branches to the point at which each branch entered the corresponding muscle.
For tibial nerve branches, branch location was referenced to the posterior border of the tibia at the midpoint of the proximal epiphysis. For superficial and deep peroneal branches, the proximal reference point was the most superior aspect of the fibular head on its anterior surface. The distal reference point was the point of entry into the target muscle. Total leg length was measured from the knee joint line to the ankle joint line. The motor entry point was calculated as the distance to the entry point divided by total leg length. Distributions were evaluated separately for each muscle using the Shapiro-Wilk test. Means and standard deviations were calculated, and probability intervals corresponding to mean plus or minus one standard deviation and mean plus or minus two standard deviations were used to define the most likely anatomical zones of motor branch entry. When required, logarithmic, square-root, or power transformations were used to approximate normality, with results expressed on the original proportional scale.
- Being tested
- Standardized Cadaveric Lower-Limb Dissection
- Keywords
- Tibial nerve, Superficial peroneal nerve, Deep peroneal nerve, Motor entry point, Cadaveric dissection, Hyperselective neurectomy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Standardized Cadaveric Lower-Limb DissectionOther
Standardized posterior, lateral, and anterior compartment dissections were performed. The tibial nerve was identified through the posterior approach. The common peroneal nerve was identified near the biceps femoris tendon and traced to its superficial and deep divisions. Motor branches were followed to their points of entry into the target muscles. The location of each motor entry point was measured relative to prespecified tibial or fibular landmarks and normalized to total leg length measured from the knee joint line to the ankle joint line.
| Study group | Role | What they receive |
|---|---|---|
| Adult Cadaveric Lower-Limb Specimens | Twenty fresh-frozen adult lower-limb cadaveric specimens were examined. Specimens had no prior lower-limb trauma or surgical intervention. One extremity per cadaver was selected by coin toss and underwent standardized dissection for identification and measurement of terminal motor branches of the tibial, superficial peroneal, and deep peroneal nerves. Receives: Other: Standardized Cadaveric Lower-Limb Dissection |
What is being measured
The primary outcome is the main question the study is designed to answer.
Mean proportional localization of motor nerve entry points by target muscle
For each terminal motor branch, the distance from the prespecified proximal bony reference point to the point at which the branch entered the target muscle was measured. For tibial branches, the proximal reference was the posterior border of the tibia at the midpoint of the proximal epiphysis. For superficial and deep peroneal branches, the proximal reference was the most superior aspect of the fibular head on its anterior surface. Total leg length was measured from the knee joint line to the ankle joint line. The motor entry point was calculated as distance to the entry point divided by total leg length and expressed as a dimensionless proportion. For each target muscle, the mean, standard deviation, 68% probability interval (mean ±1 standard deviation), and 95% probability interval (mean ±2 standard deviations) were calculated. Target muscles included the medial and lateral gastrocnemius, soleus, flexor digitorum longus, flexor hallucis longus, tibialis posterior, fibularis/peroneus
Measured: Periprocedural, during the single standardized cadaveric dissection session for each specimen. 1 day
Secondary outcomes (1)
Number of motor branches identified by parent nerve and target muscle
Count of terminal motor branches arising from the tibial, superficial peroneal, or deep peroneal nerve and entering each dissected target muscle. Results are reported as counts by parent nerve and target muscle.
Measured: Periprocedural, during the single standardized cadaveric dissection session for each specimen. 1 day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Sep 2026
- Study start1 Oct 2026 (estimated)
- Primary completion2 Oct 2026 (estimated)
- Study completion2 Oct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (7)Papers the sponsor has linked to this study.
- Other trials for Lower Extremity AnatomyStudies of the same condition, open and under way.
- More trials run by Research IncThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 20 participants (estimated)
- Target duration
- 1 Day
Sponsor and investigators
- Lead sponsor
- Research Inc
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Maria F Garcia Rueda, MD, Orthopedist, Principal investigator
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07805902
- Sponsor's protocol ID
- 006
- Status last verified
- Sep 2026
- First submitted
- 1 Sep 2026
- Last updated
- 8 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: it is a research performed by one one surgeon, we do not requiere any other surgeon, once finished is going to be published in a journal
Publications
Baroncini M, Baiz H, Wavreille G, Demondion X, Maurage CA, Buisset N, Blond S, Kim HJ, Fontaine C. Anatomical bases of tibial neurotomy for treatment of spastic foot. Surg Radiol Anat. 2008 Aug;30(6):503-8. doi: 10.1007/s00276-008-0359-9. Epub 2008 May 15.
PubMed 18480959Sindou MP, Simon F, Mertens P, Decq P. Selective peripheral neurotomy (SPN) for spasticity in childhood. Childs Nerv Syst. 2007 Sep;23(9):957-70. doi: 10.1007/s00381-007-0399-1. Epub 2007 Jun 29.
PubMed 17605016Leclercq C, Perruisseau-Carrier A, Gras M, Panciera P, Fulchignoni C, Fulchignoni M. Hyperselective neurectomy for the treatment of upper limb spasticity in adults and children: a prospective study. J Hand Surg Eur Vol. 2021 Sep;46(7):708-716. doi: 10.1177/17531934211027499. Epub 2021 Jul 13.
PubMed 34256619Kim SC, Kang MH, Ock JJ. Calf-contouring surgery of gastrocnemius hypertrophy: selective neurectomy of the sural nerve. Aesthetic Plast Surg. 2008 Nov;32(6):889-93. doi: 10.1007/s00266-007-9107-5.
PubMed 18363052Abbruzzese G. The medical management of spasticity. Eur J Neurol. 2002 May;9 Suppl 1:30-4; discussion 53-61. doi: 10.1046/j.1468-1331.2002.0090s1030.x.
PubMed 11918647Dauleac C, Sindou M, Mertens P. How I do it: selective tibial neurotomy. Acta Neurochir (Wien). 2020 Aug;162(8):1921-1923. doi: 10.1007/s00701-020-04314-9. Epub 2020 May 7.
PubMed 32377951Mikalef P, Power D. The role of neurectomy in the management of spasticity of the upper limb. EFORT Open Rev. 2017 Nov 27;2(11):469-473. doi: 10.1302/2058-5241.2.160074. eCollection 2017 Nov.
PubMed 29218232
Study at a glance
From the registry record, last updated by the sponsor on 8 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Anatomical Probability Model for Tibial and Peroneal Motor Entry Points
- ClinicalTrials.gov ID
- NCT07805902
- Acronym / sponsor ID
- 006
- Keywords
- Tibial nerve, Superficial peroneal nerve, Deep peroneal nerve, Motor entry point, Cadaveric dissection, Hyperselective neurectomy
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- Research IncIndustry (pharma, biotech, devices)
- Study start
- 1 Oct 2026 (estimated)
- Primary completion
- 2 Oct 2026 (estimated)
- Study completion
- 2 Oct 2026 (estimated)
- First posted
- 8 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This completed descriptive cadaveric study mapped the motor entry points of lower-leg muscles supplied by the tibial, superficial peroneal, and deep peroneal nerves. Twenty fresh-frozen adult lower-limb specimens without prior trauma or surgery were examined. One extremity from each cadaver was selected by coin toss. Investigators performed standardized posterior, lateral, and anterior compartment dissections, followed each terminal motor branch to the point where it entered the target muscle, and measured its location relative to total leg length. For each muscle, motor entry point location was expressed as a proportion of leg length and summarized using the mean, standard deviation, and probability intervals corresponding to mean plus or minus one and two standard deviations. The study was designed to provide quantitative anatomical reference zones that may support surgical planning for hyperselective neurectomy and related lower-leg procedures.
Detailed description
Hyperselective neurectomy requires accurate localization of terminal motor branches and their neuromuscular entry points in the lower leg. This descriptive cadaveric study was designed to establish proportional anatomical reference zones for motor branches of the tibial, superficial peroneal, and deep peroneal nerves.
Fresh-frozen adult lower-limb specimens without prior trauma or prior surgical intervention were examined. One extremity per cadaver was selected by coin toss. Standardized posterior, lateral, and anterior compartment dissections were performed to identify the tibial nerve and the common peroneal nerve, trace the superficial and deep peroneal divisions, and follow terminal motor branches to the point at which each branch entered the corresponding muscle.
For tibial nerve branches, branch location was referenced to the posterior border of the tibia at the midpoint of the proximal epiphysis. For superficial and deep peroneal branches, the proximal reference point was the most superior aspect of the fibular head on its anterior surface. The distal reference point was the point of entry into the target muscle. Total leg length was measured from the knee joint line to the ankle joint line. The motor entry point was calculated as the distance to the entry point divided by total leg length. Distributions were evaluated separately for each muscle using the Shapiro-Wilk test. Means and standard deviations were calculated, and probability intervals corresponding to mean plus or minus one standard deviation and mean plus or minus two standard deviations were used to define the most likely anatomical zones of motor branch entry. When required, logarithmic, square-root, or power transformations were used to approximate normality, with results expressed on the original proportional scale.
Study design
- Observational model
- Other
- Time perspective
- Cross-sectional
- Target follow-up
- 1 Day
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Adult Cadaveric Lower-Limb Specimens | – | Other: Standardized Cadaveric Lower-Limb DissectionTwenty fresh-frozen adult lower-limb cadaveric specimens were examined. Specimens had no prior lower-limb trauma or surgical intervention. One extremity per cadaver was selected by coin toss and underwent standardized dissection for identification and measurement of terminal motor branches of the tibial, superficial peroneal, and deep peroneal nerves. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Fresh-frozen adult cadaveric lower-limb specimens available through the institutional cadaveric program at CLEMI in Cundinamarca, Colombia. Specimens were selected according to institutional procurement standards and were required to have no prior trauma or surgical intervention involving the lower limbs. One extremity per cadaver was selected by coin toss for dissection.
Key inclusion criteria (4 listed)
- Adult cadaveric specimen (age at death 18 years or older)
- Fresh-frozen lower-limb specimen made available under institutional standards for cadaveric research
- No prior trauma involving the selected lower limb
- No prior surgical intervention involving the selected lower limb
Key exclusion criteria (3 listed)
- Cadaveric specimen from an individual younger than 18 years at death
- Prior trauma involving the lower limb
- Prior surgical intervention involving the lower limb
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Standardized Cadaveric Lower-Limb DissectionStandardized posterior, lateral, and anterior compartment dissections were performed. The tibial nerve was identified through the posterior approach. The common peroneal nerve was identified near the biceps femoris tendon and traced to its superficial and deep divisions. Motor branches were followed to their points of entry into the target muscles. The location of each motor entry point was measured relative to prespecified tibial or fibular landmarks and normalized to total leg length measured from the knee joint line to the ankle joint line. | Other | Adult Cadaveric Lower-Limb Specimens |
Primary outcome
Mean proportional localization of motor nerve entry points by target muscle
Time frame: Periprocedural, during the single standardized cadaveric dissection session for each specimen. 1 day
For each terminal motor branch, the distance from the prespecified proximal bony reference point to the point at which the branch entered the target muscle was measured. For tibial branches, the proximal reference was the posterior border of the tibia at the midpoint of the proximal epiphysis. For superficial and deep peroneal branches, the proximal reference was the most superior aspect of the fibular head on its anterior surface. Total leg length was measured from the knee joint line to the ankle joint line. The motor entry point was calculated as distance to the entry point divided by total leg length and expressed as a dimensionless proportion. For each target muscle, the mean, standard deviation, 68% probability interval (mean ±1 standard deviation), and 95% probability interval (mean ±2 standard deviations) were calculated. Target muscles included the medial and lateral gastrocnemius, soleus, flexor digitorum longus, flexor hallucis longus, tibialis posterior, fibularis/peroneus
1 secondary outcome
Number of motor branches identified by parent nerve and target muscle
Time frame: Periprocedural, during the single standardized cadaveric dissection session for each specimen. 1 day
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Sep 2026.
- Background: PubMed 18480959Baroncini M, Baiz H, Wavreille G, Demondion X, Maurage CA, Buisset N, Blond S, Kim HJ, Fontaine C. Anatomical bases of tibial neurotomy for treatment of spastic foot. Surg Radiol Anat. 2008 Aug;30(6):503-8. doi: 10.1007/s00276-008-0359-9. Epub 2008 May 15.
- Background: PubMed 17605016Sindou MP, Simon F, Mertens P, Decq P. Selective peripheral neurotomy (SPN) for spasticity in childhood. Childs Nerv Syst. 2007 Sep;23(9):957-70. doi: 10.1007/s00381-007-0399-1. Epub 2007 Jun 29.
- Background: PubMed 34256619Leclercq C, Perruisseau-Carrier A, Gras M, Panciera P, Fulchignoni C, Fulchignoni M. Hyperselective neurectomy for the treatment of upper limb spasticity in adults and children: a prospective study. J Hand Surg Eur Vol. 2021 Sep;46(7):708-716. doi: 10.1177/17531934211027499. Epub 2021 Jul 13.
- Background: PubMed 18363052Kim SC, Kang MH, Ock JJ. Calf-contouring surgery of gastrocnemius hypertrophy: selective neurectomy of the sural nerve. Aesthetic Plast Surg. 2008 Nov;32(6):889-93. doi: 10.1007/s00266-007-9107-5.
- Background: PubMed 11918647Abbruzzese G. The medical management of spasticity. Eur J Neurol. 2002 May;9 Suppl 1:30-4; discussion 53-61. doi: 10.1046/j.1468-1331.2002.0090s1030.x.
- Background: PubMed 32377951Dauleac C, Sindou M, Mertens P. How I do it: selective tibial neurotomy. Acta Neurochir (Wien). 2020 Aug;162(8):1921-1923. doi: 10.1007/s00701-020-04314-9. Epub 2020 May 7.
- Background: PubMed 29218232Mikalef P, Power D. The role of neurectomy in the management of spasticity of the upper limb. EFORT Open Rev. 2017 Nov 27;2(11):469-473. doi: 10.1302/2058-5241.2.160074. eCollection 2017 Nov.
- Individual participant dataSharing planned: No. it is a research performed by one one surgeon, we do not requiere any other surgeon, once finished is going to be published in a journal
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Maria F Garcia Rueda, MD, Orthopedist principal investigator
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Lower Extremity Anatomy and Peripheral Nerve Anatomy, run by Research Inc at 1 site in Colombia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 8 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Colombia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact MARIA F GARCIA RUEDA, MD, Orthopedist (+57 3208541343, m-garciar@javeriana.edu.co), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Mean proportional localization of motor nerve entry points by target muscle (time frame: Periprocedural, during the single standardized cadaveric dissection session for each specimen. 1 day). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07805902, which also lists 7 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Sep 2026.