Skin Barrier to Water LossAPC-SKINNCT07807085
Apple Peptide Complex for Post-Surgical and Aesthetic Skin Recovery
A study testing Apple Peptide Complex Post-Aesthetic Care Protocol in people with Skin Barrier to Water Loss and Skin Health, run by Grow Out Oils Clinical Aromatherapy Company at 1 site in United States.
Trial summary
This clinical study evaluates a topical botanical formulation for supporting skin recovery following invasive and non-invasive aesthetic procedures. These procedures include liposuction, breast augmentation, Brazilian butt lift (BBL), laser treatments, and micro needling, pregnancy stretch mark and weight loss skin. Read more about this study
- Who is it for?
- Any age, women onlyHealthy volunteers can take part
- Conditions the study is for
- Skin Barrier to Water Loss, Skin Health, Skin Discoloration
- What is being tested?
- Apple Peptide Complex Post-Aesthetic Care Protocol
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteUnited States
- Study dates
- 20 Jan 2021to 29 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- Women only
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- Female participants aged 45-65 years
- Undergoing or have undergone aesthetic or surgical procedures (e.g., liposuction, breast augmentation, laser treatments, microneedling)
- Presence of skin concerns such as hyperpigmentation, scarring, or reduced elasticity
- Willing and able to comply with study procedures and follow-up
- Physician clearance for participation
Who cannot join
- Active skin infections, open wounds, or delayed wound healing
- Pregnancy or breastfeeding
- Use of conflicting topical or systemic treatments
- Known allergy to botanical ingredients in the formulation
Trial locations and contacts
1 site in 1 country.
United States1 site
Grow Out Oils Clinical Aromatherapy Company
Weston, Florida, 33326
About this study
Official title: Evaluation of the Efficacy of the Breast and Body Apple Peptide Complex in Post-Surgical Recovery and Non-Invasive Aesthetic Treatments in Medical Aesthetic Clinics, Dermatology Practices, and Med Spas
This clinical study evaluates a topical botanical formulation for supporting skin recovery following invasive and non-invasive aesthetic procedures. These procedures include liposuction, breast augmentation, Brazilian butt lift (BBL), laser treatments, and micro needling, pregnancy stretch mark and weight loss skin.
The study will assess the effects of the formulation on skin elasticity, hydration, and overall appearance when used as part of post-procedure care under the supervision of licensed medical professionals. Participants will apply the product to treatment areas over a defined study period, and outcomes will be compared to a control group receiving standard care or placebo.
Read the detailed description
The investigational product is a topical botanical formulation composed of plant-derived extracts including Pyrus malus (apple) fruit extract, Vanilla planifolia fruit extract, Jasminum officinale (jasmine) flower extract, and Vitis vinifera derivatives. These components are commonly used in dermatologic and cosmetic applications for their antioxidant, emollient, and skin barrier-supporting properties.
The formulation contains fatty acid components, including linoleic acid, which may contribute to maintaining skin hydration and barrier integrity. The product is intended for topical use following invasive and non-invasive aesthetic procedures, including liposuction, breast augmentation, Brazilian butt lift (BBL), laser therapies, and micro needling, pregnancy stretch mark and weight loss skin.
This study is designed as a randomized, interventional clinical trial conducted in medical aesthetic clinics, dermatology practices, and med spa settings. Participants were assigned to either an intervention group receiving the investigational product for standard post-procedure usage for topical skincare use.
Primary outcome measures include assessment of skin elasticity, hydration, and visible skin appearance. Secondary outcomes include time to visible recovery and incidence of adverse skin reactions.
- Conditions
- Skin Barrier to Water Loss, Skin Health, Skin Discoloration, Skin Irritation, Skin Abnormalities, Hyperpigmentation
- Being tested
- Apple Peptide Complex Post-Aesthetic Care Protocol
- Keywords
- aesthetic care healing modality, bbl post care treatment, breast augmentation and reconstructive post care treatment, stretch marks, skin hyperpigmentation, skin irritation, skin barrier health, skin discoloration
- Medical subject headings
- Skin Abnormalities, Hyperpigmentation, Striae Distensae, Lymphatic Abnormalities
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Apple Peptide Complex Post-Aesthetic Care ProtocolOther
Participants receive the Apple Peptide Complex topical formulation as a standardized post-aesthetic care intervention following invasive and non-invasive aesthetic procedures. Participants apply the formulation to designated treatment areas according to the protocol-defined frequency, amount, and duration. Outcomes are evaluated to assess the formulation's effects on post-procedural skin recovery and overall cellular repair. Apple Peptide Complex is administered topically as a standardized post-aesthetic care intervention following invasive and non-invasive aesthetic procedures. Participants apply the formulation to designated treatment areas according to protocol-defined instructions regarding frequency and duration. The study evaluates predefined outcomes associated with post-procedural recovery and overall cellular repair.
| Study group | Role | What they receive |
|---|---|---|
| Apple Peptide Complex Post-Aesthetic Care Protocol | Experimental | Participants receive the Apple Peptide Complex topical formulation as a standardized post-aesthetic care intervention following an invasive or non-invasive aesthetic procedure. The formulation is applied to designated treatment areas according to the study protocol-defined frequency and duration. Participants are evaluated for predefined biomedical and/or health-related outcomes associated with post-procedural recovery and overall cellular repair. Receives: Other: Apple Peptide Complex Post-Aesthetic Care Protocol |
What is being measured
The primary outcome is the main question the study is designed to answer.
Clinician-Graded Visual Skin Evaluation Score
Clinician assessment of skin surface appearance to monitor reductions in post-procedural redness and dryness. Evaluation is performed using a standard 0 to 4 scale, where 0 indicates no redness/dryness and 4 indicates severe redness/dryness. Unit of Measure: Units on a scale (0 to 4)
Measured: Baseline, Day 14, and Day 28 post-procedure
Change in Trans epidermal Water Loss (TEWL)
Evaluation of skin barrier function following daily topical use of the cosmetic Apple Peptide Complex. Data are collected via a tewameter to assess absolute changes in skin moisture retention. Unit of Measure: g/h/m²
Measured: 28 days post-procedure (with assessments conducted at day 14 and day 28)
Participant Comfort Rating Score
Self-reported participant feedback regarding skin comfort, including soothing sensations and lack of irritation. Scores are recorded using a feedback scale from 0 (extreme discomfort/irritation) to 10 (complete skin comfort/highly soothed). Unit of Measure: Units on a scale (0 to 10)
Measured: Baseline, Day 14, and Day 28 post-procedure
Secondary outcomes (2)
Presence of Post-Inflammatory Hyperpigmentation (PIH)Description
Clinical observation of the treated area to identify the development of post-procedural hyperpigmentation. Unit of Measure: Percentage of participants with observed hyperpigmentation.
Measured: Baseline (pre-procedure), immediately post-procedure, Day 14, and Day 28
Clinician-Graded Skin Desquamation Score
Assessment of skin flaking or peeling in the treated area using a standard clinical scaling chart. Evaluation is graded on a 0 to 4 scale, where 0 indicates no desquamation and 4 indicates severe desquamation.
Measured: Baseline (pre-procedure), immediately post-procedure, Day 14, and Day 28
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Sep 2026
- Study start20 Jan 2021
- Primary completion4 Dec 2025
- Study completion29 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Skin Barrier to Water LossStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- Participants were randomized into two parallel groups: an intervention group receiving the topical Apple Peptide Complex as part of post-procedural care, and a control group receiving standard post-procedure care. Both groups were monitored over the same study period following invasive and non-invasive aesthetic procedures, including surgical and dermatologic treatments, to evaluate skin recovery outcomes.
- Masking
- None (open label)
- Enrolment
- 50 participants (actual)
Sponsor and investigators
- Lead sponsor
- Grow Out Oils Clinical Aromatherapy Company
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Shanna Bynes Bradford, Master Aromatherapy, Principal investigator, Grow Out Oils Clinical Aromatherapy CompanyDr. Lane Rolling MD, Virologist, Epidemiologist,, Study director
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07807085
- Sponsor's protocol ID
- GOO-APPLE-PEPTIDE-001
- Acronym
- APC-SKIN
- Status last verified
- Sep 2026
- First submitted
- 27 Apr 2026
- Last updated
- 8 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Detailed information for each subject, such as participant ID, treatment received, age, race, gender, disease, aesthetic surgical procedure specific outcomes at different time points during the post care treatment healing process and protocol timeline.
Publications
Proksch E, Brandner JM, Jensen JM. The skin: an indispensable barrier. Exp Dermatol. 2008 Dec;17(12):1063-72. doi: 10.1111/j.1600-0625.2008.00786.x.
PubMed 19043850Citation 3 (Post-Procedure Skin Care) Draelos ZD. The role of skin care in optimizing outcomes following cosmetic procedures. Journal of Cosmetic Dermatology. 2012;11(3):169-173.
Pullar JM, Carr AC, Vissers MCM. The Roles of Vitamin C in Skin Health. Nutrients. 2017 Aug 12;9(8):866. doi: 10.3390/nu9080866.
PubMed 28805671Saxena S. Mobile pediatric service. Indian Pediatr. 1972 Nov;9(11):641-2. No abstract available.
PubMed 4658681
Study at a glance
From the registry record, last updated by the sponsor on 8 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Efficacy of the Breast and Body Apple Peptide Complex in Post-Surgical Recovery and Non-Invasive Aesthetic Treatments in Medical Aesthetic Clinics, Dermatology Practices, and Med Spas
- ClinicalTrials.gov ID
- NCT07807085
- Acronym / sponsor ID
- APC-SKIN / GOO-APPLE-PEPTIDE-001
- Conditions
- Skin Barrier to Water Loss, Skin Health, Skin Discoloration, Skin Irritation, Skin Abnormalities, Hyperpigmentation
- Keywords
- aesthetic care healing modality, bbl post care treatment, breast augmentation and reconstructive post care treatment, stretch marks, skin hyperpigmentation, skin irritation, skin barrier health, skin discoloration
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 50 participants (actual)
- Lead sponsor
- Grow Out Oils Clinical Aromatherapy CompanyIndustry (pharma, biotech, devices)
- Study start
- 20 Jan 2021 (actual)
- Primary completion
- 4 Dec 2025 (actual)
- Study completion
- 29 Dec 2025 (actual)
- First posted
- 8 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This clinical study evaluates a topical botanical formulation for supporting skin recovery following invasive and non-invasive aesthetic procedures. These procedures include liposuction, breast augmentation, Brazilian butt lift (BBL), laser treatments, and micro needling, pregnancy stretch mark and weight loss skin.
The study will assess the effects of the formulation on skin elasticity, hydration, and overall appearance when used as part of post-procedure care under the supervision of licensed medical professionals. Participants will apply the product to treatment areas over a defined study period, and outcomes will be compared to a control group receiving standard care or placebo.
Detailed description
The investigational product is a topical botanical formulation composed of plant-derived extracts including Pyrus malus (apple) fruit extract, Vanilla planifolia fruit extract, Jasminum officinale (jasmine) flower extract, and Vitis vinifera derivatives. These components are commonly used in dermatologic and cosmetic applications for their antioxidant, emollient, and skin barrier-supporting properties.
The formulation contains fatty acid components, including linoleic acid, which may contribute to maintaining skin hydration and barrier integrity. The product is intended for topical use following invasive and non-invasive aesthetic procedures, including liposuction, breast augmentation, Brazilian butt lift (BBL), laser therapies, and micro needling, pregnancy stretch mark and weight loss skin.
This study is designed as a randomized, interventional clinical trial conducted in medical aesthetic clinics, dermatology practices, and med spa settings. Participants were assigned to either an intervention group receiving the investigational product for standard post-procedure usage for topical skincare use.
Primary outcome measures include assessment of skin elasticity, hydration, and visible skin appearance. Secondary outcomes include time to visible recovery and incidence of adverse skin reactions.
Study design
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- Participants were randomized into two parallel groups: an intervention group receiving the topical Apple Peptide Complex as part of post-procedural care, and a control group receiving standard post-procedure care. Both groups were monitored over the same study period following invasive and non-invasive aesthetic procedures, including surgical and dermatologic treatments, to evaluate skin recovery outcomes.
| Arm | Type | Receives |
|---|---|---|
| Apple Peptide Complex Post-Aesthetic Care Protocol | Experimental | Other: Apple Peptide Complex Post-Aesthetic Care ProtocolParticipants receive the Apple Peptide Complex topical formulation as a standardized post-aesthetic care intervention following an invasive or non-invasive aesthetic procedure. The formulation is applied to designated treatment areas according to the study protocol-defined frequency and duration. Participants are evaluated for predefined biomedical and/or health-related outcomes associated with post-procedural recovery and overall cellular repair. |
Who may qualify
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (5 listed)
- Female participants aged 45-65 years
- Undergoing or have undergone aesthetic or surgical procedures (e.g., liposuction, breast augmentation, laser treatments, microneedling)
- Presence of skin concerns such as hyperpigmentation, scarring, or reduced elasticity
- Willing and able to comply with study procedures and follow-up
- Physician clearance for participation
Key exclusion criteria (4 listed)
- Active skin infections, open wounds, or delayed wound healing
- Pregnancy or breastfeeding
- Use of conflicting topical or systemic treatments
- Known allergy to botanical ingredients in the formulation
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Apple Peptide Complex Post-Aesthetic Care ProtocolParticipants receive the Apple Peptide Complex topical formulation as a standardized post-aesthetic care intervention following invasive and non-invasive aesthetic procedures. Participants apply the formulation to designated treatment areas according to the protocol-defined frequency, amount, and duration. Outcomes are evaluated to assess the formulation's effects on post-procedural skin recovery and overall cellular repair. Apple Peptide Complex is administered topically as a standardized post-aesthetic care intervention following invasive and non-invasive aesthetic procedures. Participants apply the formulation to designated treatment areas according to protocol-defined instructions regarding frequency and duration. The study evaluates predefined outcomes associated with post-procedural recovery and overall cellular repair. | Other | Apple Peptide Complex Post-Aesthetic Care Protocol |
Primary outcome
Clinician-Graded Visual Skin Evaluation Score
Time frame: Baseline, Day 14, and Day 28 post-procedure
Clinician assessment of skin surface appearance to monitor reductions in post-procedural redness and dryness. Evaluation is performed using a standard 0 to 4 scale, where 0 indicates no redness/dryness and 4 indicates severe redness/dryness. Unit of Measure: Units on a scale (0 to 4)
Change in Trans epidermal Water Loss (TEWL)
Time frame: 28 days post-procedure (with assessments conducted at day 14 and day 28)
Evaluation of skin barrier function following daily topical use of the cosmetic Apple Peptide Complex. Data are collected via a tewameter to assess absolute changes in skin moisture retention. Unit of Measure: g/h/m²
Participant Comfort Rating Score
Time frame: Baseline, Day 14, and Day 28 post-procedure
Self-reported participant feedback regarding skin comfort, including soothing sensations and lack of irritation. Scores are recorded using a feedback scale from 0 (extreme discomfort/irritation) to 10 (complete skin comfort/highly soothed). Unit of Measure: Units on a scale (0 to 10)
2 secondary outcomes
Presence of Post-Inflammatory Hyperpigmentation (PIH)Description
Time frame: Baseline (pre-procedure), immediately post-procedure, Day 14, and Day 28
Clinician-Graded Skin Desquamation Score
Time frame: Baseline (pre-procedure), immediately post-procedure, Day 14, and Day 28
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Sep 2026.
- Results publication: PubMed 19043850Proksch E, Brandner JM, Jensen JM. The skin: an indispensable barrier. Exp Dermatol. 2008 Dec;17(12):1063-72. doi: 10.1111/j.1600-0625.2008.00786.x.
- Results publicationCitation 3 (Post-Procedure Skin Care) Draelos ZD. The role of skin care in optimizing outcomes following cosmetic procedures. Journal of Cosmetic Dermatology. 2012;11(3):169-173.
- Results publication: PubMed 28805671Pullar JM, Carr AC, Vissers MCM. The Roles of Vitamin C in Skin Health. Nutrients. 2017 Aug 12;9(8):866. doi: 10.3390/nu9080866.
- Results publication: PubMed 4658681Saxena S. Mobile pediatric service. Indian Pediatr. 1972 Nov;9(11):641-2. No abstract available.
- Grow Out Oils Company WebsiteLink provided by the sponsor.
- Investor-grade white paper detailing clinical rationale and study design available at:Link provided by the sponsor.
- Individual participant dataSharing planned: Yes. Detailed information for each subject, such as participant ID, treatment received, age, race, gender, disease, aesthetic surgical procedure specific outcomes at different time points during the post care treatment healing process and protocol timeline.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Shanna Bynes Bradford, Master Aromatherapy principal investigator
Grow Out Oils Clinical Aromatherapy Company
Dr. Lane Rolling MD, Virologist, Epidemiologist, study director
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Apple Peptide Complex Post-Aesthetic Care Protocol in people with Skin Barrier to Water Loss and Skin Health, run by Grow Out Oils Clinical Aromatherapy Company at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Clinician-Graded Visual Skin Evaluation Score (time frame: Baseline, Day 14, and Day 28 post-procedure). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07807085, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Sep 2026.