Mental DiseaseMCS ImpactNCT07808801
Mental Health Reinforcement in Wayapi and Teko Communities in French Guiana : Evaluation of the Impact of a Mediation Based Activity in Municipalities of Camopi and Trois Saut in French Guiana
An observational study of Mental Disease, run by Centre Hospitalier de Cayenne at 1 site in French Guiana.
Trial summary
In French Guiana, Indigenous people experience high levels of psychological distress and higher rates of suicidal behavior than the rest of the population. The Wayãpi and Teko communities living in Camopi and Trois-Sauts are particularly affected. Read more about this study
- Who is it for?
- Ages 12 years and olderHealthy volunteers can take part
- Conditions the study is for
- Mental Disease
- How many people
- 300 participants
- Where
- 1 siteFrench Guiana
- Study dates
- 1 Sep 2026to 30 Aug 2029
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 12 years and older
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Study population: Adults and children over 12 years of age from the Wayapi and Teko communities in the villages of Camopi and Trois-Saut in French Guiana
Who may be able to join
- Age > 12 years
- Members of the Wayãpi or Teko communities residing in Camopi or Trois-Sauts.
- No objection to participating in the study and to the use of their data after receiving information in local languages and in French
Who cannot join
- Individuals under legal guardianship
- Health conditions that prevent them from understanding or completing questionnaires or participating in interviews.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
French Guiana1 site
Centre Hospitalier de Cayenne
Cayenne, French Guiana, 97300
Cassio De Figueiredo Azze, MSc, +33594395050, cassiofr@gmail.com
Estelle Thomas, MPH, +33594395050, drci.promotion-cay@chu-guyane.fr
About this study
In French Guiana, Indigenous people experience high levels of psychological distress and higher rates of suicidal behavior than the rest of the population.
The Wayãpi and Teko communities living in Camopi and Trois-Sauts are particularly affected.
Read more
Since 2025, Community Workers (CHWs) from these communities have been appointed to facilitate access to care, improve communication between residents and health services, and strengthen support in situations of distress.
To date, no scientific evaluation has been conducted to measure the actual impact of this initiative. This research therefore aims to better understand mental health in these communities and to assess the effect of the community mediators' work.
The results will help improve suicide prevention efforts and adapt public health policies to local realities.
The purpose of this study is to assess the impact of CHWs activities on:
- suicidal behavior,
- psychological distress,
- alcohol use,
- use of health care services, within the Wayãpi and Teko communities of Camopi and Trois-Sauts.
Read the detailed description
- Rational of the study
The mental health of Indigenous peoples is a major public health and social justice issue. Approximately 370 million Indigenous people live in more than 90 countries, sharing common experiences of historical exclusion, territorial dispossession, and socioeconomic marginalization. These structural determinants result in persistent health inequalities, including suicide rates that are frequently higher than national averages.
International data show significant variability-ranging from 0 to 187.5 suicides per 100,000 people -highlighting the importance of cultural and historical contexts. Ethnicity is not a risk factor in and of itself; vulnerabilities arise from the interaction between historical trauma, socioeconomic conditions, and local cultural dynamics.
The literature highlights three key factors:
- Structural vulnerability, linked to poverty, discrimination, and limited access to specialized services.
- Historical and intergenerational trauma linked to colonization, forced displacement, and assimilation policies, which contribute to mental health disorders.
- Resources for resilience: cultural continuity, local governance, and strong kinship networks.
International comparisons confirm that communities with territorial control, autonomous institutions, or adapted educational systems have significantly lower suicide rates.
The Amazon is a region particularly affected by inequalities in Indigenous mental health. Despite remarkable linguistic and cultural diversity, the region remains marked by the legacy of colonization, resource exploitation, missionary activity, and a chronic lack of health and educational infrastructure.
Available data indicate that suicide rates reach particularly high levels in several Amazonian contexts: up to twenty times the national average among the Guarani-Kaiowá in Brazil, 247.9 per 100,000 inhabitants among the Emberá Dobidá in Colombia, and rates higher than the national average in the Ecuadorian Amazon. These situations reflect the cumulative effect of structural, social, and historical vulnerabilities, the manifestation of which varies according to national and local contexts.
Although it is a department of a high-income country, French Guiana exhibits health inequalities comparable to those observed in low-resource settings. The Amazonian interior, accessible only by canoe or plane, suffers from significant geographic isolation, limiting access to specialized care.
In French Guiana, the municipality of Camopi, which includes the village of Trois-Sauts, has particularly high suicide rates, estimated at 113 and 137 per 100,000 inhabitants, respectively, with suicide attempt rates approaching 400 per 100,000 inhabitants. Suicides primarily affect young people aged 10 to 29, who account for more than 60% of suicide deaths, with an average age of 25 in the interior compared to 36 on the coast.
The observed vulnerabilities result from a complex interplay of factors: alcohol abuse and substance use disorders, domestic violence, a loss of identity due to rapid sociocultural changes, as well as the social and environmental impacts of illegal gold mining. These factors interact within a context of severe social precariousness and the erosion of community structures.
The concentration of psychiatric services in the prefecture and main French Guina town, Cayenne, the language barrier (with Wayãpi and Teko being the predominant languages), and the lack of interventions that are sustainably adapted to Indigenous contexts hinder the effectiveness of existing systems, exacerbating inequalities in access to and care for mental health.
Beyond socioeconomic and health determinants, the situations of psychological distress observed in Wayãpi and Teko communities are embedded in culturally situated frameworks of understanding. Representations of psychological distress, illness, and suicide are inseparable from a relational worldview in which bodily, social, territorial, and symbolic dimensions are closely intertwined.
In this context, psychological distress is not viewed exclusively as an individual disorder, but as an imbalance affecting the relationships between the individual, their social environment, and the symbolic frameworks mobilized to make sense of their lived experience. The failure to take these interpretive frameworks into account in healthcare systems constitutes an additional factor contributing to underutilization of services and the ineffectiveness of interventions.
In many countries, community health workers (CHWs) are a key lever for reducing health inequalities. Their cultural proximity facilitates early detection of health issues, language mediation, psychosocial support, and adherence to care.
In French Guiana, six Wayãpi and Teko Community Health Workers (CHWs) were deployed in 2025 in the municipalities of Camopi and Trois-Sauts. They serve as a bridge between so-called "traditional" medicine and allopathic medicine, facilitating access to care and the management of distressing situations.
Despite these advances, several gaps remain:
- A lack of standardized epidemiological data on the mental health of the Wayãpi and Teko peoples, aside from suicide mortality.
- Limited qualitative documentation, particularly regarding perceptions of suffering, addiction, and suicide.
- A complete lack of scientific evaluation of the role and impact of CHWs in French Guiana. Their effectiveness is assumed by analogy with the Brazilian model but has never been empirically verified.
These gaps hinder the development of appropriate prevention policies and keep the communities' real needs hidden. Three key findings emerge:
- Indigenous peoples are disproportionately vulnerable to suicide, with significant variations depending on context.
- The Amazon, and French Guiana in particular, is an area with a very high incidence of suicide.
- CHWs represent a promising avenue, but require rigorous scientific evaluation.
- Hypothesis of the study
- The cultural and linguistic background of the CHWs, who come from the Wayãpi and Teko communities, fosters trust, improves communication, and facilitates access to care, thereby contributing to a reduction in suicidal behaviors.
- The integration of cultural representations and traditional practices (Tupi-Guarani worldview, rituals, and symbols of suffering) into mediation strengthens individual and collective resilience in the face of mental health disorders.
- The community mediation model, inspired by the Brazilian Agentes Indígenas de Saúde, is transferable and effective in French Guiana, provided it is adapted to local social, linguistic, and territorial specificities.
- The close ties between CHWs and their communities are an essential resource for the early detection of crises, but can also lead to emotional overload, requiring appropriate supervision and support.
- The introduction of CHWs has a measurable positive effect on social cohesion by strengthening community ties, reducing stigma, and facilitating the integration of biomedical care with traditional knowledge.
- Design of the study
This is a single-center, quasi-experimental, prospective before-and-after study conducted in the municipality of Camopi (including Trois-Sauts).
- Retrospective phase: analysis of the 5 years preceding the introduction of MCS (aggregated data from institutional records).
- Inclusion: random selection of participants by drawing households at random from a georeferenced aerial map.
- Prospective phase: individual longitudinal follow-up over 30 months.
- Repeated assessments: M0, M12, M24, M30.
- Mixed-methods approach: standardized quantitative questionnaires (K10, AUDIT-C, WHO SUPRE-MISS/CIDI suicide module) and qualitative investigations (interviews, focus groups).
- Objectives of the study
- Primary Objective To evaluate the effectiveness of the CHWs intervention in preventing suicide and reducing suicidal behaviors among the Wayãpi and Teko populations of Camopi and Trois-Sauts.
- Secondary Objectives
The secondary objectives aim to document the mechanisms, cultural dimensions, and social effects associated with the CHWs' intervention:
- Estimate the prevalence of psychological distress and alcohol use among the Wayãpi and Teko communities.
- Estimate the use of psychiatric health care services.
- Describe cultural representations of distress, suffering, and suicide, as well as the relational and cosmological dynamics mobilized to account for them.
- Analyze the role of CHWs as an intercultural interface by documenting how they integrate traditional practices with biomedical care.
- Assess the perceived impact of CHWs on social cohesion, the reduction of stigma, and the strengthening of community support resources.
- Identify the needs, limitations, working conditions, and burnout factors among CHWs, in order to evaluate the feasibility, sustainability, and conditions for the effectiveness of the program.
- Benefits
The expected benefits apply to communities, health institutions, and scientific knowledge alike.
For the Wayãpi and Teko communities:
- improved access to care and early detection of distress
- reduction of stigma related to mental health
- strengthening of social cohesion and the integration of traditional healing with biomedicine.
For institutional stakeholders:
- unprecedented epidemiological data enabling the adaptation of suicide prevention strategies
- support for the implementation of a structured model of intercultural intervention based on the work of the CHWs
- improved training for professionals on intercultural approaches.
For research:
- generation of the first quantitative and qualitative data on the mental health of the Wayãpi and Teko
- development of a methodological framework that can be applied in other Amazonian context
- Conditions
- Mental Disease
- Keywords
- Indigenous mental health, Suicide prevention, Community Health Workers, Amazonia / French Guiana, Intercultural mediation
- Medical subject headings
- Mental Disorders, Suicide Prevention
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in the incidence of suicidal behaviours (suicidal ideation, suicide attempts, and suicide deaths) in the villages of Camopi and Trois-Sauts before and after the deployment of CHWs
Change in the incidence of suicidal behaviours (suicidal ideation, suicide attempts, and suicide deaths) in the study population, comparing retrospective suicidal behaviour rates in the 5 years before with propective suicidal behaviour rates at 12, 24 and 30 months after the intervention of CHWs among the study population
Measured: From inclusion to 12, 24 and 30 months after CHWs intervention
Secondary outcomes (7)
Prevalence of psychological distres
Measurement of psychological distress score using the validated K10 scale
Measured: From inclusion to 12, 24 and 30 months
Prevalence of alcohol use pattern
Measurement of alcohol use pattern using the validated AUDIT-C scale
Measured: From inclusion to 12, 24 and 30 months
Health-care utilisation
Number of out patient visits and hospitalisations in psychiatric and general medical services
Measured: From inclusion to 12, 24 and 30 months
Cultural representations of mental health and CHWs intervention
Analysis of the cultural representations of mental health and CHWs intervention using a qualitative questionnaire with individuals and focus group strategy with groups of participants
Measured: From inclusion to 12, 24 and 30 months
Community perceptions of mental health and of CHWs intervention
Analysis of the community perceptions of mental health and CHWs intervention using a qualitative questionnaire with individuals and focus group strategy with groups of participants
Measured: From inclusion to 12, 24 and 30 months
Social cohesion and community resilience indicators
Measurement of the community solidarity and perception of community stigma using individual qualitative questionnaires and focus group strategies
Measured: From inclusion to 12, 24 and 30 months
Management needs of CHWs
Measurement of the level of management and support needed by CHWs in their activities using qualitative questionnaires
Measured: At 12, 24 and 30 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Sep 2026
- Study start1 Sep 2026 (estimated)
- Primary completion30 Aug 2029 (estimated)
- Study completion30 Aug 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (7)Papers the sponsor has linked to this study.
- Other trials for Mental DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Other
- Enrolment
- 300 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier de Cayenne
- Sponsor type
- University, hospital or other
- Collaborators
- Regional Health Agency (ARS)
- Responsible party
- Sponsor
- Investigators
- Mathieu Nacher, MD, PhD, Study director, Centre Hospitalier de Cayenne, Inserm CIC 1424 Guyane-Amazonie
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07808801
- Sponsor's protocol ID
- MCS Impact
- Acronym
- MCS Impact
- Status last verified
- Aug 2026
- First submitted
- 2 Sep 2026
- Last updated
- 9 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: Only aggregated data will be shared
Publications
Pollock NJ, Naicker K, Loro A, Mulay S, Colman I. Global incidence of suicide among Indigenous peoples: a systematic review. BMC Med. 2018 Aug 20;16(1):145. doi: 10.1186/s12916-018-1115-6.
PubMed 30122155Pacot R, Garmit B, Pradem M, Nacher M, Brousse P. The problem of suicide among Amerindians in Camopi-Trois Sauts, French Guiana 2008-2015. BMC Psychiatry. 2018 Apr 11;18(1):99. doi: 10.1186/s12888-018-1670-6.
PubMed 29642878Elias B, Mignone J, Hall M, Hong SP, Hart L, Sareen J. Trauma and suicide behaviour histories among a Canadian indigenous population: an empirical exploration of the potential role of Canada's residential school system. Soc Sci Med. 2012 May;74(10):1560-9. doi: 10.1016/j.socscimed.2012.01.026. Epub 2012 Mar 6.
PubMed 22464223Diehl EE, Langdon EJ, Dias-Scopel RP. [The contribution of indigenous community health workers to special healthcare for Brazilian indigenous peoples]. Cad Saude Publica. 2012 May;28(5):819-31. doi: 10.1590/s0102-311x2012000500002. Portuguese.
PubMed 22641506Chandler, M. J., & Lalonde, C. (1998). Cultural Continuity as a Hedge against Suicide in Canada's First Nations. Transcultural Psychiatry, 35(2), 191-219. https://doi.org/10.1177/136346159803500202
Burn H, Black J, Harwood M, Gordon I, Burnett AM, Hamm LM, Evans J, Ramke J. Eye care delivery models to improve access to eye care for Indigenous people in high-income countries: protocol for a scoping review. BMJ Open. 2019 Jul 29;9(7):e029214. doi: 10.1136/bmjopen-2019-029214.
PubMed 31362967Agudelo-Hernandez F, Amaya NV, Cardona M. Suicide in a Colombian indigenous community: Beyond mental illness. Int J Soc Psychiatry. 2023 Dec;69(8):1986-1995. doi: 10.1177/00207640231183922. Epub 2023 Jun 30.
PubMed 37392003
Study at a glance
From the registry record, last updated by the sponsor on 9 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Mental Health Reinforcement in Wayapi and Teko Communities in French Guiana : Evaluation of the Impact of a Mediation Based Activity in Municipalities of Camopi and Trois Saut in French Guiana
- ClinicalTrials.gov ID
- NCT07808801
- Acronym / sponsor ID
- MCS Impact / MCS Impact
- Conditions
- Mental Disease
- Keywords
- Indigenous mental health, Suicide prevention, Community Health Workers, Amazonia / French Guiana, Intercultural mediation
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 300 participants (estimated)
- Lead sponsor
- Centre Hospitalier de CayenneUniversity, hospital or other
- Collaborators
- Regional Health Agency (ARS)
- Study start
- 1 Sep 2026 (estimated)
- Primary completion
- 30 Aug 2029 (estimated)
- Study completion
- 30 Aug 2029 (estimated)
- First posted
- 9 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
In French Guiana, Indigenous people experience high levels of psychological distress and higher rates of suicidal behavior than the rest of the population.
The Wayãpi and Teko communities living in Camopi and Trois-Sauts are particularly affected.
Since 2025, Community Workers (CHWs) from these communities have been appointed to facilitate access to care, improve communication between residents and health services, and strengthen support in situations of distress.
To date, no scientific evaluation has been conducted to measure the actual impact of this initiative. This research therefore aims to better understand mental health in these communities and to assess the effect of the community mediators' work.
The results will help improve suicide prevention efforts and adapt public health policies to local realities.
The purpose of this study is to assess the impact of CHWs activities on:
- suicidal behavior,
- psychological distress,
- alcohol use,
- use of health care services, within the Wayãpi and Teko communities of Camopi and Trois-Sauts.
Detailed description
- Rational of the study
The mental health of Indigenous peoples is a major public health and social justice issue. Approximately 370 million Indigenous people live in more than 90 countries, sharing common experiences of historical exclusion, territorial dispossession, and socioeconomic marginalization. These structural determinants result in persistent health inequalities, including suicide rates that are frequently higher than national averages.
International data show significant variability-ranging from 0 to 187.5 suicides per 100,000 people -highlighting the importance of cultural and historical contexts. Ethnicity is not a risk factor in and of itself; vulnerabilities arise from the interaction between historical trauma, socioeconomic conditions, and local cultural dynamics.
The literature highlights three key factors:
- Structural vulnerability, linked to poverty, discrimination, and limited access to specialized services.
- Historical and intergenerational trauma linked to colonization, forced displacement, and assimilation policies, which contribute to mental health disorders.
- Resources for resilience: cultural continuity, local governance, and strong kinship networks.
International comparisons confirm that communities with territorial control, autonomous institutions, or adapted educational systems have significantly lower suicide rates.
The Amazon is a region particularly affected by inequalities in Indigenous mental health. Despite remarkable linguistic and cultural diversity, the region remains marked by the legacy of colonization, resource exploitation, missionary activity, and a chronic lack of health and educational infrastructure.
Available data indicate that suicide rates reach particularly high levels in several Amazonian contexts: up to twenty times the national average among the Guarani-Kaiowá in Brazil, 247.9 per 100,000 inhabitants among the Emberá Dobidá in Colombia, and rates higher than the national average in the Ecuadorian Amazon. These situations reflect the cumulative effect of structural, social, and historical vulnerabilities, the manifestation of which varies according to national and local contexts.
Although it is a department of a high-income country, French Guiana exhibits health inequalities comparable to those observed in low-resource settings. The Amazonian interior, accessible only by canoe or plane, suffers from significant geographic isolation, limiting access to specialized care.
In French Guiana, the municipality of Camopi, which includes the village of Trois-Sauts, has particularly high suicide rates, estimated at 113 and 137 per 100,000 inhabitants, respectively, with suicide attempt rates approaching 400 per 100,000 inhabitants. Suicides primarily affect young people aged 10 to 29, who account for more than 60% of suicide deaths, with an average age of 25 in the interior compared to 36 on the coast.
The observed vulnerabilities result from a complex interplay of factors: alcohol abuse and substance use disorders, domestic violence, a loss of identity due to rapid sociocultural changes, as well as the social and environmental impacts of illegal gold mining. These factors interact within a context of severe social precariousness and the erosion of community structures.
The concentration of psychiatric services in the prefecture and main French Guina town, Cayenne, the language barrier (with Wayãpi and Teko being the predominant languages), and the lack of interventions that are sustainably adapted to Indigenous contexts hinder the effectiveness of existing systems, exacerbating inequalities in access to and care for mental health.
Beyond socioeconomic and health determinants, the situations of psychological distress observed in Wayãpi and Teko communities are embedded in culturally situated frameworks of understanding. Representations of psychological distress, illness, and suicide are inseparable from a relational worldview in which bodily, social, territorial, and symbolic dimensions are closely intertwined.
In this context, psychological distress is not viewed exclusively as an individual disorder, but as an imbalance affecting the relationships between the individual, their social environment, and the symbolic frameworks mobilized to make sense of their lived experience. The failure to take these interpretive frameworks into account in healthcare systems constitutes an additional factor contributing to underutilization of services and the ineffectiveness of interventions.
In many countries, community health workers (CHWs) are a key lever for reducing health inequalities. Their cultural proximity facilitates early detection of health issues, language mediation, psychosocial support, and adherence to care.
In French Guiana, six Wayãpi and Teko Community Health Workers (CHWs) were deployed in 2025 in the municipalities of Camopi and Trois-Sauts. They serve as a bridge between so-called "traditional" medicine and allopathic medicine, facilitating access to care and the management of distressing situations.
Despite these advances, several gaps remain:
- A lack of standardized epidemiological data on the mental health of the Wayãpi and Teko peoples, aside from suicide mortality.
- Limited qualitative documentation, particularly regarding perceptions of suffering, addiction, and suicide.
- A complete lack of scientific evaluation of the role and impact of CHWs in French Guiana. Their effectiveness is assumed by analogy with the Brazilian model but has never been empirically verified.
These gaps hinder the development of appropriate prevention policies and keep the communities' real needs hidden. Three key findings emerge:
- Indigenous peoples are disproportionately vulnerable to suicide, with significant variations depending on context.
- The Amazon, and French Guiana in particular, is an area with a very high incidence of suicide.
- CHWs represent a promising avenue, but require rigorous scientific evaluation.
- Hypothesis of the study
- The cultural and linguistic background of the CHWs, who come from the Wayãpi and Teko communities, fosters trust, improves communication, and facilitates access to care, thereby contributing to a reduction in suicidal behaviors.
- The integration of cultural representations and traditional practices (Tupi-Guarani worldview, rituals, and symbols of suffering) into mediation strengthens individual and collective resilience in the face of mental health disorders.
- The community mediation model, inspired by the Brazilian Agentes Indígenas de Saúde, is transferable and effective in French Guiana, provided it is adapted to local social, linguistic, and territorial specificities.
- The close ties between CHWs and their communities are an essential resource for the early detection of crises, but can also lead to emotional overload, requiring appropriate supervision and support.
- The introduction of CHWs has a measurable positive effect on social cohesion by strengthening community ties, reducing stigma, and facilitating the integration of biomedical care with traditional knowledge.
- Design of the study
This is a single-center, quasi-experimental, prospective before-and-after study conducted in the municipality of Camopi (including Trois-Sauts).
- Retrospective phase: analysis of the 5 years preceding the introduction of MCS (aggregated data from institutional records).
- Inclusion: random selection of participants by drawing households at random from a georeferenced aerial map.
- Prospective phase: individual longitudinal follow-up over 30 months.
- Repeated assessments: M0, M12, M24, M30.
- Mixed-methods approach: standardized quantitative questionnaires (K10, AUDIT-C, WHO SUPRE-MISS/CIDI suicide module) and qualitative investigations (interviews, focus groups).
- Objectives of the study
- Primary Objective To evaluate the effectiveness of the CHWs intervention in preventing suicide and reducing suicidal behaviors among the Wayãpi and Teko populations of Camopi and Trois-Sauts.
- Secondary Objectives
The secondary objectives aim to document the mechanisms, cultural dimensions, and social effects associated with the CHWs' intervention:
- Estimate the prevalence of psychological distress and alcohol use among the Wayãpi and Teko communities.
- Estimate the use of psychiatric health care services.
- Describe cultural representations of distress, suffering, and suicide, as well as the relational and cosmological dynamics mobilized to account for them.
- Analyze the role of CHWs as an intercultural interface by documenting how they integrate traditional practices with biomedical care.
- Assess the perceived impact of CHWs on social cohesion, the reduction of stigma, and the strengthening of community support resources.
- Identify the needs, limitations, working conditions, and burnout factors among CHWs, in order to evaluate the feasibility, sustainability, and conditions for the effectiveness of the program.
- Benefits
The expected benefits apply to communities, health institutions, and scientific knowledge alike.
For the Wayãpi and Teko communities:
- improved access to care and early detection of distress
- reduction of stigma related to mental health
- strengthening of social cohesion and the integration of traditional healing with biomedicine.
For institutional stakeholders:
- unprecedented epidemiological data enabling the adaptation of suicide prevention strategies
- support for the implementation of a structured model of intercultural intervention based on the work of the CHWs
- improved training for professionals on intercultural approaches.
For research:
- generation of the first quantitative and qualitative data on the mental health of the Wayãpi and Teko
- development of a methodological framework that can be applied in other Amazonian context
Study design
- Observational model
- Other
- Time perspective
- Other
Who may qualify
- Ages
- 12 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Adults and children over 12 years of age from the Wayapi and Teko communities in the villages of Camopi and Trois-Saut in French Guiana
Key inclusion criteria (3 listed)
- Age > 12 years
- Members of the Wayãpi or Teko communities residing in Camopi or Trois-Sauts.
- No objection to participating in the study and to the use of their data after receiving information in local languages and in French
Key exclusion criteria (2 listed)
- Individuals under legal guardianship
- Health conditions that prevent them from understanding or completing questionnaires or participating in interviews.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Change in the incidence of suicidal behaviours (suicidal ideation, suicide attempts, and suicide deaths) in the villages of Camopi and Trois-Sauts before and after the deployment of CHWs
Time frame: From inclusion to 12, 24 and 30 months after CHWs intervention
Change in the incidence of suicidal behaviours (suicidal ideation, suicide attempts, and suicide deaths) in the study population, comparing retrospective suicidal behaviour rates in the 5 years before with propective suicidal behaviour rates at 12, 24 and 30 months after the intervention of CHWs among the study population
7 secondary outcomes
Prevalence of psychological distres
Time frame: From inclusion to 12, 24 and 30 months
Prevalence of alcohol use pattern
Time frame: From inclusion to 12, 24 and 30 months
Health-care utilisation
Time frame: From inclusion to 12, 24 and 30 months
Cultural representations of mental health and CHWs intervention
Time frame: From inclusion to 12, 24 and 30 months
Community perceptions of mental health and of CHWs intervention
Time frame: From inclusion to 12, 24 and 30 months
Social cohesion and community resilience indicators
Time frame: From inclusion to 12, 24 and 30 months
Management needs of CHWs
Time frame: At 12, 24 and 30 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Sep 2026.
- Results publication: PubMed 30122155Pollock NJ, Naicker K, Loro A, Mulay S, Colman I. Global incidence of suicide among Indigenous peoples: a systematic review. BMC Med. 2018 Aug 20;16(1):145. doi: 10.1186/s12916-018-1115-6.
- Results publication: PubMed 29642878Pacot R, Garmit B, Pradem M, Nacher M, Brousse P. The problem of suicide among Amerindians in Camopi-Trois Sauts, French Guiana 2008-2015. BMC Psychiatry. 2018 Apr 11;18(1):99. doi: 10.1186/s12888-018-1670-6.
- Results publication: PubMed 22464223Elias B, Mignone J, Hall M, Hong SP, Hart L, Sareen J. Trauma and suicide behaviour histories among a Canadian indigenous population: an empirical exploration of the potential role of Canada's residential school system. Soc Sci Med. 2012 May;74(10):1560-9. doi: 10.1016/j.socscimed.2012.01.026. Epub 2012 Mar 6.
- Results publication: PubMed 22641506Diehl EE, Langdon EJ, Dias-Scopel RP. [The contribution of indigenous community health workers to special healthcare for Brazilian indigenous peoples]. Cad Saude Publica. 2012 May;28(5):819-31. doi: 10.1590/s0102-311x2012000500002. Portuguese.
- Results publicationChandler, M. J., & Lalonde, C. (1998). Cultural Continuity as a Hedge against Suicide in Canada's First Nations. Transcultural Psychiatry, 35(2), 191-219. https://doi.org/10.1177/136346159803500202
- Results publication: PubMed 31362967Burn H, Black J, Harwood M, Gordon I, Burnett AM, Hamm LM, Evans J, Ramke J. Eye care delivery models to improve access to eye care for Indigenous people in high-income countries: protocol for a scoping review. BMJ Open. 2019 Jul 29;9(7):e029214. doi: 10.1136/bmjopen-2019-029214.
- Results publication: PubMed 37392003Agudelo-Hernandez F, Amaya NV, Cardona M. Suicide in a Colombian indigenous community: Beyond mental illness. Int J Soc Psychiatry. 2023 Dec;69(8):1986-1995. doi: 10.1177/00207640231183922. Epub 2023 Jun 30.
- Different perspectives on suicide and suicidal behaviour in French Guiana in 2023-2024Link provided by the sponsor.
- Descriptive epidemiology of suicide attempts and suicides in remote municipalities in French Guiana 2007-2018Link provided by the sponsor.
- Individual participant dataSharing planned: Undecided. Only aggregated data will be shared
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ADHD
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Unified Protocol in Penitentiary Facilities
Depression Disorders, Anxiety
Recruiting
Safety and Performance of UCon Patch Electrode
Urinary Incontinence, Urinary Incontinence, Urge
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Mathieu Nacher, MD, PhD study director
Centre Hospitalier de Cayenne, Inserm CIC 1424 Guyane-Amazonie
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Mental Disease, run by Centre Hospitalier de Cayenne at 1 site in French Guiana.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 9 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in French Guiana. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Cassio De Figueiredo Azze, MCs (+33594395050, cassiofr@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in the incidence of suicidal behaviours (suicidal ideation, suicide attempts, and suicide deaths) in the villages of Camopi and Trois-Sauts before and after the deployment of CHWs (time frame: From inclusion to 12, 24 and 30 months after CHWs intervention). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07808801, which also lists 7 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Sep 2026.