Dental Restorations LongevityNCT07811167
3D-Printed Versus CAD/CAM-Milled Resin Restorations in Posterior Teeth.
A study testing 3D-Printed Resin Onlay/Overlay (saremco print CrownTec®) and Milled Resin Onlay/Overlay (Brilliant Crios) in people with Dental Restorations Longevity, run by University of Valencia.
Trial summary
Indirect resin restorations had become a well-established conservative alternative to direct composite restorations in posterior teeth, particularly in cases of significant loss of tooth structure requiring cuspal coverage (onlays/overlays). Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Dental Restorations Longevity
- What is being tested?
- 3D-Printed Resin Onlay/Overlay (saremco print CrownTec®) and Milled Resin Onlay/Overlay (Brilliant Crios)
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 70 participants
- Where
- No sites listed yet
- Study dates
- 1 Oct 2026to 31 Dec 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- • Adult patients (≥18 years) attending the University Dental Clinic (Universitat de València) in need of a posterior indirect partial restoration (onlay/overlay)
- Permanent posterior tooth (premolar or molar) presenting extensive coronal destruction (caries, fracture, or failed previous restoration) requiring indirect restoration, with at least one weakened or missing cusp
- Sufficient remaining tooth structure to allow adequate adhesive isolation (rubber dam) and adhesive cementation
- Tooth classified as either vital (Stratum 1) or endodontically treated with an adequate, asymptomatic root canal filling and no radiographic signs of periapical pathology (Stratum 2)
- Natural antagonist dentition
- Favorable occlusal relationship
Show all 9Show fewer
- Healthy periodontal status or adequately controlled periodontal disease (probing depth ≤ 3 mm, no active clinical attachment loss)
- Willingness and ability to attend all scheduled follow-up visits over the 24-month study period
- Signed informed consent
Who cannot join
- • Known allergy or hypersensitivity to methacrylate-based materials, Bis-EMA, or any component of the restorative materials used (per manufacturer contraindications for saremco print CrownTec® and Brilliant Crios)
- Parafunctional habits (bruxism, clenching, or foreign object chewing) without adequate occlusal protection
- Active or untreated periodontal disease
- Poor oral hygiene or inability to maintain adequate plaque control
- Temporomandibular joint disorders
- Tooth requiring full-coverage restoration (crown) rather than a partial indirect restoration
Show all 12Show fewer
- Endodontically treated tooth with inadequate root canal filling, periapical pathology, or insufficient remaining coronal structure to support the restoration without additional foundation (e.g., post/core) beyond the study protocol
- Pregnant or breastfeeding patients
- Uncontrolled systemic disease that could compromise treatment outcome or follow-up compliance
- Active substance abuse
- Participation in another interventional clinical trial that could interfere with study outcomes
- Inability to provide informed consent
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Clinical Performance of 3D-Printed Versus CAD/CAM-Milled Resin Restorations: A Randomized Controlled Clinical Trial
Indirect resin restorations had become a well-established conservative alternative to direct composite restorations in posterior teeth, particularly in cases of significant loss of tooth structure requiring cuspal coverage (onlays/overlays). Compared with direct restorations, indirect techniques reduced the impact of polymerization shrinkage and shrinkage stress, generally achieving a higher degree of monomer conversion and greater resistance to marginal microleakage and wear, although at the cost of more extensive tooth preparation.
With the advancement of digital dentistry, indirect resin restorations could be fabricated using either subtractive manufacturing (CAD/CAM milling of prefabricated resin blocks) or, more recently, additive manufacturing (3D printing). Improvements in ceramic-filled resin formulations and in printing and post-processing protocols had expanded 3D printing from provisional to definitive restorations. Among printable materials, Crowntec (Saremco Dental AG) had demonstrated the most favorable mechanical properties reported in the literature, exceeding the minimum flexural strength threshold established by ISO 6872:2024 for monolithic single-unit restorations, although generally remaining below the values achieved by milled CAD/CAM resin blocks.
Read more
Despite the increasing clinical use of 3D-printed resins, evidence on their long-term clinical performance remained scarce, particularly in comparison with CAD/CAM-milled restorations. Existing data were derived mainly from in vitro studies with heterogeneous methodologies, limiting their extrapolation to real clinical conditions, where biological aging, occlusal loading, and patient-specific factors play a determining role.
Aim of the Study
The study aimed to evaluate and compare the following:
- The clinical performance of posterior indirect resin restorations fabricated by 3D printing (Crowntec, Saremco Dental AG) versus CAD/CAM milling (Brilliant Crios, Coltene), over a follow-up period of 36 months.
- The volumetric wear of the restoration and of the antagonist tooth according to the manufacturing technique.
- The effect of pulp status (vital vs. endodontically treated tooth) on the success and survival of the restorations.
Study Summary A prospective, randomized, parallel-group, double-blind (participant and outcomes assessor) clinical trial is being conducted at the Clínica Odontológica of the Universitat de València (Fundación Lluís Alcanyís). Each patient provides informed consent prior to participation, and ethical approval has been obtained from the Comité Ético de Investigación en Humanos of the Universitat de València.
Adult patients (≥18 years, ASA I or II) requiring a posterior indirect restoration with cuspal coverage, in either vital or endodontically treated teeth, are eligible for inclusion. Restorations are randomly assigned, in permuted blocks stratified by pulp status, to be fabricated by additive manufacturing (3D-printed resin) or subtractive manufacturing (CAD/CAM-milled resin).
Standardized tooth preparations are performed under local anesthesia using cuspal-coverage preparation principles, including immediate dentin sealing for vital teeth. Intraoral digital impressions are taken, and provisional restorations are placed. Final restorations are fabricated using either 3D printing or CAD/CAM milling techniques, depending on group assignment, and are cemented using resin cement following manufacturer instructions under rubber dam isolation.
Clinical evaluation is performed by a blinded outcomes assessor at baseline (1 week) and at 3, 6, 12, 18, 24, 30, and 36 months, using the revised FDI World Dental Federation criteria (Hickel et al., 2023), assessing functional, esthetic, and biological properties. Volumetric wear of the restoration and of the antagonist tooth is quantified by superimposition of successive intraoral digital scans, and restoration color change is assessed by standardized calibrated photography. An independent, blinded statistician performs the statistical analysis.
Read the detailed description
This is a prospective, randomized, parallel-group, double-blind (participant and outcomes assessor) interventional clinical trial conducted at the Dental Clinic of the University of Valencia. Eligible restorations will be randomly allocated, in permuted blocks of variable size (4 and 6), stratified by pulp status (vital and endodontically treated tooth), using a sequence generated independently for each stratum by a Python-based algorithm.
Restorations will be assigned to one of two manufacturing techniques: additive manufacturing, using a 3D-printed resin composite (Crowntec, Saremco Dental AG), or subtractive manufacturing, using a CAD/CAM-milled resin composite block (Brilliant Crios, Coltene). Both materials share a comparable base composition (Bis-EMA methacrylate matrix with barium glass and silica filler), so that the primary variable under study is the manufacturing method rather than the material composition.
All restorations will follow a standardized clinical protocol comprising tooth preparation, immediate dentin sealing (for vital teeth), intraoral digital scanning, computer-aided design, manufacture by the assigned technique, standardized surface treatment, and adhesive cementation. Provisional restorations will be placed between the preparation and cementation visits.
Clinical follow-up assessments will be conducted at baseline (1 week after cementation) and at 3, 6, 12, 18, 24, 30, and 36 months, and will include clinical evaluation using the revised FDI World Dental Federation criteria (Hickel et al., 2023), standardized calibrated color photography, and intraoral scanning for volumetric wear analysis by superimposition of successive scans onto the baseline scan using reverse-engineering software.
Participants and outcomes assessors will remain blinded to the type of restoration received; the treating clinician cannot be blinded due to the nature of the manufacturing process. Calibration sessions will be conducted among all evaluators to ensure consistency in outcome assessment. An independent statistician, blinded to group allocation, will perform the statistical analysis.
- Conditions
- Dental Restorations Longevity
- Being tested
- 3D-Printed Resin Onlay/Overlay (saremco print CrownTec®), Milled Resin Onlay/Overlay (Brilliant Crios)
- Keywords
- Subtractive manufacturing, Additive manufacturing, Overlay, Posterior indirect restorations, Restoration survival, Randomized controlled trial
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
3D-Printed Resin Onlay/Overlay (saremco print CrownTec®)Device
Also called Additive Manufacturing; saremco print CrownTec
Onlay/overlay restorations will be fabricated using a printable resin for permanent restorations (saremco print CrownTec®). Digital intraoral scans will be used for design. Restorations will be placed in vital and endodontically treated posterior teeth and evaluated at baseline, 3, 6, 12, 18, and 24 months according to FDI criteria.
Milled Resin Onlay/Overlay (Brilliant Crios)Device
Also called Subtractive Manufacturing; Brilliant Crios
Onlay/overlay restorations will be fabricated using a milling unit and a Bis-EMA-based dispersed-filler CAD/CAM composite block (Brilliant Crios). Digital intraoral scans will be used for design. Restorations will be placed in vital and endodontically treated posterior teeth and evaluated at baseline, 3, 6, 12, 18, and 24 months according to FDI criteria.
| Study group | Role | What they receive |
|---|---|---|
| Additive Manufacturing (3D-Printed Resin Onlay/Overlay) | Experimental | Posterior partial indirect restoration (onlay/overlay) fabricated by additive manufacturing using saremco print CrownTec®, designed from a digital intraoral scan and printed on an AccuFab-L4D 3D printer. Receives: Device: 3D-Printed Resin Onlay/Overlay (saremco print CrownTec®) |
| Subtractive Manufacturing (Milled Resin Onlay/Overlay) | Active comparator | Posterior partial indirect restoration (onlay/overlay) fabricated by subtractive manufacturing (milling) from Brilliant Crios CAD/CAM blocks, designed from the same digital intraoral scan protocol used in the experimental arm. Receives: Device: Milled Resin Onlay/Overlay (Brilliant Crios) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Restoration Survival Rate According to Modified USPHS/FDI Criteria
Survival of the restoration, evaluated using the modified United States Public Health Service (USPHS)/FDI criteria (Hickel et al. 2023), assessed by a calibrated, blinded outcomes assessor. Failure is defined as the need for restoration replacement due to fracture, debonding, secondary caries, or unacceptable marginal/anatomical scores. Analysis will be stratified by pulp status (vital vs. endodontically treated) and compared between the additive and subtractive manufacturing arms.
Measured: 6, 12, 18, and 24 months
Secondary outcomes (1)
Volumetric Wear of the Restoration
Volumetric wear measured by superimposition of STL files (intraoral scans) using Geomagic Wrap software, comparing additive and subtractive manufacturing arms.
Measured: BASELINE, 6, 12, 18, and 24 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Sep 2026
- Study start1 Oct 2026 (estimated)
- Primary completion31 Dec 2028 (estimated)
- Study completion31 Dec 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Dental Restorations LongevityStudies of the same condition, open and under way.
- More trials run by University of ValenciaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 70 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Valencia
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Lucía Fernández de Estevan, University of Valencia
- Investigators
- JORGE ALONSO PEREZ-BARQUERO, PROFESSOR, Study chair, University of Valencia
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07811167
- Sponsor's protocol ID
- UV-INV_ETICA-4570075
- Status last verified
- Sep 2026
- First submitted
- 2 Sep 2026
- Last updated
- 9 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: No individual participant data will be shared. In accordance with Regulation (EU) 2016/679 of the European Parliament and of the Council (General Data Protection Regulation), Article 9, health-related data are classified as a special category of personal data subject to reinforced protection requirements. Furthermore, Spanish Organic Law 3/2018, of December 5, on the Protection of Personal Data and the Guarantee of Digital Rights (Ley Orgánica 3/2018), Additional Provision Seventeen, specifically regulates the processing of personal data for health and biomedical research in Spain, restricting the reuse and disclosure of individual-level data beyond the purposes covered by participants' informed consent. Given that data sharing through ClinicalTrials.gov would constitute an international transfer of personal health data outside the European Economic Area, such disclosure would require an additional legal basis and safeguards under Chapter V of the GDPR that are not established for this
Publications
Flottes Y, Smail Y, Palomino-Durand C, Attal JP, Ceinos R, Francois P, Dursun E. Properties of 3D printed resins for definitive dental restorations: A systematic review. J Prosthet Dent. 2026 Apr;135(4):e6-e27. doi: 10.1016/j.prosdent.2025.11.040. Epub 2025 Dec 19.
PubMed 41419355Mandurino M, Cortili S, Coccoluto L, Greco K, Cantatore G, Gherlone EF, Vichi A, Paolone G. Mechanical Properties of 3D Printed vs. Subtractively Manufactured Composite Resins for Permanent Restorations: A Systematic Review. Materials (Basel). 2025 Feb 24;18(5):985. doi: 10.3390/ma18050985.
PubMed 40077210Hickel R, Mesinger S, Opdam N, Loomans B, Frankenberger R, Cadenaro M, Burgess J, Peschke A, Heintze SD, Kuhnisch J. Revised FDI criteria for evaluating direct and indirect dental restorations-recommendations for its clinical use, interpretation, and reporting. Clin Oral Investig. 2023 Jun;27(6):2573-2592. doi: 10.1007/s00784-022-04814-1. Epub 2022 Dec 12.
PubMed 36504246Revilla-Leon M, Alonso Perez-Barquero J, Barmak AB, Agustin-Panadero R, Fernandez-Estevan L, Gomez-Polo M. Accuracy of Intraoral Scanner Systems for Fabricating Inlay, Onlay, and Veneer Restorations: A Systematic Review and Meta-Analysis. J Esthet Restor Dent. 2025 Mar;37(3):727-755. doi: 10.1111/jerd.13361. Epub 2024 Dec 11.
PubMed 39663747
Study at a glance
From the registry record, last updated by the sponsor on 9 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical Performance of 3D-Printed Versus CAD/CAM-Milled Resin Restorations: A Randomized Controlled Clinical Trial
- ClinicalTrials.gov ID
- NCT07811167
- Acronym / sponsor ID
- UV-INV_ETICA-4570075
- Conditions
- Dental Restorations Longevity
- Keywords
- Subtractive manufacturing, Additive manufacturing, Overlay, Posterior indirect restorations, Restoration survival, Randomized controlled trial
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 70 participants (estimated)
- Lead sponsor
- University of ValenciaUniversity, hospital or other
- Study start
- 1 Oct 2026 (estimated)
- Primary completion
- 31 Dec 2028 (estimated)
- Study completion
- 31 Dec 2028 (estimated)
- First posted
- 9 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Indirect resin restorations had become a well-established conservative alternative to direct composite restorations in posterior teeth, particularly in cases of significant loss of tooth structure requiring cuspal coverage (onlays/overlays). Compared with direct restorations, indirect techniques reduced the impact of polymerization shrinkage and shrinkage stress, generally achieving a higher degree of monomer conversion and greater resistance to marginal microleakage and wear, although at the cost of more extensive tooth preparation.
With the advancement of digital dentistry, indirect resin restorations could be fabricated using either subtractive manufacturing (CAD/CAM milling of prefabricated resin blocks) or, more recently, additive manufacturing (3D printing). Improvements in ceramic-filled resin formulations and in printing and post-processing protocols had expanded 3D printing from provisional to definitive restorations. Among printable materials, Crowntec (Saremco Dental AG) had demonstrated the most favorable mechanical properties reported in the literature, exceeding the minimum flexural strength threshold established by ISO 6872:2024 for monolithic single-unit restorations, although generally remaining below the values achieved by milled CAD/CAM resin blocks.
Despite the increasing clinical use of 3D-printed resins, evidence on their long-term clinical performance remained scarce, particularly in comparison with CAD/CAM-milled restorations. Existing data were derived mainly from in vitro studies with heterogeneous methodologies, limiting their extrapolation to real clinical conditions, where biological aging, occlusal loading, and patient-specific factors play a determining role.
Aim of the Study
The study aimed to evaluate and compare the following:
- The clinical performance of posterior indirect resin restorations fabricated by 3D printing (Crowntec, Saremco Dental AG) versus CAD/CAM milling (Brilliant Crios, Coltene), over a follow-up period of 36 months.
- The volumetric wear of the restoration and of the antagonist tooth according to the manufacturing technique.
- The effect of pulp status (vital vs. endodontically treated tooth) on the success and survival of the restorations.
Study Summary A prospective, randomized, parallel-group, double-blind (participant and outcomes assessor) clinical trial is being conducted at the Clínica Odontológica of the Universitat de València (Fundación Lluís Alcanyís). Each patient provides informed consent prior to participation, and ethical approval has been obtained from the Comité Ético de Investigación en Humanos of the Universitat de València.
Adult patients (≥18 years, ASA I or II) requiring a posterior indirect restoration with cuspal coverage, in either vital or endodontically treated teeth, are eligible for inclusion. Restorations are randomly assigned, in permuted blocks stratified by pulp status, to be fabricated by additive manufacturing (3D-printed resin) or subtractive manufacturing (CAD/CAM-milled resin).
Standardized tooth preparations are performed under local anesthesia using cuspal-coverage preparation principles, including immediate dentin sealing for vital teeth. Intraoral digital impressions are taken, and provisional restorations are placed. Final restorations are fabricated using either 3D printing or CAD/CAM milling techniques, depending on group assignment, and are cemented using resin cement following manufacturer instructions under rubber dam isolation.
Clinical evaluation is performed by a blinded outcomes assessor at baseline (1 week) and at 3, 6, 12, 18, 24, 30, and 36 months, using the revised FDI World Dental Federation criteria (Hickel et al., 2023), assessing functional, esthetic, and biological properties. Volumetric wear of the restoration and of the antagonist tooth is quantified by superimposition of successive intraoral digital scans, and restoration color change is assessed by standardized calibrated photography. An independent, blinded statistician performs the statistical analysis.
Detailed description
This is a prospective, randomized, parallel-group, double-blind (participant and outcomes assessor) interventional clinical trial conducted at the Dental Clinic of the University of Valencia. Eligible restorations will be randomly allocated, in permuted blocks of variable size (4 and 6), stratified by pulp status (vital and endodontically treated tooth), using a sequence generated independently for each stratum by a Python-based algorithm.
Restorations will be assigned to one of two manufacturing techniques: additive manufacturing, using a 3D-printed resin composite (Crowntec, Saremco Dental AG), or subtractive manufacturing, using a CAD/CAM-milled resin composite block (Brilliant Crios, Coltene). Both materials share a comparable base composition (Bis-EMA methacrylate matrix with barium glass and silica filler), so that the primary variable under study is the manufacturing method rather than the material composition.
All restorations will follow a standardized clinical protocol comprising tooth preparation, immediate dentin sealing (for vital teeth), intraoral digital scanning, computer-aided design, manufacture by the assigned technique, standardized surface treatment, and adhesive cementation. Provisional restorations will be placed between the preparation and cementation visits.
Clinical follow-up assessments will be conducted at baseline (1 week after cementation) and at 3, 6, 12, 18, 24, 30, and 36 months, and will include clinical evaluation using the revised FDI World Dental Federation criteria (Hickel et al., 2023), standardized calibrated color photography, and intraoral scanning for volumetric wear analysis by superimposition of successive scans onto the baseline scan using reverse-engineering software.
Participants and outcomes assessors will remain blinded to the type of restoration received; the treating clinician cannot be blinded due to the nature of the manufacturing process. Calibration sessions will be conducted among all evaluators to ensure consistency in outcome assessment. An independent statistician, blinded to group allocation, will perform the statistical analysis.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Additive Manufacturing (3D-Printed Resin Onlay/Overlay) | Experimental | Device: 3D-Printed Resin Onlay/Overlay (saremco print CrownTec®)Posterior partial indirect restoration (onlay/overlay) fabricated by additive manufacturing using saremco print CrownTec®, designed from a digital intraoral scan and printed on an AccuFab-L4D 3D printer. |
| Subtractive Manufacturing (Milled Resin Onlay/Overlay) | Active comparator | Device: Milled Resin Onlay/Overlay (Brilliant Crios)Posterior partial indirect restoration (onlay/overlay) fabricated by subtractive manufacturing (milling) from Brilliant Crios CAD/CAM blocks, designed from the same digital intraoral scan protocol used in the experimental arm. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (9 listed)
- • Adult patients (≥18 years) attending the University Dental Clinic (Universitat de València) in need of a posterior indirect partial restoration (onlay/overlay)
Key exclusion criteria (12 listed)
- • Known allergy or hypersensitivity to methacrylate-based materials, Bis-EMA, or any component of the restorative materials used (per manufacturer contraindications for saremco print CrownTec® and Brilliant Crios)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| 3D-Printed Resin Onlay/Overlay (saremco print CrownTec®)Also: Additive Manufacturing; saremco print CrownTecOnlay/overlay restorations will be fabricated using a printable resin for permanent restorations (saremco print CrownTec®). Digital intraoral scans will be used for design. Restorations will be placed in vital and endodontically treated posterior teeth and evaluated at baseline, 3, 6, 12, 18, and 24 months according to FDI criteria. | Device | Additive Manufacturing (3D-Printed Resin Onlay/Overlay) |
| Milled Resin Onlay/Overlay (Brilliant Crios)Also: Subtractive Manufacturing; Brilliant CriosOnlay/overlay restorations will be fabricated using a milling unit and a Bis-EMA-based dispersed-filler CAD/CAM composite block (Brilliant Crios). Digital intraoral scans will be used for design. Restorations will be placed in vital and endodontically treated posterior teeth and evaluated at baseline, 3, 6, 12, 18, and 24 months according to FDI criteria. | Device | Subtractive Manufacturing (Milled Resin Onlay/Overlay) |
Primary outcome
Restoration Survival Rate According to Modified USPHS/FDI Criteria
Time frame: 6, 12, 18, and 24 months
Survival of the restoration, evaluated using the modified United States Public Health Service (USPHS)/FDI criteria (Hickel et al. 2023), assessed by a calibrated, blinded outcomes assessor. Failure is defined as the need for restoration replacement due to fracture, debonding, secondary caries, or unacceptable marginal/anatomical scores. Analysis will be stratified by pulp status (vital vs. endodontically treated) and compared between the additive and subtractive manufacturing arms.
1 secondary outcome
Volumetric Wear of the Restoration
Time frame: BASELINE, 6, 12, 18, and 24 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Sep 2026.
- Results publication: PubMed 41419355Flottes Y, Smail Y, Palomino-Durand C, Attal JP, Ceinos R, Francois P, Dursun E. Properties of 3D printed resins for definitive dental restorations: A systematic review. J Prosthet Dent. 2026 Apr;135(4):e6-e27. doi: 10.1016/j.prosdent.2025.11.040. Epub 2025 Dec 19.
- Results publication: PubMed 40077210Mandurino M, Cortili S, Coccoluto L, Greco K, Cantatore G, Gherlone EF, Vichi A, Paolone G. Mechanical Properties of 3D Printed vs. Subtractively Manufactured Composite Resins for Permanent Restorations: A Systematic Review. Materials (Basel). 2025 Feb 24;18(5):985. doi: 10.3390/ma18050985.
- Results publication: PubMed 36504246Hickel R, Mesinger S, Opdam N, Loomans B, Frankenberger R, Cadenaro M, Burgess J, Peschke A, Heintze SD, Kuhnisch J. Revised FDI criteria for evaluating direct and indirect dental restorations-recommendations for its clinical use, interpretation, and reporting. Clin Oral Investig. 2023 Jun;27(6):2573-2592. doi: 10.1007/s00784-022-04814-1. Epub 2022 Dec 12.
- Results publication: PubMed 39663747Revilla-Leon M, Alonso Perez-Barquero J, Barmak AB, Agustin-Panadero R, Fernandez-Estevan L, Gomez-Polo M. Accuracy of Intraoral Scanner Systems for Fabricating Inlay, Onlay, and Veneer Restorations: A Systematic Review and Meta-Analysis. J Esthet Restor Dent. 2025 Mar;37(3):727-755. doi: 10.1111/jerd.13361. Epub 2024 Dec 11.
- Individual participant dataSharing planned: No. No individual participant data will be shared. In accordance with Regulation (EU) 2016/679 of the European Parliament and of the Council (General Data Protection Regulation), Article 9, health-related data are classified as a special category of personal data subject to reinforced protection requirements. Furthermore, Spanish Organic Law 3/2018, of December 5, on the Protection of Personal Data and the Guarantee of Digital Rights (Ley Orgánica 3/2018), Additional Provision Seventeen, specifically regulates the processing of personal data for health and biomedical research in Spain, restricting the reuse and disclosure of individual-level data beyond the purposes covered by participants' informed consent. Given that data sharing through ClinicalTrials.gov would constitute an international transfer of personal health data outside the European Economic Area, such disclosure would require an additional legal basis and safeguards under Chapter V of the GDPR that are not established for this
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
JORGE ALONSO PEREZ-BARQUERO, PROFESSOR study chair
University of Valencia
Questions about this trial
What is this clinical trial studying?
A study testing 3D-Printed Resin Onlay/Overlay (saremco print CrownTec®) and Milled Resin Onlay/Overlay (Brilliant Crios) in people with Dental Restorations Longevity, run by University of Valencia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 9 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact LUCIA FERNANDEZ-ESTEVAN, PROFESSOR (659560097, lucia.fernandez-estevan@uv.es), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Restoration Survival Rate According to Modified USPHS/FDI Criteria (time frame: 6, 12, 18, and 24 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07811167, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Sep 2026.