Post Cardiac Surgery Atrial FibrillationNCT07811817
The Outcomes of Sympathetic Cardiac Denervation on Postoperative Atrial Fibrillation After Cardiac Surgery, Randomized Controlled Trial
A study testing cardiac sympathetic denervation and Standard open-heart surgery without additional epicardial or fat pad dissection. in people with Post Cardiac Surgery Atrial Fibrillation, run by Zagazig University at 1 site in Egypt.
Trial summary
we compare the effect of cutting heart nerves in one group of patients with open heart surgery and other group without cutting oh development of disturbance of heart beat after surgery Read more about this study
- Who is it for?
- Ages 18 to 70 years
- Conditions the study is for
- Post Cardiac Surgery Atrial Fibrillation
- What is being tested?
- cardiac sympathetic denervation and Standard open-heart surgery without additional epicardial or fat pad dissection.
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 560 participants
- Where
- 1 siteEgypt
- Study dates
- 20 Oct 2025to Nov 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age ≥18 years scheduled for elective open-heart surgery via median sternotomy (CABG, valve repair/replacement, or combined procedures).
- -
Who cannot join
- Preoperative permanent pacemaker or ICD.
- Emergency surgery, active endocarditis, or severe hemodynamic instability.
- Concomitant planned surgical ablation (e.g., Cox-Maze procedure) or left atrial appendage occlusion.
- Preoperative use of antiarrhythmic drugs (AADs) other than beta-blockers within 5 half-lives of surgery.
Trial locations and contacts
1 site in 1 country.
About this study
we compare the effect of cutting heart nerves in one group of patients with open heart surgery and other group without cutting oh development of disturbance of heart beat after surgery
Read the detailed description
identifying the outcome of sympathetic denervation on postoperative atrial fibrillation post cardiac surgery
- Conditions
- Post Cardiac Surgery Atrial Fibrillation
- Being tested
- cardiac sympathetic denervation, Standard open-heart surgery without additional epicardial or fat pad dissection.
- Keywords
- sympathetic cardiac denervation, post cardiac surgery atrial fibrillation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
cardiac sympathetic denervationProcedure or surgery
Before CPB initiation or during aortic cross-clamping, surgical denervation will be performed via meticulous blunt and sharp dissection. Target sites include [e.g., complete transection/resection of the ligament of Marshall, fat pad mobilization at Waterston's groove, and epicardial neural pathway division].
Standard open-heart surgery without additional epicardial or fat pad dissection.Procedure or surgery
Standard open-heart surgery without additional epicardial or fat pad dissection.
| Study group | Role | What they receive |
|---|---|---|
| sympathetic cardiac denervation | Active comparator | Before CPB initiation or during aortic cross-clamping, surgical denervation will be performed via meticulous blunt and sharp dissection. Target sites include [e.g., complete transection/resection of the ligament of Marshall, fat pad mobilization at Waterston's groove, and epicardial neural pathway division]. Receives: Procedure: cardiac sympathetic denervation |
| control | Other | Standard open-heart surgery without additional epicardial or fat pad dissection. Receives: Procedure: Standard open-heart surgery without additional epicardial or fat pad dissection. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Incidence of overall Post operative atrial fibrillation
defined as any telemetry-documented or 12-lead ECG-confirmed episode of atrial fibrillation, atrial flutter, or atrial tachycardia lasting ≥30 continuous seconds through POD 7 or hospital discharge defined as any telemetry-documented or 12-lead ECG-confirmed episode of atrial fibrillation, atrial flutter, or atrial tachycardia lasting ≥30 continuous seconds through POD 7 or hospital discharge (whichever comes first
Measured: 7th Post operative day or hospital discharge (whichever comes first).
Incidence of persistent Post operative atrial fibrillation
(duration >24 continuous hours or requiring urgent chemical/electrical cardioversion due to hemodynamic instability).
Measured: 3 months posoperative
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Sep 2026
- Study start20 Oct 2025
- Primary completionSep 2026 (estimated)
- Study completionNov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Post Cardiac Surgery Atrial FibrillationStudies of the same condition, open and under way.
- More trials run by Zagazig UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 560 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Zagazig University
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Amr Elsayed Tawfek Ibrahim, Zagazig University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07811817
- Sponsor's protocol ID
- ZU-IRB #1782/19-10-2025
- Status last verified
- Sep 2026
- First submitted
- 4 Sep 2026
- Last updated
- 10 Sep 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 10 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Outcomes of Sympathetic Cardiac Denervation on Postoperative Atrial Fibrillation After Cardiac Surgery, Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07811817
- Acronym / sponsor ID
- ZU-IRB #1782/19-10-2025
- Conditions
- Post Cardiac Surgery Atrial Fibrillation
- Keywords
- sympathetic cardiac denervation, post cardiac surgery atrial fibrillation
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 560 participants (estimated)
- Lead sponsor
- Zagazig UniversityOther government
- Study start
- 20 Oct 2025 (actual)
- Primary completion
- Sep 2026 (estimated)
- Study completion
- Nov 2026 (estimated)
- First posted
- 10 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
we compare the effect of cutting heart nerves in one group of patients with open heart surgery and other group without cutting oh development of disturbance of heart beat after surgery
Detailed description
identifying the outcome of sympathetic denervation on postoperative atrial fibrillation post cardiac surgery
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| sympathetic cardiac denervation | Active comparator | Procedure: cardiac sympathetic denervationBefore CPB initiation or during aortic cross-clamping, surgical denervation will be performed via meticulous blunt and sharp dissection. Target sites include [e.g., complete transection/resection of the ligament of Marshall, fat pad mobilization at Waterston's groove, and epicardial neural pathway division]. |
| control | Other | Procedure: Standard open-heart surgery without additional epicardial or fat pad dissection.Standard open-heart surgery without additional epicardial or fat pad dissection. |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Age ≥18 years scheduled for elective open-heart surgery via median sternotomy (CABG, valve repair/replacement, or combined procedures).
- -
Key exclusion criteria (4 listed)
- Preoperative permanent pacemaker or ICD.
- Emergency surgery, active endocarditis, or severe hemodynamic instability.
- Concomitant planned surgical ablation (e.g., Cox-Maze procedure) or left atrial appendage occlusion.
- Preoperative use of antiarrhythmic drugs (AADs) other than beta-blockers within 5 half-lives of surgery.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| cardiac sympathetic denervationBefore CPB initiation or during aortic cross-clamping, surgical denervation will be performed via meticulous blunt and sharp dissection. Target sites include [e.g., complete transection/resection of the ligament of Marshall, fat pad mobilization at Waterston's groove, and epicardial neural pathway division]. | Procedure or surgery | sympathetic cardiac denervation |
| Standard open-heart surgery without additional epicardial or fat pad dissection.Standard open-heart surgery without additional epicardial or fat pad dissection. | Procedure or surgery | control |
Primary outcome
Incidence of overall Post operative atrial fibrillation
Time frame: 7th Post operative day or hospital discharge (whichever comes first).
defined as any telemetry-documented or 12-lead ECG-confirmed episode of atrial fibrillation, atrial flutter, or atrial tachycardia lasting ≥30 continuous seconds through POD 7 or hospital discharge defined as any telemetry-documented or 12-lead ECG-confirmed episode of atrial fibrillation, atrial flutter, or atrial tachycardia lasting ≥30 continuous seconds through POD 7 or hospital discharge (whichever comes first
Incidence of persistent Post operative atrial fibrillation
Time frame: 3 months posoperative
(duration >24 continuous hours or requiring urgent chemical/electrical cardioversion due to hemodynamic instability).
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Sep 2026.
- Individual participant dataSharing planned: Yes
Related trials for Post Cardiac Surgery Atrial Fibrillation
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SGB for Prevention of Postop A-Fib After Cardiac SurgeryTrial
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Can Patients With Atrial Fibrillation Safely Discontinue Anticoagulant Therapy After Cardiac Surgery? (ATLAAC)
Atrial Fibrillation, Left Atrial Appendage Absent
Not yet recruitingPhase 3
Randomized Interventional Clinical Trial on the Prevention of Atrial Fibrillation Using Colchicine, Amiodarone And a Posterior Pericardiotomy.
Atrial Fibrillation (AF)
Recruiting
Pericardiotomy in Cardiac Surgery
Atrial Fibrillation, Atrial Flutter
Not yet recruiting
Multiparametric MRI Assessment of Atrial Heart Disease as a Predictor of Atrial Fibrillation After Myocardial Revascularization Surgery
Postoperative Atrial Fibrillation
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing cardiac sympathetic denervation and Standard open-heart surgery without additional epicardial or fat pad dissection. in people with Post Cardiac Surgery Atrial Fibrillation, run by Zagazig University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 10 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Incidence of overall Post operative atrial fibrillation (time frame: 7th Post operative day or hospital discharge (whichever comes first).). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Sep 2026.