Chronic Kidney DiseasesNCT07817953
AVF Awareness Among Advanced CKD Patients
An observational study of Chronic Kidney Diseases and Dialysis; Complications, run by Assiut University.
Trial summary
This cross-sectional study aims to assess awareness regarding arteriovenous fistula creation among patients with advanced chronic kidney disease, including pre-dialysis patients and those receiving maintenance hemodialysis, at Assiut University Hospital. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Chronic Kidney Diseases, Dialysis; Complications, Arteriovenous Fistula
- How many people
- 116 participants
- Where
- No sites listed yet
- Study dates
- 10 Sep 2026to 20 Feb 2028
- How long will I take part?
- 1 Day
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adults with advanced chronic kidney disease (CKD stage 4-5 not on maintenance hemodialysis or currently receiving maintenance hemodialysis) attending the Nephrology Unit and Maintenance Hemodialysis Unit of Assiut University Hospital.
Who may be able to join
- Age 18 years or older
- Documented chronic kidney disease
- CKD stage 4-5 not on maintenance hemodialysis OR currently on maintenance hemodialysis for established CKD
- Able to understand and answer the questionnaire
- Written informed consent
Who cannot join
- Acute kidney injury without established CKD
- Previous kidney transplantation (if considered to affect homogeneity)
- Severe cognitive or communication impairment preventing reliable questionnaire completion
- Unable or unwilling to provide informed consent
- Inability to provide reasonably reliable information about the pre-dialysis period (for retrospective questions)
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Assessment of Knowledge Regarding Arteriovenous Fistula Creation as a Requirement for Hemodialysis Among Chronic Kidney Disease Patients: A Cross-Sectional Study
This cross-sectional study aims to assess awareness regarding arteriovenous fistula creation among patients with advanced chronic kidney disease, including pre-dialysis patients and those receiving maintenance hemodialysis, at Assiut University Hospital.
Read the detailed description
Timely creation of arteriovenous fistula (AVF) is preferred for patients requiring maintenance hemodialysis. Many patients in Egypt initiate hemodialysis with temporary catheters. This hospital-based cross-sectional study will assess the level of knowledge regarding AVF creation among adults with advanced CKD (stage 4-5 not on dialysis and patients on maintenance hemodialysis).
A structured interviewer-administered questionnaire will be used to evaluate current awareness in pre-dialysis patients and retrospectively assessed pre-dialysis awareness in current hemodialysis patients.
- Conditions
- Chronic Kidney Diseases, Dialysis; Complications, Arteriovenous Fistula, Kidney Failure, Chronic
- Keywords
- Arteriovenous fistula, AVF awareness, Hemodialysis, Chronic kidney disease, Vascular access, Assiut
- Medical subject headings
- Renal Insufficiency, Chronic, Arteriovenous Fistula, Kidney Failure, Chronic
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Single cohort: Adults with advanced CKD | Adults with advanced chronic kidney disease (pre-dialysis stage 4-5 and maintenance hemodialysis patients) who will complete a structured questionnaire assessing awareness of arteriovenous fistula creation. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pre-dialysis AVF awareness score
Mean score of knowledge regarding arteriovenous fistula creation (including its use for hemodialysis, need for pre-dialysis preparation, maturation time, arm protection, and differences from catheter) assessed by a structured questionnaire. For patients already on maintenance hemodialysis, awareness will be assessed retrospectively for the period before dialysis initiation.
Measured: Baseline
Secondary outcomes (5)
Proportion with prior AVF counseling
Percentage of participants who report receiving counseling about arteriovenous fistula before initiation of maintenance hemodialysis.
Measured: Baseline
Vascular access used at first hemodialysis session
Percentage of maintenance hemodialysis patients who started dialysis with arteriovenous fistula versus temporary central venous catheter.
Measured: Baseline
Timing of AVF creation
Percentage of participants in whom arteriovenous fistula was created before versus after initiation of maintenance hemodialysis.
Measured: Baseline
Willingness to undergo AVF creation
Percentage of participants willing to undergo arteriovenous fistula creation when indicated.
Measured: Baseline
Sources of AVF information
Distribution of reported sources of information about arteriovenous fistula (nephrologist, nurse, family, other patients, or media).
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Sep 2026
- Study start10 Sep 2026 (estimated)
- Primary completion10 Sep 2027 (estimated)
- Study completion20 Feb 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Chronic Kidney DiseasesStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Enrolment
- 116 participants (estimated)
- Target duration
- 1 Day
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Boliss Sydhom Henain Ragheb, Assiut University
- Investigators
- Mohamed A Abozaid, prof, Study chair, Internal Medicine Department, Assiut University Hospitals
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07817953
- Sponsor's protocol ID
- AVF-Awareness-CKD-Assiut-2026
- Status last verified
- Sep 2026
- First submitted
- 9 Sep 2026
- Last updated
- 14 Sep 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Yuan S, Hu D, Gao D, Butch CJ, Wang Y, Zheng H, Sheng Z. Recent advances of engineering cell membranes for nanomedicine delivery across the blood-brain barrier. J Nanobiotechnology. 2025 Jul 8;23(1):493. doi: 10.1186/s12951-025-03572-y.
PubMed 40624508Cavanaugh KL, Wingard RL, Hakim RM, Elasy TA, Ikizler TA. Patient dialysis knowledge is associated with permanent arteriovenous access use in chronic hemodialysis. Clin J Am Soc Nephrol. 2009 May;4(5):950-6. doi: 10.2215/CJN.04580908. Epub 2009 Apr 23.
PubMed 19389825Shamasneh AO, Atieh AS, Gharaibeh KA, Hamadah A. Perceived barriers and attitudes toward arteriovenous fistula creation and use in hemodialysis patients in Palestine. Ren Fail. 2020 Nov;42(1):343-349. doi: 10.1080/0886022X.2020.1748650.
PubMed 32338112
Study at a glance
From the registry record, last updated by the sponsor on 14 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Assessment of Knowledge Regarding Arteriovenous Fistula Creation as a Requirement for Hemodialysis Among Chronic Kidney Disease Patients: A Cross-Sectional Study
- ClinicalTrials.gov ID
- NCT07817953
- Acronym / sponsor ID
- AVF-Awareness-CKD-Assiut-2026
- Conditions
- Chronic Kidney Diseases, Dialysis; Complications, Arteriovenous Fistula, Kidney Failure, Chronic
- Keywords
- Arteriovenous fistula, AVF awareness, Hemodialysis, Chronic kidney disease, Vascular access, Assiut
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 116 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 10 Sep 2026 (estimated)
- Primary completion
- 10 Sep 2027 (estimated)
- Study completion
- 20 Feb 2028 (estimated)
- First posted
- 14 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This cross-sectional study aims to assess awareness regarding arteriovenous fistula creation among patients with advanced chronic kidney disease, including pre-dialysis patients and those receiving maintenance hemodialysis, at Assiut University Hospital.
Detailed description
Timely creation of arteriovenous fistula (AVF) is preferred for patients requiring maintenance hemodialysis. Many patients in Egypt initiate hemodialysis with temporary catheters. This hospital-based cross-sectional study will assess the level of knowledge regarding AVF creation among adults with advanced CKD (stage 4-5 not on dialysis and patients on maintenance hemodialysis).
A structured interviewer-administered questionnaire will be used to evaluate current awareness in pre-dialysis patients and retrospectively assessed pre-dialysis awareness in current hemodialysis patients.
Study design
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Target follow-up
- 1 Day
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Single cohort: Adults with advanced CKD | – | –Adults with advanced chronic kidney disease (pre-dialysis stage 4-5 and maintenance hemodialysis patients) who will complete a structured questionnaire assessing awareness of arteriovenous fistula creation. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adults with advanced chronic kidney disease (CKD stage 4-5 not on maintenance hemodialysis or currently receiving maintenance hemodialysis) attending the Nephrology Unit and Maintenance Hemodialysis Unit of Assiut University Hospital.
Key inclusion criteria (5 listed)
- Age 18 years or older
- Documented chronic kidney disease
- CKD stage 4-5 not on maintenance hemodialysis OR currently on maintenance hemodialysis for established CKD
- Able to understand and answer the questionnaire
- Written informed consent
Key exclusion criteria (5 listed)
- Acute kidney injury without established CKD
- Previous kidney transplantation (if considered to affect homogeneity)
- Severe cognitive or communication impairment preventing reliable questionnaire completion
- Unable or unwilling to provide informed consent
- Inability to provide reasonably reliable information about the pre-dialysis period (for retrospective questions)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Pre-dialysis AVF awareness score
Time frame: Baseline
Mean score of knowledge regarding arteriovenous fistula creation (including its use for hemodialysis, need for pre-dialysis preparation, maturation time, arm protection, and differences from catheter) assessed by a structured questionnaire. For patients already on maintenance hemodialysis, awareness will be assessed retrospectively for the period before dialysis initiation.
5 secondary outcomes
Proportion with prior AVF counseling
Time frame: Baseline
Vascular access used at first hemodialysis session
Time frame: Baseline
Timing of AVF creation
Time frame: Baseline
Willingness to undergo AVF creation
Time frame: Baseline
Sources of AVF information
Time frame: Baseline
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Sep 2026.
- Background: PubMed 40624508Yuan S, Hu D, Gao D, Butch CJ, Wang Y, Zheng H, Sheng Z. Recent advances of engineering cell membranes for nanomedicine delivery across the blood-brain barrier. J Nanobiotechnology. 2025 Jul 8;23(1):493. doi: 10.1186/s12951-025-03572-y.
- Background: PubMed 19389825Cavanaugh KL, Wingard RL, Hakim RM, Elasy TA, Ikizler TA. Patient dialysis knowledge is associated with permanent arteriovenous access use in chronic hemodialysis. Clin J Am Soc Nephrol. 2009 May;4(5):950-6. doi: 10.2215/CJN.04580908. Epub 2009 Apr 23.
- Background: PubMed 32338112Shamasneh AO, Atieh AS, Gharaibeh KA, Hamadah A. Perceived barriers and attitudes toward arteriovenous fistula creation and use in hemodialysis patients in Palestine. Ren Fail. 2020 Nov;42(1):343-349. doi: 10.1080/0886022X.2020.1748650.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Mohamed A Abozaid, prof study chair
Internal Medicine Department, Assiut University Hospitals
Questions about this trial
What is this clinical trial studying?
An observational study of Chronic Kidney Diseases and Dialysis; Complications, run by Assiut University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 14 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Boliss s Ragheb, Resident (+201003957926, Poles18313386@med.aun.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pre-dialysis AVF awareness score (time frame: Baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07817953, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Sep 2026.