To Compare the Effect of Nanoparticle Coated Orthodontic Brackets Versus Standard Ones on the Rate of Canine RetractionNCT07818590
The Effect of Nanoparticle Coating of Orthodontic Brackets on The Rate of Canine Retraction: A Randomized Clinical Trial
A study testing nanoparticle coated maxillary canine bracket in people with To Compare the Effect of Nanoparticle Coated Orthodontic Brackets Versus Standard Ones on the Rate of Canine Retraction, run by Cairo University at 2 sites in Egypt.
Trial summary
Orthodontic treatment often requires prolonged periods to achieve desired tooth movements, particularly in procedures like canine retraction. Traditional orthodontic brackets, while effective in aligning teeth, are limited by frictional resistance between the brackets and archwires, which can slow down the tooth… Read more about this study
- Who is it for?
- Ages 13 to 30 yearsHealthy volunteers can take part
- Conditions the study is for
- To Compare the Effect of Nanoparticle Coated Orthodontic Brackets Versus Standard Ones on the Rate of Canine Retraction
- What is being tested?
- nanoparticle coated maxillary canine bracket
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 28 participants
- Where
- 2 sitesEgypt
- Study dates
- 1 Oct 2025to 1 Mar 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 13 to 30 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Who may be able to join
- Patients aged 13 to 30 years.
- Treatment plan requiring extraction of both upper first premolars.
- Anterior teeth protrusion necessitating canine retraction.
- No previous orthodontic treatment.
- No systemic diseases.
- Not taking routinely used drugs.
- Good oral hygiene.
- No extractions required other than the specified upper first premolars.
Who cannot join
- Poor oral hygiene.
- Previous orthodontic treatment.
- Patients with active periodontal disease.
- Presence of any craniofacial syndromes.
Trial locations and contacts
2 sites in 1 country.
Egypt2 sites
Ahmed Mohamed Ebrahim Zarzora
Giza, 12573
Ahmed Mohamed Ebrahim Zarzora
Giza
About this study
Orthodontic treatment often requires prolonged periods to achieve desired tooth movements, particularly in procedures like canine retraction. Traditional orthodontic brackets, while effective in aligning teeth, are limited by frictional resistance between the brackets and archwires, which can slow down the tooth movement process. This extended treatment time not only increases the discomfort and inconvenience for patients but also raises the risk of complications, including enamel decalcification, root resorption, and periodontal issues. Recent advancements in nanotechnology have introduced the possibility of nanoparticle coatings, which may reduce friction and improve the efficiency of tooth movement.
However, there is limited clinical evidence on the effectiveness of nanoparticle-coated brackets in enhancing the rate of orthodontic tooth movement, particularly in canine retraction. Additionally, while laboratory studies suggest benefits, there is a lack of randomized clinical trials to validate these findings in real-world orthodontic settings.
This study aims to address this gap by investigating the effect of nanoparticle coating on the rate of canine retraction using a randomized clinical trial design. The findings could potentially offer insights into whether nanoparticle-coated brackets present a viable option to enhance treatment efficiency and improve patient outcomes in orthodontics.
- Being tested
- nanoparticle coated maxillary canine bracket
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
nanoparticle coated maxillary canine bracketOther
Bonding of nanoparticle coated maxillary canine bracket Canine retraction Digital model will be taken every one month (T0, initial; T1, 4 weeks; T2, 8 weeks; T3, 12 weeks) to compare the rate of canine retraction.
| Study group | Role | What they receive |
|---|---|---|
| standard maxillary canine bracket. | Experimental | Not described Receives: Other: nanoparticle coated maxillary canine bracket |
| nanoparticle coated maxillary canine bracket | Active comparator | Not described Receives: Other: nanoparticle coated maxillary canine bracket |
What is being measured
The primary outcome is the main question the study is designed to answer.
The rate of canine retraction
The null hypothesis (H0) of this research is that there is no significant difference in the rate of canine retraction between patients treated with nanoparticle-coated orthodontic brackets and those treated with standard orthodontic brackets
Measured: T0, initial; T1, 4 weeks; T2, 8 weeks; T3, 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Sep 2026
- Study start1 Oct 2025
- Primary completion1 Jan 2026
- Study completion1 Mar 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for To Compare the Effect of Nanoparticle Coated Orthodontic Brackets Versus Standard Ones on the Rate of Canine RetractionStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 28 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ahmed Mohamed Ebrahim Zarzora, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07818590
- Sponsor's protocol ID
- ORTH 3.4.1
- Status last verified
- Sep 2026
- First submitted
- 8 Sep 2026
- Last updated
- 15 Sep 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Nanoparticle Coating of Orthodontic Brackets on The Rate of Canine Retraction: A Randomized Clinical Trial
- ClinicalTrials.gov ID
- NCT07818590
- Acronym / sponsor ID
- ORTH 3.4.1
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 28 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 Oct 2025 (actual)
- Primary completion
- 1 Jan 2026 (actual)
- Study completion
- 1 Mar 2026 (actual)
- First posted
- 14 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Orthodontic treatment often requires prolonged periods to achieve desired tooth movements, particularly in procedures like canine retraction. Traditional orthodontic brackets, while effective in aligning teeth, are limited by frictional resistance between the brackets and archwires, which can slow down the tooth movement process. This extended treatment time not only increases the discomfort and inconvenience for patients but also raises the risk of complications, including enamel decalcification, root resorption, and periodontal issues. Recent advancements in nanotechnology have introduced the possibility of nanoparticle coatings, which may reduce friction and improve the efficiency of tooth movement.
However, there is limited clinical evidence on the effectiveness of nanoparticle-coated brackets in enhancing the rate of orthodontic tooth movement, particularly in canine retraction. Additionally, while laboratory studies suggest benefits, there is a lack of randomized clinical trials to validate these findings in real-world orthodontic settings.
This study aims to address this gap by investigating the effect of nanoparticle coating on the rate of canine retraction using a randomized clinical trial design. The findings could potentially offer insights into whether nanoparticle-coated brackets present a viable option to enhance treatment efficiency and improve patient outcomes in orthodontics.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| standard maxillary canine bracket. | Experimental | Other: nanoparticle coated maxillary canine bracket |
| nanoparticle coated maxillary canine bracket | Active comparator | Other: nanoparticle coated maxillary canine bracket |
Who may qualify
- Ages
- 13 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
Key inclusion criteria (8 listed)
- Patients aged 13 to 30 years.
- Treatment plan requiring extraction of both upper first premolars.
- Anterior teeth protrusion necessitating canine retraction.
- No previous orthodontic treatment.
- No systemic diseases.
Key exclusion criteria (4 listed)
- Poor oral hygiene.
- Previous orthodontic treatment.
- Patients with active periodontal disease.
- Presence of any craniofacial syndromes.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| nanoparticle coated maxillary canine bracketBonding of nanoparticle coated maxillary canine bracket Canine retraction Digital model will be taken every one month (T0, initial; T1, 4 weeks; T2, 8 weeks; T3, 12 weeks) to compare the rate of canine retraction. | Other | nanoparticle coated maxillary canine bracket, standard maxillary canine bracket. |
Primary outcome
The rate of canine retraction
Time frame: T0, initial; T1, 4 weeks; T2, 8 weeks; T3, 12 weeks
The null hypothesis (H0) of this research is that there is no significant difference in the rate of canine retraction between patients treated with nanoparticle-coated orthodontic brackets and those treated with standard orthodontic brackets
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Sep 2026.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing nanoparticle coated maxillary canine bracket in people with To Compare the Effect of Nanoparticle Coated Orthodontic Brackets Versus Standard Ones on the Rate of Canine Retraction, run by Cairo University at 2 sites in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 15 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The rate of canine retraction (time frame: T0, initial; T1, 4 weeks; T2, 8 weeks; T3, 12 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Sep 2026.