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Ankle RehabilitationNCT07820449

Ankle Evertor and Invertor Strength Training

A study testing Ankle Evertor and Invertor Strength Training in people with Ankle Rehabilitation and Ankle Instability, run by University of Ljubljana at 1 site in Slovenia.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The aim of this study was to investigate the effects of a 12-week ankle evertor and invertor strength training program performed on a specially designed device, which allows isolated strengthening of evertor and invertor muscles. Read more about this study

Who is it for?
Ages 18 to 50 years, men onlyHealthy volunteers can take part
What is being tested?
Ankle Evertor and Invertor Strength Training
Could I receive a placebo?
No, everyone receives an active treatment
How many people
32 participants
Where
1 siteSlovenia
Study dates
2 Feb 2017to 31 May 2017
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 50 years
  • Men only
  • Healthy volunteers accepted
  • Adult

Who may be able to join

  • Male, aged 18 to 50 Years
  • Recreationally active (regularly participating in running or sport)
  • No history of ankle injury or surgery
  • No musculoskeletal disorders affecting the lower extremity
  • Able to perform physical exercise without restrictions

Who cannot join

  • History of ankle sprain or ligament injury in the past 12 months
  • Any lower extremity injury or surgery
  • Neurological or cardiovascular conditions affecting exercise participation
  • Currently receiving physiotherapy for lower extremity conditions

Trial locations and contacts

1 site in 1 country.

Slovenia1 site

  • Faculty of Sport, University of Ljubljana

    Ljubljana, 1000

Other trials in Slovenia

About this study

Official title: Neuromuscular Adaptations to a 12-Week Ankle Evertor and Invertor Strength Training Program in Healthy Adults

The aim of this study was to investigate the effects of a 12-week ankle evertor and invertor strength training program performed on a specially designed device, which allows isolated strengthening of evertor and invertor muscles. Outcome measures included isometric ankle torque, EMG activity of six tibial muscles, muscle coactivation, and kinematic parameters during three walking conditions. This trial was retrospectively registered. The study was conducted in 2017 as part of a doctoral dissertation at the Faculty of Sport, University of Ljubljana, prior to the authors' awareness of prospective registration requirements.

Being tested
Ankle Evertor and Invertor Strength Training
Keywords
ankle evertors, ankle invertors, ankle joint, strength training, subtalar axis, peroneal muscles, tibial muscles, ankle sprains
Medical subject headings
Ankle Injuries, Disease

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Ankle Evertor and Invertor Strength TrainingBehavioural

    Participants in experimental group were performing strength training on a specially designed device. The program consisted of 8 weeks of hypertrophy-oriented training followed by 4 weeks of neural activation training.

Study groups in NCT07820449
Study groupRoleWhat they receive
Experimental GroupExperimentalParticipants performed a 12-week ankle evertor and invertor strength training program on a specially designed device.
Receives: Behavioral: Ankle Evertor and Invertor Strength Training
Control GroupNo interventionParticipants maintained habitual activity without any structured strength training.

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Isometric Ankle Torque

    Maximal isometric torque in foot eversion and inversion direction measured with a isometric device.

    Measured: Baseline and 12 weeks

Secondary outcomes (7)

  1. EMG Activity of Tibial Muscles

    Monitoring normalized RMS EMG amplitude of peroneus longus, peroneus brevis, tibialis anterior, gastrocnemius medialis, gastrocnemius lateralis, and soleus during different walking conditions.

    Measured: Baseline and 12 weeks

  2. Walking Speed

    Monitoring walking speed (m/s) during three walking conditions.

    Measured: Baseline and 12 weeks

  3. Stretch Reflex Response

    Electromyographic reflex response of ankle evertor (m. PL and PB) and invertor muscles (m TA) following mechanical perturbation.

    Measured: Baseline and 12 weeks

  4. Muscle Co-activation Index Between Pairs of Tibial Muscles During Walking

    Coactivation index (%) calculated between pairs of tibial muscles (PL, PB, TA, SOL, GM, GL) during three different types of walking (normal walking, medially inclined, laterally inclined surface).

    Measured: Baseline and 12 weeks

  5. Foot Position During Walking

    Monitoring foot elevation angle (degrees) during three different types of walking.

    Measured: Baseline and 12 weeks

  6. Contact Time

    Monitoring contact time (s) during three different types of walking (flat surface, medially inclined laterally inclined).

    Measured: Baseline and 12 weeks

  7. Stride Length

    Monitoring stride length (m) during three different types of walking (flat surface, medially inclined, laterally inclined).

    Measured: Baseline and 12 weeks

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted15 Sep 2026
  2. Study start2 Feb 2017
  3. Primary completion31 May 2017
  4. Study completion31 May 2017

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Prevention
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
32 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07820449
Sponsor's protocol ID
EVE/INV 49382013
Other IDs
P5-0124
Status last verified
Sep 2026
First submitted
3 Sep 2026
Last updated
15 Sep 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Yes: Individual participant data may be shared upon reasonable request to the corresponding author.

Publications

  • Winter DA, Patla AE, Frank JS, Walt SE. Biomechanical walking pattern changes in the fit and healthy elderly. Phys Ther. 1990 Jun;70(6):340-7. doi: 10.1093/ptj/70.6.340.

    PubMed 2345777

  • Voloshina AS, Ferris DP. Biomechanics and energetics of running on uneven terrain. J Exp Biol. 2015 Mar;218(Pt 5):711-9. doi: 10.1242/jeb.106518. Epub 2015 Jan 23.

    PubMed 25617451

  • Santilli V, Frascarelli MA, Paoloni M, Frascarelli F, Camerota F, De Natale L, De Santis F. Peroneus longus muscle activation pattern during gait cycle in athletes affected by functional ankle instability: a surface electromyographic study. Am J Sports Med. 2005 Aug;33(8):1183-7. doi: 10.1177/0363546504274147. Epub 2005 Jul 6.

    PubMed 16000658

  • Murley GS, Menz HB, Landorf KB. Foot posture influences the electromyographic activity of selected lower limb muscles during gait. J Foot Ankle Res. 2009 Nov 26;2:35. doi: 10.1186/1757-1146-2-35.

    PubMed 19939283

  • Louwerens JW, van Linge B, de Klerk LW, Mulder PG, Snijders CJ. Peroneus longus and tibialis anterior muscle activity in the stance phase. A quantified electromyographic study of 10 controls and 25 patients with chronic ankle instability. Acta Orthop Scand. 1995 Dec;66(6):517-23. doi: 10.3109/17453679509002306.

    PubMed 8553819

  • Ha SC, Fong DT, Chan KM. Review of ankle inversion sprain simulators in the biomechanics laboratory. Asia Pac J Sports Med Arthrosc Rehabil Technol. 2015 Oct 21;2(4):114-121. doi: 10.1016/j.asmart.2015.08.002. eCollection 2015 Oct.

    PubMed 29264250

  • Garrick JG. The frequency of injury, mechanism of injury, and epidemiology of ankle sprains. Am J Sports Med. 1977 Nov-Dec;5(6):241-2. doi: 10.1177/036354657700500606. No abstract available.

    PubMed 563179

  • Ferran NA, Maffulli N. Epidemiology of sprains of the lateral ankle ligament complex. Foot Ankle Clin. 2006 Sep;11(3):659-62. doi: 10.1016/j.fcl.2006.07.002.

    PubMed 16971255

  • Falconer K, Winter DA. Quantitative assessment of co-contraction at the ankle joint in walking. Electromyogr Clin Neurophysiol. 1985 Mar-Apr;25(2-3):135-49. No abstract available.

    PubMed 3987606

  • Docherty CL, Moore JH, Arnold BL. Effects of strength training on strength development and joint position sense in functionally unstable ankles. J Athl Train. 1998 Oct;33(4):310-4.

    PubMed 16558526

  • DeMers MS, Hicks JL, Delp SL. Preparatory co-activation of the ankle muscles may prevent ankle inversion injuries. J Biomech. 2017 Feb 8;52:17-23. doi: 10.1016/j.jbiomech.2016.11.002. Epub 2016 Dec 7.

    PubMed 28057351

  • Chan CW, Rudins A. Foot biomechanics during walking and running. Mayo Clin Proc. 1994 May;69(5):448-61. doi: 10.1016/s0025-6196(12)61642-5.

    PubMed 8170197

  • Brockett CL, Chapman GJ. Biomechanics of the ankle. Orthop Trauma. 2016 Jun;30(3):232-238. doi: 10.1016/j.mporth.2016.04.015.

    PubMed 27594929

  • Bavdek R, Zdolsek A, Strojnik V, Dolenec A. Peroneal muscle activity during different types of walking. J Foot Ankle Res. 2018 Sep 3;11:50. doi: 10.1186/s13047-018-0291-0. eCollection 2018.

    PubMed 30202446

  • Apps C, Sterzing T, O'Brien T, Lake M. Lower limb joint stiffness and muscle co-contraction adaptations to instability footwear during locomotion. J Electromyogr Kinesiol. 2016 Dec;31:55-62. doi: 10.1016/j.jelekin.2016.09.003. Epub 2016 Sep 20.

    PubMed 27684529

Questions about this trial

What is this clinical trial studying?

A study testing Ankle Evertor and Invertor Strength Training in people with Ankle Rehabilitation and Ankle Instability, run by University of Ljubljana at 1 site in Slovenia.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 15 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Slovenia. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Isometric Ankle Torque (time frame: Baseline and 12 weeks). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07820449, which also lists 15 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Sep 2026.

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