Pulmonary InfectionNCT07821710
Efficacy of Infection-site-targeted Postural Drainage in Mechanically Ventilated ICU Patients With Pulmonary Infection
A study testing Imaging-guided infection-site-targeted postural drainage plus mechanical vibration chest physiotherapy. and Routine position change combined with mechanical vibration in people with Pulmonary Infection and Mechanical Ventilation, run by Affiliated Hospital of Jiangnan University at 1 site in China.
Trial summary
This single-center, 1:1 randomized controlled trial aimed to evaluate the efficacy of infection-site-targeted postural drainage combined with mechanical vibration for mechanically ventilated ICU patients with pulmonary infection. Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- Pulmonary Infection, Mechanical Ventilation, Respiratory Failure
- What is being tested?
- Imaging-guided infection-site-targeted postural drainage plus mechanical vibration chest physiotherapy. and Routine position change combined with mechanical vibration
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 384 participants
- Where
- 1 siteChina
- Study dates
- 1 May 2022to 30 Oct 2024
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Aged 18-80 years old;
- Admitted to ICU and receiving invasive mechanical ventilation;
- Clinically confirmed pulmonary infection;
- Enrolled between May 2022 and October 2024.
Who cannot join
- Unstable systemic disease contraindicating postural changes;
- Active bleeding (gastrointestinal, intracranial, or pulmonary);
- Requirement for continuous renal replacement therapy;
- Raised intracranial pressure;
- Neuromuscular disorder;
- Multiple fractures or major trauma;
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- Severe hemodynamic instability;
- Significant arrhythmias;
- Severe delirium or altered mental status;
- Pregnancy or lactation;
- Currently participating in another interventional clinical trial.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: A Randomized Controlled Trial of Infection-site-targeted Postural Drainage Combined With Mechanical Vibration for Mechanically Ventilated ICU Patients With Pulmonary Infection
This single-center, 1:1 randomized controlled trial aimed to evaluate the efficacy of infection-site-targeted postural drainage combined with mechanical vibration for mechanically ventilated ICU patients with pulmonary infection.
Eligible subjects were randomly assigned to either the personalized-care group (PCG, intervention) or routine-care group (RCG, control).
Read more
Patients in PCG received imaging-guided infection-site-targeted postural drainage plus mechanical vibration. Patients in RCG received standard routine position changes and mechanical vibration without imaging-guided targeted positional adjustment.
The primary outcome was duration of invasive mechanical ventilation. Secondary outcomes included PaO₂/FiO₂ ratio, ICU length of stay, total hospital length of stay, and 28-day all-cause mortality.
- Being tested
- Imaging-guided infection-site-targeted postural drainage plus mechanical vibration chest physiotherapy., Routine position change combined with mechanical vibration
- Medical subject headings
- Respiratory Insufficiency
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Imaging-guided infection-site-targeted postural drainage plus mechanical vibration chest physiotherapy.Procedure or surgery
Imaging-guided infection-site-targeted postural drainage combined with mechanical vibration chest physiotherapy. The body position is individually adjusted according to pulmonary infection location shown on imaging examinations to facilitate sputum drainage.
Routine position change combined with mechanical vibrationProcedure or surgery
Routine regular position change combined with mechanical vibration chest physiotherapy. No imaging-guided targeted positional adjustment is performed; body position is changed following standard ICU nursing protocol only.
| Study group | Role | What they receive |
|---|---|---|
| Intervention group | Experimental | Not described Receives: Procedure: Imaging-guided infection-site-targeted postural drainage plus mechanical vibration chest physiotherapy. |
| Routine-care group | Active comparator | Not described Receives: Procedure: Routine position change combined with mechanical vibration |
What is being measured
The primary outcome is the main question the study is designed to answer.
Duration of mechanical ventilation
Measured: From initiation of invasive mechanical ventilation until successful extubation or death, assessed up to day 28.
Secondary outcomes (4)
28-day mortality
Measured: All-cause mortality assessed at 28 calendar days from the date of randomization
PaO₂/FiO₂ ratio
Measured: Measured at baseline (X1), Day 1, Day 2, Day 3, Day 4 post-randomization (X2-X4), and at weaning preparation (X5), all within 28 calendar days from randomization
ICU length of stay
Measured: From randomization until ICU discharge, assessed up to 28 calendar days from randomization
Total hospital length of stay
Measured: From randomization until hospital discharge, assessed up to 28 calendar days from randomization
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Sep 2026
- Study start1 May 2022
- Primary completion30 Oct 2024
- Study completion30 Oct 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Pulmonary InfectionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 384 participants (actual)
Sponsor and investigators
- Lead sponsor
- Affiliated Hospital of Jiangnan University
- Sponsor type
- University, hospital or other
- Collaborators
- Wuxi Taihu Hospital
- Responsible party
- Principal investigator, Jun Liu, Affiliated Hospital of Jiangnan University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07821710
- Sponsor's protocol ID
- AHJN-NURS-20240232
- Status last verified
- Sep 2026
- First submitted
- 10 Sep 2026
- Last updated
- 16 Sep 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Randomized Controlled Trial of Infection-site-targeted Postural Drainage Combined With Mechanical Vibration for Mechanically Ventilated ICU Patients With Pulmonary Infection
- ClinicalTrials.gov ID
- NCT07821710
- Acronym / sponsor ID
- AHJN-NURS-20240232
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 384 participants (actual)
- Lead sponsor
- Affiliated Hospital of Jiangnan UniversityUniversity, hospital or other
- Collaborators
- Wuxi Taihu Hospital
- Study start
- 1 May 2022 (actual)
- Primary completion
- 30 Oct 2024 (actual)
- Study completion
- 30 Oct 2024 (actual)
- First posted
- 16 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This single-center, 1:1 randomized controlled trial aimed to evaluate the efficacy of infection-site-targeted postural drainage combined with mechanical vibration for mechanically ventilated ICU patients with pulmonary infection.
Eligible subjects were randomly assigned to either the personalized-care group (PCG, intervention) or routine-care group (RCG, control).
Patients in PCG received imaging-guided infection-site-targeted postural drainage plus mechanical vibration. Patients in RCG received standard routine position changes and mechanical vibration without imaging-guided targeted positional adjustment.
The primary outcome was duration of invasive mechanical ventilation. Secondary outcomes included PaO₂/FiO₂ ratio, ICU length of stay, total hospital length of stay, and 28-day all-cause mortality.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Intervention group | Experimental | Procedure: Imaging-guided infection-site-targeted postural drainage plus mechanical vibration chest physiotherapy. |
| Routine-care group | Active comparator | Procedure: Routine position change combined with mechanical vibration |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Aged 18-80 years old;
- Admitted to ICU and receiving invasive mechanical ventilation;
- Clinically confirmed pulmonary infection;
- Enrolled between May 2022 and October 2024.
Key exclusion criteria (11 listed)
- Unstable systemic disease contraindicating postural changes;
- Active bleeding (gastrointestinal, intracranial, or pulmonary);
- Requirement for continuous renal replacement therapy;
- Raised intracranial pressure;
- Neuromuscular disorder;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Imaging-guided infection-site-targeted postural drainage plus mechanical vibration chest physiotherapy.Imaging-guided infection-site-targeted postural drainage combined with mechanical vibration chest physiotherapy. The body position is individually adjusted according to pulmonary infection location shown on imaging examinations to facilitate sputum drainage. | Procedure or surgery | Intervention group |
| Routine position change combined with mechanical vibrationRoutine regular position change combined with mechanical vibration chest physiotherapy. No imaging-guided targeted positional adjustment is performed; body position is changed following standard ICU nursing protocol only. | Procedure or surgery | Routine-care group |
Primary outcome
Duration of mechanical ventilation
Time frame: From initiation of invasive mechanical ventilation until successful extubation or death, assessed up to day 28.
4 secondary outcomes
28-day mortality
Time frame: All-cause mortality assessed at 28 calendar days from the date of randomization
PaO₂/FiO₂ ratio
Time frame: Measured at baseline (X1), Day 1, Day 2, Day 3, Day 4 post-randomization (X2-X4), and at weaning preparation (X5), all within 28 calendar days from randomization
ICU length of stay
Time frame: From randomization until ICU discharge, assessed up to 28 calendar days from randomization
Total hospital length of stay
Time frame: From randomization until hospital discharge, assessed up to 28 calendar days from randomization
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Imaging-guided infection-site-targeted postural drainage plus mechanical vibration chest physiotherapy. and Routine position change combined with mechanical vibration in people with Pulmonary Infection and Mechanical Ventilation, run by Affiliated Hospital of Jiangnan University at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Duration of mechanical ventilation (time frame: From initiation of invasive mechanical ventilation until successful extubation or death, assessed up to day 28.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Sep 2026.