Reducing GingivitisNCT07826390
Effectiveness of Coconut Oil Pulling and Moringa Mouthwash Versus Chlorhexidine in Reducing Gingivitis in Diabetic Children
A study testing Chlorhexidine mouthwash, Moringa olfera mouthwash and coconut oil pulling in people with Reducing Gingivitis and Clinical Effect, run by Amira Yehia Zakaria at 1 site in Egypt.
Trial summary
Gingivitis is a common and reversible inflammatory condition, mainly caused by dental plaque, and is particularly prevalent among children. Children with diabetes mellitus are more susceptible because of altered immune responses, impaired healing, and changes in the oral microbiota. Read more about this study
- Who is it for?
- Ages 6 to 12 years
- Conditions the study is for
- Reducing Gingivitis, Clinical Effect
- What is being tested?
- Chlorhexidine mouthwash, Moringa olfera mouthwash and coconut oil pulling
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Oct 2026to 1 Nov 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 6 to 12 years
- All sexes
- No healthy volunteers
- Child
Who may be able to join
- Age from 6 to 12 years.
- Both males and females.
- Diabetic Children with mild to moderate gingivitis.
- Medically stable, without other systemic conditions affecting oral health.
- Written informed consent obtained from parents or legal guardians and assent from the child.
Who cannot join
- Severe gingival or periodontal disease
- Hypersensitivity or allergy to coconut oil, moringa, chlorhexidine, or any component of the study interventions.
- Presence of systemic conditions other than diabetes that may affect results
- Antibiotics use, corticosteroids, that may influence gingival health within the past 4 weeks.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Effectiveness of Coconut Oil Pulling and Moringa Mouthwash Versus Chlorhexidine in Reducing Gingivitis in Diabetic Children: A Randomized Controlled Pilot Study
Gingivitis is a common and reversible inflammatory condition, mainly caused by dental plaque, and is particularly prevalent among children. Children with diabetes mellitus are more susceptible because of altered immune responses, impaired healing, and changes in the oral microbiota.
Although mechanical plaque control is the primary method of prevention, poor oral hygiene compliance in children highlights the need for safe adjunctive treatments. Chlorhexidine, while highly effective, can cause staining, taste alteration, and mucosal irritation, limiting its long term pediatric use.
Read more
Natural alternatives such as coconut oil and Moringa oleifera have attracted attention because of their antimicrobial, anti-inflammatory, and antioxidant properties. Coconut oil, particularly its lauric acid content, may reduce oral pathogens, plaque, and gingival inflammation. Moringa contains bioactive compounds such as flavonoids, phenolic acids, and isothiocyanates that may help reduce inflammation, oxidative stress, and microbial load.
However, comparative clinical evidence on coconut oil versus Moringa for managing gingivitis in diabetic children remains limited, highlighting the need for further clinical research to determine their safety and effectiveness in this vulnerable population.
Read the detailed description
Gingivitis represents one of the most prevalent inflammatory diseases affecting the gingival tissues and remains a major public health concern worldwide, particularly among pediatric populations. It is primarily induced by dental plaque biofilm accumulation along the gingival margin, resulting in gingival inflammation characterized by redness, swelling, bleeding on probing, and discomfort. Although gingivitis is considered a reversible condition, if left untreated, it may progress to periodontitis, leading to irreversible destruction of periodontal supporting structures and eventual tooth loss.
Children with systemic conditions, especially diabetes mellitus, exhibit a higher susceptibility to gingival inflammation due to altered immune responses, impaired wound healing, and changes in oral microbial flora.
Mechanical plaque control through tooth brushing and professional prophylaxis remains the cornerstone of gingivitis prevention and management. However, compliance with routine oral hygiene practices among children is often suboptimal. Therefore, adjunctive therapeutic agents with antimicrobial and anti-inflammatory properties have gained increasing attention. Chlorhexidine mouthwash is widely considered the gold standard chemical plaque control agent; nevertheless, its long-term use is associated with adverse effects including tooth staining, taste alteration, and mucosal irritation, limiting its acceptability among pediatric patients. This has led to growing interest in exploring natural and herbal alternatives that are safe, cost-effective, and well tolerated. Coconut oil has recently gained popularity as a natural oral health agent, particularly through the practice of oil pulling, which is a traditional Ayurvedic technique involving swishing oil in the oral cavity. Coconut oil contains a high concentration of medium-chain fatty acids, predominantly lauric acid, which possesses potent antimicrobial, anti-inflammatory, and antioxidant properties. Lauric acid has demonstrated effectiveness against various oral pathogens, including Streptococcus mutans and Candida species, by disrupting microbial cell membranes and inhibiting biofilm formation. Additionally, coconut oil may reduce gingival inflammation by modulating inflammatory mediators and enhancing tissue healing. Several clinical studies have reported improvements in plaque and gingival indices following coconut oil use, suggesting its potential as a safe adjunctive therapy in managing gingivitis.
Moringa oleifera, commonly referred to as the "miracle tree," is another herbal product that has gained considerable attention for its medicinal and nutritional benefits. It is rich in bioactive compounds including flavonoids, phenolic acids, vitamins, minerals, and essential amino acids. Moringa extracts exhibit strong antimicrobial activity against a broad spectrum of oral microorganisms and possess significant anti-inflammatory and antioxidant effects. These properties are primarily attributed to phytochemicals such as quercetin, chlorogenic acid, and isothiocyanates, which reduce oxidative stress and suppress inflammatory pathways. Recent experimental and clinical studies have suggested that moringa based formulations may improve periodontal health by reducing plaque accumulation, gingival inflammation, and microbial load, making it a promising natural therapeutic agent.
Despite the documented therapeutic potential of coconut oil and moringa individually, comparative clinical studies evaluating their effectiveness in reducing gingivitis, particularly among diabetic children, remain limited. Pediatric diabetic patients constitute a vulnerable group requiring safe, well-tolerated, and effective adjunctive oral health interventions. Natural herbal agents such as coconut oil and moringa may provide affordable and culturally acceptable alternatives, especially in developing countries where access to conventional dental care may be limited.
- Conditions
- Reducing Gingivitis, Clinical Effect
- Being tested
- Chlorhexidine mouthwash, Moringa olfera mouthwash, coconut oil pulling
- Keywords
- Moringa olfera, Coconut oil pulling, Diabetic children
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Chlorhexidine mouthwashOther
Active comparator
Moringa olfera mouthwashOther
Intervetion
coconut oil pullingOther
Intervention
| Study group | Role | What they receive |
|---|---|---|
| Moringa olfera mouthwash | Experimental | Children will swish aqueous extract preparation from moringa leaves for 1 minute daily for 4 weeks Receives: Other: Chlorhexidine mouthwash |
| Coconut oil pulling | Experimental | Oil pulling with 5 mL of virgin coconut oil will be used for swishing for 1 minute once daily under parental supervision. Receives: Other: Chlorhexidine mouthwash |
| Chlorhexidine mouthwash | Active comparator | 0.12% chlorhexidine mouthwash will be used for Swishing for 1 minute once daily for 4 weeks Receives: Other: Moringa olfera mouthwash; Other: coconut oil pulling |
What is being measured
The primary outcome is the main question the study is designed to answer.
Gingival Health
Clinical examination using the Gingival Index Score 0-3 where: 0 Normal gingiva; no inflammation
- Mild inflammation: slight change in color and slight edema; no bleeding on probing
- Moderate inflammation: redness, edema, and glazing; bleeding on probing
- Severe inflammation: marked redness and edema, ulceration, and spontaneous bleeding
Measured: baseline immediately after week 2 week 4.
Secondary outcomes (1)
Porphyromonas gingivalis count
Microbiological analysis manual colony counting using agar
Measured: baseline immediately after week 2 week 4
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Sep 2026
- Study start1 Oct 2026 (estimated)
- Primary completion1 Nov 2026 (estimated)
- Study completion1 Nov 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (24)Papers the sponsor has linked to this study.
- Other trials for Reducing GingivitisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Will use moringa mouthwash in one group and coconut oil pulling in another group versus the standard chlorhexidine mouthwash
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Amira Yehia Zakaria
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Amira Yehia Zakaria, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07826390
- Sponsor's protocol ID
- Gingivitis reducing mouthwash
- Status last verified
- Sep 2026
- First submitted
- 12 Sep 2026
- Last updated
- 22 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: supporting information
Publications
23. Zeeshan, A., Munir, M. & Sadia, S. 2024. Unlocking the promise of the "miracle tree: A review on therapeutic applications and phytochemistry of moringa oleifera l. J bioresour manag, 11, 18-22.
Kamath NP, Tandon S, Nayak R, Naidu S, Anand PS, Kamath YS. The effect of aloe vera and tea tree oil mouthwashes on the oral health of school children. Eur Arch Paediatr Dent. 2020 Feb;21(1):61-66. doi: 10.1007/s40368-019-00445-5. Epub 2019 May 20.
PubMed 31111439Woolley J, Gibbons T, Patel K, Sacco R. The effect of oil pulling with coconut oil to improve dental hygiene and oral health: A systematic review. Heliyon. 2020 Aug 27;6(8):e04789. doi: 10.1016/j.heliyon.2020.e04789. eCollection 2020 Aug.
PubMed 32923724Van der Weijden GAF, van Loveren C. Mechanical plaque removal in step-1 of care. Periodontol 2000. 2023 Dec 26. doi: 10.1111/prd.12541. Online ahead of print.
PubMed 3814848120. Srivastava, A., Bhatt, N., Raghunath, V., Bhatt, S., Tekam, D. A. & Sagar, S. 2025. Herbal dentistry: A comprehensive review. JAMDSR 13, 1-5.
Shafiq NE, Mahdee AF. Moringa oleifera Use in Maintaining Oral Health and Its Potential Use in Regenerative Dentistry. ScientificWorldJournal. 2023 Oct 17;2023:8876189. doi: 10.1155/2023/8876189. eCollection 2023.
PubMed 37881795Rao W, Hussain M, Naseem N, Siddiqui WA. The intricacies of advanced glycation end products (AGEs) in diabetic neuropathy. 3 Biotech. 2026 Jan;16(1):24. doi: 10.1007/s13205-025-04652-4. Epub 2025 Dec 8.
PubMed 4137689017. Priya, R., Kaur, N., Rawat, A., Sharma, V., Bhalla, M. & Gupta, R. 2023. Effect of coconut oil pulling on plaque-induced gingivitis: A prospective clinical study. J Indian Assoc Public Health Dent, 21, 238-41.
Peedikayil FC, Sreenivasan P, Narayanan A. Effect of coconut oil in plaque related gingivitis - A preliminary report. Niger Med J. 2015 Mar-Apr;56(2):143-7. doi: 10.4103/0300-1652.153406.
PubMed 25838632Pardinas Lopez S, Garcia-Caro ME, Vallejo JA, Aja-Macaya P, Conde-Perez K, Nion-Cabeza P, Khouly I, Bou G, Cendal AIR, Diaz-Prado S, Poza M. Anti-inflammatory and antimicrobial efficacy of coconut oil for periodontal pathogens: a triple-blind randomized clinical trial. Clin Oral Investig. 2025 Mar 14;29(4):182. doi: 10.1007/s00784-025-06267-8.
PubMed 4008530214. Nitbani, F. O., Tjitda, P. J. P., Nitti, F., Jumina, J. & Detha, A. I. R. 2022. Antimicrobial properties of lauric acid and monolaurin in virgin coconut oil: a review. ChemBioEng Rev, 9, 442-61.
13. Mohapatra, S., Mohandas, R., Rajpurohit, L. & Patil, S. 2024. Comparative evaluation of the efficacy of cetylpyridinium chloride mouthwash and chlorhexidine mouthwash in plaque reduction: A systematic review and meta-analysis. Curr Oral Health Rep, 12, 32-40.
Maia MB, Souza JGS, Bertolini M, Costa RC, Costa GS, Torres SAS, Ferreira EF, Martins AMEBL. Knowledge of bidirectional relationship between diabetes and periodontal disease among diabetes patients: A systematic review. Int J Dent Hyg. 2023 Feb;21(1):28-40. doi: 10.1111/idh.12586. Epub 2022 Feb 4.
PubMed 3508034411. Kulkarni, V. K., Dixit, M., Balasubramanian, S. & Jetpurwala, A. 2023. Gingival and periodontal diseases in children. Pediatr Dent, 21, 264-70.
10. Jadon, A. S., Kaushik, M. P., Anitha, K., Bhatt, S., Bhadauriya, P. & Sharma, M. 2024. Types of diabetes mellitus, mechanism of insulin resistance and associated complications. Biochemical immunology of diabetes and associated complications. Elsevier. 1-18.
Study at a glance
From the registry record, last updated by the sponsor on 22 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effectiveness of Coconut Oil Pulling and Moringa Mouthwash Versus Chlorhexidine in Reducing Gingivitis in Diabetic Children: A Randomized Controlled Pilot Study
- ClinicalTrials.gov ID
- NCT07826390
- Acronym / sponsor ID
- Gingivitis reducing mouthwash
- Conditions
- Reducing Gingivitis, Clinical Effect
- Keywords
- Moringa olfera, Coconut oil pulling, Diabetic children
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Amira Yehia ZakariaUniversity, hospital or other
- Study start
- 1 Oct 2026 (estimated)
- Primary completion
- 1 Nov 2026 (estimated)
- Study completion
- 1 Nov 2026 (estimated)
- First posted
- 17 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Gingivitis is a common and reversible inflammatory condition, mainly caused by dental plaque, and is particularly prevalent among children. Children with diabetes mellitus are more susceptible because of altered immune responses, impaired healing, and changes in the oral microbiota.
Although mechanical plaque control is the primary method of prevention, poor oral hygiene compliance in children highlights the need for safe adjunctive treatments. Chlorhexidine, while highly effective, can cause staining, taste alteration, and mucosal irritation, limiting its long term pediatric use.
Natural alternatives such as coconut oil and Moringa oleifera have attracted attention because of their antimicrobial, anti-inflammatory, and antioxidant properties. Coconut oil, particularly its lauric acid content, may reduce oral pathogens, plaque, and gingival inflammation. Moringa contains bioactive compounds such as flavonoids, phenolic acids, and isothiocyanates that may help reduce inflammation, oxidative stress, and microbial load.
However, comparative clinical evidence on coconut oil versus Moringa for managing gingivitis in diabetic children remains limited, highlighting the need for further clinical research to determine their safety and effectiveness in this vulnerable population.
Detailed description
Gingivitis represents one of the most prevalent inflammatory diseases affecting the gingival tissues and remains a major public health concern worldwide, particularly among pediatric populations. It is primarily induced by dental plaque biofilm accumulation along the gingival margin, resulting in gingival inflammation characterized by redness, swelling, bleeding on probing, and discomfort. Although gingivitis is considered a reversible condition, if left untreated, it may progress to periodontitis, leading to irreversible destruction of periodontal supporting structures and eventual tooth loss.
Children with systemic conditions, especially diabetes mellitus, exhibit a higher susceptibility to gingival inflammation due to altered immune responses, impaired wound healing, and changes in oral microbial flora.
Mechanical plaque control through tooth brushing and professional prophylaxis remains the cornerstone of gingivitis prevention and management. However, compliance with routine oral hygiene practices among children is often suboptimal. Therefore, adjunctive therapeutic agents with antimicrobial and anti-inflammatory properties have gained increasing attention. Chlorhexidine mouthwash is widely considered the gold standard chemical plaque control agent; nevertheless, its long-term use is associated with adverse effects including tooth staining, taste alteration, and mucosal irritation, limiting its acceptability among pediatric patients. This has led to growing interest in exploring natural and herbal alternatives that are safe, cost-effective, and well tolerated. Coconut oil has recently gained popularity as a natural oral health agent, particularly through the practice of oil pulling, which is a traditional Ayurvedic technique involving swishing oil in the oral cavity. Coconut oil contains a high concentration of medium-chain fatty acids, predominantly lauric acid, which possesses potent antimicrobial, anti-inflammatory, and antioxidant properties. Lauric acid has demonstrated effectiveness against various oral pathogens, including Streptococcus mutans and Candida species, by disrupting microbial cell membranes and inhibiting biofilm formation. Additionally, coconut oil may reduce gingival inflammation by modulating inflammatory mediators and enhancing tissue healing. Several clinical studies have reported improvements in plaque and gingival indices following coconut oil use, suggesting its potential as a safe adjunctive therapy in managing gingivitis.
Moringa oleifera, commonly referred to as the "miracle tree," is another herbal product that has gained considerable attention for its medicinal and nutritional benefits. It is rich in bioactive compounds including flavonoids, phenolic acids, vitamins, minerals, and essential amino acids. Moringa extracts exhibit strong antimicrobial activity against a broad spectrum of oral microorganisms and possess significant anti-inflammatory and antioxidant effects. These properties are primarily attributed to phytochemicals such as quercetin, chlorogenic acid, and isothiocyanates, which reduce oxidative stress and suppress inflammatory pathways. Recent experimental and clinical studies have suggested that moringa based formulations may improve periodontal health by reducing plaque accumulation, gingival inflammation, and microbial load, making it a promising natural therapeutic agent.
Despite the documented therapeutic potential of coconut oil and moringa individually, comparative clinical studies evaluating their effectiveness in reducing gingivitis, particularly among diabetic children, remain limited. Pediatric diabetic patients constitute a vulnerable group requiring safe, well-tolerated, and effective adjunctive oral health interventions. Natural herbal agents such as coconut oil and moringa may provide affordable and culturally acceptable alternatives, especially in developing countries where access to conventional dental care may be limited.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 3
- Model description
- Will use moringa mouthwash in one group and coconut oil pulling in another group versus the standard chlorhexidine mouthwash
| Arm | Type | Receives |
|---|---|---|
| Moringa olfera mouthwash | Experimental | Other: Chlorhexidine mouthwashChildren will swish aqueous extract preparation from moringa leaves for 1 minute daily for 4 weeks |
| Coconut oil pulling | Experimental | Other: Chlorhexidine mouthwashOil pulling with 5 mL of virgin coconut oil will be used for swishing for 1 minute once daily under parental supervision. |
| Chlorhexidine mouthwash | Active comparator | Other: Moringa olfera mouthwash, Other: coconut oil pulling0.12% chlorhexidine mouthwash will be used for Swishing for 1 minute once daily for 4 weeks |
Who may qualify
- Ages
- 6 to 12 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
Key inclusion criteria (5 listed)
- Age from 6 to 12 years.
- Both males and females.
- Diabetic Children with mild to moderate gingivitis.
- Medically stable, without other systemic conditions affecting oral health.
- Written informed consent obtained from parents or legal guardians and assent from the child.
Key exclusion criteria (4 listed)
- Severe gingival or periodontal disease
- Hypersensitivity or allergy to coconut oil, moringa, chlorhexidine, or any component of the study interventions.
- Presence of systemic conditions other than diabetes that may affect results
- Antibiotics use, corticosteroids, that may influence gingival health within the past 4 weeks.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Chlorhexidine mouthwashActive comparator | Other | Coconut oil pulling, Moringa olfera mouthwash |
| Moringa olfera mouthwashIntervetion | Other | Chlorhexidine mouthwash |
| coconut oil pullingIntervention | Other | Chlorhexidine mouthwash |
Primary outcome
Gingival Health
Time frame: baseline immediately after week 2 week 4.
Clinical examination using the Gingival Index Score 0-3 where: 0 Normal gingiva; no inflammation 1. Mild inflammation: slight change in color and slight edema; no bleeding on probing 2. Moderate inflammation: redness, edema, and glazing; bleeding on probing 3. Severe inflammation: marked redness and edema, ulceration, and spontaneous bleeding
1 secondary outcome
Porphyromonas gingivalis count
Time frame: baseline immediately after week 2 week 4
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Sep 2026.
- Background23. Zeeshan, A., Munir, M. & Sadia, S. 2024. Unlocking the promise of the "miracle tree: A review on therapeutic applications and phytochemistry of moringa oleifera l. J bioresour manag, 11, 18-22.
- Results publication: PubMed 31111439Kamath NP, Tandon S, Nayak R, Naidu S, Anand PS, Kamath YS. The effect of aloe vera and tea tree oil mouthwashes on the oral health of school children. Eur Arch Paediatr Dent. 2020 Feb;21(1):61-66. doi: 10.1007/s40368-019-00445-5. Epub 2019 May 20.
- Results publication: PubMed 32923724Woolley J, Gibbons T, Patel K, Sacco R. The effect of oil pulling with coconut oil to improve dental hygiene and oral health: A systematic review. Heliyon. 2020 Aug 27;6(8):e04789. doi: 10.1016/j.heliyon.2020.e04789. eCollection 2020 Aug.
- Results publication: PubMed 38148481Van der Weijden GAF, van Loveren C. Mechanical plaque removal in step-1 of care. Periodontol 2000. 2023 Dec 26. doi: 10.1111/prd.12541. Online ahead of print.
- Results publication20. Srivastava, A., Bhatt, N., Raghunath, V., Bhatt, S., Tekam, D. A. & Sagar, S. 2025. Herbal dentistry: A comprehensive review. JAMDSR 13, 1-5.
- Results publication: PubMed 37881795Shafiq NE, Mahdee AF. Moringa oleifera Use in Maintaining Oral Health and Its Potential Use in Regenerative Dentistry. ScientificWorldJournal. 2023 Oct 17;2023:8876189. doi: 10.1155/2023/8876189. eCollection 2023.
- Results publication: PubMed 41376890Rao W, Hussain M, Naseem N, Siddiqui WA. The intricacies of advanced glycation end products (AGEs) in diabetic neuropathy. 3 Biotech. 2026 Jan;16(1):24. doi: 10.1007/s13205-025-04652-4. Epub 2025 Dec 8.
- Results publication17. Priya, R., Kaur, N., Rawat, A., Sharma, V., Bhalla, M. & Gupta, R. 2023. Effect of coconut oil pulling on plaque-induced gingivitis: A prospective clinical study. J Indian Assoc Public Health Dent, 21, 238-41.
- Results publication: PubMed 25838632Peedikayil FC, Sreenivasan P, Narayanan A. Effect of coconut oil in plaque related gingivitis - A preliminary report. Niger Med J. 2015 Mar-Apr;56(2):143-7. doi: 10.4103/0300-1652.153406.
- Results publication: PubMed 40085302Pardinas Lopez S, Garcia-Caro ME, Vallejo JA, Aja-Macaya P, Conde-Perez K, Nion-Cabeza P, Khouly I, Bou G, Cendal AIR, Diaz-Prado S, Poza M. Anti-inflammatory and antimicrobial efficacy of coconut oil for periodontal pathogens: a triple-blind randomized clinical trial. Clin Oral Investig. 2025 Mar 14;29(4):182. doi: 10.1007/s00784-025-06267-8.
- Results publication14. Nitbani, F. O., Tjitda, P. J. P., Nitti, F., Jumina, J. & Detha, A. I. R. 2022. Antimicrobial properties of lauric acid and monolaurin in virgin coconut oil: a review. ChemBioEng Rev, 9, 442-61.
- Results publication13. Mohapatra, S., Mohandas, R., Rajpurohit, L. & Patil, S. 2024. Comparative evaluation of the efficacy of cetylpyridinium chloride mouthwash and chlorhexidine mouthwash in plaque reduction: A systematic review and meta-analysis. Curr Oral Health Rep, 12, 32-40.
- Related informationLink provided by the sponsor.
- Individual participant dataSharing planned: Yes. supporting information
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Chlorhexidine mouthwash, Moringa olfera mouthwash and coconut oil pulling in people with Reducing Gingivitis and Clinical Effect, run by Amira Yehia Zakaria at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 22 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Amira Yehia Zakaria (+02 01226000741, amira.zakaria@dentistry.cu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Gingival Health (time frame: baseline immediately after week 2 week 4.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07826390, which also lists 24 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Sep 2026.