Osteoarthritis, KneeNCT07827443
mFFE MRI Versus CT for Cortical Bone Evaluation in Knee Osteoarthritis
An observational study of Osteoarthritis, Knee and Bone Diseases, run by Assiut University.
Trial summary
This cross-sectional study aims to evaluate the accuracy of multi-echo fast field echo (mFFE) MRI in depicting cortical bone changes in knee osteoarthritis compared with CT. Read more about this study
- Who is it for?
- Ages 40 years and older
- Conditions the study is for
- Osteoarthritis, Knee, Bone Diseases
- How many people
- 80 participants
- Where
- No sites listed yet
- Study dates
- 15 Sep 2026to 20 Feb 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients aged 40 years or older with clinically suspected or confirmed knee osteoarthritis attending the Diagnostic and Interventional Radiology Department at Assiut University Hospital.
Who may be able to join
- - Age 40 years or older
- Clinically suspected or confirmed knee osteoarthritis
- Able and willing to provide informed consent
Who cannot join
- - Implanted electronic devices (pacemakers, ICDs, neurostimulators, cochlear implants)
- Metallic foreign bodies in the eyes or orbits
- Ferromagnetic cerebral aneurysm clips
- Implantable infusion pumps
- Pregnancy
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Beyond Conventional MRI: Multi-Echo Fast Field Echo (mFFE) MRI for Cortical Bone Evaluation in Knee Osteoarthritis Compared With CT
This cross-sectional study aims to evaluate the accuracy of multi-echo fast field echo (mFFE) MRI in depicting cortical bone changes in knee osteoarthritis compared with CT.
Read the detailed description
Knee osteoarthritis involves microstructural alterations in subchondral and cortical bone. Conventional MRI has limitations in visualizing cortical bone due to short T2 relaxation times. Multi-echo fast field echo (mFFE) sequences can produce CT-like images of cortical bone without ionizing radiation.
This observational study will include patients aged 40 years or older with clinically suspected or confirmed knee osteoarthritis. All participants will undergo both mFFE MRI and CT of the knee. The accuracy of mFFE MRI in detecting cortical bone degenerative changes will be compared with CT as the reference standard.
- Conditions
- Osteoarthritis, Knee, Bone Diseases
- Keywords
- mFFE MRI, Knee osteoarthritis, Cortical bone, CT-like MRI, Assiut
- Medical subject headings
- Osteoarthritis, Knee, Bone Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Single cohort: Patients with knee osteoarthritis | Patients aged 40 years or older with knee osteoarthritis who will undergo both multi-echo fast field echo (mFFE) MRI and CT of the knee for comparison of cortical bone evaluation. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Diagnostic accuracy of mFFE MRI for cortical bone changes
Overall diagnostic accuracy percentage of multi-echo fast field echo MRI in detecting cortical bone degenerative changes in knee osteoarthritis, using CT as the reference standard
Measured: Baseline
Secondary outcomes (6)
Sensitivity of mFFE MRI for cortical bone changes
Sensitivity percentage of multi-echo fast field echo MRI in detecting cortical bone degenerative changes in knee osteoarthritis, using CT as the reference standard
Measured: Baseline
Specificity of mFFE MRI for cortical bone changes
Specificity percentage of multi-echo fast field echo MRI in detecting cortical bone degenerative changes in knee osteoarthritis, using CT as the reference standard
Measured: Baseline
Detection of subchondral sclerosis
Number of cases in which mFFE MRI correctly identifies subchondral sclerosis compared with CT
Measured: Baseline
Detection of osteophytes
Number of cases in which mFFE MRI correctly identifies osteophytes compared with CT
Measured: Baseline
Detection of joint space narrowing
Number of cases in which mFFE MRI correctly identifies joint space narrowing compared with CT
Measured: Baseline
Image quality score
Mean subjective image quality score of mFFE MRI for cortical bone visualization on a predefined scale from 1 to 5, with higher scores indicating better image quality
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Sep 2026
- Study start15 Sep 2026 (estimated)
- Primary completion20 Sep 2027 (estimated)
- Study completion20 Feb 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Osteoarthritis, KneeStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Fatima Mahmoud Hammad Eltony, Assiut University
- Investigators
- Ehab M Mohammed, prof, Study chair, Diagnostic and interventional radiology Department, Assiut University Hospitals
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07827443
- Sponsor's protocol ID
- mFFE-MRI-KneeOA-Assiut-2026
- Status last verified
- Sep 2026
- First submitted
- 14 Sep 2026
- Last updated
- 18 Sep 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 18 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Beyond Conventional MRI: Multi-Echo Fast Field Echo (mFFE) MRI for Cortical Bone Evaluation in Knee Osteoarthritis Compared With CT
- ClinicalTrials.gov ID
- NCT07827443
- Acronym / sponsor ID
- mFFE-MRI-KneeOA-Assiut-2026
- Conditions
- Osteoarthritis, Knee, Bone Diseases
- Keywords
- mFFE MRI, Knee osteoarthritis, Cortical bone, CT-like MRI, Assiut
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 15 Sep 2026 (estimated)
- Primary completion
- 20 Sep 2027 (estimated)
- Study completion
- 20 Feb 2028 (estimated)
- First posted
- 18 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This cross-sectional study aims to evaluate the accuracy of multi-echo fast field echo (mFFE) MRI in depicting cortical bone changes in knee osteoarthritis compared with CT.
Detailed description
Knee osteoarthritis involves microstructural alterations in subchondral and cortical bone. Conventional MRI has limitations in visualizing cortical bone due to short T2 relaxation times. Multi-echo fast field echo (mFFE) sequences can produce CT-like images of cortical bone without ionizing radiation.
This observational study will include patients aged 40 years or older with clinically suspected or confirmed knee osteoarthritis. All participants will undergo both mFFE MRI and CT of the knee. The accuracy of mFFE MRI in detecting cortical bone degenerative changes will be compared with CT as the reference standard.
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Single cohort: Patients with knee osteoarthritis | – | –Patients aged 40 years or older with knee osteoarthritis who will undergo both multi-echo fast field echo (mFFE) MRI and CT of the knee for comparison of cortical bone evaluation. |
Who may qualify
- Ages
- 40 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients aged 40 years or older with clinically suspected or confirmed knee osteoarthritis attending the Diagnostic and Interventional Radiology Department at Assiut University Hospital.
Key inclusion criteria (3 listed)
- - Age 40 years or older
- Clinically suspected or confirmed knee osteoarthritis
- Able and willing to provide informed consent
Key exclusion criteria (5 listed)
- - Implanted electronic devices (pacemakers, ICDs, neurostimulators, cochlear implants)
- Metallic foreign bodies in the eyes or orbits
- Ferromagnetic cerebral aneurysm clips
- Implantable infusion pumps
- Pregnancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Diagnostic accuracy of mFFE MRI for cortical bone changes
Time frame: Baseline
Overall diagnostic accuracy percentage of multi-echo fast field echo MRI in detecting cortical bone degenerative changes in knee osteoarthritis, using CT as the reference standard
6 secondary outcomes
Sensitivity of mFFE MRI for cortical bone changes
Time frame: Baseline
Specificity of mFFE MRI for cortical bone changes
Time frame: Baseline
Detection of subchondral sclerosis
Time frame: Baseline
Detection of osteophytes
Time frame: Baseline
Detection of joint space narrowing
Time frame: Baseline
Image quality score
Time frame: Baseline
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Sep 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Ehab M Mohammed, prof study chair
Diagnostic and interventional radiology Department, Assiut University Hospitals
Questions about this trial
What is this clinical trial studying?
An observational study of Osteoarthritis, Knee and Bone Diseases, run by Assiut University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 18 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Fatima M Eltony, Resident (+20 10 15712606, fatima.18313255@med.aun.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Diagnostic accuracy of mFFE MRI for cortical bone changes (time frame: Baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Sep 2026.