Tooth LossNCT07827976
Immediate Implant Placement by Drilling Through Roots
A study testing Immediate Implant Placement in fresh extraction socket and Interradicular Bone Drilling Before Molar Extraction in people with Tooth Loss, run by Cairo University at 1 site in Egypt.
Trial summary
This randomized clinical trial compared two techniques for immediate dental implant placement in molar extraction sites. In the intervention group, implant osteotomy preparation was performed through the interradicular bone before molar extraction, while in the control group the tooth was extracted first and the… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Tooth Loss
- What is being tested?
- Immediate Implant Placement in fresh extraction socket and Interradicular Bone Drilling Before Molar Extraction
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteEgypt
- Study dates
- 18 Feb 2024to 15 Aug 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age 18 years or older.
- Both sexes.
- Cooperative patients likely to maintain good dental health.
- Adequate bone height for placement of implants with a minimum implant length of 7 mm.
Who cannot join
- * Patients who had undergone previous extraction of all remaining teeth.
- Implant placement in both healed bone and extraction sites during the same procedure.
- Presence of any local or systemic factors contraindicating oral surgery.
- Poor oral hygiene.
- Conditions that may complicate wound healing, including uncontrolled diabetes, smoking of 10 cigarettes per day, pregnancy, history of drug or alcohol abuse, and inability or unwillingness to return for follow-up.
Trial locations and contacts
1 site in 1 country.
Egypt1 site
Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University
Cairo, Cairo Governorate
About this study
Official title: Immediate Implant Placement by Drilling Through Roots Compared to Immediate Implant Placement in Fresh Socket
This randomized clinical trial compared two techniques for immediate dental implant placement in molar extraction sites. In the intervention group, implant osteotomy preparation was performed through the interradicular bone before molar extraction, while in the control group the tooth was extracted first and the implant was placed immediately in the fresh extraction socket. The study evaluated implant stability, accuracy of implant positioning, surgical time, and postoperative pain
Read the detailed description
Immediate implant placement in molar extraction sockets can be challenging because of the anatomy of multirooted teeth and the difficulty of achieving an optimal implant position within the interradicular septum. Preparing the implant osteotomy before tooth extraction may allow the retained roots to guide drilling and improve implant positioning.
Participants requiring molar extraction and immediate implant placement were randomly allocated to one of two groups. In Group A, the implant osteotomy was prepared through the interradicular bone before extraction of the molar roots, followed by root extraction and immediate implant placement. In Group B, the molar was extracted first, followed by conventional osteotomy preparation and immediate implant placement in the fresh extraction socket.
The primary outcome was implant stability measured using implant stability quotient (ISQ). Secondary outcomes included implant positioning and deviation from the furcation area, surgical time, and postoperative pain.
- Conditions
- Tooth Loss
- Being tested
- Immediate Implant Placement in fresh extraction socket, Interradicular Bone Drilling Before Molar Extraction
- Medical subject headings
- Tooth Loss
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Immediate Implant Placement in fresh extraction socketProcedure or surgery
The molar was extracted first, followed by preparation of the implant osteotomy and immediate implant placement in the fresh extraction socket.
Interradicular Bone Drilling Before Molar ExtractionProcedure or surgery
Implant osteotomy preparation was performed through the interradicular bone before molar extraction. After completion of the drilling sequence, the remaining roots were carefully extracted and the implant was immediately placed in the prepared interradicular osteotomy site
| Study group | Role | What they receive |
|---|---|---|
| Interradicular Bone Drilling Before Molar Extraction | Experimental | Immediate implant placement after preparing the implant osteotomy through the interradicular bone before molar extraction Receives: Procedure: Interradicular Bone Drilling Before Molar Extraction |
| Immediate Implant Placement in Fresh Extraction Socket | Active comparator | Conventional immediate implant placement after molar extraction and osteotomy preparation in the fresh extraction socket. Receives: Procedure: Immediate Implant Placement in fresh extraction socket |
What is being measured
The primary outcome is the main question the study is designed to answer.
Implant Stability Quotient (ISQ)
Implant stability was measured using resonance frequency analysis with the Osstell device. Implant Stability Quotient (ISQ) values range from 1 to 100, with higher values indicating greater implant stability. Measurements were obtained immediately after implant placement and before tightening the cover screw.
Measured: Immediately after implant placement.
Secondary outcomes (3)
Accuracy of Implant Placement and Deviation From the Furcation Area
Implant position and deviation from the furcation area were assessed using cone-beam computed tomography (CBCT) preoperatively and immediately postoperatively.
Measured: Immediately postoperatively
Surgical Time
Surgical time was measured using a stopwatch starting after local anesthesia injection and ending at implant insertion.
Measured: During the surgical procedure.
Postoperative Pain
Postoperative pain intensity was assessed using a 0-10 Visual Analogue Scale (VAS), where 0 indicated no pain and 10 indicated the worst imaginable pain. Higher scores indicated greater postoperative pain.
Measured: Postoperative days 1, 3, and 7
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Sep 2026
- Study start18 Feb 2024
- Primary completion9 Feb 2026
- Study completion15 Aug 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Tooth LossStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants were randomly assigned in a 1:1 ratio to one of two parallel intervention groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 20 participants (actual)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Omar Ahmed Shawki Hamza, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07827976
- Sponsor's protocol ID
- 14422022430098
- Status last verified
- Sep 2026
- First submitted
- 14 Sep 2026
- Last updated
- 18 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 18 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Immediate Implant Placement by Drilling Through Roots Compared to Immediate Implant Placement in Fresh Socket
- ClinicalTrials.gov ID
- NCT07827976
- Acronym / sponsor ID
- 14422022430098
- Conditions
- Tooth Loss
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 20 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 18 Feb 2024 (actual)
- Primary completion
- 9 Feb 2026 (actual)
- Study completion
- 15 Aug 2026 (actual)
- First posted
- 18 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized clinical trial compared two techniques for immediate dental implant placement in molar extraction sites. In the intervention group, implant osteotomy preparation was performed through the interradicular bone before molar extraction, while in the control group the tooth was extracted first and the implant was placed immediately in the fresh extraction socket. The study evaluated implant stability, accuracy of implant positioning, surgical time, and postoperative pain
Detailed description
Immediate implant placement in molar extraction sockets can be challenging because of the anatomy of multirooted teeth and the difficulty of achieving an optimal implant position within the interradicular septum. Preparing the implant osteotomy before tooth extraction may allow the retained roots to guide drilling and improve implant positioning.
Participants requiring molar extraction and immediate implant placement were randomly allocated to one of two groups. In Group A, the implant osteotomy was prepared through the interradicular bone before extraction of the molar roots, followed by root extraction and immediate implant placement. In Group B, the molar was extracted first, followed by conventional osteotomy preparation and immediate implant placement in the fresh extraction socket.
The primary outcome was implant stability measured using implant stability quotient (ISQ). Secondary outcomes included implant positioning and deviation from the furcation area, surgical time, and postoperative pain.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
- Model description
- Participants were randomly assigned in a 1:1 ratio to one of two parallel intervention groups
| Arm | Type | Receives |
|---|---|---|
| Interradicular Bone Drilling Before Molar Extraction | Experimental | Procedure: Interradicular Bone Drilling Before Molar ExtractionImmediate implant placement after preparing the implant osteotomy through the interradicular bone before molar extraction |
| Immediate Implant Placement in Fresh Extraction Socket | Active comparator | Procedure: Immediate Implant Placement in fresh extraction socketConventional immediate implant placement after molar extraction and osteotomy preparation in the fresh extraction socket. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Age 18 years or older.
- Both sexes.
- Cooperative patients likely to maintain good dental health.
- Adequate bone height for placement of implants with a minimum implant length of 7 mm.
Key exclusion criteria (5 listed)
- * Patients who had undergone previous extraction of all remaining teeth.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Immediate Implant Placement in fresh extraction socketThe molar was extracted first, followed by preparation of the implant osteotomy and immediate implant placement in the fresh extraction socket. | Procedure or surgery | Immediate Implant Placement in Fresh Extraction Socket |
| Interradicular Bone Drilling Before Molar ExtractionImplant osteotomy preparation was performed through the interradicular bone before molar extraction. After completion of the drilling sequence, the remaining roots were carefully extracted and the implant was immediately placed in the prepared interradicular osteotomy site | Procedure or surgery | Interradicular Bone Drilling Before Molar Extraction |
Primary outcome
Implant Stability Quotient (ISQ)
Time frame: Immediately after implant placement.
Implant stability was measured using resonance frequency analysis with the Osstell device. Implant Stability Quotient (ISQ) values range from 1 to 100, with higher values indicating greater implant stability. Measurements were obtained immediately after implant placement and before tightening the cover screw.
3 secondary outcomes
Accuracy of Implant Placement and Deviation From the Furcation Area
Time frame: Immediately postoperatively
Surgical Time
Time frame: During the surgical procedure.
Postoperative Pain
Time frame: Postoperative days 1, 3, and 7
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Sep 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Immediate Implant Placement in fresh extraction socket and Interradicular Bone Drilling Before Molar Extraction in people with Tooth Loss, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 18 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Implant Stability Quotient (ISQ) (time frame: Immediately after implant placement.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Sep 2026.