Knee OsteoarthritisKNEENCT07833488
Exploring Factors Linked to Worsening Over Time in People With Early-stage Knee Osteoarthritis and Those With Prior Proven Acute Knee Injury.
An observational study of Knee Osteoarthritis, run by Imperial College London at 1 site in United Kingdom.
Trial summary
The goal of this observational, non-interventional cohort study is to identify tests or markers in blood or knee fluid, or any genetic risk factors that might contribute to worsening or improvement of knee osteoarthritis. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Knee Osteoarthritis
- How many people
- 200 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 14 Sep 2026to 31 Jul 2031
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Participants will be recruited across Imperial College Healthcare NHS Trust (ICHNT) through four primary pathways: 1. Elective Orthopaedic Lists: Patients scheduled for relevant procedures on elective orthopaedic surgical lists. 2. Outpatient Procedural Lists: Patients scheduled for joint drainage or intra-articular injections within musculoskeletal specialties, including rheumatology, sports and exercise medicine, and musculoskeletal radiology. 3. Participants from existing research cohorts, such as the Imperial College Healthcare Tissue Bank (ICHTB), i.e., i-Bank, who are eligible and have previously consented to be re-contacted for future studies. 4. Research Registries: Individuals identified via research registries and mailing lists, including the Imperial Joint Health: Understanding, Monitoring and Prevention (JUMP) Registry, the Northwest London Health Research Register, and the Imperial Health Knowledge Bank (IHKB).
Who may be able to join
- ALL participants must meet the following criteria:
- Male or female, aged ≥18 years of age AND at least one of the following (a-d):
- A definite diagnosis of knee osteoarthritis , evidenced by consistent knee symptoms and imaging findings, commensurate with non-advanced KL grade changes (KL 0-2 where an X-ray grade is available)
- A symptomatic degenerative meniscal tear with or without definite imaging findings suggesting knee osteoarthritis
- Probable early-stage symptomatic knee osteoarthritis without definite imaging changes, fulfilling NICE diagnostic criteria for osteoarthritis:
- Age 45 or over
Show all 13Show fewer
- Activity-related knee pain.
- Either no morning stiffness or that lasts <30 minutes
- A definite clinically significant acute knee injury at the age of 50 or younger at any stage in the past, evidenced by appropriate clinical history of a traumatic knee episode AND documented imaging or surgical confirmation of a relevant structural injury.
- Willing to provide at least one of the following samples: synovial fluid or blood (a salivary sample is an acceptable alternative for remote participants with a history of knee injury. This alternative also applies to existing participants from ICHTB/IHKB, for whom no prior DNA sample is currently banked)
- Understand English sufficiently to be able to read PIS, ICF and/or Participant Invitation Letter
- Provide an ICF, signed by the participant
- Be capable of complying with Protocol requirements, i.e. completing study questionnaire packs.
Who cannot join
- Known advanced radiographic changes of KOA on available imaging (KL grade 3-4 where available), or other commensurate findings, such as those present on MRI
- Knee joint replacement (uni-compartmental arthroplasty or total knee arthroplasty) of the index knee, prior to consent, or planned during current episode of care, or within next 12 months
- Other clinically significant knee pathology such as infection or malignancy affecting the index knee joint or surrounding bone (at any time)
- Surgery to the index knee in the last 3 months
- Any other systemic inflammatory disease (e.g. inflammatory bowel disease), systemic infection, or inflammatory arthritis (e.g. rheumatoid arthritis, psoriatic arthritis, gout)
- Systemic/intra-articular steroid use to index knee in the last 3 months
Show all 10Show fewer
- Any use of immunosuppressive drugs or chemotherapy in the last 12 months
- Unwilling or unable to provide follow-up data for minimum 2 years and/or maximum 5 years
- Pregnancy, expecting to be pregnant, near the scheduled Year 2 or Year 3 X-ray visit.
- Other medical reason which would prevent participation, at the discretion of the investigator.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United Kingdom1 site, 1 recruiting
- Recruiting
Centre for Inflammatory Disease, 9th Floor, Commonwealth Building, Imperial College London, Department of Immunology and Inflammation, Hammersmith Campus, Du Cane Road, London
London, W12 0NN
Fiona Watt, +44 07858 367326, f.watt@imperial.ac.uk
Malgorzata Kochanska, +44 07858 367326 ext. +44 07858 3673, oaresearchgroup@imperial.ac.uk
About this study
Official title: Imperial Knee Health Cohort: New Exploration of Early-stage Changes Study.
The goal of this observational, non-interventional cohort study is to identify tests or markers in blood or knee fluid, or any genetic risk factors that might contribute to worsening or improvement of knee osteoarthritis.
Males and females aged ≥18 with early-stage knee osteoarthritis, prior proven acute knee injury, or degenerative meniscal tear will be recruited at Imperial College Healthcare NHS Trust. Participants with prior proven acute knee injury must be aged ≤ 50. A single knee per participant will be followed throughout the study; this will be referred to as ''affected knee'', identified at baseline.
Read more
The study involves:
- Samples collection:
- From individuals recruited in-person: blood or buccal (cheek) swab and/or knee joint (synovial) fluid - this will be collected during routine NHS visit, if individuals undergo scheduled knee surgery or knee aspiration procedure (Knee aspiration is a procedure to remove excess fluid from the knee joint for diagnosis or treatment).
- From individuals recruited remotely: saliva sample.
- Clinical data collection at baseline: Participants will complete study Core Questionnaire Pack. These are questionnaires asking about participants' knee pain, function, and activity level.
- Clinical data collection at yearly remote visits, through years 1-5: Participants will complete study Follow-Up Questionnaire Pack, asking about participants' knee pain, function, and activity level - same as at baseline, but additionally participants will be asked about any knee surgeries on the affected knee, since the last study visit.
- Imaging data collection at baseline and at Year 2 or Year 3 follow-up visit:
If at baseline visit X-ray imaging is available as a part of usual NHS care, then participants will only be invited to attend one X-ray appointment at Year 2 or Year 3 follow-up visit.
The study expect to recruit up to 200 participants with approximately 100 participants having early-stage knee osteoarthritis or degenerative meniscal tear and the remaining participants having prior proven acute knee injury.
Individuals will be able join the study for between 2-3 years. Follow up visits will last up to 5 years.
Read the detailed description
The study aims to identify people who are in the early-stage of knee osteoarthritis or at risk of knee osteoarthritis. The current course of osteoarthritis is quite unpredictable. Early on symptoms (and structural changes) can get worse or can get better, yet the exact etiology remains unclear. Current treatments are often reactive, meaning doctors wait until the disease is advanced before they do much. This study is designed to help better predict this process.
- Conditions
- Knee Osteoarthritis
- Keywords
- post-traumatic knee osteoarthritis, genetics, synovial fluid, protein marker, knee injury, knee
- Medical subject headings
- Osteoarthritis, Knee, Knee Injuries
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Individuals with early-stage knee osteoarthritis (or degenerative meniscal tear). | Males and females aged ≥18. | |
| Individuals with prior proven acute knee injury. | Males and females must be aged ≤ 50. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Knee injury and Osteoarthritis Outcome Score (KOOS)
Collected via study questionnaires completed by participants. Knee Injury and Osteoarthritis Outcome Score (KOOS) is a knee-specific self-reported instrument, developed to assess participant's opinions about their knee and associated problems. The KOOS evaluates both short-term and long-term consequences of knee injury and osteoarthritis. It holds 42 items in 5 separately scored subscales: Pain, other Symptoms, Function in daily living , Function in Sport and Recreation, and knee-related Quality of Life.
The KOOS is scored from 0 to 100, where higher scores indicate a better outcome, representing fewer symptoms and better knee-related quality of life.
Measured: Baseline and 2 years
Secondary outcomes (3)
Tegner Activity Score (TAS)
Collected via study questionnaires completed by participants.
Tegner Activity Score (TAS) is a rating system that measures participant's physical activity level on a scale from 0 to 10, where 0 indicates being on sick leave due to knee problems, and 10 represents participation in competitive sports at an elite or professional level (with higher scores indicating greater physical activity and sports participation).
Measured: Baseline and minimum at 2 years/maximum 5 years
Post enrolment surgical intervention data (arthroplasty)
Collected via study questionnaires completed by participants to track the incidence and type of subsequent knee surgeries. This outcome measures the occurrence of an event (such as whether a surgical intervention took place, and if so what was the date of the intervention).
Measured: Years 1-5
X-ray radiographs of the index knee
Evaluation of joint space narrowing in the tibio-femoral and patello-femoral joints, and the presence of osteophyte formation, using the Kellgren-Lawrence scale, a widely accepted method of assessing radiographic osteoarthritis.
The Kellgren-Lawrence scale ranges from grade 0 to 4, where grade 0 indicates no osteoarthritis changes and grade 4 represents the most severe degree of joint degeneration.
Measured: Baseline and 2 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Sep 2026
- Study start14 Sep 2026
- Primary completion31 Jul 2031 (estimated)
- Study completion31 Jul 2031 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (16)Papers the sponsor has linked to this study.
- Other trials for Knee OsteoarthritisStudies of the same condition, open and under way.
- More trials run by Imperial College LondonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 200 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Imperial College London
- Sponsor type
- University, hospital or other
- Collaborators
- Arthritis UK, UK Research and Innovation
- Responsible party
- Sponsor
- Investigators
- Fiona Watt, Dr, Principal investigator, Imperial College London
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07833488
- Sponsor's protocol ID
- 26/LO/0569
- Other IDs
- IRAS ID: 323431, 26/LO/0569
- Acronym
- KNEE
- Status last verified
- Nov 2026
- First submitted
- 16 Sep 2026
- Last updated
- 6 Nov 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Perry T, Deng Y, Hulley P, et al. Deconvoluting synovial fluid molecular endotypes in knee osteoarthritis: primary results from the STEpUP OA Consortium. medRxiv; 2024. DOI: 10.1101/2024.06.05.24308485.
Osteoarthritis in over 16s: diagnosis and management. London: National Institute for Health and Care Excellence (NICE); 2022 Oct 19. Available from http://www.ncbi.nlm.nih.gov/books/NBK588843/
PubMed 36745715Burn E, Murray DW, Hawker GA, Pinedo-Villanueva R, Prieto-Alhambra D. Lifetime risk of knee and hip replacement following a GP diagnosis of osteoarthritis: a real-world cohort study. Osteoarthritis Cartilage. 2019 Nov;27(11):1627-1635. doi: 10.1016/j.joca.2019.06.004. Epub 2019 Jun 17.
PubMed 31220608Garriga C, Goff M, Paterson E, Hrusecka R, Hamid B, Alderson J, Leyland K, Honeyfield L, Greenshields L, Satchithananda K, Lim A, Arden NK, Judge A, Williams A, Vincent TL, Watt FE. Clinical and molecular associations with outcomes at 2 years after acute knee injury: a longitudinal study in the Knee Injury Cohort at the Kennedy (KICK). Lancet Rheumatol. 2021 Jun 24;3(9):e648-e658. doi: 10.1016/S2665-9913(21)00116-8. eCollection 2021 Sep.
PubMed 34476411Kalsoum R, Minns Lowe CJ, Gilbert S, McCaskie AW, Snow M, Wright K, Bruce G, Mason DJ, Watt FE. A mixed-methods approach exploring acceptability and feasibility of trials designed to test drugs targeting prevention of post-traumatic osteoarthritis after knee injury. Bone Joint Res. 2024 Sep 19;13(9):513-524. doi: 10.1302/2046-3758.139.BJR-2024-0109.
PubMed 39293808Hollis B, Chatzigeorgiou C, Southam L, Hatzikotoulas K, Kluzek S, Williams A; Genetics of Osteoarthritis Consortium; Zeggini E, Jostins-Dean L, Watt FE. Lifetime risk and genetic predisposition to post-traumatic OA of the knee in the UK Biobank. Osteoarthritis Cartilage. 2023 Oct;31(10):1377-1387. doi: 10.1016/j.joca.2023.05.012. Epub 2023 May 27.
PubMed 37247657Watt FE, Paterson E, Freidin A, Kenny M, Judge A, Saklatvala J, Williams A, Vincent TL. Acute Molecular Changes in Synovial Fluid Following Human Knee Injury: Association With Early Clinical Outcomes. Arthritis Rheumatol. 2016 Sep;68(9):2129-40. doi: 10.1002/art.39677.
PubMed 26991527Paskins Z, Farmer CE, Manning F, Andersson DA, Barlow T, Bishop FL, Brown CA, Clark A, Clark EM, Dulake D, Gulati M, Le Maitre CL, Jones RK, Loughlin J, Mason DJ, McCarron M, Millar NL, Pandit H, Peat G, Richardson SM, Salt EJ, Taylor EJ, Troeberg L, Wilcox RK, Wise E, Wilkinson C, Watt FE; Musculoskeletal Disorders Research Advisory Group Versus Arthritis. Research priorities to reduce the impact of musculoskeletal disorders: a priority setting exercise with the child health and nutrition research initiative method. Lancet Rheumatol. 2022 Jul 27;4(9):e635-e645. doi: 10.1016/S2665-9913(22)00136-9. eCollection 2022 Sep.
PubMed 36275038Liu Q, Chu H, LaValley MP, Hunter DJ, Zhang H, Tao L, Zhan S, Lin J, Zhang Y. Prediction models for the risk of total knee replacement: development and validation using data from multicentre cohort studies. Lancet Rheumatol. 2022 Feb;4(2):e125-e134. doi: 10.1016/s2665-9913(21)00324-6. Epub 2022 Jan 5.
PubMed 36177295Lo GH, Schneider E, Driban JB, Price LL, Hunter DJ, Eaton CB, Hochberg MC, Jackson RD, Kwoh CK, Nevitt MC, Lynch JA, McAlindon TE; OAI Investigators Group. Periarticular bone predicts knee osteoarthritis progression: Data from the Osteoarthritis Initiative. Semin Arthritis Rheum. 2018 Oct;48(2):155-161. doi: 10.1016/j.semarthrit.2018.01.008. Epub 2018 Jan 31.
PubMed 29449014Collins NJ, Misra D, Felson DT, Crossley KM, Roos EM. Measures of knee function: International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form, Knee Injury and Osteoarthritis Outcome Score (KOOS), Knee Injury and Osteoarthritis Outcome Score Physical Function Short Form (KOOS-PS), Knee Outcome Survey Activities of Daily Living Scale (KOS-ADL), Lysholm Knee Scoring Scale, Oxford Knee Score (OKS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Activity Rating Scale (ARS), and Tegner Activity Score (TAS). Arthritis Care Res (Hoboken). 2011 Nov;63 Suppl 11(0 11):S208-28. doi: 10.1002/acr.20632. No abstract available.
PubMed 22588746Roos EM, Lohmander LS. The Knee injury and Osteoarthritis Outcome Score (KOOS): from joint injury to osteoarthritis. Health Qual Life Outcomes. 2003 Nov 3;1:64. doi: 10.1186/1477-7525-1-64.
PubMed 14613558Brown TD, Johnston RC, Saltzman CL, Marsh JL, Buckwalter JA. Posttraumatic osteoarthritis: a first estimate of incidence, prevalence, and burden of disease. J Orthop Trauma. 2006 Nov-Dec;20(10):739-44. doi: 10.1097/01.bot.0000246468.80635.ef.
PubMed 17106388Lohmander LS, Englund PM, Dahl LL, Roos EM. The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis. Am J Sports Med. 2007 Oct;35(10):1756-69. doi: 10.1177/0363546507307396. Epub 2007 Aug 29.
PubMed 17761605Nicholls E, Thomas E, van der Windt DA, Croft PR, Peat G. Pain trajectory groups in persons with, or at high risk of, knee osteoarthritis: findings from the Knee Clinical Assessment Study and the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2014 Dec;22(12):2041-50. doi: 10.1016/j.joca.2014.09.026. Epub 2014 Oct 8.
PubMed 25305072
Study at a glance
From the registry record, last updated by the sponsor on 6 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Imperial Knee Health Cohort: New Exploration of Early-stage Changes Study.
- ClinicalTrials.gov ID
- NCT07833488
- Acronym / sponsor ID
- KNEE / 26/LO/0569
- Conditions
- Knee Osteoarthritis
- Keywords
- post-traumatic knee osteoarthritis, genetics, synovial fluid, protein marker, knee injury, knee
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 200 participants (estimated)
- Lead sponsor
- Imperial College LondonUniversity, hospital or other
- Collaborators
- Arthritis UK, UK Research and Innovation
- Study start
- 14 Sep 2026 (actual)
- Primary completion
- 31 Jul 2031 (estimated)
- Study completion
- 31 Jul 2031 (estimated)
- First posted
- 22 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this observational, non-interventional cohort study is to identify tests or markers in blood or knee fluid, or any genetic risk factors that might contribute to worsening or improvement of knee osteoarthritis.
Males and females aged ≥18 with early-stage knee osteoarthritis, prior proven acute knee injury, or degenerative meniscal tear will be recruited at Imperial College Healthcare NHS Trust. Participants with prior proven acute knee injury must be aged ≤ 50. A single knee per participant will be followed throughout the study; this will be referred to as ''affected knee'', identified at baseline.
The study involves:
- Samples collection:
- From individuals recruited in-person: blood or buccal (cheek) swab and/or knee joint (synovial) fluid - this will be collected during routine NHS visit, if individuals undergo scheduled knee surgery or knee aspiration procedure (Knee aspiration is a procedure to remove excess fluid from the knee joint for diagnosis or treatment).
- From individuals recruited remotely: saliva sample.
- Clinical data collection at baseline: Participants will complete study Core Questionnaire Pack. These are questionnaires asking about participants' knee pain, function, and activity level.
- Clinical data collection at yearly remote visits, through years 1-5: Participants will complete study Follow-Up Questionnaire Pack, asking about participants' knee pain, function, and activity level - same as at baseline, but additionally participants will be asked about any knee surgeries on the affected knee, since the last study visit.
- Imaging data collection at baseline and at Year 2 or Year 3 follow-up visit:
If at baseline visit X-ray imaging is available as a part of usual NHS care, then participants will only be invited to attend one X-ray appointment at Year 2 or Year 3 follow-up visit.
The study expect to recruit up to 200 participants with approximately 100 participants having early-stage knee osteoarthritis or degenerative meniscal tear and the remaining participants having prior proven acute knee injury.
Individuals will be able join the study for between 2-3 years. Follow up visits will last up to 5 years.
Detailed description
The study aims to identify people who are in the early-stage of knee osteoarthritis or at risk of knee osteoarthritis. The current course of osteoarthritis is quite unpredictable. Early on symptoms (and structural changes) can get worse or can get better, yet the exact etiology remains unclear. Current treatments are often reactive, meaning doctors wait until the disease is advanced before they do much. This study is designed to help better predict this process.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Individuals with early-stage knee osteoarthritis (or degenerative meniscal tear). | – | –Males and females aged ≥18. |
| Individuals with prior proven acute knee injury. | – | –Males and females must be aged ≤ 50. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Participants will be recruited across Imperial College Healthcare NHS Trust (ICHNT) through four primary pathways: 1. Elective Orthopaedic Lists: Patients scheduled for relevant procedures on elective orthopaedic surgical lists. 2. Outpatient Procedural Lists: Patients scheduled for joint drainage or intra-articular injections within musculoskeletal specialties, including rheumatology, sports and exercise medicine, and musculoskeletal radiology. 3. Participants from existing research cohorts, such as the Imperial College Healthcare Tissue Bank (ICHTB), i.e., i-Bank, who are eligible and have previously consented to be re-contacted for future studies. 4. Research Registries: Individuals identified via research registries and mailing lists, including the Imperial Joint Health: Understanding, Monitoring and Prevention (JUMP) Registry, the Northwest London Health Research Register, and the Imperial Health Knowledge Bank (IHKB).
Key inclusion criteria (13 listed)
- Male or female, aged ≥18 years of age AND at least one of the following (a-d):
- Willing to provide at least one of the following samples: synovial fluid or blood (a salivary sample is an acceptable alternative for remote participants with a history of knee injury. This alternative also applies to existing participants from ICHTB/IHKB, for whom no prior DNA sample is currently banked)
- Understand English sufficiently to be able to read PIS, ICF and/or Participant Invitation Letter
- Provide an ICF, signed by the participant
- Be capable of complying with Protocol requirements, i.e. completing study questionnaire packs.
Key exclusion criteria (10 listed)
- Known advanced radiographic changes of KOA on available imaging (KL grade 3-4 where available), or other commensurate findings, such as those present on MRI
- Knee joint replacement (uni-compartmental arthroplasty or total knee arthroplasty) of the index knee, prior to consent, or planned during current episode of care, or within next 12 months
- Other clinically significant knee pathology such as infection or malignancy affecting the index knee joint or surrounding bone (at any time)
- Surgery to the index knee in the last 3 months
- Any other systemic inflammatory disease (e.g. inflammatory bowel disease), systemic infection, or inflammatory arthritis (e.g. rheumatoid arthritis, psoriatic arthritis, gout)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Knee injury and Osteoarthritis Outcome Score (KOOS)
Time frame: Baseline and 2 years
Collected via study questionnaires completed by participants. Knee Injury and Osteoarthritis Outcome Score (KOOS) is a knee-specific self-reported instrument, developed to assess participant's opinions about their knee and associated problems. The KOOS evaluates both short-term and long-term consequences of knee injury and osteoarthritis. It holds 42 items in 5 separately scored subscales: Pain, other Symptoms, Function in daily living , Function in Sport and Recreation, and knee-related Quality of Life. The KOOS is scored from 0 to 100, where higher scores indicate a better outcome, representing fewer symptoms and better knee-related quality of life.
3 secondary outcomes
Tegner Activity Score (TAS)
Time frame: Baseline and minimum at 2 years/maximum 5 years
Post enrolment surgical intervention data (arthroplasty)
Time frame: Years 1-5
X-ray radiographs of the index knee
Time frame: Baseline and 2 years
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Nov 2026.
- BackgroundPerry T, Deng Y, Hulley P, et al. Deconvoluting synovial fluid molecular endotypes in knee osteoarthritis: primary results from the STEpUP OA Consortium. medRxiv; 2024. DOI: 10.1101/2024.06.05.24308485.
- Background: PubMed 36745715Osteoarthritis in over 16s: diagnosis and management. London: National Institute for Health and Care Excellence (NICE); 2022 Oct 19. Available from http://www.ncbi.nlm.nih.gov/books/NBK588843/
- Background: PubMed 31220608Burn E, Murray DW, Hawker GA, Pinedo-Villanueva R, Prieto-Alhambra D. Lifetime risk of knee and hip replacement following a GP diagnosis of osteoarthritis: a real-world cohort study. Osteoarthritis Cartilage. 2019 Nov;27(11):1627-1635. doi: 10.1016/j.joca.2019.06.004. Epub 2019 Jun 17.
- Background: PubMed 34476411Garriga C, Goff M, Paterson E, Hrusecka R, Hamid B, Alderson J, Leyland K, Honeyfield L, Greenshields L, Satchithananda K, Lim A, Arden NK, Judge A, Williams A, Vincent TL, Watt FE. Clinical and molecular associations with outcomes at 2 years after acute knee injury: a longitudinal study in the Knee Injury Cohort at the Kennedy (KICK). Lancet Rheumatol. 2021 Jun 24;3(9):e648-e658. doi: 10.1016/S2665-9913(21)00116-8. eCollection 2021 Sep.
- Background: PubMed 39293808Kalsoum R, Minns Lowe CJ, Gilbert S, McCaskie AW, Snow M, Wright K, Bruce G, Mason DJ, Watt FE. A mixed-methods approach exploring acceptability and feasibility of trials designed to test drugs targeting prevention of post-traumatic osteoarthritis after knee injury. Bone Joint Res. 2024 Sep 19;13(9):513-524. doi: 10.1302/2046-3758.139.BJR-2024-0109.
- Background: PubMed 37247657Hollis B, Chatzigeorgiou C, Southam L, Hatzikotoulas K, Kluzek S, Williams A; Genetics of Osteoarthritis Consortium; Zeggini E, Jostins-Dean L, Watt FE. Lifetime risk and genetic predisposition to post-traumatic OA of the knee in the UK Biobank. Osteoarthritis Cartilage. 2023 Oct;31(10):1377-1387. doi: 10.1016/j.joca.2023.05.012. Epub 2023 May 27.
- Background: PubMed 26991527Watt FE, Paterson E, Freidin A, Kenny M, Judge A, Saklatvala J, Williams A, Vincent TL. Acute Molecular Changes in Synovial Fluid Following Human Knee Injury: Association With Early Clinical Outcomes. Arthritis Rheumatol. 2016 Sep;68(9):2129-40. doi: 10.1002/art.39677.
- Background: PubMed 36275038Paskins Z, Farmer CE, Manning F, Andersson DA, Barlow T, Bishop FL, Brown CA, Clark A, Clark EM, Dulake D, Gulati M, Le Maitre CL, Jones RK, Loughlin J, Mason DJ, McCarron M, Millar NL, Pandit H, Peat G, Richardson SM, Salt EJ, Taylor EJ, Troeberg L, Wilcox RK, Wise E, Wilkinson C, Watt FE; Musculoskeletal Disorders Research Advisory Group Versus Arthritis. Research priorities to reduce the impact of musculoskeletal disorders: a priority setting exercise with the child health and nutrition research initiative method. Lancet Rheumatol. 2022 Jul 27;4(9):e635-e645. doi: 10.1016/S2665-9913(22)00136-9. eCollection 2022 Sep.
- Background: PubMed 36177295Liu Q, Chu H, LaValley MP, Hunter DJ, Zhang H, Tao L, Zhan S, Lin J, Zhang Y. Prediction models for the risk of total knee replacement: development and validation using data from multicentre cohort studies. Lancet Rheumatol. 2022 Feb;4(2):e125-e134. doi: 10.1016/s2665-9913(21)00324-6. Epub 2022 Jan 5.
- Background: PubMed 29449014Lo GH, Schneider E, Driban JB, Price LL, Hunter DJ, Eaton CB, Hochberg MC, Jackson RD, Kwoh CK, Nevitt MC, Lynch JA, McAlindon TE; OAI Investigators Group. Periarticular bone predicts knee osteoarthritis progression: Data from the Osteoarthritis Initiative. Semin Arthritis Rheum. 2018 Oct;48(2):155-161. doi: 10.1016/j.semarthrit.2018.01.008. Epub 2018 Jan 31.
- Background: PubMed 22588746Collins NJ, Misra D, Felson DT, Crossley KM, Roos EM. Measures of knee function: International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form, Knee Injury and Osteoarthritis Outcome Score (KOOS), Knee Injury and Osteoarthritis Outcome Score Physical Function Short Form (KOOS-PS), Knee Outcome Survey Activities of Daily Living Scale (KOS-ADL), Lysholm Knee Scoring Scale, Oxford Knee Score (OKS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Activity Rating Scale (ARS), and Tegner Activity Score (TAS). Arthritis Care Res (Hoboken). 2011 Nov;63 Suppl 11(0 11):S208-28. doi: 10.1002/acr.20632. No abstract available.
- Background: PubMed 14613558Roos EM, Lohmander LS. The Knee injury and Osteoarthritis Outcome Score (KOOS): from joint injury to osteoarthritis. Health Qual Life Outcomes. 2003 Nov 3;1:64. doi: 10.1186/1477-7525-1-64.
- Imperial JUMP RegistryLink provided by the sponsor.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Fiona Watt, Dr principal investigator
Imperial College London
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Knee Osteoarthritis, run by Imperial College London at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 13 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 6 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Fiona Watt (+44 07858 367326, f.watt@imperial.ac.uk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Knee injury and Osteoarthritis Outcome Score (KOOS) (time frame: Baseline and 2 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07833488, which also lists 16 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Nov 2026.