MisophoniaNCT07833709
Effectiveness of a Mindfulness-Based Cognitive Behavioral Mobile Intervention for Misophonia
A study testing Mindfulness-Based Cognitive Behavioral Mobile Intervention in people with Misophonia and Misophonia Treatment, run by Sakarya University at 1 site in Turkey (Türkiye).
Trial summary
Misophonia is characterized by strong emotional and physiological reactions to specific trigger sounds and may interfere with daily functioning and emotional well-being. This randomized controlled trial will evaluate the effectiveness of a mobile application based on mindfulness-based cognitive behavioral… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Misophonia, Misophonia Treatment
- What is being tested?
- Mindfulness-Based Cognitive Behavioral Mobile Intervention
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Oct 2026to 3 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age 18 years or older.
- Meeting the misophonia criteria proposed by Jager et al. (2020).
- Reporting at least one trigger sound.
- Having a Misophonia Scale total score greater than 60.5.
- Owning a smartphone or tablet.
- Having sufficient technological literacy to use the mobile application.
Who cannot join
- Misophonia symptoms being better explained by another condition or disorder based on the eligibility screening.
- A Misophonia Scale total score of 60.5 or lower.
- Development of marked distress or functional impairment during the study that requires discontinuation and referral for professional mental health support.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site
Sakarya University, Faculty of Health Sciences
Sakarya, Sakarya Üniversitesi, 54050
Sevgi Koroglu Gokbel, MSc, +90 264 295 74 28, sevgikoroglu@sakarya.edu.tr
About this study
Official title: Effectiveness of a Mobile Application Based on Mindfulness-Based Cognitive Behavioral Interventions for the Management of Misophonia: A Randomized Controlled Trial
Misophonia is characterized by strong emotional and physiological reactions to specific trigger sounds and may interfere with daily functioning and emotional well-being. This randomized controlled trial will evaluate the effectiveness of a mobile application based on mindfulness-based cognitive behavioral interventions for adults with misophonia symptoms.
A total of 60 participants will be randomly assigned to either an intervention group or a control group. Participants in the intervention group will use a three-week mobile intervention that includes psychoeducation, cognitive behavioral techniques, gradual exposure to trigger sounds, mindfulness, breathing and relaxation exercises, and self-monitoring tools. The control group will not receive the mobile intervention during the study period.
Outcomes will be assessed before the intervention, immediately after the three-week intervention, and four weeks after the intervention. The main outcome will be change in misophonia symptoms. Secondary outcomes will include depression, anxiety, stress, and difficulties in emotion regulation.
Read the detailed description
This study is a randomized controlled trial designed to evaluate the effectiveness of a mobile application based on mindfulness-based cognitive behavioral interventions for individuals with misophonia symptoms.
The mobile intervention was developed to address cognitive, emotional, behavioral, and physiological processes associated with misophonia. The intervention integrates psychoeducation, cognitive behavioral therapy, mindfulness-based strategies, gradual exposure and desensitization, breathing and relaxation exercises, and self-monitoring. The intervention specifically targets threat appraisal, automatic thoughts, avoidance behaviors, physiological arousal, and difficulties in emotion regulation.
A total of 60 eligible participants will be randomly assigned to an intervention group or a control group using stratified block randomization. The intervention group will receive access to the mobile application for three weeks. The application includes educational content about misophonia, identification of individual trigger sounds, cognitive restructuring exercises, a thought diary, graded exposure to trigger sounds, Subjective Units of Distress Scale (SUDS) monitoring, breathing exercises, mindfulness practices, relaxation tools, and supportive audio content. The exposure component includes graded exposure, distress monitoring, breathing support, and a safe-stop option.
Participants will be evaluated at three time points: baseline before the intervention, immediately after completion of the three-week intervention, and four weeks after the intervention. The primary outcome will be change in misophonia symptoms. Secondary outcomes will include depression, anxiety, stress, and difficulties in emotion regulation. These outcomes will be assessed using the Misophonia Scale, the Depression Anxiety Stress Scale-21 (DASS-21), and the 16-item Difficulties in Emotion Regulation Scale.
The study will examine whether the mobile intervention produces improvements in misophonia symptoms and related psychological outcomes compared with the control condition.
- Conditions
- Misophonia, Misophonia Treatment
- Being tested
- Mindfulness-Based Cognitive Behavioral Mobile Intervention
- Keywords
- Misophonia, Mindfulness, Cognitive Behavioral Therapy, Mobile Health, mHealth, Digital Intervention, Emotion Regulation, Exposure Therapy, Depression, Anxiety, Stress
- Medical subject headings
- misophonia, Emotional Regulation, Depression, Anxiety Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Mindfulness-Based Cognitive Behavioral Mobile InterventionBehavioural
A three-week mobile behavioral intervention developed for adults with misophonia symptoms. The intervention integrates psychoeducation, cognitive behavioral techniques, self-monitoring, cognitive restructuring, graded exposure to trigger sounds, Subjective Units of Distress Scale (SUDS) monitoring, mindfulness practices, breathing exercises, relaxation techniques, and supportive audio content. The program is designed to target maladaptive thoughts, avoidance behaviors, emotional reactivity, physiological arousal, and difficulties in emotion regulation associated with misophonia.
| Study group | Role | What they receive |
|---|---|---|
| Intervention Group | Experimental | Participants assigned to this arm will use the mindfulness-based cognitive behavioral mobile application for three weeks. The intervention includes psychoeducation, cognitive restructuring, graded exposure to trigger sounds, mindfulness practices, breathing and relaxation exercises, and self-monitoring tools. Receives: Behavioral: Mindfulness-Based Cognitive Behavioral Mobile Intervention |
| Control Group | No intervention | Participants assigned to this arm will not receive the mobile intervention during the study period. They will complete the same outcome assessments as the intervention group at baseline, post-intervention, and follow-up. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Misophonia Scale Total Score
Misophonia symptoms will be assessed using the 30-item Misophonia Scale developed by Koroglu and Durat (2024). Each item is rated on a 5-point Likert scale, yielding a total score ranging from 30 to 150. Higher scores indicate lower misophonia severity, whereas lower scores indicate greater misophonia severity. Changes in total scores will be compared between the intervention and control groups.
Measured: Baseline, 3 weeks, and 7 weeks
Secondary outcomes (4)
Change in DASS-21 Depression Subscale Score
Depressive symptoms will be assessed using the Depression subscale of the 21-item Depression Anxiety Stress Scale (DASS-21). The subscale consists of 7 items rated on a 4-point Likert scale from 0 to 3. Higher scores indicate greater severity of depressive symptoms. Changes in depression scores will be compared between the intervention and control groups.
Measured: Baseline, 3 weeks, and 7 weeks
Change in DASS-21 Anxiety Subscale Score
Anxiety symptoms will be assessed using the Anxiety subscale of the 21-item Depression Anxiety Stress Scale (DASS-21). The subscale consists of 7 items rated on a 4-point Likert scale from 0 to 3. Higher scores indicate greater severity of anxiety symptoms. Changes in anxiety scores will be compared between the intervention and control groups.
Measured: Baseline, 3 weeks, and 7 weeks
Change in DASS-21 Stress Subscale Score
Stress symptoms will be assessed using the Stress subscale of the 21-item Depression Anxiety Stress Scale (DASS-21). The subscale consists of 7 items rated on a 4-point Likert scale from 0 to 3. Higher scores indicate greater severity of stress symptoms. Changes in stress scores will be compared between the intervention and control groups.
Measured: Baseline, 3 weeks, and 7 weeks
Change in Difficulties in Emotion Regulation Scale-16 (DERS-16) Total Score
Difficulties in emotion regulation will be assessed using the 16-item Difficulties in Emotion Regulation Scale (DERS-16). The scale consists of 16 items rated on a 5-point Likert scale. Higher total scores indicate greater difficulties in emotion regulation. Changes in DERS-16 total scores will be compared between the intervention and control groups.
Measured: Baseline, 3 weeks, and 7 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Sep 2026
- Study start15 Oct 2026 (estimated)
- Primary completion3 Dec 2026 (estimated)
- Study completion3 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for MisophoniaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomized in parallel to an intervention group or a control group.
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Sakarya University
- Sponsor type
- University, hospital or other
- Collaborators
- The Scientific and Technological Research Council of Turkey
- Responsible party
- Principal investigator, SEVGI KOROGLU, Sakarya University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07833709
- Sponsor's protocol ID
- SK_16092026
- Other IDs
- 425K267
- Status last verified
- Sep 2026
- First submitted
- 16 Sep 2026
- Last updated
- 25 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 25 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effectiveness of a Mobile Application Based on Mindfulness-Based Cognitive Behavioral Interventions for the Management of Misophonia: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07833709
- Acronym / sponsor ID
- SK_16092026
- Conditions
- Misophonia, Misophonia Treatment
- Keywords
- Misophonia, Mindfulness, Cognitive Behavioral Therapy, Mobile Health, mHealth, Digital Intervention, Emotion Regulation, Exposure Therapy
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Sakarya UniversityUniversity, hospital or other
- Collaborators
- The Scientific and Technological Research Council of Turkey
- Study start
- 15 Oct 2026 (estimated)
- Primary completion
- 3 Dec 2026 (estimated)
- Study completion
- 3 Dec 2026 (estimated)
- First posted
- 22 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Misophonia is characterized by strong emotional and physiological reactions to specific trigger sounds and may interfere with daily functioning and emotional well-being. This randomized controlled trial will evaluate the effectiveness of a mobile application based on mindfulness-based cognitive behavioral interventions for adults with misophonia symptoms.
A total of 60 participants will be randomly assigned to either an intervention group or a control group. Participants in the intervention group will use a three-week mobile intervention that includes psychoeducation, cognitive behavioral techniques, gradual exposure to trigger sounds, mindfulness, breathing and relaxation exercises, and self-monitoring tools. The control group will not receive the mobile intervention during the study period.
Outcomes will be assessed before the intervention, immediately after the three-week intervention, and four weeks after the intervention. The main outcome will be change in misophonia symptoms. Secondary outcomes will include depression, anxiety, stress, and difficulties in emotion regulation.
Detailed description
This study is a randomized controlled trial designed to evaluate the effectiveness of a mobile application based on mindfulness-based cognitive behavioral interventions for individuals with misophonia symptoms.
The mobile intervention was developed to address cognitive, emotional, behavioral, and physiological processes associated with misophonia. The intervention integrates psychoeducation, cognitive behavioral therapy, mindfulness-based strategies, gradual exposure and desensitization, breathing and relaxation exercises, and self-monitoring. The intervention specifically targets threat appraisal, automatic thoughts, avoidance behaviors, physiological arousal, and difficulties in emotion regulation.
A total of 60 eligible participants will be randomly assigned to an intervention group or a control group using stratified block randomization. The intervention group will receive access to the mobile application for three weeks. The application includes educational content about misophonia, identification of individual trigger sounds, cognitive restructuring exercises, a thought diary, graded exposure to trigger sounds, Subjective Units of Distress Scale (SUDS) monitoring, breathing exercises, mindfulness practices, relaxation tools, and supportive audio content. The exposure component includes graded exposure, distress monitoring, breathing support, and a safe-stop option.
Participants will be evaluated at three time points: baseline before the intervention, immediately after completion of the three-week intervention, and four weeks after the intervention. The primary outcome will be change in misophonia symptoms. Secondary outcomes will include depression, anxiety, stress, and difficulties in emotion regulation. These outcomes will be assessed using the Misophonia Scale, the Depression Anxiety Stress Scale-21 (DASS-21), and the 16-item Difficulties in Emotion Regulation Scale.
The study will examine whether the mobile intervention produces improvements in misophonia symptoms and related psychological outcomes compared with the control condition.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- Participants will be randomized in parallel to an intervention group or a control group.
| Arm | Type | Receives |
|---|---|---|
| Intervention Group | Experimental | Behavioral: Mindfulness-Based Cognitive Behavioral Mobile InterventionParticipants assigned to this arm will use the mindfulness-based cognitive behavioral mobile application for three weeks. The intervention includes psychoeducation, cognitive restructuring, graded exposure to trigger sounds, mindfulness practices, breathing and relaxation exercises, and self-monitoring tools. |
| Control Group | No intervention | –Participants assigned to this arm will not receive the mobile intervention during the study period. They will complete the same outcome assessments as the intervention group at baseline, post-intervention, and follow-up. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Age 18 years or older.
- Meeting the misophonia criteria proposed by Jager et al. (2020).
- Reporting at least one trigger sound.
- Having a Misophonia Scale total score greater than 60.5.
- Owning a smartphone or tablet.
Key exclusion criteria (3 listed)
- Misophonia symptoms being better explained by another condition or disorder based on the eligibility screening.
- A Misophonia Scale total score of 60.5 or lower.
- Development of marked distress or functional impairment during the study that requires discontinuation and referral for professional mental health support.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Mindfulness-Based Cognitive Behavioral Mobile InterventionA three-week mobile behavioral intervention developed for adults with misophonia symptoms. The intervention integrates psychoeducation, cognitive behavioral techniques, self-monitoring, cognitive restructuring, graded exposure to trigger sounds, Subjective Units of Distress Scale (SUDS) monitoring, mindfulness practices, breathing exercises, relaxation techniques, and supportive audio content. The program is designed to target maladaptive thoughts, avoidance behaviors, emotional reactivity, physiological arousal, and difficulties in emotion regulation associated with misophonia. | Behavioural | Intervention Group |
Primary outcome
Change in Misophonia Scale Total Score
Time frame: Baseline, 3 weeks, and 7 weeks
Misophonia symptoms will be assessed using the 30-item Misophonia Scale developed by Koroglu and Durat (2024). Each item is rated on a 5-point Likert scale, yielding a total score ranging from 30 to 150. Higher scores indicate lower misophonia severity, whereas lower scores indicate greater misophonia severity. Changes in total scores will be compared between the intervention and control groups.
4 secondary outcomes
Change in DASS-21 Depression Subscale Score
Time frame: Baseline, 3 weeks, and 7 weeks
Change in DASS-21 Anxiety Subscale Score
Time frame: Baseline, 3 weeks, and 7 weeks
Change in DASS-21 Stress Subscale Score
Time frame: Baseline, 3 weeks, and 7 weeks
Change in Difficulties in Emotion Regulation Scale-16 (DERS-16) Total Score
Time frame: Baseline, 3 weeks, and 7 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Mindfulness-Based Cognitive Behavioral Mobile Intervention in people with Misophonia and Misophonia Treatment, run by Sakarya University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 25 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Sevgi Koroglu Gokbel, Research Assistant (+90 264 295 74 28, sevgikoroglu@sakarya.edu.tr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Misophonia Scale Total Score (time frame: Baseline, 3 weeks, and 7 weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Sep 2026.