Thoracic HypomobilityNCT07834190
Immediate Effects of Sustained Versus Oscillatory Mobilization in Patients With Thoracic Hypo-mobility
A study testing oscillatory mobilization and Sustained Mobilizations in people with Thoracic Hypomobility, run by Foundation University Islamabad at 1 site in Pakistan.
Trial summary
This randomized controlled trial compares two manual therapy interventions for adults with thoracic spine hypo mobility. Fifty-two participants are randomly allocated by coin toss to one of two equal groups (n = 26 each). Read more about this study
- Who is it for?
- Ages 25 to 44 years
- Conditions the study is for
- Thoracic Hypomobility
- What is being tested?
- oscillatory mobilization and Sustained Mobilizations
- Type of treatment
- Injection or infusion, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 52 participants
- Where
- 1 sitePakistan
- Study dates
- 13 Feb 2026to 18 Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 25 to 44 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- adults (ages 25-44)
- both male and female
- localized thoracic pain (T1-T12)
- Pain intensity of ≥ 3/10 on NPRS at baseline
- reduced segmental mobility on PA spring test compared to adjacent segments
- positive thoracic schober's test, indicating reduced thoracic mobility
Who cannot join
- recent surgery (at least6 months ago) Diagnosed diseases
- systemic diseases (e.g. RA, SLE etc)
- spinal surgery
- ankylosing spondylitis
- recent history of fracture
- scoliosis
Show all 12Show fewer
- spondylolisthesis and spondylosis
- spinal TB
- spinal stenosis
- degenerative disc
- fibromyalgia
- malignancy
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site, 1 recruiting
- Recruiting
Foundation University College of Physical Therapy
Islamabad, Punjab Province, 46000
Muhammad Furqan Hassan, MS-OMPT, 051-5788171 ext. 733, furqan.hassan@fui.edu.pk
About this study
This randomized controlled trial compares two manual therapy interventions for adults with thoracic spine hypo mobility. Fifty-two participants are randomly allocated by coin toss to one of two equal groups (n = 26 each). Both groups first receive an identical preparatory protocol consisting of a combined session of TENS (transcutaneous electrical nerve stimulation) and hot pack application for 20 minutes, intended to reduce baseline pain and prepare the tissue for mobilization. Following this preparatory phase, Group A receives Maitland oscillatory mobilization, applied as small and large amplitude rhythmic passive movements directed at the spinous processes of the thoracic vertebrae (T1-T12). This is delivered as 3 sets of 15 repetitions, using Grades I-II to reduce pain and Grades III-IV to increase range of motion once pain has eased. Group B receives Kaltenborn sustained mobilization, which applies a slower, held stretch to the same thoracic spinous processes. This consists of 3 repetitions of a 30-60 second sustained hold, using Grades I-II for pain relief and Grade III (stretch beyond the point of restriction) to improve mobility once pain has decreased. Both interventions target the same spinal segments and are delivered in a single session by the same non-blinded protocol. Immediately after treatment, outcomes are reassessed: pain via the Numeric Pain Rating Scale (NPRS) and thoracic range of motion (flexion, extension, and right/left rotation in a lumbar-locked position) via a smartphone inclinometer application. The trial thus isolates the difference between a rhythmic, oscillatory mobilization technique and a slower, sustained-hold mobilization technique, allowing a direct immediate-effect comparison of the two manual therapy approaches for thoracic hypo mobility.
Read the detailed description
Both intervention arms in this study address thoracic spine hypo mobility using manual mobilization techniques, but they differ fundamentally in the speed, rhythm, and mechanical strategy through which force is applied to the joint. Before either technique is applied, all participants in both groups receive an identical preparatory protocol: a combined 20 minute session of transcutaneous electrical nerve stimulation (TENS) and hot pack application. This preparatory phase serves to desensitize the local pain response and increase tissue extensibility, ensuring that any subsequent differences observed between groups can be attributed to the mobilization technique itself rather than to unequal baseline pain relief. Group A receives Maitland oscillatory mobilization, a passive accessory movement technique applied directly to the spinous processes of the thoracic vertebrae ranging from T1 through T12. The defining feature of this technique is its rhythmic, oscillatory character: the therapist applies small or large amplitude back and forth movements at a chosen point within or at the limit of the available range, rather than a single sustained push. Treatment is delivered as 3 sets of 15 repetitions per hypo mobile segment. The technique follows a graded progression. Grades I and II involve small amplitude oscillations performed well within the pain free range, and are used first, while pain remains elevated. These lower grades are believed to work primarily through neurophysiological pain modulation, stimulating mechanoreceptors that activate the spinal gating mechanism for pain, and through increasing the viscosity and circulation of synovial fluid within the facet joints, which may reduce joint stiffness. Once the participant's pain has decreased sufficiently, the therapist progresses to Grades III and IV, which are larger amplitude oscillations performed up to the end of the available range and into tissue resistance. These higher grades are intended primarily to produce mechanical effects, stretching peri-articular and capsular structures, thereby directly increasing thoracic range of motion rather than only modulating pain. Throughout the session, grade selection is adjusted according to the participant's real time pain response, so that pain relieving oscillations always precede range focused ones. Group B receives Kaltenborn sustained mobilization, applied to the hypo mobile T1-T12 spinous processes but using a fundamentally different mechanical approach: instead of rhythmic movement, the therapist applies a slow, sustained force and holds it at a chosen point in the range. This is delivered as 3 repetitions, each held for 30 to 60 seconds, with a brief rest between repetitions. As with Group A, treatment follows a graded, pain guided progression. Grades I and II involve a gentle sustained traction or glide that takes up the tissue slack without provoking pain, and are applied first. These lower grades are thought to act mainly through sustained stimulation of Type II mechanoreceptors, which are slow adapting joint receptors associated with reducing pain and muscle guarding, as well as through a general neurophysiological relaxation effect on the surrounding musculature. Once pain has eased, the therapist progresses to a Grade III sustained stretch, in which the joint is held beyond the point of tissue resistance for the full 30 to 60 second duration. This sustained end range hold is intended to produce a viscoelastic stretching effect on the joint capsule and surrounding connective tissue, gradually lengthening shortened structures and thereby increasing range of motion. Because the force is held rather than oscillated, this technique relies on sustained tissue creep over time rather than repeated movement to achieve its mechanical effect. In both groups, all mobilizations are performed manually by the treating therapist within a single treatment session, targeting identical spinal levels and using the same pain guided, low grade to high grade progression logic. The essential distinction lies in delivery: Group A's oscillatory technique relies on repeated rhythmic movement through the range, drawing primarily on neurophysiological gating and fluid dynamics, while Group B's sustained technique relies on a held end range stretch, drawing primarily on mechanoreceptor stimulation and viscoelastic tissue creep. This design allows the study to isolate whether the manner of force application i.e. oscillatory versus sustained, produces different immediate effects on pain and thoracic range of motion, even when the target tissue, dosage intensity, and preparatory protocol are held constant across groups.
- Conditions
- Thoracic Hypomobility
- Being tested
- oscillatory mobilization, Sustained Mobilizations
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
oscillatory mobilizationProcedure or surgery
Group A first receives a combined 20-minute session of TENS (transcutaneous electrical nerve stimulation) and hot pack application to reduce baseline pain. This is followed by Maitland oscillatory mobilization, applied manually to the spinous processes of the thoracic vertebrae (T1-T12), delivered as 3 sets of 15 repetitions. Treatment begins with Grade I-II oscillations, which are small- to large-amplitude rhythmic movements performed within the pain-free range to reduce pain through activation of inhibitory pain-gate mechanisms and increased joint fluid viscosity. Once pain decreases, Grade III-IV oscillations are introduced, involving larger-amplitude movement up to end-range resistance, to improve thoracic range of motion. All mobilizations are performed by the treating therapist in a single session.
Sustained MobilizationsProcedure or surgery
Group B first receives the same combined 20-minute session of TENS and hot pack application to reduce baseline pain. This is followed by Kaltenborn sustained mobilization, applied manually to the spinous processes of the thoracic vertebrae (T1-T12), delivered as 3 repetitions of a 30-60 second sustained hold. Treatment begins with Grade I-II holds, involving slight distraction and taking up slack to the point of restriction, aimed at reducing pain and stimulating Type II mechanoreceptors. Once pain decreases, a Grade III sustained stretch is applied, held beyond the point of restriction in the range of motion, to improve thoracic mobility. All mobilizations are performed by the treating therapist in a single session.
| Study group | Role | What they receive |
|---|---|---|
| Group A oscillatory mobilizations | Experimental | Not described Receives: Procedure: oscillatory mobilization |
| Group B sustained mobilizations | Experimental | Not described Receives: Procedure: Sustained Mobilizations |
What is being measured
The primary outcome is the main question the study is designed to answer.
Thoracic Pain (T1-T12)
Numeric Pain Rating Scale is an 11 point pain rating scale from 0-10 where 0 represents no pain and 10 represents the worst pain imaginable.
Measured: Before and right after immediately the intervention.
Thoracic Range of Motion
Smartphone inclinometer will be used to assess the range of motion of the thoracic spine. The baseline assessment will establish each participant's pre-intervention ROM values, which will serve as the reference (baseline) values for subsequent comparison, changes in the thoracic ROM from baseline to post-intervention will be determined within each group.
Measured: Before and immediately after the intervention is applied.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Sep 2026
- Study start13 Feb 2026
- Primary completion18 Dec 2026 (estimated)
- Study completion18 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Thoracic HypomobilityStudies of the same condition, open and under way.
- More trials run by Foundation University IslamabadThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 52 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Foundation University Islamabad
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07834190
- Sponsor's protocol ID
- FUI/FUCP/CTR/MS-MSK/ZahaAsif
- Status last verified
- Sep 2026
- First submitted
- 16 Sep 2026
- Last updated
- 22 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Immediate Effects of Sustained Versus Oscillatory Mobilization in Patients With Thoracic Hypo-mobility
- ClinicalTrials.gov ID
- NCT07834190
- Acronym / sponsor ID
- FUI/FUCP/CTR/MS-MSK/ZahaAsif
- Conditions
- Thoracic Hypomobility
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 52 participants (estimated)
- Lead sponsor
- Foundation University IslamabadUniversity, hospital or other
- Study start
- 13 Feb 2026 (actual)
- Primary completion
- 18 Dec 2026 (estimated)
- Study completion
- 18 Jan 2027 (estimated)
- First posted
- 22 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial compares two manual therapy interventions for adults with thoracic spine hypo mobility. Fifty-two participants are randomly allocated by coin toss to one of two equal groups (n = 26 each). Both groups first receive an identical preparatory protocol consisting of a combined session of TENS (transcutaneous electrical nerve stimulation) and hot pack application for 20 minutes, intended to reduce baseline pain and prepare the tissue for mobilization. Following this preparatory phase, Group A receives Maitland oscillatory mobilization, applied as small and large amplitude rhythmic passive movements directed at the spinous processes of the thoracic vertebrae (T1-T12). This is delivered as 3 sets of 15 repetitions, using Grades I-II to reduce pain and Grades III-IV to increase range of motion once pain has eased. Group B receives Kaltenborn sustained mobilization, which applies a slower, held stretch to the same thoracic spinous processes. This consists of 3 repetitions of a 30-60 second sustained hold, using Grades I-II for pain relief and Grade III (stretch beyond the point of restriction) to improve mobility once pain has decreased. Both interventions target the same spinal segments and are delivered in a single session by the same non-blinded protocol. Immediately after treatment, outcomes are reassessed: pain via the Numeric Pain Rating Scale (NPRS) and thoracic range of motion (flexion, extension, and right/left rotation in a lumbar-locked position) via a smartphone inclinometer application. The trial thus isolates the difference between a rhythmic, oscillatory mobilization technique and a slower, sustained-hold mobilization technique, allowing a direct immediate-effect comparison of the two manual therapy approaches for thoracic hypo mobility.
Detailed description
Both intervention arms in this study address thoracic spine hypo mobility using manual mobilization techniques, but they differ fundamentally in the speed, rhythm, and mechanical strategy through which force is applied to the joint. Before either technique is applied, all participants in both groups receive an identical preparatory protocol: a combined 20 minute session of transcutaneous electrical nerve stimulation (TENS) and hot pack application. This preparatory phase serves to desensitize the local pain response and increase tissue extensibility, ensuring that any subsequent differences observed between groups can be attributed to the mobilization technique itself rather than to unequal baseline pain relief. Group A receives Maitland oscillatory mobilization, a passive accessory movement technique applied directly to the spinous processes of the thoracic vertebrae ranging from T1 through T12. The defining feature of this technique is its rhythmic, oscillatory character: the therapist applies small or large amplitude back and forth movements at a chosen point within or at the limit of the available range, rather than a single sustained push. Treatment is delivered as 3 sets of 15 repetitions per hypo mobile segment. The technique follows a graded progression. Grades I and II involve small amplitude oscillations performed well within the pain free range, and are used first, while pain remains elevated. These lower grades are believed to work primarily through neurophysiological pain modulation, stimulating mechanoreceptors that activate the spinal gating mechanism for pain, and through increasing the viscosity and circulation of synovial fluid within the facet joints, which may reduce joint stiffness. Once the participant's pain has decreased sufficiently, the therapist progresses to Grades III and IV, which are larger amplitude oscillations performed up to the end of the available range and into tissue resistance. These higher grades are intended primarily to produce mechanical effects, stretching peri-articular and capsular structures, thereby directly increasing thoracic range of motion rather than only modulating pain. Throughout the session, grade selection is adjusted according to the participant's real time pain response, so that pain relieving oscillations always precede range focused ones. Group B receives Kaltenborn sustained mobilization, applied to the hypo mobile T1-T12 spinous processes but using a fundamentally different mechanical approach: instead of rhythmic movement, the therapist applies a slow, sustained force and holds it at a chosen point in the range. This is delivered as 3 repetitions, each held for 30 to 60 seconds, with a brief rest between repetitions. As with Group A, treatment follows a graded, pain guided progression. Grades I and II involve a gentle sustained traction or glide that takes up the tissue slack without provoking pain, and are applied first. These lower grades are thought to act mainly through sustained stimulation of Type II mechanoreceptors, which are slow adapting joint receptors associated with reducing pain and muscle guarding, as well as through a general neurophysiological relaxation effect on the surrounding musculature. Once pain has eased, the therapist progresses to a Grade III sustained stretch, in which the joint is held beyond the point of tissue resistance for the full 30 to 60 second duration. This sustained end range hold is intended to produce a viscoelastic stretching effect on the joint capsule and surrounding connective tissue, gradually lengthening shortened structures and thereby increasing range of motion. Because the force is held rather than oscillated, this technique relies on sustained tissue creep over time rather than repeated movement to achieve its mechanical effect. In both groups, all mobilizations are performed manually by the treating therapist within a single treatment session, targeting identical spinal levels and using the same pain guided, low grade to high grade progression logic. The essential distinction lies in delivery: Group A's oscillatory technique relies on repeated rhythmic movement through the range, drawing primarily on neurophysiological gating and fluid dynamics, while Group B's sustained technique relies on a held end range stretch, drawing primarily on mechanoreceptor stimulation and viscoelastic tissue creep. This design allows the study to isolate whether the manner of force application i.e. oscillatory versus sustained, produces different immediate effects on pain and thoracic range of motion, even when the target tissue, dosage intensity, and preparatory protocol are held constant across groups.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group A oscillatory mobilizations | Experimental | Procedure: oscillatory mobilization |
| Group B sustained mobilizations | Experimental | Procedure: Sustained Mobilizations |
Who may qualify
- Ages
- 25 to 44 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- adults (ages 25-44)
- both male and female
- localized thoracic pain (T1-T12)
- Pain intensity of ≥ 3/10 on NPRS at baseline
- reduced segmental mobility on PA spring test compared to adjacent segments
Key exclusion criteria (12 listed)
- recent surgery (at least6 months ago) Diagnosed diseases
- systemic diseases (e.g. RA, SLE etc)
- spinal surgery
- ankylosing spondylitis
- recent history of fracture
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| oscillatory mobilizationGroup A first receives a combined 20-minute session of TENS (transcutaneous electrical nerve stimulation) and hot pack application to reduce baseline pain. This is followed by Maitland oscillatory mobilization, applied manually to the spinous processes of the thoracic vertebrae (T1-T12), delivered as 3 sets of 15 repetitions. Treatment begins with Grade I-II oscillations, which are small- to large-amplitude rhythmic movements performed within the pain-free range to reduce pain through activation of inhibitory pain-gate mechanisms and increased joint fluid viscosity. Once pain decreases, Grade III-IV oscillations are introduced, involving larger-amplitude movement up to end-range resistance, to improve thoracic range of motion. All mobilizations are performed by the treating therapist in a single session. | Procedure or surgery | Group A oscillatory mobilizations |
| Sustained MobilizationsGroup B first receives the same combined 20-minute session of TENS and hot pack application to reduce baseline pain. This is followed by Kaltenborn sustained mobilization, applied manually to the spinous processes of the thoracic vertebrae (T1-T12), delivered as 3 repetitions of a 30-60 second sustained hold. Treatment begins with Grade I-II holds, involving slight distraction and taking up slack to the point of restriction, aimed at reducing pain and stimulating Type II mechanoreceptors. Once pain decreases, a Grade III sustained stretch is applied, held beyond the point of restriction in the range of motion, to improve thoracic mobility. All mobilizations are performed by the treating therapist in a single session. | Procedure or surgery | Group B sustained mobilizations |
Primary outcome
Thoracic Pain (T1-T12)
Time frame: Before and right after immediately the intervention.
Numeric Pain Rating Scale is an 11 point pain rating scale from 0-10 where 0 represents no pain and 10 represents the worst pain imaginable.
Thoracic Range of Motion
Time frame: Before and immediately after the intervention is applied.
Smartphone inclinometer will be used to assess the range of motion of the thoracic spine. The baseline assessment will establish each participant's pre-intervention ROM values, which will serve as the reference (baseline) values for subsequent comparison, changes in the thoracic ROM from baseline to post-intervention will be determined within each group.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Sep 2026.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing oscillatory mobilization and Sustained Mobilizations in people with Thoracic Hypomobility, run by Foundation University Islamabad at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 22 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Zaha Asif, DPT (03185971608, zaha9801@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Thoracic Pain (T1-T12) (time frame: Before and right after immediately the intervention.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Sep 2026.