Cardiac Arrest (CA)NCT07834294
Ventilation During CPR and Return of Spontaneous Circulation
An observational study of Cardiac Arrest (CA), run by Rush University Medical Center at 1 site in United States.
Trial summary
During cardiopulmonary resuscitation (CPR), rescue breaths help move air into the lungs, but the amount of air delivered is rarely measured. This study examined whether the amount and rate of air delivered during CPR were related to the heart restarting its own circulation, called return of spontaneous circulation… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cardiac Arrest (CA)
- How many people
- 100 participants
- Where
- 1 siteUnited States
- Study dates
- 11 Sep 2023to 4 Jan 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adults who experienced in-hospital cardiac arrest at one of three participating hospitals and received manual ventilation through a mask or advanced airway during cardiopulmonary resuscitation (CPR).
Who may be able to join
- Adult subjects 18 years and older
- Admitted to any area of the hospital, including the emergency department
- Receiving manual ventilation by mask or artificial airway (laryngeal mask airway, endotracheal tube, or tracheostomy tube)
- Cardiac arrest requiring CPR, including chest compressions
Who cannot join
- anyone under 18 years of age
Trial locations and contacts
1 site in 1 country.
United States1 site
Rush University Medical Center
Chicago, Illinois, 60612
About this study
Official title: Delivered Ventilation During Cardiopulmonary Resuscitation and Its Association With Return of Spontaneous Circulation: A Multicenter Observational Study
During cardiopulmonary resuscitation (CPR), rescue breaths help move air into the lungs, but the amount of air delivered is rarely measured. This study examined whether the amount and rate of air delivered during CPR were related to the heart restarting its own circulation, called return of spontaneous circulation (ROSC).
- Conditions
- Cardiac Arrest (CA)
- Medical subject headings
- Heart Arrest
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of Participants Who Achieved Return of Spontaneous Circulation (ROSC)
ROSC status was obtained from the medical record for the monitored resuscitation event and recorded as a binary outcome (yes/no). The number and percentage of participants with documented ROSC will be reported.
Measured: At the end of the monitored resuscitation event (Day 1).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Sep 2026
- Study start11 Sep 2023
- Primary completion4 Jan 2025
- Study completion4 Jan 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cardiac Arrest (CA)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 100 participants (actual)
Sponsor and investigators
- Lead sponsor
- Rush University Medical Center
- Sponsor type
- University, hospital or other
- Collaborators
- University of Maryland, Baltimore, Hospital Civil Fray Antonio Alcalde
- Responsible party
- Principal investigator, Brady Scott, Rush University Medical Center
- Investigators
- Jie Li, PhD, Principal investigator, Rush University Medical Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07834294
- Sponsor's protocol ID
- 22031602
- Status last verified
- Sep 2026
- First submitted
- 9 Sep 2026
- Last updated
- 22 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Delivered Ventilation During Cardiopulmonary Resuscitation and Its Association With Return of Spontaneous Circulation: A Multicenter Observational Study
- ClinicalTrials.gov ID
- NCT07834294
- Acronym / sponsor ID
- 22031602
- Conditions
- Cardiac Arrest (CA)
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 100 participants (actual)
- Lead sponsor
- Rush University Medical CenterUniversity, hospital or other
- Collaborators
- University of Maryland, Baltimore, Hospital Civil Fray Antonio Alcalde
- Study start
- 11 Sep 2023 (actual)
- Primary completion
- 4 Jan 2025 (actual)
- Study completion
- 4 Jan 2025 (actual)
- First posted
- 22 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
During cardiopulmonary resuscitation (CPR), rescue breaths help move air into the lungs, but the amount of air delivered is rarely measured. This study examined whether the amount and rate of air delivered during CPR were related to the heart restarting its own circulation, called return of spontaneous circulation (ROSC).
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adults who experienced in-hospital cardiac arrest at one of three participating hospitals and received manual ventilation through a mask or advanced airway during cardiopulmonary resuscitation (CPR).
Key inclusion criteria (4 listed)
- Adult subjects 18 years and older
- Admitted to any area of the hospital, including the emergency department
- Receiving manual ventilation by mask or artificial airway (laryngeal mask airway, endotracheal tube, or tracheostomy tube)
- Cardiac arrest requiring CPR, including chest compressions
Key exclusion criteria (1 listed)
- anyone under 18 years of age
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Number of Participants Who Achieved Return of Spontaneous Circulation (ROSC)
Time frame: At the end of the monitored resuscitation event (Day 1).
ROSC status was obtained from the medical record for the monitored resuscitation event and recorded as a binary outcome (yes/no). The number and percentage of participants with documented ROSC will be reported.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jie Li, PhD principal investigator
Rush University Medical Center
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Cardiac Arrest (CA), run by Rush University Medical Center at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 22 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of Participants Who Achieved Return of Spontaneous Circulation (ROSC) (time frame: At the end of the monitored resuscitation event (Day 1).). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Sep 2026.