Third Molar SurgeryNCT07835373
A-PRF AND HA AFTER IMPACTED THIRD MOLAR SURGERY
A study testing Advanced Platelet-Rich Fibrin and Sodium hyaluronate in people with Third Molar Surgery, run by Inonu University at 1 site in Turkey (Türkiye).
Trial summary
This randomized controlled clinical trial evaluated the effects of advanced platelet-rich fibrin (A-PRF) and hyaluronic acid (HA) on healing after surgical removal of impacted mandibular third molars. Read more about this study
- Who is it for?
- Ages 19 to 29 yearsHealthy volunteers can take part
- Conditions the study is for
- Third Molar Surgery
- What is being tested?
- Advanced Platelet-Rich Fibrin and Sodium hyaluronate
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 47 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 11 Aug 2025to 30 Jun 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 19 to 29 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Patients aged 19-29 years. American Society of Anesthesiologists (ASA) physical status I. Presence of an impacted mandibular third molar indicated for surgical removal. Ability and willingness to comply with the study procedures and follow-up visits.
- Provision of written informed consent.
Who cannot join
- Smoking. Poor oral hygiene. Presence of acute infection in the surgical area. Presence of a cystic or tumoral lesion associated with the impacted tooth. Uncontrolled periodontal disease. Refusal to participate or withdrawal of consent. Use of analgesics or antibiotics within 12 hours before surgery. Surgical procedure lasting longer than 40 minutes.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Inonu University Faculty of Dentistry
Malatya, Battalgazi, 44200
About this study
Official title: Effects of Advanced Platelet-Rich Fibrin and Hyaluronic Acid on Radiographic and Clinical Healing Following Impacted Mandibular Third Molar Surgery: A Randomized Controlled Clinical Trial
This randomized controlled clinical trial evaluated the effects of advanced platelet-rich fibrin (A-PRF) and hyaluronic acid (HA) on healing after surgical removal of impacted mandibular third molars. Participants were assigned to one of three groups: A-PRF applied to the extraction socket, HA applied to the extraction socket, or a control group receiving no additional biomaterial. Postoperative pain, facial swelling, and maximum mouth opening were assessed during the first postoperative week. Radiographic bone healing was evaluated using fractal dimension and mean gray value measurements on panoramic radiographs obtained on postoperative days 7 and 90. The study aimed to determine whether A-PRF or HA could improve postoperative clinical recovery and radiographic bone healing compared with standard treatment alone.
- Conditions
- Third Molar Surgery
- Being tested
- Advanced Platelet-Rich Fibrin, Sodium hyaluronate
- Keywords
- Hyaluronic acid, impacted third molar, fractal analysis, Radiographic gray value, advanced platelet-rich fibrin
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Advanced Platelet-Rich FibrinBiological
Advanced platelet-rich fibrin (A-PRF) was prepared from autologous venous blood by centrifugation at 1500 rpm for 14 minutes. The resulting A-PRF membrane was placed into the extraction socket immediately after surgical removal of the impacted mandibular third molar.
Sodium hyaluronateDrug
One milliliter of 0.8% sodium hyaluronate gel was applied directly into the extraction socket immediately after surgical removal of the impacted mandibular third molar.
| Study group | Role | What they receive |
|---|---|---|
| A-PRF Group | Experimental | Advanced platelet-rich fibrin (A-PRF) was applied to the extraction socket following surgical removal of the impacted mandibular third molar. Receives: Biological: Advanced Platelet-Rich Fibrin |
| Hyaluronic Acid Group | Experimental | One milliliter of 0.8% sodium hyaluronate gel was applied to the extraction socket following surgical removal of the impacted mandibular third molar. Receives: Drug: Sodium hyaluronate |
| Control Group | No intervention | No additional biomaterial was applied to the extraction socket following surgical removal of the impacted mandibular third molar. Participants received the same surgical procedure and standard postoperative care as the other groups. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Fractal Dimension of the Extraction Socket
Fractal dimension (FD) was used to evaluate the trabecular bone pattern within the extraction socket on digital panoramic radiographs. A standardized 32 × 32-pixel region of interest was selected at the center of the extraction socket, and FD was calculated using the box-counting method in ImageJ.
Measured: Postoperative days 7 and 90
Secondary outcomes (4)
Mean Radiographic Gray Value
Mean radiographic gray value was measured within a standardized 32 × 32-pixel region of interest located at the center of the extraction socket on digital panoramic radiographs using ImageJ software.
Measured: Postoperative days 7 and 90
Postoperative Pain
Postoperative pain intensity was assessed using a visual analog scale (VAS).
Measured: Postoperative days 1, 3, and 7
Postoperative Facial Swelling
Facial swelling was assessed using standardized facial measurements obtained between predefined anatomical landmarks before surgery and during postoperative follow-up.
Measured: Baseline and postoperative days 1, 3, and 7
Maximum Mouth Opening
Maximum mouth opening was measured in millimeters as the maximum interincisal distance.
Measured: Baseline and postoperative days 1, 3, and 7
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Sep 2026
- Study start11 Aug 2025
- Primary completion30 Jun 2026
- Study completion30 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Third Molar SurgeryStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 47 participants (actual)
Sponsor and investigators
- Lead sponsor
- Inonu University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Hadi Nasrollahi, Inonu University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07835373
- Sponsor's protocol ID
- 2025/8124
- Status last verified
- Sep 2026
- First submitted
- 17 Sep 2026
- Last updated
- 29 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: De-identified individual participant data underlying the results reported in the published article will be shared. These data will include demographic characteristics, group allocation, postoperative pain scores, facial swelling measurements, maximum mouth opening measurements, fractal dimension values, and mean radiographic gray values.
Study at a glance
From the registry record, last updated by the sponsor on 29 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Advanced Platelet-Rich Fibrin and Hyaluronic Acid on Radiographic and Clinical Healing Following Impacted Mandibular Third Molar Surgery: A Randomized Controlled Clinical Trial
- ClinicalTrials.gov ID
- NCT07835373
- Acronym / sponsor ID
- 2025/8124
- Conditions
- Third Molar Surgery
- Keywords
- Hyaluronic acid, impacted third molar, fractal analysis, Radiographic gray value, advanced platelet-rich fibrin
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 47 participants (actual)
- Lead sponsor
- Inonu UniversityUniversity, hospital or other
- Study start
- 11 Aug 2025 (actual)
- Primary completion
- 30 Jun 2026 (actual)
- Study completion
- 30 Jun 2026 (actual)
- First posted
- 22 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled clinical trial evaluated the effects of advanced platelet-rich fibrin (A-PRF) and hyaluronic acid (HA) on healing after surgical removal of impacted mandibular third molars. Participants were assigned to one of three groups: A-PRF applied to the extraction socket, HA applied to the extraction socket, or a control group receiving no additional biomaterial. Postoperative pain, facial swelling, and maximum mouth opening were assessed during the first postoperative week. Radiographic bone healing was evaluated using fractal dimension and mean gray value measurements on panoramic radiographs obtained on postoperative days 7 and 90. The study aimed to determine whether A-PRF or HA could improve postoperative clinical recovery and radiographic bone healing compared with standard treatment alone.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| A-PRF Group | Experimental | Biological: Advanced Platelet-Rich FibrinAdvanced platelet-rich fibrin (A-PRF) was applied to the extraction socket following surgical removal of the impacted mandibular third molar. |
| Hyaluronic Acid Group | Experimental | Drug: Sodium hyaluronateOne milliliter of 0.8% sodium hyaluronate gel was applied to the extraction socket following surgical removal of the impacted mandibular third molar. |
| Control Group | No intervention | –No additional biomaterial was applied to the extraction socket following surgical removal of the impacted mandibular third molar. Participants received the same surgical procedure and standard postoperative care as the other groups. |
Who may qualify
- Ages
- 19 to 29 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Patients aged 19-29 years. American Society of Anesthesiologists (ASA) physical status I. Presence of an impacted mandibular third molar indicated for surgical removal. Ability and willingness to comply with the study procedures and follow-up visits.
- Provision of written informed consent.
Key exclusion criteria (1 listed)
- Smoking. Poor oral hygiene. Presence of acute infection in the surgical area. Presence of a cystic or tumoral lesion associated with the impacted tooth. Uncontrolled periodontal disease. Refusal to participate or withdrawal of consent. Use of analgesics or antibiotics within 12 hours before surgery. Surgical procedure lasting longer than 40 minutes.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Advanced Platelet-Rich FibrinAdvanced platelet-rich fibrin (A-PRF) was prepared from autologous venous blood by centrifugation at 1500 rpm for 14 minutes. The resulting A-PRF membrane was placed into the extraction socket immediately after surgical removal of the impacted mandibular third molar. | Biological | A-PRF Group |
| Sodium hyaluronateOne milliliter of 0.8% sodium hyaluronate gel was applied directly into the extraction socket immediately after surgical removal of the impacted mandibular third molar. | Drug | Hyaluronic Acid Group |
Primary outcome
Fractal Dimension of the Extraction Socket
Time frame: Postoperative days 7 and 90
Fractal dimension (FD) was used to evaluate the trabecular bone pattern within the extraction socket on digital panoramic radiographs. A standardized 32 × 32-pixel region of interest was selected at the center of the extraction socket, and FD was calculated using the box-counting method in ImageJ.
4 secondary outcomes
Mean Radiographic Gray Value
Time frame: Postoperative days 7 and 90
Postoperative Pain
Time frame: Postoperative days 1, 3, and 7
Postoperative Facial Swelling
Time frame: Baseline and postoperative days 1, 3, and 7
Maximum Mouth Opening
Time frame: Baseline and postoperative days 1, 3, and 7
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Sep 2026.
- Individual participant dataSharing planned: Yes. De-identified individual participant data underlying the results reported in the published article will be shared. These data will include demographic characteristics, group allocation, postoperative pain scores, facial swelling measurements, maximum mouth opening measurements, fractal dimension values, and mean radiographic gray values.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Advanced Platelet-Rich Fibrin and Sodium hyaluronate in people with Third Molar Surgery, run by Inonu University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Fractal Dimension of the Extraction Socket (time frame: Postoperative days 7 and 90). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Sep 2026.