Complex Regional Pain Syndrome (CRPS)NCT07838376
Preceding Pain and Development of Additional Pain in Patients With CRPS
An observational study of Complex Regional Pain Syndrome (CRPS), run by Walton Centre NHS Foundation Trust at 1 site in United Kingdom.
Trial summary
Complex regional pain syndrome (CRPS) is a very painful condition that can have a huge impact on people's lives. Despite progress having been made in understanding what CRPS is and how it affects people, there are still many questions that remain unanswered. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Complex Regional Pain Syndrome (CRPS)
- How many people
- 705 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 30 Oct 2024to 5 Oct 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Adult, Older adult
Study population: People with CRPS first seen in outpatient clinic by Walton Centre Pain consultants between 2007 and 2023, who had consented to have their data entered into the Walton Centre CRPS database
Who may be able to join
- Confirmed CRPS diagnosis
- Age 18+ at time of study
- Seen by Prof. A. Goebel or another Walton Centre Pain Consultant as a new patient between 2007 and 2023.
- Data previously entered into the Walton Centre Registry.
- Patients, whose clinic letters who have been analysed for the previous 2014 study, will not be excluded.
Who cannot join
- Under the age of 18 at time of survey
Trial locations and contacts
1 site in 1 country.
United Kingdom1 site
The Walton Centre NHS Foundation Trust
Liverpool, Merseyside, L109LY
About this study
Official title: Preceding Pain and Development of Additional Pain in Patients With Complex Regional Pain Syndrome
Complex regional pain syndrome (CRPS) is a very painful condition that can have a huge impact on people's lives. Despite progress having been made in understanding what CRPS is and how it affects people, there are still many questions that remain unanswered. Research plays an important role in helping healthcare professionals understand illness and develop new treatments. The purpose of this study is to contribute to understanding of CRPS, specifically by seeing whether there are links between CRPS and other chronic pains. A study done at the Walton Centre in the past suggested that there may be some links, which the investigators will re-examine in this study in more detail, as well as asking other important questions which may bring new information to light.
Read the detailed description
This cross-sectional study will use a questionnaire-based method to gather information on pre-existing pain, before CRPS development, at the same site where CRPS then develops, and on additional pain (pre-existing or later developing) from a large cohort of patients with CRPS. This will allow a large amount of data to be collected in a time-efficient manner and enable comparison between different groups, for example, those who developed widespread pain before or after their diagnosis of CRPS. The investigators know from existing research that widespread pain is a relatively common phenomenon in patients with CRPS; on this basis they expect its frequency in the cohort to be such that they may be able to detect statistically significant patterns in its development, for example a different frequency in certain age groups. Thus the questionnaire will feature questions about the patient's CRPS diagnosis and any additional pain they have experienced, including its time course of development and nature. It will also include questions about other symptoms that are more commonly observed in chronic widespread pain than in CRPS, such as cognitive symptoms and sleep disturbance, and which form part of the ACR 2016 criteria for fibromyalgia syndrome diagnosis. Independently, given the unexpected finding of CRPS-preceding pains in the later CRPS-affected limb in a previous Walton Centre study, the investigators will also more systematically evaluate this phenomenon.
- Conditions
- Complex Regional Pain Syndrome (CRPS)
- Keywords
- CRPS, Fibromyalgia
- Medical subject headings
- Complex Regional Pain Syndromes, Fibromyalgia
What is being measured
The primary outcome is the main question the study is designed to answer.
Frequency and nature of chronic pain preceding CRPS onset, and additional pain development in patients with CRPS
Bespoke questionnaire tracking preceding pain location and intensity prior to CRPS, initial CRPS location and intensity and impact and pain following CRPS diagnosis. Included EQ-5D-5L questionnaire to track current overall quality of life.
Measured: From date recorded by patient of first preceding pain / CRPS diagnosis, to date questionnaire received by patient. Expected time frame from this of 1-20 years based on patient response.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Sep 2026
- Study start30 Oct 2024
- Primary completion30 Jun 2025
- Study completion5 Oct 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Complex Regional Pain Syndrome (CRPS)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 705 participants (actual)
Sponsor and investigators
- Lead sponsor
- Walton Centre NHS Foundation Trust
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Andreas Goebel, Principal investigator, Walton Centre NHS Foundation Trust
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07838376
- Sponsor's protocol ID
- RG581-24
- Status last verified
- Sep 2026
- First submitted
- 3 Sep 2026
- Last updated
- 13 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 13 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Preceding Pain and Development of Additional Pain in Patients With Complex Regional Pain Syndrome
- ClinicalTrials.gov ID
- NCT07838376
- Acronym / sponsor ID
- RG581-24
- Conditions
- Complex Regional Pain Syndrome (CRPS)
- Keywords
- CRPS, Fibromyalgia
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 705 participants (actual)
- Lead sponsor
- Walton Centre NHS Foundation TrustUniversity, hospital or other
- Study start
- 30 Oct 2024 (actual)
- Primary completion
- 30 Jun 2025 (actual)
- Study completion
- 5 Oct 2026 (actual)
- First posted
- 24 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Complex regional pain syndrome (CRPS) is a very painful condition that can have a huge impact on people's lives. Despite progress having been made in understanding what CRPS is and how it affects people, there are still many questions that remain unanswered. Research plays an important role in helping healthcare professionals understand illness and develop new treatments. The purpose of this study is to contribute to understanding of CRPS, specifically by seeing whether there are links between CRPS and other chronic pains. A study done at the Walton Centre in the past suggested that there may be some links, which the investigators will re-examine in this study in more detail, as well as asking other important questions which may bring new information to light.
Detailed description
This cross-sectional study will use a questionnaire-based method to gather information on pre-existing pain, before CRPS development, at the same site where CRPS then develops, and on additional pain (pre-existing or later developing) from a large cohort of patients with CRPS. This will allow a large amount of data to be collected in a time-efficient manner and enable comparison between different groups, for example, those who developed widespread pain before or after their diagnosis of CRPS. The investigators know from existing research that widespread pain is a relatively common phenomenon in patients with CRPS; on this basis they expect its frequency in the cohort to be such that they may be able to detect statistically significant patterns in its development, for example a different frequency in certain age groups. Thus the questionnaire will feature questions about the patient's CRPS diagnosis and any additional pain they have experienced, including its time course of development and nature. It will also include questions about other symptoms that are more commonly observed in chronic widespread pain than in CRPS, such as cognitive symptoms and sleep disturbance, and which form part of the ACR 2016 criteria for fibromyalgia syndrome diagnosis. Independently, given the unexpected finding of CRPS-preceding pains in the later CRPS-affected limb in a previous Walton Centre study, the investigators will also more systematically evaluate this phenomenon.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Age groups
- Adult, Older adult
- Study population
- People with CRPS first seen in outpatient clinic by Walton Centre Pain consultants between 2007 and 2023, who had consented to have their data entered into the Walton Centre CRPS database
Key inclusion criteria (5 listed)
- Confirmed CRPS diagnosis
- Age 18+ at time of study
- Seen by Prof. A. Goebel or another Walton Centre Pain Consultant as a new patient between 2007 and 2023.
- Data previously entered into the Walton Centre Registry.
- Patients, whose clinic letters who have been analysed for the previous 2014 study, will not be excluded.
Key exclusion criteria (1 listed)
- Under the age of 18 at time of survey
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Frequency and nature of chronic pain preceding CRPS onset, and additional pain development in patients with CRPS
Time frame: From date recorded by patient of first preceding pain / CRPS diagnosis, to date questionnaire received by patient. Expected time frame from this of 1-20 years based on patient response.
Bespoke questionnaire tracking preceding pain location and intensity prior to CRPS, initial CRPS location and intensity and impact and pain following CRPS diagnosis. Included EQ-5D-5L questionnaire to track current overall quality of life.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Oct 2026.
Related trials for Complex Regional Pain Syndrome (CRPS)
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Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE)
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Recruiting
The Effectiveness of Conservative Treatment in Patients With Complex Regional Pain Syndrome.
CRPS (Complex Regional Pain Syndromes)
RecruitingPhase 3
Phase 3, Open-Label Extension Study of AMBTX-01 (Neridronate) for Complex Regional Pain Syndrome Type 1
Complex Regional Pain Syndrome Type I
Active, not recruiting
Transcranial Magnetic Stimulation for Chronic Neuropathic Pain
Chronic Neuropathic Pain, Post-Stroke Pain
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Andreas Goebel principal investigator
Walton Centre NHS Foundation Trust
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Complex Regional Pain Syndrome (CRPS), run by Walton Centre NHS Foundation Trust at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Frequency and nature of chronic pain preceding CRPS onset, and additional pain development in patients with CRPS (time frame: From date recorded by patient of first preceding pain / CRPS diagnosis, to date questionnaire received by patient. Expected time frame from this of 1-20 years based on patient response.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Oct 2026.