Post Traumatic HeadacheNCT07838545
Comparative Effects of Post Isometric Relaxation and Reciprocal Inhibition in Individuals With Cervicogenic Headache.
A study testing Post Isometric Relaxation and Reciprocal Inhibition in people with Post Traumatic Headache and Cervicogenic Headache, run by Foundation University Islamabad at 1 site in Pakistan.
Trial summary
This study aims to compare the effects of Post Isometric Relaxation (PIR) and Reciprocal Inhibition (RI) in individuals with cervicogenic headache, a secondary headache originating from dysfunction of the cervical spine, particularly the upper cervical segments. Read more about this study
- Who is it for?
- Ages 18 to 45 years
- Conditions the study is for
- Post Traumatic Headache, Cervicogenic Headache
- What is being tested?
- Post Isometric Relaxation and Reciprocal Inhibition
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 46 participants
- Where
- 1 sitePakistan
- Study dates
- 12 Feb 2026to 18 Jan 2027
- Phase
- Interventional
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Patients are diagnosed according to ICH criteria.
- Age 18-45 years.
- Both Genders (Male and Female).
- Headache > 3 months.
- Unilateral neck pain and associated headache.
- Headache is precipitated by neck movements or sustained positions.
- Restricted upper cervical segmental mobility.
- Positive cervical flexion rotation test, restriction greater than 10°.
Who cannot join
- History of head and neck trauma.
- Neoplasm.
- Cognitive disability.
- Inherited disorders such as scoliosis and torticollis.
- Other chronic pain syndrome (i.e.: fibromyalgia, systematic inflammatory disease).
- History of recent surgery of cervical spine.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site, 1 recruiting
- Recruiting
Foundation University College of Physical Therapy
Islamabad, Punjab Province, 44000
Anam Rehman, MS-OMPT, +923355082299, anam.rehman@fui.edu.pk
About this study
This study aims to compare the effects of Post Isometric Relaxation (PIR) and Reciprocal Inhibition (RI) in individuals with cervicogenic headache, a secondary headache originating from dysfunction of the cervical spine, particularly the upper cervical segments. Cervicogenic headache is characterized by unilateral head and neck pain, restricted cervical mobility, muscle tightness, and functional limitations that negatively affect daily activities and quality of life. The study will employ a randomized controlled trial involving 46 participants aged 18-45 years who meet the inclusion criteria. Participants will be randomly allocated into two groups: Group A will receive Post Isometric Relaxation, while Group B will receive Reciprocal Inhibition. Both groups will also receive a standard physiotherapy protocol consisting of hot packs, cervical isometric exercises, and C1-C2 Sustained Natural Apophyseal Glides (SNAGs), administered three times per week for four weeks. Pain intensity, functional disability, and cervical range of motion will be assessed before and after the intervention using the Numeric Pain Rating Scale (NPRS), Neck Disability Index (NDI), and goniometric measurements, respectively. By comparing these two muscle energy techniques, the study seeks to determine which intervention is more effective in reducing pain, improving cervical mobility, and enhancing functional outcomes, thereby providing evidence to support clinical decision-making and optimize physiotherapy management for individuals with cervicogenic headache.
Read the detailed description
"Comparative Effects of Post Isometric Relaxation and Reciprocal Inhibition in Individuals with Cervicogenic Headache," is designed to compare the effectiveness of two muscle energy techniques-Post Isometric Relaxation (PIR) and Reciprocal Inhibition (RI)-in reducing pain, improving cervical range of motion, and decreasing functional disability among individuals with cervicogenic headache (CGH). Cervicogenic headache is defined as a secondary headache caused by disorders of the cervical spine or its associated bony, disc, or soft tissue structures. It typically presents as unilateral pain that begins in the neck or occipital region and radiates toward the front of the head. Patients often experience restricted neck movement, cervical stiffness, muscle tightness, and occasionally ipsilateral shoulder or arm discomfort. These symptoms may significantly interfere with daily activities, work performance, and overall quality of life. The condition is commonly associated with dysfunction of the upper cervical spine, particularly the C1-C2 segment, where altered joint mobility and muscle imbalance contribute to the development and persistence of symptoms. The synopsis highlights that cervicogenic headache is a common musculoskeletal disorder with a considerable health burden worldwide. It is frequently triggered or aggravated by sustained neck postures, repetitive cervical movements, or prolonged physical activity. Diagnosis requires a detailed subjective and physical examination, with particular emphasis on assessing upper cervical mobility. The Cervical Flexion-Rotation Test (CFRT) is identified as a reliable and valid clinical test for confirming cervicogenic headache because it specifically evaluates C1-C2 rotation, which is often limited in affected individuals. Patients with CGH also commonly exhibit tightness in muscles such as the upper trapezius, levator scapulae, sternocleidomastoid, scalene, suboccipital muscles, and pectoral muscles, making manual therapy an important component of rehabilitation. The study focuses on two commonly used muscle energy techniques. Post Isometric Relaxation (PIR) is based on the principle that following an isometric muscle contraction, muscle tone decreases temporarily, allowing the therapist to gently stretch the muscle into a new range of motion. During the technique, the therapist applies resistance while the patient performs a gentle isometric contraction for a specified duration, after which the muscle is passively stretched. This process aims to reduce muscle tightness, improve flexibility, restore normal muscle length, and increase cervical mobility. Reciprocal Inhibition (RI), in contrast, relies on the physiological inhibition of a tight muscle through isometric contraction of its antagonist. When the antagonist contracts, the agonist muscle experiences reduced muscle tone, allowing a more effective passive stretch. Both techniques are intended to relieve pain, restore normal muscle function, and improve joint mobility in patients with cervicogenic headache. The rationale for this research is based on evidence from previous studies demonstrating the effectiveness of manual therapy and muscle energy techniques in treating neck pain and cervicogenic headache. Earlier research has shown that PIR, hold-relax techniques, SNAGs, and other manual therapy interventions significantly reduce pain, improve cervical range of motion, and decrease disability. However, limited evidence directly compares PIR and RI in individuals with cervicogenic headache. Therefore, this study seeks to determine which of these two techniques provides superior clinical outcomes and may guide physiotherapists in selecting the most effective treatment approach. The research will be conducted as a randomized controlled trial (RCT) over one year at the Foundation University College of Physical Therapy. A total of 46 participants, aged 18-45 years, diagnosed with cervicogenic headache according to the International Classification of Headache criteria, will be recruited using non-probability purposive sampling. Eligible participants must have unilateral neck pain associated with headache for more than three months, headache provoked by neck movement or sustained postures, restricted upper cervical mobility, and a positive Cervical Flexion-Rotation Test with a restriction greater than 10 degrees. Individuals with recent cervical trauma, cervical surgery, neoplasms, inherited spinal deformities, cognitive impairment, or other chronic pain syndromes will be excluded to ensure a more homogeneous study population. Participants will be randomly allocated into two equal groups using sealed opaque envelopes. Group A will receive Post Isometric Relaxation, while Group B will receive Reciprocal Inhibition. Both groups will receive the same standard physiotherapy protocol consisting of a 10-minute hot pack, cervical isometric exercises (10 repetitions with a 5-second hold), and C1-C2 Sustained Natural Apophyseal Glides (SNAGs) (10 repetitions with a 5-second hold). Treatment sessions will be conducted three times per week for four weeks, resulting in a total of twelve treatment sessions. PIR and RI techniques will be applied to muscles commonly involved in cervicogenic headache, including the upper trapezius, levator scapulae, suboccipital muscles, and sternocleidomastoid, using standardized positioning, therapist resistance, isometric contractions, and gentle stretching procedures. The effectiveness of the interventions will be assessed using validated outcome measures. Pain intensity will be evaluated using the Numeric Pain Rating Scale (NPRS), functional disability will be measured using the Neck Disability Index (NDI), and cervical range of motion will be assessed with a goniometer. Baseline measurements will be recorded before treatment begins, and the same assessments will be repeated after completion of the twelfth treatment session. These outcome measures will allow comparison of changes in pain severity, neck function, and cervical mobility between the two intervention groups. The study emphasizes that identifying the more effective muscle energy technique could improve evidence-based physiotherapy management of cervicogenic headache. The findings may help clinicians make informed treatment decisions by determining whether Post Isometric Relaxation or Reciprocal Inhibition provides greater improvements in pain reduction, cervical mobility, and functional ability. Ultimately, the study aims to enhance patient outcomes, improve quality of life, reduce disability associated with cervicogenic headache, and contribute to the growing body of evidence supporting manual therapy interventions in musculoskeletal physiotherapy. Additionally, the research follows ethical principles by obtaining informed consent from all participants, ensuring confidentiality, allowing voluntary withdrawal from the study at any stage, and maintaining equal treatment without discrimination throughout the research process.
- Conditions
- Post Traumatic Headache, Cervicogenic Headache
- Being tested
- Post Isometric Relaxation, Reciprocal Inhibition
- Medical subject headings
- Post-Traumatic Headache
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Post Isometric RelaxationProcedure or surgery
Post Isometric Relaxation (PIR) is a muscle energy technique used to reduce pain, decrease muscle tightness, and improve cervical mobility in individuals with cervicogenic headache. The technique is based on the principle that muscle tone temporarily decreases after a gentle isometric contraction, allowing the muscle to be stretched more effectively. During the intervention, the therapist positions the affected muscle at its resistance barrier and asks the patient to perform a 10-second isometric contraction against therapist-applied resistance. After relaxation, a gentle passive stretch is applied to achieve a new range of motion. The procedure is repeated 3-5 times for each targeted muscle, including the upper trapezius, levator scapulae, suboccipital, and sternocleidomastoid muscles.
Reciprocal InhibitionProcedure or surgery
Reciprocal Inhibition (RI) is a muscle energy technique used to reduce muscle tightness, relieve pain, and improve cervical range of motion by utilizing the neurological principle of reciprocal inhibition. During the technique, the therapist positions the patient appropriately and instructs the patient to perform a gentle 10-second isometric contraction of the antagonist muscle against therapist-applied resistance. This contraction inhibits the activity of the tight agonist muscle, resulting in decreased muscle tone and facilitating relaxation. Following the contraction, the therapist applies a gentle passive stretch to the affected muscle to achieve a new range of motion. The technique is repeated 3-5 times for each targeted muscle to improve flexibility and cervical function.
| Study group | Role | What they receive |
|---|---|---|
| Group A Post Isometric Relaxation | Experimental | Not described Receives: Procedure: Post Isometric Relaxation |
| Group B Reciprocal Inhibition | Experimental | Not described Receives: Procedure: Reciprocal Inhibition |
What is being measured
The primary outcome is the main question the study is designed to answer.
Head Pain
Pain intensity will be assessed using the Numeric Pain Rating Scale(NPRS).The NPRS is an 11-point self reported scale ranging from 0 to 10,where 0 indicates no pain and 10 reprents the worst pain.
Measured: Baseline and after 4 weeks of intervention
Cervical Range of Motion
Cervical range of motion (ROM) will be assessed as an outcome measure using a goniometer. The assessment will be performed before the intervention and after completion of the treatment protocol to determine changes in cervical mobility. The cervical movements assessed will include flexion, extension, right and left lateral flexion, and right and left rotation. The participant will be positioned appropriately, and the goniometer will be aligned according to the anatomical landmarks for each movement. The available cervical ROM will be measured in degrees and recorded on the data collection form. Goniometry has demonstrated good reliability for assessing cervical ROM, with reported intraclass correlation coefficients (ICC) ranging from 0.79 to 0.98.
Measured: Baseline and after 4 weeks of treatment
Neck Disability
Neck disability will be assessed as an outcome measure using the Neck Disability Index (NDI). The NDI is a valid and reliable self-report questionnaire designed to evaluate the level of disability associated with neck pain and its effects on daily activities. It consists of 10 items covering pain intensity, personal care, lifting, reading, headaches, concentration, work, driving, sleeping, and recreation. Each item is scored from 0 to 5, with higher scores indicating greater disability. The total score ranges from 0 to 50 and is used to determine the severity of functional disability. A score of 0-4 indicates no disability, 5-14 mild disability, 15-24 moderate disability, 25-34 severe disability, and 35 or more complete disability.
Measured: Baseline and after 4 weeks of treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Sep 2026
- Study start12 Feb 2026
- Primary completion18 Dec 2026 (estimated)
- Study completion18 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Post Traumatic HeadacheStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 46 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Foundation University Islamabad
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07838545
- Sponsor's protocol ID
- FUI/FUCP/CTR/MSMSK/KinzaHafeez
- Status last verified
- Sep 2026
- First submitted
- 18 Sep 2026
- Last updated
- 24 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No