Activity, MotorNCT07840508
Velocity-Loss Training and Parkinson's Disease
A study testing 10% Velocity-Loss Threshold Resistance Training and 30% Velocity-Loss Threshold Resistance Training in people with Activity, Motor, run by University of Miami at 1 site in United States.
Trial summary
This study will compare the effects of velocity-loss resistance training at 10% and 30% velocity loss thresholds on measures of muscle strength and power and tests of daily performance in older adults with Parkinson's disease. Read more about this study
- Who is it for?
- Ages 50 to 85 years
- Conditions the study is for
- Activity, Motor
- What is being tested?
- 10% Velocity-Loss Threshold Resistance Training and 30% Velocity-Loss Threshold Resistance Training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteUnited States
- Study dates
- 25 Sep 2026to 30 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 85 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Parkinson's Disease Hoehn \& Yahr Stages 1-3
- Able to walk 50 meters unassisted
- Able to understand and communicate in English
Who cannot join
- Uncontrolled cardiovascular or other neuromuscular disease that prevent participation in a training program
- Any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, or other serious concomitant medical illness
- Unresolved injury or surgery to the upper or lower limbs that prevents weight training.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Laboratory of Neruomuscular Research and Active Aging
Coral Gables, Florida, 33147
Joseph F Signorile, PhD, 305-284-3105, jsignorile@miami.edu
Joseph Signorile, PhD
About this study
Official title: Comparison of Neuromuscular and Functional Adaptations to 10% and 30% Velocity-Loss Threshold Resistance Training in Persons With Parkinson's Disease
This study will compare the effects of velocity-loss resistance training at 10% and 30% velocity loss thresholds on measures of muscle strength and power and tests of daily performance in older adults with Parkinson's disease.
- Conditions
- Activity, Motor
- Being tested
- 10% Velocity-Loss Threshold Resistance Training, 30% Velocity-Loss Threshold Resistance Training
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
10% Velocity-Loss Threshold Resistance TrainingBehavioural
Participants will receive a total of twenty-four 45-minutes in-person training sessions at 10% velocity-loss threshold, twice per week using three sets of eight repetitions per set. During training participants will be allowed 1-minute rests between sets. Exercises will include four upper-body exercises and 2 lower-body exercises.
30% Velocity-Loss Threshold Resistance TrainingBehavioural
Participants will receive a total of twenty-four 45-minutes in-person training sessions at 30% velocity-loss threshold, twice per week using three sets of eight repetitions per set. During training participants will be allowed 1-minute rests between sets. Exercises will include four upper-body exercises and 2 lower-body exercises.
| Study group | Role | What they receive |
|---|---|---|
| 10% Velocity-Loss Threshold Resistance Training | Active comparator | Participants will receive velocity-based resistance training at 10% velocity-loss threshold, twice per week for at least 24 sessions for up to 12 weeks. Receives: Behavioral: 10% Velocity-Loss Threshold Resistance Training |
| 30% Velocity-Loss Threshold Resistance Training | Experimental | Participants will receive velocity-based resistance training at 30% velocity-loss threshold, twice per week for at least 24 sessions for up to 12 weeks. Receives: Behavioral: 30% Velocity-Loss Threshold Resistance Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in neuromuscular performance as measured by 1-repetition maximum (1RM)
Maximal load that can be lifted in one repetition (1RM) will be assessed in both leg press and chest press exercises. The loads on the testing equipment will be increased across 5 to 7 testing repetitions. The persons 1RM will be the highest load the person can move through the range of motion of the exercise. There are no minimum or maximum scores for this test. The higher the 1RM the stronger the person is. The unit of measurement is kilograms.
Measured: Baseline, 12 weeks
Change in neuromuscular performance as measured by Watts
This test measures the power a person can produce at maximal speed using loads of 20%, 40%, 60%, 80%, and 90% of 1RM for the chest press and leg press. Power shows how fast a person can do work. There are no minimum or maximum possible values. Higher values indicate better neuromuscular performance. Unit of measure is Watts.
Measured: Baseline, 12 weeks
Secondary outcomes (6)
Change in the Speed of the Ten-Meter Walk Test.
The ten-meter walk test will be used to assess gait velocity. The participants will be asked to walk at usual walking speed and as quickly as possible in a straight line on a 10-meter (m) course marked at 0, 2, 8 and 10 m. On verbal command, participants will start on the 0-m mark and stop when the 10-m mark is crossed. The total time to ambulate from the 2-m mark to the 8-m mark (6 m total) will be timed to the hundredth of a second. Two trials will be performed at each speed, and the average will be documented in meters per second. One-minute recoveries will be provided between trials.
Measured: Baseline, 12 weeks
Change in Time for the Five Times Sit-to-Stand Test.
The five-time sit-to-stand test will be used to assess functional lower body strength. The participant will sit with arms folded across the chest and the back against the chair. On a verbal command, the participant will stand up and sit down five times as quickly as possible. Timing begins at the word go and ends when the buttocks touch the chair after the fifth repetition. One practice and two testing trials will be performed. Time will be measured in seconds.
Measured: Baseline, 12 weeks
Change in the time required to complete the timed Up-and-Go Test.
Upon verbal cue, participants will stand up, walk around a cone placed three meters from the front edge of the chair and then returns to a seated position as quickly as possible. Time is measured in seconds.
Measured: Baseline, 12 weeks
Change in Distance of the Seated Medicine Ball Throw.
Upper body power will be assessed using the Seated Medicine Ball Throw test. Participants will sit in an armless chair with their back against the chair back and throw a 6-pound medicine ball from the chest as far as possible at an approximate 45-degree angle. Participants will complete three recorded test attempts. The distance thrown in meters will be measured. There are no minimum or maximum possible values. Greater throwing distances indicate better upper body power.
Measured: Baseline, 12 weeks
Change in Muscle Thickness using Ultrasound.
Muscle thickness will be assessed using B-mode ultrasonography. Three longitudinal-view images will be obtained for each muscle assessed. Muscle thickness will be measured by drawing a perpendicular line from the superficial aponeurosis to the deep aponeurosis at the thickest region of the muscle. Assessments will be performed on selected thigh and upper arm muscles. Muscle thickness is measured in centimeters (cm). Higher values indicate greater muscle thickness.
Measured: Baseline, 12 weeks
Change in Muscle Quality using Ultrasound.
Muscle quality will be measured using a gray scale. Grayscale values range from 0 to 255 units, where lower values (darker pixels) indicate greater muscle tissue content and higher values (lighter pixels) indicate greater intramuscular fat. The muscle to be tested will be the thigh muscles and the back of your arm. Lower grayscale values indicate better muscle quality.
Measured: Baseline, 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Sep 2026
- Study start25 Sep 2026
- Primary completion30 Dec 2026 (estimated)
- Study completion30 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Activity, MotorStudies of the same condition, open and under way.
- More trials run by University of MiamiThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Miami
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Joseph Signorile, University of Miami
- Investigators
- Joseph F. Signorile, PhD, Principal investigator, University of Miami - Coral Gables Campus
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07840508
- Sponsor's protocol ID
- 20260975
- Status last verified
- Sep 2026
- First submitted
- 18 Sep 2026
- Last updated
- 28 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 28 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Neuromuscular and Functional Adaptations to 10% and 30% Velocity-Loss Threshold Resistance Training in Persons With Parkinson's Disease
- ClinicalTrials.gov ID
- NCT07840508
- Acronym / sponsor ID
- 20260975
- Conditions
- Activity, Motor
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- University of MiamiUniversity, hospital or other
- Study start
- 25 Sep 2026 (actual)
- Primary completion
- 30 Dec 2026 (estimated)
- Study completion
- 30 Dec 2026 (estimated)
- First posted
- 25 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will compare the effects of velocity-loss resistance training at 10% and 30% velocity loss thresholds on measures of muscle strength and power and tests of daily performance in older adults with Parkinson's disease.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| 10% Velocity-Loss Threshold Resistance Training | Active comparator | Behavioral: 10% Velocity-Loss Threshold Resistance TrainingParticipants will receive velocity-based resistance training at 10% velocity-loss threshold, twice per week for at least 24 sessions for up to 12 weeks. |
| 30% Velocity-Loss Threshold Resistance Training | Experimental | Behavioral: 30% Velocity-Loss Threshold Resistance TrainingParticipants will receive velocity-based resistance training at 30% velocity-loss threshold, twice per week for at least 24 sessions for up to 12 weeks. |
Who may qualify
- Ages
- 50 to 85 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Parkinson's Disease Hoehn \& Yahr Stages 1-3
- Able to walk 50 meters unassisted
- Able to understand and communicate in English
Key exclusion criteria (3 listed)
- Uncontrolled cardiovascular or other neuromuscular disease that prevent participation in a training program
- Any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, or other serious concomitant medical illness
- Unresolved injury or surgery to the upper or lower limbs that prevents weight training.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| 10% Velocity-Loss Threshold Resistance TrainingParticipants will receive a total of twenty-four 45-minutes in-person training sessions at 10% velocity-loss threshold, twice per week using three sets of eight repetitions per set. During training participants will be allowed 1-minute rests between sets. Exercises will include four upper-body exercises and 2 lower-body exercises. | Behavioural | 10% Velocity-Loss Threshold Resistance Training |
| 30% Velocity-Loss Threshold Resistance TrainingParticipants will receive a total of twenty-four 45-minutes in-person training sessions at 30% velocity-loss threshold, twice per week using three sets of eight repetitions per set. During training participants will be allowed 1-minute rests between sets. Exercises will include four upper-body exercises and 2 lower-body exercises. | Behavioural | 30% Velocity-Loss Threshold Resistance Training |
Primary outcome
Change in neuromuscular performance as measured by 1-repetition maximum (1RM)
Time frame: Baseline, 12 weeks
Maximal load that can be lifted in one repetition (1RM) will be assessed in both leg press and chest press exercises. The loads on the testing equipment will be increased across 5 to 7 testing repetitions. The persons 1RM will be the highest load the person can move through the range of motion of the exercise. There are no minimum or maximum scores for this test. The higher the 1RM the stronger the person is. The unit of measurement is kilograms.
Change in neuromuscular performance as measured by Watts
Time frame: Baseline, 12 weeks
This test measures the power a person can produce at maximal speed using loads of 20%, 40%, 60%, 80%, and 90% of 1RM for the chest press and leg press. Power shows how fast a person can do work. There are no minimum or maximum possible values. Higher values indicate better neuromuscular performance. Unit of measure is Watts.
6 secondary outcomes
Change in the Speed of the Ten-Meter Walk Test.
Time frame: Baseline, 12 weeks
Change in Time for the Five Times Sit-to-Stand Test.
Time frame: Baseline, 12 weeks
Change in the time required to complete the timed Up-and-Go Test.
Time frame: Baseline, 12 weeks
Change in Distance of the Seated Medicine Ball Throw.
Time frame: Baseline, 12 weeks
Change in Muscle Thickness using Ultrasound.
Time frame: Baseline, 12 weeks
Change in Muscle Quality using Ultrasound.
Time frame: Baseline, 12 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Joseph F. Signorile, PhD principal investigator
University of Miami - Coral Gables Campus
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing 10% Velocity-Loss Threshold Resistance Training and 30% Velocity-Loss Threshold Resistance Training in people with Activity, Motor, run by University of Miami at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 28 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ethan A Elkins, MS (3052844173, exe453@miami.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in neuromuscular performance as measured by 1-repetition maximum (1RM) (time frame: Baseline, 12 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Sep 2026.