Preterm Prelabor Rupture of Membranes (PPROM)NCT07841587
Prediction of Latency Interval in Patients With Preterm Prelabor Rupture of Membranes
An observational study of Preterm Prelabor Rupture of Membranes (PPROM), run by Ain Shams Maternity Hospital at 1 site in Egypt.
Trial summary
Prediction of latency interval in Preterm prelabor rupture of membranes (PPROM) remains challenging in clinical practice, Myometrial thickness (MT) has emerged as a potential ultrasound marker for predicting the risk of preterm labor. Read more about this study
- Who is it for?
- Ages 18 to 40 years, women only
- Conditions the study is for
- Preterm Prelabor Rupture of Membranes (PPROM)
- How many people
- 50 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Oct 2026to Mar 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- Women only
- No healthy volunteers
- Adult
Study population: Pregnant women with preterm prelabor rupture of membranes presenting to Ain Shams University Maternity Hospital.
Who may be able to join
- Gestational age 28-34 weeks at membrane rupture
- Presenting to the hospital within 24 hours of PPROM
Who cannot join
- Women with contraindications to conservative management. Clinical chorioamnionitis at presentation. Patients presenting in labor Intrauterine fetal death
- Medical/Obstetric indications for immediate delivery at presentation:
- Severe preeclampsia. Bleeding: placenta previa or placental abruption
- Women with other risk factors for preterm birth. Fetal growth restriction with lost end-diastolic flow in umbilical artery Known uterine anomalies Multifetal gestation
- Previous uterine surgery (e.g., myomectomy, classical cesarean section)
- Morbidly obese women rendering sonographic assessment inaccurate
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Hamdy Alqenawy, M.D., contact
Egypt1 site
Ainshams University maternity hospital
Cairo
Ahmed M ElMaraghy, ahmedelmaraghy@med.asu.edu.eg
About this study
Official title: Myometrial Thickness as a Predictor of Latency Interval in Preterm Prelabor Rupture of Membranes: A Prospective Cohort Study
Prediction of latency interval in Preterm prelabor rupture of membranes (PPROM) remains challenging in clinical practice, Myometrial thickness (MT) has emerged as a potential ultrasound marker for predicting the risk of preterm labor.
This study aims to prospectively evaluate the correlation between MT measurements at multiple uterine sites and latency interval in women with PPROM.
Read the detailed description
PPROM is a major obstetric complication, occurring in approximately 3% of pregnancies and accounting for 30-40% of preterm births worldwide. It is defined as rupture of the fetal membranes before the onset of labor and prior to 37 weeks of gestation, creating a clinical dilemma that balances the risks of prematurity against the dangers of prolonged membrane rupture. The condition carries significant perinatal morbidity and mortality, including respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis, and neonatal sepsis, alongside maternal complications such as chorioamnionitis and postpartum hemorrhage.
The latency period, defined as the interval between membrane rupture and delivery, is a critical determinant of neonatal outcomes. A longer latency permits completion of antenatal corticosteroid therapy for fetal lung maturation and antibiotic prophylaxis, thereby improving neonatal prognosis. Conversely, prolonged latency increases the risk of ascending infection, chorioamnionitis, and placental abruption, necessitating careful and individualized management, Current evidence indicates that approximately 50% of affected women deliver within 48 hours, and 70-90% within one week of membrane rupture, although latency may occasionally extend for several weeks in cases of very early PPROM according to recommendations of the American College of Obstetricians and Gynecologists.
Standard management between 24 and 34 weeks includes hospitalization, antibiotic prophylaxis, antenatal corticosteroids, and magnesium sulfate for neuroprotection before 32 weeks, alongside close maternal-fetal surveillance. Despite these well-established interventions, accurate prediction of latency duration remains a significant clinical challenge. Traditional predictors such as gestational age at rupture, amniotic fluid volume, cervical length, fetal fibronectin, and inflammatory markers have demonstrated variable sensitivity and specificity across different populations, limiting their widespread clinical utility.
Ultrasonographic assessment has become integral to PPROM management, and recent attention has focused on myometrial thickness (MT) as a potential non-invasive predictor of labor onset and delivery timing. The myometrium undergoes dynamic structural and functional changes throughout pregnancy, with thickness variations reflecting uterine contractility patterns, inflammatory responses, and the risk of imminent delivery. Studies in women with threatened preterm labor have shown that increased MT particularly at the lower uterine segment correlates with heightened uterine activity and a shorter interval to delivery . Ultrasonography provides a non-invasive method for assessing uterine morphology and myometrial activity, with increasing interest in its potential role in predicting the onset of preterm labor.
Despite encouraging preliminary findings, evidence regarding the predictive value of MT in women with PPROM remains limited, and further prospective studies are required before its routine clinical application. Furthermore, in middle-income countries, such as Egypt, where preterm birth remains a major contributor to neonatal morbidity and mortality, the development of accessible, affordable, and non-invasive predictive tools for women with PPROM is of particular clinical importance. The wide availability of ultrasound equipment makes MT measurement a feasible and cost-effective addition to routine PPROM assessment, without requiring specialized biochemical assays or advanced technology.
This study therefore aims to prospectively evaluate the association between MT at multiple uterine sites and the latency interval in women with PPROM. Cut-off values predictive of imminent delivery can be incorporated into clinical management algorithms for this challenging obstetric condition.
- Keywords
- Myometrial thickness - Latency interval, Preterm prelabor rupture of membranes
What is being measured
The primary outcome is the main question the study is designed to answer.
Myometrial thickness as a predictor of latency interval in patients with preterm prelabor rupture of membranes
Correlation between myometrial thickness at each uterine measurement site and latency interval in patients with preterm prelabor rupture of membranes
Measured: the period from membrane rupture to 24 hours after membrane rupture
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Sep 2026
- Study start1 Oct 2026 (estimated)
- Primary completionMar 2027 (estimated)
- Study completionMar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (13)Papers the sponsor has linked to this study.
- Other trials for Preterm Prelabor Rupture of Membranes (PPROM)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ain Shams Maternity Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ahmed Mohammed Elmaraghy, Ain Shams Maternity Hospital
- Investigators
- Mohamed Serag, Study chair, Faculty of Medicine - Ain Shams universityWalid Tantawy, M.D.,, Study director, Faculty of Medicine - Modern University for Technology and Information
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07841587
- Sponsor's protocol ID
- 19
- Status last verified
- Oct 2026
- First submitted
- 20 Sep 2026
- Last updated
- 6 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Prelabor Rupture of Membranes: ACOG Practice Bulletin, Number 217. Obstet Gynecol. 2020 Mar;135(3):e80-e97. doi: 10.1097/AOG.0000000000003700.
PubMed 32080050Anil, A., Srinivas, S. B., Hebbar, S., & Pai, M. V. (2020). The upper and lower uterine segment thickness ratio: A simple sonographic tool to triage for preterm delivery among women with threatened preterm labor. Current Women's Health Reviews, 16(3), 236-243. https://doi.org/10.2174/1573404816666200309153236
Atarjavdan L, Khazaeipour Z, Shahbazi F. Correlation of myometrial thickness and the latency interval of women with preterm premature rupture of the membranes. Arch Gynecol Obstet. 2011 Dec;284(6):1339-43. doi: 10.1007/s00404-011-1841-x. Epub 2011 Feb 5.
PubMed 21298281Chawanpaiboon S, Vogel JP, Moller AB, Lumbiganon P, Petzold M, Hogan D, Landoulsi S, Jampathong N, Kongwattanakul K, Laopaiboon M, Lewis C, Rattanakanokchai S, Teng DN, Thinkhamrop J, Watananirun K, Zhang J, Zhou W, Gulmezoglu AM. Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis. Lancet Glob Health. 2019 Jan;7(1):e37-e46. doi: 10.1016/S2214-109X(18)30451-0. Epub 2018 Oct 30.
PubMed 30389451Feduniw S, Pruc M, Ciebiera M, Zeber-Lubecka N, Massalska D, Zgliczynska M, Pawlowska A, Szarpak L. Biomarkers for Pregnancy Latency Prediction after Preterm Premature Rupture of Membranes-A Systematic Review. Int J Mol Sci. 2023 Apr 28;24(9):8027. doi: 10.3390/ijms24098027.
PubMed 37175733Gupta R, Nagarsenkar A. Using Sonographically Estimated Myometrial Thickness in Prediction of Latency Interval in Cases of Preterm Premature Rupture of Membranes (PPROM). J Obstet Gynaecol India. 2016 Dec;66(6):431-435. doi: 10.1007/s13224-015-0711-z. Epub 2015 Jul 11.
PubMed 27821983Park JH, Bae JG, Chang YS. Neonatal Outcomes according to the Latent Period from Membrane Rupture to Delivery among Extremely Preterm Infants Exposed to Preterm Premature Rupture of Membrane: a Nationwide Cohort Study. J Korean Med Sci. 2021 Apr 12;36(14):e93. doi: 10.3346/jkms.2021.36.e93.
PubMed 33847083Ronzoni S, Boucoiran I, Yudin MH, Coolen J, Pylypjuk C, Melamed N, Holden AC, Smith G, Barrett J. Guideline No. 430: Diagnosis and management of preterm prelabour rupture of membranes. J Obstet Gynaecol Can. 2022 Nov;44(11):1193-1208.e1. doi: 10.1016/j.jogc.2022.08.014. Epub 2022 Oct 2.
PubMed 36410937Schmitz T, Sentilhes L, Lorthe E, Gallot D, Madar H, Doret-Dion M, Beucher G, Charlier C, Cazanave C, Delorme P, Garabedian C, Azria E, Tessier V, Senat MV, Kayem G. Preterm premature rupture of the membranes: Guidelines for clinical practice from the French College of Gynaecologists and Obstetricians (CNGOF). Eur J Obstet Gynecol Reprod Biol. 2019 May;236:1-6. doi: 10.1016/j.ejogrb.2019.02.021. Epub 2019 Mar 2.
PubMed 30870741Shynlova O, Nadeem L, Zhang J, Dunk C, Lye S. Myometrial activation: Novel concepts underlying labor. Placenta. 2020 Mar;92:28-36. doi: 10.1016/j.placenta.2020.02.005. Epub 2020 Feb 4.
PubMed 32056784Singh, S., Sharma, R., Gupta, N., & Suneja, A. (2021). Sonographic evaluation of myometrial thickness at different gestations for prediction of labor in preterm premature rupture of membranes. Journal of South Asian Federation of Obstetrics and Gynaecology, 13(6), 415-421. https://doi.org/10.5005/jp-journals-10006-1981
Tchirikov M, Schlabritz-Loutsevitch N, Maher J, Buchmann J, Naberezhnev Y, Winarno AS, Seliger G. Mid-trimester preterm premature rupture of membranes (PPROM): etiology, diagnosis, classification, international recommendations of treatment options and outcome. J Perinat Med. 2018 Jul 26;46(5):465-488. doi: 10.1515/jpm-2017-0027.
PubMed 28710882Thomson AJ; Royal College of Obstetricians and Gynaecologists. Care of Women Presenting with Suspected Preterm Prelabour Rupture of Membranes from 24+0 Weeks of Gestation: Green-top Guideline No. 73. BJOG. 2019 Aug;126(9):e152-e166. doi: 10.1111/1471-0528.15803. Epub 2019 Jun 17. No abstract available.
PubMed 31207667
Study at a glance
From the registry record, last updated by the sponsor on 6 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Myometrial Thickness as a Predictor of Latency Interval in Preterm Prelabor Rupture of Membranes: A Prospective Cohort Study
- ClinicalTrials.gov ID
- NCT07841587
- Acronym / sponsor ID
- 19
- Keywords
- Myometrial thickness - Latency interval, Preterm prelabor rupture of membranes
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Ain Shams Maternity HospitalUniversity, hospital or other
- Study start
- 1 Oct 2026 (estimated)
- Primary completion
- Mar 2027 (estimated)
- Study completion
- Mar 2027 (estimated)
- First posted
- 25 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Prediction of latency interval in Preterm prelabor rupture of membranes (PPROM) remains challenging in clinical practice, Myometrial thickness (MT) has emerged as a potential ultrasound marker for predicting the risk of preterm labor.
This study aims to prospectively evaluate the correlation between MT measurements at multiple uterine sites and latency interval in women with PPROM.
Detailed description
PPROM is a major obstetric complication, occurring in approximately 3% of pregnancies and accounting for 30-40% of preterm births worldwide. It is defined as rupture of the fetal membranes before the onset of labor and prior to 37 weeks of gestation, creating a clinical dilemma that balances the risks of prematurity against the dangers of prolonged membrane rupture. The condition carries significant perinatal morbidity and mortality, including respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis, and neonatal sepsis, alongside maternal complications such as chorioamnionitis and postpartum hemorrhage.
The latency period, defined as the interval between membrane rupture and delivery, is a critical determinant of neonatal outcomes. A longer latency permits completion of antenatal corticosteroid therapy for fetal lung maturation and antibiotic prophylaxis, thereby improving neonatal prognosis. Conversely, prolonged latency increases the risk of ascending infection, chorioamnionitis, and placental abruption, necessitating careful and individualized management, Current evidence indicates that approximately 50% of affected women deliver within 48 hours, and 70-90% within one week of membrane rupture, although latency may occasionally extend for several weeks in cases of very early PPROM according to recommendations of the American College of Obstetricians and Gynecologists.
Standard management between 24 and 34 weeks includes hospitalization, antibiotic prophylaxis, antenatal corticosteroids, and magnesium sulfate for neuroprotection before 32 weeks, alongside close maternal-fetal surveillance. Despite these well-established interventions, accurate prediction of latency duration remains a significant clinical challenge. Traditional predictors such as gestational age at rupture, amniotic fluid volume, cervical length, fetal fibronectin, and inflammatory markers have demonstrated variable sensitivity and specificity across different populations, limiting their widespread clinical utility.
Ultrasonographic assessment has become integral to PPROM management, and recent attention has focused on myometrial thickness (MT) as a potential non-invasive predictor of labor onset and delivery timing. The myometrium undergoes dynamic structural and functional changes throughout pregnancy, with thickness variations reflecting uterine contractility patterns, inflammatory responses, and the risk of imminent delivery. Studies in women with threatened preterm labor have shown that increased MT particularly at the lower uterine segment correlates with heightened uterine activity and a shorter interval to delivery . Ultrasonography provides a non-invasive method for assessing uterine morphology and myometrial activity, with increasing interest in its potential role in predicting the onset of preterm labor.
Despite encouraging preliminary findings, evidence regarding the predictive value of MT in women with PPROM remains limited, and further prospective studies are required before its routine clinical application. Furthermore, in middle-income countries, such as Egypt, where preterm birth remains a major contributor to neonatal morbidity and mortality, the development of accessible, affordable, and non-invasive predictive tools for women with PPROM is of particular clinical importance. The wide availability of ultrasound equipment makes MT measurement a feasible and cost-effective addition to routine PPROM assessment, without requiring specialized biochemical assays or advanced technology.
This study therefore aims to prospectively evaluate the association between MT at multiple uterine sites and the latency interval in women with PPROM. Cut-off values predictive of imminent delivery can be incorporated into clinical management algorithms for this challenging obstetric condition.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 to 40 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
- Study population
- Pregnant women with preterm prelabor rupture of membranes presenting to Ain Shams University Maternity Hospital.
Key inclusion criteria (2 listed)
- Gestational age 28-34 weeks at membrane rupture
- Presenting to the hospital within 24 hours of PPROM
Key exclusion criteria (6 listed)
- Women with contraindications to conservative management. Clinical chorioamnionitis at presentation. Patients presenting in labor Intrauterine fetal death
- Severe preeclampsia. Bleeding: placenta previa or placental abruption
- Women with other risk factors for preterm birth. Fetal growth restriction with lost end-diastolic flow in umbilical artery Known uterine anomalies Multifetal gestation
- Previous uterine surgery (e.g., myomectomy, classical cesarean section)
- Morbidly obese women rendering sonographic assessment inaccurate
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Myometrial thickness as a predictor of latency interval in patients with preterm prelabor rupture of membranes
Time frame: the period from membrane rupture to 24 hours after membrane rupture
Correlation between myometrial thickness at each uterine measurement site and latency interval in patients with preterm prelabor rupture of membranes
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Oct 2026.
- Background: PubMed 32080050Prelabor Rupture of Membranes: ACOG Practice Bulletin, Number 217. Obstet Gynecol. 2020 Mar;135(3):e80-e97. doi: 10.1097/AOG.0000000000003700.
- BackgroundAnil, A., Srinivas, S. B., Hebbar, S., & Pai, M. V. (2020). The upper and lower uterine segment thickness ratio: A simple sonographic tool to triage for preterm delivery among women with threatened preterm labor. Current Women's Health Reviews, 16(3), 236-243. https://doi.org/10.2174/1573404816666200309153236
- Background: PubMed 21298281Atarjavdan L, Khazaeipour Z, Shahbazi F. Correlation of myometrial thickness and the latency interval of women with preterm premature rupture of the membranes. Arch Gynecol Obstet. 2011 Dec;284(6):1339-43. doi: 10.1007/s00404-011-1841-x. Epub 2011 Feb 5.
- Background: PubMed 30389451Chawanpaiboon S, Vogel JP, Moller AB, Lumbiganon P, Petzold M, Hogan D, Landoulsi S, Jampathong N, Kongwattanakul K, Laopaiboon M, Lewis C, Rattanakanokchai S, Teng DN, Thinkhamrop J, Watananirun K, Zhang J, Zhou W, Gulmezoglu AM. Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis. Lancet Glob Health. 2019 Jan;7(1):e37-e46. doi: 10.1016/S2214-109X(18)30451-0. Epub 2018 Oct 30.
- Background: PubMed 37175733Feduniw S, Pruc M, Ciebiera M, Zeber-Lubecka N, Massalska D, Zgliczynska M, Pawlowska A, Szarpak L. Biomarkers for Pregnancy Latency Prediction after Preterm Premature Rupture of Membranes-A Systematic Review. Int J Mol Sci. 2023 Apr 28;24(9):8027. doi: 10.3390/ijms24098027.
- Background: PubMed 27821983Gupta R, Nagarsenkar A. Using Sonographically Estimated Myometrial Thickness in Prediction of Latency Interval in Cases of Preterm Premature Rupture of Membranes (PPROM). J Obstet Gynaecol India. 2016 Dec;66(6):431-435. doi: 10.1007/s13224-015-0711-z. Epub 2015 Jul 11.
- Background: PubMed 33847083Park JH, Bae JG, Chang YS. Neonatal Outcomes according to the Latent Period from Membrane Rupture to Delivery among Extremely Preterm Infants Exposed to Preterm Premature Rupture of Membrane: a Nationwide Cohort Study. J Korean Med Sci. 2021 Apr 12;36(14):e93. doi: 10.3346/jkms.2021.36.e93.
- Background: PubMed 36410937Ronzoni S, Boucoiran I, Yudin MH, Coolen J, Pylypjuk C, Melamed N, Holden AC, Smith G, Barrett J. Guideline No. 430: Diagnosis and management of preterm prelabour rupture of membranes. J Obstet Gynaecol Can. 2022 Nov;44(11):1193-1208.e1. doi: 10.1016/j.jogc.2022.08.014. Epub 2022 Oct 2.
- Background: PubMed 30870741Schmitz T, Sentilhes L, Lorthe E, Gallot D, Madar H, Doret-Dion M, Beucher G, Charlier C, Cazanave C, Delorme P, Garabedian C, Azria E, Tessier V, Senat MV, Kayem G. Preterm premature rupture of the membranes: Guidelines for clinical practice from the French College of Gynaecologists and Obstetricians (CNGOF). Eur J Obstet Gynecol Reprod Biol. 2019 May;236:1-6. doi: 10.1016/j.ejogrb.2019.02.021. Epub 2019 Mar 2.
- Background: PubMed 32056784Shynlova O, Nadeem L, Zhang J, Dunk C, Lye S. Myometrial activation: Novel concepts underlying labor. Placenta. 2020 Mar;92:28-36. doi: 10.1016/j.placenta.2020.02.005. Epub 2020 Feb 4.
- BackgroundSingh, S., Sharma, R., Gupta, N., & Suneja, A. (2021). Sonographic evaluation of myometrial thickness at different gestations for prediction of labor in preterm premature rupture of membranes. Journal of South Asian Federation of Obstetrics and Gynaecology, 13(6), 415-421. https://doi.org/10.5005/jp-journals-10006-1981
- Background: PubMed 28710882Tchirikov M, Schlabritz-Loutsevitch N, Maher J, Buchmann J, Naberezhnev Y, Winarno AS, Seliger G. Mid-trimester preterm premature rupture of membranes (PPROM): etiology, diagnosis, classification, international recommendations of treatment options and outcome. J Perinat Med. 2018 Jul 26;46(5):465-488. doi: 10.1515/jpm-2017-0027.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Hamdy Alqenawy, M.D., contact
Mohamed Serag study chair
Faculty of Medicine - Ain Shams university
Walid Tantawy, M.D., study director
Faculty of Medicine - Modern University for Technology and Information
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Preterm Prelabor Rupture of Membranes (PPROM), run by Ain Shams Maternity Hospital at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 6 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ahmed ElMaraghy, M.D, (+201010370980, ahmedelmaraghy@med.asu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Myometrial thickness as a predictor of latency interval in patients with preterm prelabor rupture of membranes (time frame: the period from membrane rupture to 24 hours after membrane rupture). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07841587, which also lists 13 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Oct 2026.