Neuromuscular PerformanceNCT07843199
Effects of Resistance Exercise Timing on Midday Muscle Performance in Athletes
A study testing Resistance-Based PAPE Intervention in people with Neuromuscular Performance and Post-Activation Performance Enhancement (PAPE), run by Manisa Celal Bayar University at 1 site in Turkey (Türkiye).
Trial summary
This study investigated whether the timing of a resistance-based post-activation performance enhancement (PAPE) intervention performed during the morning influences muscle performance and muscle electrical activity during a standardized midday assessment in trained male athletes. Read more about this study
- Who is it for?
- Any age, men onlyHealthy volunteers can take part
- Conditions the study is for
- Neuromuscular Performance, Post-Activation Performance Enhancement (PAPE)
- What is being tested?
- Resistance-Based PAPE Intervention
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 13 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 3 Jun 2025to 15 Sep 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- Men only
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- Regularly participating in systematic sport-specific training (minimum training age of 3 years)
- Able to comply with pre-testing restrictions (avoidance of intense physical activity for 72 hours and caffeine for 2 hours prior to testing sessions)
Who cannot join
- Any musculoskeletal, orthopedic, or health condition preventing safe participation in maximal isokinetic exercise testing
- Current or recent injury affecting lower-limb strength or performance testing
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Manisa Celal Bayar University, Faculty of Sport Sciences
Manisa, 45040
About this study
Official title: Time-Course Effect of Post-Activation Performance Enhancement on Midday Peak Torque and Muscle Activation
This study investigated whether the timing of a resistance-based post-activation performance enhancement (PAPE) intervention performed during the morning influences muscle performance and muscle electrical activity during a standardized midday assessment in trained male athletes. Participants completed a control condition and three PAPE conditions performed at different times during the morning. The PAPE intervention consisted of back squat, kettlebell swing, and barbell hip thrust exercises. In all conditions, muscle performance was assessed between 12:00 and 12:15 using an isokinetic dynamometer, while surface electromyography (sEMG) of the rectus femoris muscle was recorded. The study compared relative peak torque and sEMG spectral power across the different PAPE timing conditions and the control condition.
- Being tested
- Resistance-Based PAPE Intervention
- Keywords
- Time of Day, spectral power, Midday performance
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Resistance-Based PAPE InterventionBehavioural
The resistance-based PAPE intervention consisted of three exercises performed in the following order: back squat, kettlebell swing, and barbell hip thrust. Participants performed one set of six repetitions at 80% of their individual estimated one-repetition maximum (e1RM) for each exercise, with a 1-minute rest interval between exercises. The intervention was preceded by a 5-minute standardized cycling warm-up at 60 rpm followed by 5 minutes of passive rest. The same PAPE protocol was performed in the T1, T2, and T3 conditions at different times before the standardized midday performance assessment.
| Study group | Role | What they receive |
|---|---|---|
| Control (C) | No intervention | Participants completed the standardized midday isokinetic performance assessment without a PAPE intervention. The assessment consisted of four maximal repetitions on an isokinetic dynamometer at 60°·s-¹ between 12:00 and 12:15, while rectus femoris surface electromyography was recorded. |
| PAPE T1 | Experimental | Participants performed the standardized PAPE intervention between 08:00 and 09:00 before the midday performance assessment. The PAPE intervention consisted of back squat, kettlebell swing, and barbell hip thrust exercises, with one set of six repetitions at 80% of the individual estimated one-repetition maximum (e1RM) for each exercise and a 1-minute rest interval between exercises. The intervention was preceded by a 5-minute cycling warm-up at 60 rpm and 5 minutes of passive rest. Receives: Behavioral: Resistance-Based PAPE Intervention |
| PAPE T2 | Experimental | Participants performed the standardized PAPE intervention between 10:00 and 11:00 before the midday performance assessment. The PAPE intervention consisted of back squat, kettlebell swing, and barbell hip thrust exercises, with one set of six repetitions at 80% of the individual estimated one-repetition maximum (e1RM) for each exercise and a 1-minute rest interval between exercises. The intervention was preceded by a 5-minute cycling warm-up at 60 rpm and 5 minutes of passive rest. Receives: Behavioral: Resistance-Based PAPE Intervention |
| PAPE T3 | Experimental | Participants performed the standardized PAPE intervention between 11:45 and 12:00 before the midday performance assessment. The PAPE intervention consisted of back squat, kettlebell swing, and barbell hip thrust exercises, with one set of six repetitions at 80% of the individual estimated one-repetition maximum (e1RM) for each exercise and a 1-minute rest interval between exercises. The intervention was preceded by a 5-minute cycling warm-up at 60 rpm and 5 minutes of passive rest. Receives: Behavioral: Resistance-Based PAPE Intervention |
What is being measured
The primary outcome is the main question the study is designed to answer.
Relative Peak Torque (RPT)
Relative peak torque (RPT) was determined from the highest peak torque value obtained during four maximal knee extension repetitions performed on an isokinetic dynamometer at 60°·s-¹. Peak torque was normalized to body mass and expressed as N·m·kg-¹.
Measured: Measured once per condition (control, T1, T2, T3) at a fixed assessment time (12:00-12:15 PM). PAPE was performed 3.5 hours (T1), 1.5 hours (T2), or immediately (T3) before assessment. Each condition was separated by at least 48 hours.
Rectus Femoris sEMG Spectral Power
Surface electromyography (sEMG) of the rectus femoris muscle was recorded during the maximal isokinetic knee extension repetitions. Spectral power was calculated from the processed sEMG signal using fast Fourier transform (FFT) analysis and expressed as µV²/Hz.
Measured: Measured once per condition (control, T1, T2, T3) at a fixed assessment time (12:00-12:15 PM). PAPE was performed 3.5 hours (T1), 1.5 hours (T2), or immediately (T3) before assessment. Each condition was separated by at least 48 hours.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Sep 2026
- Study start3 Jun 2025
- Primary completion20 Aug 2025
- Study completion15 Sep 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Neuromuscular PerformanceStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- All participants completed four experimental conditions (control, T1, T2, and T3) in a randomized order, with at least 48 hours between conditions. The performance assessment was conducted between 12:00 and 12:15 in all conditions.
- Masking
- None (open label)
- Enrolment
- 13 participants (actual)
Sponsor and investigators
- Lead sponsor
- Manisa Celal Bayar University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07843199
- Sponsor's protocol ID
- MCBU_PAPE_2025
- Status last verified
- Sep 2026
- First submitted
- 15 Sep 2026
- Last updated
- 25 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data are not planned to be publicly shared due to participant confidentiality and data protection considerations.
Study at a glance
From the registry record, last updated by the sponsor on 25 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Time-Course Effect of Post-Activation Performance Enhancement on Midday Peak Torque and Muscle Activation
- ClinicalTrials.gov ID
- NCT07843199
- Acronym / sponsor ID
- MCBU_PAPE_2025
- Keywords
- Time of Day, spectral power, Midday performance
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 13 participants (actual)
- Lead sponsor
- Manisa Celal Bayar UniversityUniversity, hospital or other
- Study start
- 3 Jun 2025 (actual)
- Primary completion
- 20 Aug 2025 (actual)
- Study completion
- 15 Sep 2025 (actual)
- First posted
- 25 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study investigated whether the timing of a resistance-based post-activation performance enhancement (PAPE) intervention performed during the morning influences muscle performance and muscle electrical activity during a standardized midday assessment in trained male athletes. Participants completed a control condition and three PAPE conditions performed at different times during the morning. The PAPE intervention consisted of back squat, kettlebell swing, and barbell hip thrust exercises. In all conditions, muscle performance was assessed between 12:00 and 12:15 using an isokinetic dynamometer, while surface electromyography (sEMG) of the rectus femoris muscle was recorded. The study compared relative peak torque and sEMG spectral power across the different PAPE timing conditions and the control condition.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 4
- Model description
- All participants completed four experimental conditions (control, T1, T2, and T3) in a randomized order, with at least 48 hours between conditions. The performance assessment was conducted between 12:00 and 12:15 in all conditions.
| Arm | Type | Receives |
|---|---|---|
| Control (C) | No intervention | –Participants completed the standardized midday isokinetic performance assessment without a PAPE intervention. The assessment consisted of four maximal repetitions on an isokinetic dynamometer at 60°·s-¹ between 12:00 and 12:15, while rectus femoris surface electromyography was recorded. |
| PAPE T1 | Experimental | Behavioral: Resistance-Based PAPE InterventionParticipants performed the standardized PAPE intervention between 08:00 and 09:00 before the midday performance assessment. The PAPE intervention consisted of back squat, kettlebell swing, and barbell hip thrust exercises, with one set of six repetitions at 80% of the individual estimated one-repetition maximum (e1RM) for each exercise and a 1-minute rest interval between exercises. The intervention was preceded by a 5-minute cycling warm-up at 60 rpm and 5 minutes of passive rest. |
| PAPE T2 | Experimental | Behavioral: Resistance-Based PAPE InterventionParticipants performed the standardized PAPE intervention between 10:00 and 11:00 before the midday performance assessment. The PAPE intervention consisted of back squat, kettlebell swing, and barbell hip thrust exercises, with one set of six repetitions at 80% of the individual estimated one-repetition maximum (e1RM) for each exercise and a 1-minute rest interval between exercises. The intervention was preceded by a 5-minute cycling warm-up at 60 rpm and 5 minutes of passive rest. |
| PAPE T3 | Experimental | Behavioral: Resistance-Based PAPE InterventionParticipants performed the standardized PAPE intervention between 11:45 and 12:00 before the midday performance assessment. The PAPE intervention consisted of back squat, kettlebell swing, and barbell hip thrust exercises, with one set of six repetitions at 80% of the individual estimated one-repetition maximum (e1RM) for each exercise and a 1-minute rest interval between exercises. The intervention was preceded by a 5-minute cycling warm-up at 60 rpm and 5 minutes of passive rest. |
Who may qualify
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (2 listed)
- Regularly participating in systematic sport-specific training (minimum training age of 3 years)
- Able to comply with pre-testing restrictions (avoidance of intense physical activity for 72 hours and caffeine for 2 hours prior to testing sessions)
Key exclusion criteria (2 listed)
- Any musculoskeletal, orthopedic, or health condition preventing safe participation in maximal isokinetic exercise testing
- Current or recent injury affecting lower-limb strength or performance testing
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Resistance-Based PAPE InterventionThe resistance-based PAPE intervention consisted of three exercises performed in the following order: back squat, kettlebell swing, and barbell hip thrust. Participants performed one set of six repetitions at 80% of their individual estimated one-repetition maximum (e1RM) for each exercise, with a 1-minute rest interval between exercises. The intervention was preceded by a 5-minute standardized cycling warm-up at 60 rpm followed by 5 minutes of passive rest. The same PAPE protocol was performed in the T1, T2, and T3 conditions at different times before the standardized midday performance assessment. | Behavioural | PAPE T1, PAPE T2, PAPE T3 |
Primary outcome
Relative Peak Torque (RPT)
Time frame: Measured once per condition (control, T1, T2, T3) at a fixed assessment time (12:00-12:15 PM). PAPE was performed 3.5 hours (T1), 1.5 hours (T2), or immediately (T3) before assessment. Each condition was separated by at least 48 hours.
Relative peak torque (RPT) was determined from the highest peak torque value obtained during four maximal knee extension repetitions performed on an isokinetic dynamometer at 60°·s-¹. Peak torque was normalized to body mass and expressed as N·m·kg-¹.
Rectus Femoris sEMG Spectral Power
Time frame: Measured once per condition (control, T1, T2, T3) at a fixed assessment time (12:00-12:15 PM). PAPE was performed 3.5 hours (T1), 1.5 hours (T2), or immediately (T3) before assessment. Each condition was separated by at least 48 hours.
Surface electromyography (sEMG) of the rectus femoris muscle was recorded during the maximal isokinetic knee extension repetitions. Spectral power was calculated from the processed sEMG signal using fast Fourier transform (FFT) analysis and expressed as µV²/Hz.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Sep 2026.
- Individual participant dataSharing planned: No. Individual participant data are not planned to be publicly shared due to participant confidentiality and data protection considerations.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Resistance-Based PAPE Intervention in people with Neuromuscular Performance and Post-Activation Performance Enhancement (PAPE), run by Manisa Celal Bayar University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 25 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Relative Peak Torque (RPT) (time frame: Measured once per condition (control, T1, T2, T3) at a fixed assessment time (12:00-12:15 PM). PAPE was performed 3.5 hours (T1), 1.5 hours (T2), or immediately (T3) before assessment. Each condition was separated by at least 48 hours.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Sep 2026.