Postoperative PainNCT07845591
Comparison of Nerve Blocks for Pain Relief After Knee Surgery
An observational study of Postoperative Pain and Knee Surgery, run by University of Gaziantep at 1 site in Turkey (Türkiye).
Trial summary
This retrospective observational study compares the postoperative analgesic effectiveness of ultrasound-guided fascia iliaca compartment block (FICB) with combined IPACK and genicular nerve block (GNB) in patients undergoing knee surgery under spinal anesthesia. Read more about this study
- Who is it for?
- Ages 18 to 75 years
- Conditions the study is for
- Postoperative Pain, Knee Surgery
- What is being tested?
- Ultrasound-Guided Fascia Iliaca Compartment Block and Ultrasound-Guided Combined IPACK and Genicular Nerve Block
- Type of treatment
- Surgery or procedure
- How many people
- 70 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jul 2022to 31 Jul 2024
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients aged 18-75 years with ASA physical status I-III who underwent elective knee surgery under spinal anesthesia at Gaziantep University Şahinbey Research and Training Hospital were included. Eligible patients had a BMI of 18-30 kg/m² and no contraindication to regional anesthesia. The study retrospectively evaluated patients who received either an ultrasound-guided fascia iliaca compartment block or a combined IPACK and genicular nerve block for postoperative analgesia.
Who may be able to join
- Age 18-75 years American Society of Anesthesiologists (ASA) physical status I-III Written and verbal informed consent for participation Undergoing elective knee surgery Body mass index (BMI) between 18 and 30 kg/m² No contraindication to regional anesthesia
Who cannot join
- Age <18 years or >75 years ASA physical status IV-V BMI >30 kg/m² Allergy to local anesthetics Emergency surgery Inability to cooperate Receiving treatment for chronic pain Known neuropsychiatric disease Contraindication to neuraxial anesthesia or peripheral nerve block, including infection at the injection site, coagulation disorder, or anticoagulant use Conversion to general anesthesia before completion of surgery Severe organ failure Inaccessible medical records or refusal to participate
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparison of the Postoperative Analgesic Efficacy of Ultrasound-Guided Fascia Iliaca Compartment Block With Combined IPACK and Genicular Nerve Block in Patients Undergoing Knee Surgery
This retrospective observational study compares the postoperative analgesic effectiveness of ultrasound-guided fascia iliaca compartment block (FICB) with combined IPACK and genicular nerve block (GNB) in patients undergoing knee surgery under spinal anesthesia. The study includes 70 patients treated between July 2022 and July 2024. Postoperative pain scores, tramadol consumption, time to first mobilization, motor block, need for rescue analgesia, complications, and patient satisfaction are evaluated during the first 24 hours after surgery.
- Conditions
- Postoperative Pain, Knee Surgery
- Being tested
- Ultrasound-Guided Fascia Iliaca Compartment Block, Ultrasound-Guided Combined IPACK and Genicular Nerve Block
- Medical subject headings
- Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Ultrasound-Guided Fascia Iliaca Compartment BlockProcedure or surgery
Patients received an ultrasound-guided infrainguinal fascia iliaca compartment block using 40 mL of 0.25% bupivacaine for postoperative analgesia after knee surgery.
Ultrasound-Guided Combined IPACK and Genicular Nerve BlockProcedure or surgery
Patients received an ultrasound-guided IPACK block combined with genicular nerve block for postoperative analgesia after knee surgery. The IPACK block was performed with 20 mL of 0.25% bupivacaine.
| Study group | Role | What they receive |
|---|---|---|
| Fascia Iliaca Compartment Block Group | Not described Receives: Procedure: Ultrasound-Guided Fascia Iliaca Compartment Block | |
| Combined IPACK and Genicular Nerve Block Group | Not described Receives: Procedure: Ultrasound-Guided Combined IPACK and Genicular Nerve Block |
What is being measured
The primary outcome is the main question the study is designed to answer.
Postoperative Pain Intensity
Postoperative pain intensity was assessed using the Visual Analog Scale (VAS) at rest and during 45° knee flexion. VAS scores range from 0 to 10, with higher scores indicating greater pain intensity.
Measured: At postoperative 1, 6, 12, and 24 hours
Total Postoperative Tramadol Consumption
Total tramadol consumption during the first 24 postoperative hours was recorded in milligrams (mg) and compared between the two study groups.
Measured: Within the first 24 hours after surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Sep 2026
- Study start1 Jul 2022
- Primary completion1 Jul 2024
- Study completion31 Jul 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Postoperative PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 70 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Gaziantep
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Elzem SEN, University of Gaziantep
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07845591
- Sponsor's protocol ID
- 2024/261
- Status last verified
- Sep 2026
- First submitted
- 22 Sep 2026
- Last updated
- 29 Sep 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 29 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of the Postoperative Analgesic Efficacy of Ultrasound-Guided Fascia Iliaca Compartment Block With Combined IPACK and Genicular Nerve Block in Patients Undergoing Knee Surgery
- ClinicalTrials.gov ID
- NCT07845591
- Acronym / sponsor ID
- 2024/261
- Conditions
- Postoperative Pain, Knee Surgery
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 70 participants (actual)
- Lead sponsor
- University of GaziantepUniversity, hospital or other
- Study start
- 1 Jul 2022 (actual)
- Primary completion
- 1 Jul 2024 (actual)
- Study completion
- 31 Jul 2024 (actual)
- First posted
- 29 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This retrospective observational study compares the postoperative analgesic effectiveness of ultrasound-guided fascia iliaca compartment block (FICB) with combined IPACK and genicular nerve block (GNB) in patients undergoing knee surgery under spinal anesthesia. The study includes 70 patients treated between July 2022 and July 2024. Postoperative pain scores, tramadol consumption, time to first mobilization, motor block, need for rescue analgesia, complications, and patient satisfaction are evaluated during the first 24 hours after surgery.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Fascia Iliaca Compartment Block Group | – | Procedure: Ultrasound-Guided Fascia Iliaca Compartment Block |
| Combined IPACK and Genicular Nerve Block Group | – | Procedure: Ultrasound-Guided Combined IPACK and Genicular Nerve Block |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients aged 18-75 years with ASA physical status I-III who underwent elective knee surgery under spinal anesthesia at Gaziantep University Şahinbey Research and Training Hospital were included. Eligible patients had a BMI of 18-30 kg/m² and no contraindication to regional anesthesia. The study retrospectively evaluated patients who received either an ultrasound-guided fascia iliaca compartment block or a combined IPACK and genicular nerve block for postoperative analgesia.
Key inclusion criteria (1 listed)
- Age 18-75 years American Society of Anesthesiologists (ASA) physical status I-III Written and verbal informed consent for participation Undergoing elective knee surgery Body mass index (BMI) between 18 and 30 kg/m² No contraindication to regional anesthesia
Key exclusion criteria (1 listed)
- Age <18 years or >75 years ASA physical status IV-V BMI >30 kg/m² Allergy to local anesthetics Emergency surgery Inability to cooperate Receiving treatment for chronic pain Known neuropsychiatric disease Contraindication to neuraxial anesthesia or peripheral nerve block, including infection at the injection site, coagulation disorder, or anticoagulant use Conversion to general anesthesia before completion of surgery Severe organ failure Inaccessible medical records or refusal to participate
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Ultrasound-Guided Fascia Iliaca Compartment BlockPatients received an ultrasound-guided infrainguinal fascia iliaca compartment block using 40 mL of 0.25% bupivacaine for postoperative analgesia after knee surgery. | Procedure or surgery | Fascia Iliaca Compartment Block Group |
| Ultrasound-Guided Combined IPACK and Genicular Nerve BlockPatients received an ultrasound-guided IPACK block combined with genicular nerve block for postoperative analgesia after knee surgery. The IPACK block was performed with 20 mL of 0.25% bupivacaine. | Procedure or surgery | Combined IPACK and Genicular Nerve Block Group |
Primary outcome
Postoperative Pain Intensity
Time frame: At postoperative 1, 6, 12, and 24 hours
Postoperative pain intensity was assessed using the Visual Analog Scale (VAS) at rest and during 45° knee flexion. VAS scores range from 0 to 10, with higher scores indicating greater pain intensity.
Total Postoperative Tramadol Consumption
Time frame: Within the first 24 hours after surgery
Total tramadol consumption during the first 24 postoperative hours was recorded in milligrams (mg) and compared between the two study groups.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Postoperative Pain and Knee Surgery, run by University of Gaziantep at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Postoperative Pain Intensity (time frame: At postoperative 1, 6, 12, and 24 hours). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Sep 2026.