Socket Preservation and Healing Following Simple, Non-surgical ExtractionARPNCT07846384
Assessment of Volumetric Changes After Socket Preservation in the Anterior Region Using Sticky Dentin Versus Sticky Bone
A study testing sticky dentin group and sticky bone in people with Socket Preservation and Healing Following Simple, Non-surgical Extraction and Socket Preservation, run by October University for Modern Sciences and Arts at 1 site in Egypt.
Trial summary
After tooth extraction the alveolar ridge undergoes an unescapable physiological phase of remodeling. The major changes occur during the first three months of healing with a reduction in the dimension of the socket of about 11%-22% vertical bone loss and 29%-63% horizontal bone loss. Read more about this study
- Who is it for?
- Ages 20 to 55 yearsHealthy volunteers can take part
- Conditions the study is for
- Socket Preservation and Healing Following Simple, Non-surgical Extraction, Socket Preservation
- What is being tested?
- sticky dentin group and sticky bone
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 28 participants
- Where
- 1 siteEgypt
- Study dates
- 25 Apr 2025to 1 Aug 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 55 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- patient (20-55) years old
- non-smoker
- medically free
- non-restorable tooth.
- anterior zone
- Type 1 extraction socket
Who cannot join
- medically compromised patient (uncontrolled diabetes, hyperthyroidism).
- pregnant female.
- history of chemo or radiotherapy
Trial locations and contacts
1 site in 1 country.
Egypt1 site
Faculty of Dentistry, October University for Modern Sciences and Arts (MSA University)
Giza, 02
About this study
Official title: Assessment of Volumetric Changes After Socket Preservation in the Anterior Region Using Sticky Dentin Versus Sticky Bone: A Randomized Controlled Clinical Trial.
After tooth extraction the alveolar ridge undergoes an unescapable physiological phase of remodeling. The major changes occur during the first three months of healing with a reduction in the dimension of the socket of about 11%-22% vertical bone loss and 29%-63% horizontal bone loss. Such dimensional change will compromise prosthetic replacement in the future, so we make alveolar ridge preservation in order to future complications
- Conditions
- Socket Preservation and Healing Following Simple, Non-surgical Extraction, Socket Preservation
- Being tested
- sticky dentin group, sticky bone
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
sticky dentin groupCombination product
Also called sticky tooth
The autogenous demineralized dentin is used in socket preservation. as it shares a similar composition to the bone. Demineralized dentin is an osteoinductive and osteoconductive material, making it an alternative to xenograft in socket preservation. The addition of the PRF helps in healing and pain reduction. Xenograft is an osteoconductive material, and a previous study showed a reduction in dimensional change following tooth extraction. The effect of the sticky dentin on the bone and soft tissue is measured using the CBCT, intraoral scanner, and periodontal probe.
sticky boneCombination product
Socket preservation using sticky dentin (Xenograft + I-PRF) after tooth extraction.
| Study group | Role | What they receive |
|---|---|---|
| sticky bone group | Active comparator | socket preservation using sticky bone (Xenograft + I-PRF) after tooth extraction to avoid future complications and dimensional change following tooth extraction with a bicompatible material with previous studies on the efficacy of the material in alveolar ridge preservation. Receives: Combination Product: sticky dentin group; Combination Product: sticky bone |
| sticky dentin group | Experimental | socket preservation using sticky dentin (demineralized dentin + I-PRF) Receives: Combination Product: sticky dentin group; Combination Product: sticky bone |
What is being measured
The primary outcome is the main question the study is designed to answer.
volumetric bone change after socket preservation, and it will be measured by CBCT.
Measured: CBCT will be taken 3 times: first at the baseline before extraction, second during the follow-up period after 3 months, and third after 6 months.
Change in Alveolar Bone Volume After Socket Preservation Measured by CBCT
volumetric bone change after socket preservation, and it will be measured by CBCT.
Soft tissue change is measured by a periodontal probe. Soft tissue thickness will be measured using an intraoral scanner. pain by VAS score.
Measured: 3 months and 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Sep 2026
- Study start25 Apr 2025
- Primary completion1 Aug 2026
- Study completion1 Aug 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Socket Preservation and Healing Following Simple, Non-surgical ExtractionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Research focuses on autogenous demineralized dentin bone in order to overcome problems with the autograft or allograft or synthetic bone. Bone and teeth are very similar in their composition, as both are composed of inorganic substances such as hydroxyapatite and calcium phosphate and organic substances like collagen, as dentin is composed of 65% inorganic and 35% organic substances such as collagen type 1 , growth factors such as bone morphogenic protein, as the perivascular mesenchymal stem cells will differentiate into cartilage and bone through bone morphogenic protein (BMP), so the BMP is responsible for osteoinductivity
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 28 participants (actual)
Sponsor and investigators
- Lead sponsor
- October University for Modern Sciences and Arts
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mazied Mohamed Zaki, October University for Modern Sciences and Arts
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07846384
- Sponsor's protocol ID
- 47115
- Acronym
- ARP
- Status last verified
- Nov 2024
- First submitted
- 23 Sep 2026
- Last updated
- 29 Sep 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 29 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Assessment of Volumetric Changes After Socket Preservation in the Anterior Region Using Sticky Dentin Versus Sticky Bone: A Randomized Controlled Clinical Trial.
- ClinicalTrials.gov ID
- NCT07846384
- Acronym / sponsor ID
- ARP / 47115
- Conditions
- Socket Preservation and Healing Following Simple, Non-surgical Extraction, Socket Preservation
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 28 participants (actual)
- Lead sponsor
- October University for Modern Sciences and ArtsUniversity, hospital or other
- Study start
- 25 Apr 2025 (actual)
- Primary completion
- 1 Aug 2026 (actual)
- Study completion
- 1 Aug 2026 (actual)
- First posted
- 29 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
After tooth extraction the alveolar ridge undergoes an unescapable physiological phase of remodeling. The major changes occur during the first three months of healing with a reduction in the dimension of the socket of about 11%-22% vertical bone loss and 29%-63% horizontal bone loss. Such dimensional change will compromise prosthetic replacement in the future, so we make alveolar ridge preservation in order to future complications
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
- Model description
- Research focuses on autogenous demineralized dentin bone in order to overcome problems with the autograft or allograft or synthetic bone. Bone and teeth are very similar in their composition, as both are composed of inorganic substances such as hydroxyapatite and calcium phosphate and organic substances like collagen, as dentin is composed of 65% inorganic and 35% organic substances such as collagen type 1 , growth factors such as bone morphogenic protein, as the perivascular mesenchymal stem cells will differentiate into cartilage and bone through bone morphogenic protein (BMP), so the BMP is responsible for osteoinductivity
| Arm | Type | Receives |
|---|---|---|
| sticky bone group | Active comparator | Combination Product: sticky dentin group, Combination Product: sticky bonesocket preservation using sticky bone (Xenograft + I-PRF) after tooth extraction to avoid future complications and dimensional change following tooth extraction with a bicompatible material with previous studies on the efficacy of the material in alveolar ridge preservation. |
| sticky dentin group | Experimental | Combination Product: sticky dentin group, Combination Product: sticky bonesocket preservation using sticky dentin (demineralized dentin + I-PRF) |
Who may qualify
- Ages
- 20 to 55 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- patient (20-55) years old
- non-smoker
- medically free
- non-restorable tooth.
- anterior zone
Key exclusion criteria (3 listed)
- medically compromised patient (uncontrolled diabetes, hyperthyroidism).
- pregnant female.
- history of chemo or radiotherapy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| sticky dentin groupAlso: sticky toothThe autogenous demineralized dentin is used in socket preservation. as it shares a similar composition to the bone. Demineralized dentin is an osteoinductive and osteoconductive material, making it an alternative to xenograft in socket preservation. The addition of the PRF helps in healing and pain reduction. Xenograft is an osteoconductive material, and a previous study showed a reduction in dimensional change following tooth extraction. The effect of the sticky dentin on the bone and soft tissue is measured using the CBCT, intraoral scanner, and periodontal probe. | Combination product | sticky bone group, sticky dentin group |
| sticky boneSocket preservation using sticky dentin (Xenograft + I-PRF) after tooth extraction. | Combination product | sticky bone group, sticky dentin group |
Primary outcome
volumetric bone change after socket preservation, and it will be measured by CBCT.
Time frame: CBCT will be taken 3 times: first at the baseline before extraction, second during the follow-up period after 3 months, and third after 6 months.
Change in Alveolar Bone Volume After Socket Preservation Measured by CBCT
Time frame: 3 months and 6 months
volumetric bone change after socket preservation, and it will be measured by CBCT. Soft tissue change is measured by a periodontal probe. Soft tissue thickness will be measured using an intraoral scanner. pain by VAS score.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing sticky dentin group and sticky bone in people with Socket Preservation and Healing Following Simple, Non-surgical Extraction and Socket Preservation, run by October University for Modern Sciences and Arts at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
volumetric bone change after socket preservation, and it will be measured by CBCT. (time frame: CBCT will be taken 3 times: first at the baseline before extraction, second during the follow-up period after 3 months, and third after 6 months.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Sep 2026.