Healthy ParticipantsNCT07848048
Acute Musculoskeletal Responses to Blood Flow Restriction Training
A study testing High-Intensity Isometric Exercise and Low-Intensity Isometric Exercise With Blood Flow Restriction in people with Healthy Participants, run by University of Valencia at 1 site in Spain.
Trial summary
This randomized controlled trial investigated the acute musculoskeletal responses to isometric exercise with and without blood flow restriction in healthy, physically active young adults. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy Participants
- What is being tested?
- High-Intensity Isometric Exercise and Low-Intensity Isometric Exercise With Blood Flow Restriction
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 66 participants
- Where
- 1 siteSpain
- Study dates
- 13 Oct 2025to 24 Apr 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy men and women aged 18-40 years.
Who cannot join
- Current musculoskeletal injury.
- Cardiovascular disease.
- Inability to complete the study protocol.
- Diagnosis of patellar tendinopathy within the previous 6 months.
- Contraindications to blood flow restriction, including pregnancy, thrombosis, excessive varicose veins, or a prosthesis in the region to be occluded.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Acute Musculoskeletal Responses to Isometric Blood Flow Restriction Training of the Patellar Tendon in Healthy, Active Young Adults: A Randomized Controlled Trial
This randomized controlled trial investigated the acute musculoskeletal responses to isometric exercise with and without blood flow restriction in healthy, physically active young adults. Participants were randomly assigned to one of three groups: high-intensity isometric exercise (HI), low-intensity isometric exercise with blood flow restriction (LI-BFR), or low-intensity isometric exercise with sham blood flow restriction (LI-Sham). Ultrasound measurements of patellar tendon and vastus medialis muscle thickness were obtained before and immediately after the exercise intervention. Knee-extension maximal voluntary isometric contraction was also assessed. The study aimed to compare the acute changes in these outcomes among the three exercise conditions.
- Conditions
- Healthy Participants
- Being tested
- High-Intensity Isometric Exercise, Low-Intensity Isometric Exercise With Blood Flow Restriction, Low-Intensity Isometric Exercise With Sham Blood Flow Restriction
- Keywords
- low-intensity resistance exercise, Rehabilitation, Vascular occlusion, Tendon morphology, Isometric contraction, Ultrasonography
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
High-Intensity Isometric ExerciseBehavioural
Participants performed five 30-second isometric knee-extension contractions at 70% of maximal voluntary isometric contraction (MVIC), with 60 seconds of rest between sets.
Low-Intensity Isometric Exercise With Blood Flow RestrictionBehavioural
Participants performed five 30-second isometric knee-extension contractions at 30% of MVIC with a pneumatic cuff inflated to 80% of the individual arterial occlusion pressure (AOP) during each contraction. The cuff was deflated during the 60-second rest periods between sets.
Low-Intensity Isometric Exercise With Sham Blood Flow RestrictionBehavioural
Participants performed five 30-second isometric knee-extension contractions at 30% of MVIC with a pneumatic cuff inflated to 20 mmHg during each contraction. The cuff was deflated during the 60-second rest periods between sets.
| Study group | Role | What they receive |
|---|---|---|
| High-Intensity Isometric Exercise (HI) | Experimental | Participants performed five 30-second isometric knee-extension contractions at 70% of maximal voluntary isometric contraction (MVIC), with 60 seconds of rest between sets. Receives: Behavioral: High-Intensity Isometric Exercise |
| Low-Intensity Isometric Exercise With Blood Flow Restriction (LI-BFR) | Experimental | Participants performed five 30-second isometric knee-extension contractions at 30% of MVIC with a pneumatic cuff inflated to 80% of the individual arterial occlusion pressure (AOP) during each contraction. The cuff was deflated during the 60-second rest periods between sets. Receives: Behavioral: Low-Intensity Isometric Exercise With Blood Flow Restriction |
| Low-Intensity Isometric Exercise With Sham Blood Flow Restriction (LI-Sham) | Experimental | Participants performed five 30-second isometric knee-extension contractions at 30% of MVIC with a pneumatic cuff inflated to 20 mmHg during each contraction. The cuff was deflated during the 60-second rest periods between sets. Receives: Behavioral: Low-Intensity Isometric Exercise With Sham Blood Flow Restriction |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Patellar Tendon Thickness
Patellar tendon thickness was assessed by B-mode ultrasonography at 25%, 50%, and 75% of the tendon length, from the inferior pole of the patella to the tibial tuberosity.
Measured: Baseline and immediately post-intervention
Secondary outcomes (2)
Change in Vastus Medialis Muscle Thickness
Vastus medialis muscle thickness was assessed by B-mode ultrasonography with the transducer positioned transversely over the anteromedial thigh, approximately 3-5 cm proximal to the superior border of the patella. Muscle thickness was measured between the superficial and deep fascial borders.
Measured: Baseline and immediately post-intervention
Change in Knee-Extension Maximal Voluntary Isometric Contraction (MVIC)
Knee-extension maximal voluntary isometric contraction (MVIC) was assessed using an isokinetic dynamometer with the knee positioned at 90° of flexion.
Measured: Baseline and immediately post-intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Sep 2026
- Study start13 Oct 2025
- Primary completion24 Apr 2026
- Study completion24 Apr 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Healthy ParticipantsStudies of the same condition, open and under way.
- More trials run by University of ValenciaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 66 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Valencia
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, YASSER ALAKHDAR MOHMARA, University of Valencia
- Investigators
- Yasser Alakhdar Mohmara, Principal investigator, University of Valencia
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07848048
- Sponsor's protocol ID
- UVAL-BFR-2025-01
- Other IDs
- 2025-FIS-3834518
- Status last verified
- Sep 2026
- First submitted
- 22 Sep 2026
- Last updated
- 29 Sep 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 29 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Acute Musculoskeletal Responses to Isometric Blood Flow Restriction Training of the Patellar Tendon in Healthy, Active Young Adults: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07848048
- Acronym / sponsor ID
- UVAL-BFR-2025-01
- Conditions
- Healthy Participants
- Keywords
- low-intensity resistance exercise, Rehabilitation, Vascular occlusion, Tendon morphology, Isometric contraction, Ultrasonography
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 66 participants (actual)
- Lead sponsor
- University of ValenciaUniversity, hospital or other
- Study start
- 13 Oct 2025 (actual)
- Primary completion
- 24 Apr 2026 (actual)
- Study completion
- 24 Apr 2026 (actual)
- First posted
- 29 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial investigated the acute musculoskeletal responses to isometric exercise with and without blood flow restriction in healthy, physically active young adults. Participants were randomly assigned to one of three groups: high-intensity isometric exercise (HI), low-intensity isometric exercise with blood flow restriction (LI-BFR), or low-intensity isometric exercise with sham blood flow restriction (LI-Sham). Ultrasound measurements of patellar tendon and vastus medialis muscle thickness were obtained before and immediately after the exercise intervention. Knee-extension maximal voluntary isometric contraction was also assessed. The study aimed to compare the acute changes in these outcomes among the three exercise conditions.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| High-Intensity Isometric Exercise (HI) | Experimental | Behavioral: High-Intensity Isometric ExerciseParticipants performed five 30-second isometric knee-extension contractions at 70% of maximal voluntary isometric contraction (MVIC), with 60 seconds of rest between sets. |
| Low-Intensity Isometric Exercise With Blood Flow Restriction (LI-BFR) | Experimental | Behavioral: Low-Intensity Isometric Exercise With Blood Flow RestrictionParticipants performed five 30-second isometric knee-extension contractions at 30% of MVIC with a pneumatic cuff inflated to 80% of the individual arterial occlusion pressure (AOP) during each contraction. The cuff was deflated during the 60-second rest periods between sets. |
| Low-Intensity Isometric Exercise With Sham Blood Flow Restriction (LI-Sham) | Experimental | Behavioral: Low-Intensity Isometric Exercise With Sham Blood Flow RestrictionParticipants performed five 30-second isometric knee-extension contractions at 30% of MVIC with a pneumatic cuff inflated to 20 mmHg during each contraction. The cuff was deflated during the 60-second rest periods between sets. |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Healthy men and women aged 18-40 years.
Key exclusion criteria (5 listed)
- Current musculoskeletal injury.
- Cardiovascular disease.
- Inability to complete the study protocol.
- Diagnosis of patellar tendinopathy within the previous 6 months.
- Contraindications to blood flow restriction, including pregnancy, thrombosis, excessive varicose veins, or a prosthesis in the region to be occluded.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| High-Intensity Isometric ExerciseParticipants performed five 30-second isometric knee-extension contractions at 70% of maximal voluntary isometric contraction (MVIC), with 60 seconds of rest between sets. | Behavioural | High-Intensity Isometric Exercise (HI) |
| Low-Intensity Isometric Exercise With Blood Flow RestrictionParticipants performed five 30-second isometric knee-extension contractions at 30% of MVIC with a pneumatic cuff inflated to 80% of the individual arterial occlusion pressure (AOP) during each contraction. The cuff was deflated during the 60-second rest periods between sets. | Behavioural | Low-Intensity Isometric Exercise With Blood Flow Restriction (LI-BFR) |
| Low-Intensity Isometric Exercise With Sham Blood Flow RestrictionParticipants performed five 30-second isometric knee-extension contractions at 30% of MVIC with a pneumatic cuff inflated to 20 mmHg during each contraction. The cuff was deflated during the 60-second rest periods between sets. | Behavioural | Low-Intensity Isometric Exercise With Sham Blood Flow Restriction (LI-Sham) |
Primary outcome
Change in Patellar Tendon Thickness
Time frame: Baseline and immediately post-intervention
Patellar tendon thickness was assessed by B-mode ultrasonography at 25%, 50%, and 75% of the tendon length, from the inferior pole of the patella to the tibial tuberosity.
2 secondary outcomes
Change in Vastus Medialis Muscle Thickness
Time frame: Baseline and immediately post-intervention
Change in Knee-Extension Maximal Voluntary Isometric Contraction (MVIC)
Time frame: Baseline and immediately post-intervention
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Sep 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Yasser Alakhdar Mohmara principal investigator
University of Valencia
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing High-Intensity Isometric Exercise and Low-Intensity Isometric Exercise With Blood Flow Restriction in people with Healthy Participants, run by University of Valencia at 1 site in Spain.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 29 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Patellar Tendon Thickness (time frame: Baseline and immediately post-intervention). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Sep 2026.