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Overweight , ObesityNCT07849439

Two-Week Stair-Climbing Exercise Snacks and Metabolic Health in Adults With Overweight or Obesity: A Pilot Study

A study testing Stair-Climbing Exercise Snacks in people with Overweight , Obesity, run by St. Louis University at 1 site in United States.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

This pilot study will evaluate whether brief bouts of stair climbing performed throughout the day for two weeks can improve metabolic health, cardiovascular fitness, and other health-related outcomes in adults with overweight or obesity who do not regularly exercise. Read more about this study

Who is it for?
Ages 18 to 35 yearsHealthy volunteers can take part
Conditions the study is for
Overweight , Obesity
What is being tested?
Stair-Climbing Exercise Snacks
Could I receive a placebo?
No, everyone receives an active treatment
How many people
12 participants
Where
1 siteUnited States
Study dates
Oct 2026to Jul 2027
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 35 years
  • All sexes
  • Healthy volunteers accepted
  • Adult

Who may be able to join

  • Age 18-35 years and able to provide informed consent.
  • Body mass index (BMI) 25.0-34.99 kg/m² and otherwise healthy, without chronic disease.
  • Sedentary or low-active lifestyle, defined as no regular structured exercise ≥3 days/week for ≥30 minutes per session during the past 3 months.
  • Access to a safe staircase that permits completion of approximately 60 total stair steps per exercise bout. Approximately 60 upward steps are preferred when available; one or more flights may be used repeatedly if needed.
  • No contraindications or increased-risk findings identified on the PAR-Q+ or health history screening.

Who cannot join

  • Known cardiovascular, pulmonary, metabolic, renal, neurological, or musculoskeletal disease, or signs or symptoms suggesting increased risk during vigorous exercise, including diagnosed diabetes mellitus, cardiovascular disease, uncontrolled hypertension, chronic pulmonary disease, kidney disease, fainting or unexplained dizziness during exercise, chest pain with exertion, or severe shortness of breath with mild-to-moderate activity.
  • Current use of medications that may affect exercise tolerance, heart-rate response, balance, glucose metabolism, or safety during vigorous exercise, including insulin or other glucose-lowering medications, beta-blockers, anti-arrhythmic medications, systemic corticosteroids, or medications that may cause dizziness, impaired balance, or altered exercise response.
  • Orthopedic or joint conditions that could be aggravated by repeated stair climbing.
  • Allergy, intolerance, dietary restriction, or other condition preventing safe consumption of the standardized meal replacement shake.
  • Pregnancy or plans to become pregnant during the study period.
  • Any other medical or psychological condition that, in the investigator's judgment, could make adherence difficult or place the participant at risk.
  • Individuals currently enrolled in a course taught by the PI or other study personnel, or who are directly supervised, graded, or formally evaluated by a member of the study team.

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

Hossein Rafiei, PhD, RD contact

314-977-8675

hossein.rafiei@health.slu.edu

United States1 site, 1 recruiting
  • Saint Louis University

    St Louis, Missouri, 63104

    Hossein Rafiei, PhD RD, 314-977-8675, hossein.rafiei@health.slu.edu

    Hossein Rafiei, PhD, RD

    Recruiting

Other trials in United States

About this study

Official title: Effects of a Two-Week Stair-Climbing "Exercise Snacks" Intervention on Body Composition, Cardiovascular Fitness, and Metabolic Responses in Overweight and Obese Adults: A Pilot Study

This pilot study will evaluate whether brief bouts of stair climbing performed throughout the day for two weeks can improve metabolic health, cardiovascular fitness, and other health-related outcomes in adults with overweight or obesity who do not regularly exercise. Participants will complete approximately 6-8 brief stair-climbing "exercise snacks" per day for 14 days, with each bout consisting of approximately 60 total stair steps performed at a challenging but safe self-selected pace.

Participants will complete baseline and post-intervention assessments at Saint Louis University. These assessments will include continuous glucose monitoring and standardized meal testing to evaluate glucose responses, as well as measures of aerobic fitness, anaerobic power, body composition, waist circumference, and muscular strength. The study will also evaluate adherence, perceived exercise intensity, and the feasibility of incorporating brief stair-climbing bouts into daily life.

Read the detailed description

This is a pilot intervention study designed to examine the short-term effects and feasibility of frequent stair-climbing "exercise snacks" in adults with overweight or obesity. Exercise snacks are brief bouts of physical activity performed intermittently throughout the day and may provide a time-efficient approach to increasing physical activity.

The study will enroll approximately 12 adults aged 18-35 years with a body mass index of 25.0-34.9 kg/m² who are otherwise healthy and do not regularly participate in structured exercise. Participants must have regular access to a safe staircase.

Participants will complete three in-person study visits at Saint Louis University over approximately 15-16 days. Baseline assessments will include anthropometric and body composition measurements, resting cardiovascular measures, handgrip strength, aerobic fitness testing, and anaerobic power testing. Participants will also complete a standardized meal challenge while wearing a continuous glucose monitor to assess postprandial glucose responses.

Following baseline testing, participants will complete a two-week stair-climbing intervention. They will perform approximately 6-8 stair-climbing bouts per day for approximately 14 days. Each bout will consist of approximately 60 total stair steps completed at a self-selected challenging but safe pace. Participants may use one or more flights of stairs repeatedly if approximately 60 continuous upward steps are not available. The intervention will be completed in participants' usual daily environments, such as home, work, or campus.

Participants will wear a continuous glucose monitor during the intervention period and will complete activity, dietary, and study-related logs. After the two-week intervention, participants will repeat the standardized meal challenge and laboratory assessments.

The primary study outcomes include changes in postprandial glucose response, glycemic variability, and aerobic fitness from baseline to post-intervention. Secondary outcomes include changes in body composition, waist circumference, anaerobic power, and muscular strength. Exploratory outcomes include adherence and feasibility of the stair-climbing intervention.

Being tested
Stair-Climbing Exercise Snacks
Keywords
Exercise Snacks, Stair Climbing, Physical Activity, Metabolic Health, Postprandial Glucose, Continuous Glucose Monitoring, Glycemic Variability, Cardiorespiratory Fitness, Body Composition, Anaerobic Power, Overweight, Obesity
Medical subject headings
Overweight, Obesity, Motor Activity

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Stair-Climbing Exercise SnacksBehavioural

    Participants will perform brief stair-climbing exercise snacks 6-8 times per day for 14 days. Each bout will consist of approximately 60 total stair steps completed at a self-selected challenging but safe pace. When possible, participants will complete approximately 60 upward steps. If 60 continuous upward steps are not available, participants may use one or more flights repeatedly by ascending and descending carefully until approximately 60 total steps are completed. The intervention will be completed independently in participants' usual daily environments, such as home, work, or campus. Participants will be instructed to use the handrail when needed, descend slowly and carefully, and not run down the stairs.

Study groups in NCT07849439
Study groupRoleWhat they receive
Two-Week Stair-Climbing Exercise SnacksExperimentalParticipants will complete a two-week stair-climbing exercise snack intervention. They will perform approximately 6-8 brief stair-climbing bouts per day for approximately 14 days. Each bout will include approximately 60 total stair steps completed at a self-selected challenging but safe pace. Participants will otherwise be asked to maintain their usual diet and lifestyle and avoid beginning a new exercise or diet program during the study.
Receives: Behavioral: Stair-Climbing Exercise Snacks

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Change in 2-Hour Postprandial Glucose Area Under the Curve (AUC)

    Postprandial glucose response will be assessed using continuous glucose monitoring during a standardized meal challenge performed before and after the two-week stair-climbing intervention. Glucose area under the curve (AUC) over the approximately 2-hour post-meal period will be calculated using the trapezoidal method and compared between pre- and post-intervention assessments.

    Measured: Baseline (Day 1) and post-intervention (Day 15)

  2. Change in CGM-Derived Glucose Standard Deviation

    Glucose standard deviation will be calculated from continuous glucose monitoring data over three complete 24-hour periods during the early and late intervention periods and compared within participants.

    Measured: Early intervention (Days 2-4) and late intervention (Days 11-13)

  3. Change in Aerobic Capacity (VO₂max or Estimated VO₂max)

    Aerobic capacity will be assessed using a VO₂max or estimated VO₂max test with metabolic cart analysis/indirect calorimetry during a graded exercise test. Peak oxygen uptake will be expressed in mL/kg/min and compared between baseline and post-intervention assessments. If a maximal test is not appropriate or feasible, a submaximal test with VO₂ extrapolation may be used.

    Measured: Baseline (Day 0) and post-intervention (Day 15)

  4. Change in CGM-Derived Glucose Coefficient of Variation

    Glucose coefficient of variation will be calculated from continuous glucose monitoring data over three complete 24-hour periods during the early and late intervention periods and compared within participants.

    Measured: Early intervention (Days 2-4) and late intervention (Days 11-13)

Secondary outcomes (12)
  1. Change in Body Weight

    Body weight will be measured using the InBody 380 bioelectrical impedance analysis (BIA) system and compared between baseline and post-intervention assessments.

    Measured: Baseline (Day 0) and post-intervention (Day 15)

  2. Change in Body Fat Percentage

    Total body fat percentage will be assessed using the InBody 380 bioelectrical impedance analysis (BIA) system and compared between baseline and post-intervention assessments.

    Measured: Baseline (Day 0) and post-intervention (Day 15)

  3. Change in Fat Mass

    Total body fat mass will be assessed using the InBody 380 bioelectrical impedance analysis (BIA) system and compared between baseline and post-intervention assessments.

    Measured: Baseline (Day 0) and post-intervention (Day 15)

  4. Change in Lean Mass

    Total lean mass will be assessed using the InBody 380 bioelectrical impedance analysis (BIA) system and compared between baseline and post-intervention assessments.

    Measured: Baseline (Day 0) and post-intervention (Day 15)

  5. Change in Phase Angle

    Phase angle will be assessed using the InBody 380 bioelectrical impedance analysis (BIA) system and compared between baseline and post-intervention assessments.

    Measured: Baseline (Day 0) and post-intervention (Day 15)

  6. Change in Waist Circumference

    Waist circumference will be measured using a measuring tape at the iliac crest and compared between baseline and post-intervention assessments.

    Measured: Baseline (Day 0) and post-intervention (Day 15)

  7. Change in Wingate Peak Power

    Peak anaerobic power will be assessed during a 30-second Wingate anaerobic test performed on a cycle ergometer and compared between baseline and post-intervention assessments.

    Measured: Baseline (Day 0) and post-intervention (Day 15)

  8. Change in Wingate Mean Power

    Mean anaerobic power will be assessed during a 30-second Wingate anaerobic test performed on a cycle ergometer and compared between baseline and post-intervention assessments.

    Measured: Baseline (Day 0) and post-intervention (Day 15)

  9. Change in Handgrip Strength

    Handgrip strength will be measured using an InBody handgrip dynamometer. The best of three trials for each hand will be recorded, with dominant-hand grip strength used for the primary comparison between baseline and post-intervention assessments.

    Measured: Baseline (Day 0) and post-intervention (Day 15)

  10. Change in Segmental Body Fat Percentage

    Segmental body fat percentage will be assessed using the InBody 380 bioelectrical impedance analysis (BIA) system and compared between baseline and post-intervention assessments.

    Measured: Baseline (Day 0) and post-intervention (Day 15)

  11. Change in 24-Hour Mean Glucose

    Mean glucose will be calculated from continuous glucose monitoring data over prespecified early- and late-intervention periods and compared within participants.

    Measured: Early intervention (Days 2-4) and late intervention (Days 11-13)

  12. Change in Time in Range

    The percentage of CGM readings within the prespecified glucose target range will be calculated over early- and late-intervention periods and compared within participants.

    Measured: Early intervention (Days 2-4) and late intervention (Days 11-13)

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted30 Sep 2026
  2. Study startOct 2026 (estimated)
  3. Primary completionJul 2027 (estimated)
  4. Study completionJul 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Prevention
Allocation
Not applicable
Intervention model
Single group
Model description
Single-group pre-post pilot study in which all participants complete a two-week stair-climbing exercise snack intervention and undergo baseline and post-intervention assessments.
Masking
None (open label)
Enrolment
12 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07849439
Sponsor's protocol ID
STUDY00000657
Status last verified
Sep 2026
First submitted
24 Sep 2026
Last updated
30 Sep 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No: Individual participant data will not be shared with researchers outside the study team, in accordance with the IRB-approved protocol and informed consent. Study findings may be disseminated in aggregate form through scientific presentations and peer-reviewed publications.

Questions about this trial

What is this clinical trial studying?

A study testing Stair-Climbing Exercise Snacks in people with Overweight , Obesity, run by St. Louis University at 1 site in United States.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 30 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Hossein Rafiei, PhD, RD (314-977-8675, hossein.rafiei@health.slu.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Change in 2-Hour Postprandial Glucose Area Under the Curve (AUC) (time frame: Baseline (Day 1) and post-intervention (Day 15)). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Sep 2026.

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