Functional Neurological DisordersFTNF-SEPNCT07849816
Assessment of the Frequency of Functional Neurological Disorders in Multiple Sclerosis and Analysis of Clinical and Psychological Determinants
An observational study of Functional Neurological Disorders and Multiple Sclerosis, run by University Hospital, Strasbourg, France.
Trial summary
Multiple sclerosis (MS) and functional neurological disorders (FND) share clinical features, which may result in FND being overlooked in patients with MS. They also share common comorbidities, including depression and alexithymia. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Functional Neurological Disorders, Multiple Sclerosis
- How many people
- 100 participants
- Where
- No sites listed yet
- Study dates
- 2 Oct 2026to 1 Oct 2027
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: During a routine medical visit, eligible patients will be informed about the study and invited to participate. The two participating centers, located in Strasbourg and Nancy, each have an active cohort allowing the required number of participants to be recruited within one year.
Who may be able to join
- Adult patient (≥ 18 years of age)
- Diagnosis of multiple sclerosis (MS) according to the 2024 McDonald criteria
- Stable brain MRI performed within the previous 12 months
- No relapse between the MRI and study enrollment
- Ability to understand French
- Affiliated with the French national health insurance system
- Willing to participate in the study
Who cannot join
- Patient unwilling to participate in the study
- Known severe psychotic disorder
- Patient under judicial protection (sauvegarde de justice)
- Patient under guardianship or curatorship (tutelle or curatelle)
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Assessment of the Frequency of Functional Neurological Disorders in Multiple Sclerosis and Analysis of Clinical and Psychological Determinants: A Multicenter Cross-Sectional Study
Multiple sclerosis (MS) and functional neurological disorders (FND) share clinical features, which may result in FND being overlooked in patients with MS. They also share common comorbidities, including depression and alexithymia.
As their management differs, assessing the frequency and determinants of FND in patients with MS is important to improve diagnosis and ensure appropriate management.
Read the detailed description
Multiple sclerosis (MS) and functional neurological disorders (FND) share clinical features, which may result in FND being overlooked in patients with MS. They also share common comorbidities, including depression and alexithymia.
As their management differs, assessing the frequency and determinants of FND in patients with MS is important to improve diagnosis and ensure appropriate management.
- Keywords
- Multiple Sclerosis, Functional Neurological Symptoms Disorder, Neurological Disability, Disease Activity, Anxiety, Depression, Alexithymia, Quality of Life, Psychological Factors Comorbidities, Multiple sclerosis relapse
- Medical subject headings
- Conversion Disorder, Multiple Sclerosis, Anxiety Disorders, Depression, Affective Symptoms
What is being measured
The primary outcome is the main question the study is designed to answer.
Assessment of the frequency of TNF in patients with multiple sclerosis
Assessment of the frequency of TNF in patients with multiple sclerosis
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Sep 2026
- Study start2 Oct 2026 (estimated)
- Primary completion1 Oct 2027 (estimated)
- Study completion1 Oct 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Functional Neurological DisordersStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Prospective
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Strasbourg, France
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- BIGAUT Kevin, Doctor, Principal investigator, Hôpitaux Universitaires de Strasbourg
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07849816
- Sponsor's protocol ID
- RC26_0283
- Other IDs
- 2026-A01575-46
- Acronym
- FTNF-SEP
- Status last verified
- Oct 2026
- First submitted
- 24 Sep 2026
- Last updated
- 7 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No