Prosthesis UserNCT07850544
Optimize Pattern Recognition Control of Powered Upper Limb Prosthesis
A study testing Condition A: Electrode Configuration, Condition B: Electrode Configuration and Condition C: Electrode Configuration in people with Prosthesis User and Prosthesis, run by Liberating Technologies, Inc. at 2 sites in United States.
Trial summary
This study is focused on optimizing methods for controlling upper-limb myoelectric prosthetic arms. If you are enrolled in this study you would be expected to visit one of the research sites for approximately 5 in-lab visits lasting about 4 hours. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Prosthesis User, Prosthesis, Prosthetic
- What is being tested?
- Condition A: Electrode Configuration, Condition B: Electrode Configuration and Condition C: Electrode Configuration
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 32 participants
- Where
- 2 sitesUnited States
- Study dates
- 5 Dec 2025to Jun 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Aged 18 years or older
- Unilateral transradial level limb difference
- Current or past user of myo-electric controlled prostheses
- Six months or more post-amputation
- Have adequate limb length such that a wrist rotation device can fit in the check socket
- Have adequate limb length and diameter such that at least 9 channels of electrodes fit without cross pairing
Show all 10Show fewer
- Well-fitting socket as determined by a Socket-Comfort Score of 6 or above
- Capable of wearing and operating a prosthesis with a wrist rotator and multi-articulating hand
- Capable of understanding and following multi-step instructions and completing the tasks as described
- English speaking
Who cannot join
- Significant new injury that would prevent use of a prosthesis: The ability to consistently wear a prosthesis and perform activities of daily living and specific performance tasks is necessary to evaluate the relative benefits of the interventions.
- Cognitive impairment that would adversely affect understanding of or compliance with study requirements, ability to communicate experiences, or ability to give informed consent: The ability to understand and comply with requirements of the study is essential for the study to generate useable, reliable data. The ability to obtain relevant user feedback through questionnaires and informal discussion adds significant value to this study.
- Significant other comorbidity: Any other medical issues or injuries that would preclude completion of the study, use of the prostheses, or that would otherwise prevent acquisition of useable data by researchers.
- Pregnant participants as risk to pregnant individuals, embryos, or fetuses are not understood.
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
United States2 sites, 2 recruiting
- Recruiting
Shirley Ryan AbilityLab
Chicago, Illinois, 60611
Craig M Kelly, 508-893-6363, craig.kelly@liberatingtech.com
- Recruiting
Liberating Technologies, Inc. (LTI)
Holliston, Massachusetts, 01746
Craig M Kelly, 508-893-6363, craig.kelly@liberatingtech.com
About this study
Official title: Evaluation of Functional Performance of Persons With Limb Differences to Optimize Pattern Recognition Control of Powered Upper Limb Prosthesis
This study is focused on optimizing methods for controlling upper-limb myoelectric prosthetic arms. If you are enrolled in this study you would be expected to visit one of the research sites for approximately 5 in-lab visits lasting about 4 hours. These visits are expected to happen within a 5-week period but may take longer depending on scheduling availability. During these visits you will be completing basic tasks similar to your everyday actions using a prosthetic arm that is provided for you.
- Conditions
- Prosthesis User, Prosthesis, Prosthetic, Upper Limb Amputation, Upper Limb Amputation Below Elbow, Upper Limb Amputation Below Elbow (Injury)
- Being tested
- Condition A: Electrode Configuration, Condition B: Electrode Configuration, Condition C: Electrode Configuration, Condition D: Electrode Configuration
- Medical subject headings
- Wounds and Injuries
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Condition A: Electrode ConfigurationDevice
Each intervention is a specific blinded number and location of electrodes within the prosthetic arm used to control the prosthetic arm with pattern recognition myoelectric control.
Condition B: Electrode ConfigurationDevice
Each intervention is a specific blinded number and location of electrodes within the prosthetic arm used to control the prosthetic arm with pattern recognition myoelectric control.
Condition C: Electrode ConfigurationDevice
Each intervention is a specific blinded number and location of electrodes within the prosthetic arm used to control the prosthetic arm with pattern recognition myoelectric control.
Condition D: Electrode ConfigurationDevice
Each intervention is a specific blinded number and location of electrodes within the prosthetic arm used to control the prosthetic arm with pattern recognition myoelectric control.
| Study group | Role | What they receive |
|---|---|---|
| Sequence 1 | Experimental | Each arm will test all 4 conditions but in a different order from each other. Receives: Device: Condition A: Electrode Configuration; Device: Condition B: Electrode Configuration; Device: Condition C: Electrode Configuration; Device: Condition D: Electrode Configuration |
| Sequence 2 | Experimental | Each arm will test all 4 conditions but in a different order from each other. Receives: Device: Condition A: Electrode Configuration; Device: Condition B: Electrode Configuration; Device: Condition C: Electrode Configuration; Device: Condition D: Electrode Configuration |
| Sequence 3 | Experimental | Each arm will test all 4 conditions but in a different order from each other. Receives: Device: Condition A: Electrode Configuration; Device: Condition B: Electrode Configuration; Device: Condition C: Electrode Configuration; Device: Condition D: Electrode Configuration |
| Sequence 4 | Experimental | Each arm will test all 4 conditions but in a different order from each other. Receives: Device: Condition A: Electrode Configuration; Device: Condition B: Electrode Configuration; Device: Condition C: Electrode Configuration; Device: Condition D: Electrode Configuration |
What is being measured
The primary outcome is the main question the study is designed to answer.
ACMC
The participant will complete a daily task (such as packing a suitcase) using their prosthetic arm. A study occupational therapist will score the participants ability along different metrics.
Measured: Through study completion, an average of 1 month, 1 time at each 4 site visits.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Sep 2026
- Study start5 Dec 2025
- Primary completionJun 2027 (estimated)
- Study completionJun 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Prosthesis UserStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 32 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Liberating Technologies, Inc.
- Sponsor type
- Industry (pharma, biotech, devices)
- Collaborators
- Shirley Ryan AbilityLab, University of Hartford
- Responsible party
- Sponsor
- Investigators
- Todd Farrell, PhD, Principal investigator, Liberating Technologies, Inc.
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07850544
- Sponsor's protocol ID
- E03209.1a
- Other IDs
- W81XWH2210431
- Status last verified
- Oct 2026
- First submitted
- 23 Sep 2026
- Last updated
- 7 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
- Individual data sharing
- Yes: Deidentified outcomes results for participants such as ACMC, clothespin relocation task, and virtual EMG measures.
Study at a glance
From the registry record, last updated by the sponsor on 7 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of Functional Performance of Persons With Limb Differences to Optimize Pattern Recognition Control of Powered Upper Limb Prosthesis
- ClinicalTrials.gov ID
- NCT07850544
- Acronym / sponsor ID
- E03209.1a
- Conditions
- Prosthesis User, Prosthesis, Prosthetic, Upper Limb Amputation, Upper Limb Amputation Below Elbow, Upper Limb Amputation Below Elbow (Injury)
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 32 participants (estimated)
- Lead sponsor
- Liberating Technologies, Inc.Industry (pharma, biotech, devices)
- Collaborators
- Shirley Ryan AbilityLab, University of Hartford
- Study start
- 5 Dec 2025 (actual)
- Primary completion
- Jun 2027 (estimated)
- Study completion
- Jun 2027 (estimated)
- First posted
- 30 Sep 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is focused on optimizing methods for controlling upper-limb myoelectric prosthetic arms. If you are enrolled in this study you would be expected to visit one of the research sites for approximately 5 in-lab visits lasting about 4 hours. These visits are expected to happen within a 5-week period but may take longer depending on scheduling availability. During these visits you will be completing basic tasks similar to your everyday actions using a prosthetic arm that is provided for you.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Sequence 1 | Experimental | Device: Condition A: Electrode Configuration, Device: Condition B: Electrode Configuration, Device: Condition C: Electrode Configuration, Device: Condition D: Electrode ConfigurationEach arm will test all 4 conditions but in a different order from each other. |
| Sequence 2 | Experimental | Device: Condition A: Electrode Configuration, Device: Condition B: Electrode Configuration, Device: Condition C: Electrode Configuration, Device: Condition D: Electrode ConfigurationEach arm will test all 4 conditions but in a different order from each other. |
| Sequence 3 | Experimental | Device: Condition A: Electrode Configuration, Device: Condition B: Electrode Configuration, Device: Condition C: Electrode Configuration, Device: Condition D: Electrode ConfigurationEach arm will test all 4 conditions but in a different order from each other. |
| Sequence 4 | Experimental | Device: Condition A: Electrode Configuration, Device: Condition B: Electrode Configuration, Device: Condition C: Electrode Configuration, Device: Condition D: Electrode ConfigurationEach arm will test all 4 conditions but in a different order from each other. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (10 listed)
- Aged 18 years or older
- Unilateral transradial level limb difference
- Current or past user of myo-electric controlled prostheses
- Six months or more post-amputation
- Have adequate limb length such that a wrist rotation device can fit in the check socket
Key exclusion criteria (4 listed)
- Significant new injury that would prevent use of a prosthesis: The ability to consistently wear a prosthesis and perform activities of daily living and specific performance tasks is necessary to evaluate the relative benefits of the interventions.
- Cognitive impairment that would adversely affect understanding of or compliance with study requirements, ability to communicate experiences, or ability to give informed consent: The ability to understand and comply with requirements of the study is essential for the study to generate useable, reliable data. The ability to obtain relevant user feedback through questionnaires and informal discussion adds significant value to this study.
- Significant other comorbidity: Any other medical issues or injuries that would preclude completion of the study, use of the prostheses, or that would otherwise prevent acquisition of useable data by researchers.
- Pregnant participants as risk to pregnant individuals, embryos, or fetuses are not understood.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Condition A: Electrode ConfigurationEach intervention is a specific blinded number and location of electrodes within the prosthetic arm used to control the prosthetic arm with pattern recognition myoelectric control. | Device | Sequence 1, Sequence 2, Sequence 3, Sequence 4 |
| Condition B: Electrode ConfigurationEach intervention is a specific blinded number and location of electrodes within the prosthetic arm used to control the prosthetic arm with pattern recognition myoelectric control. | Device | Sequence 1, Sequence 2, Sequence 3, Sequence 4 |
| Condition C: Electrode ConfigurationEach intervention is a specific blinded number and location of electrodes within the prosthetic arm used to control the prosthetic arm with pattern recognition myoelectric control. | Device | Sequence 1, Sequence 2, Sequence 3, Sequence 4 |
| Condition D: Electrode ConfigurationEach intervention is a specific blinded number and location of electrodes within the prosthetic arm used to control the prosthetic arm with pattern recognition myoelectric control. | Device | Sequence 1, Sequence 2, Sequence 3, Sequence 4 |
Primary outcome
ACMC
Time frame: Through study completion, an average of 1 month, 1 time at each 4 site visits.
The participant will complete a daily task (such as packing a suitcase) using their prosthetic arm. A study occupational therapist will score the participants ability along different metrics.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Oct 2026.
- Individual participant dataSharing planned: Yes. Deidentified outcomes results for participants such as ACMC, clothespin relocation task, and virtual EMG measures.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Todd Farrell, PhD principal investigator
Liberating Technologies, Inc.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Condition A: Electrode Configuration, Condition B: Electrode Configuration and Condition C: Electrode Configuration in people with Prosthesis User and Prosthesis, run by Liberating Technologies, Inc. at 2 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 10 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 7 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Craig M Kelly (508-893-6363, craig.kelly@liberatingtech.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
ACMC (time frame: Through study completion, an average of 1 month, 1 time at each 4 site visits.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Oct 2026.