Mental HealthSAMPLEXNCT07851051
Study of Individual Neurocognitive Changes Associated With the Training of the Working Memory.
An observational study of Mental Health, run by Centre Hospitalier St Anne at 1 site in France.
Trial summary
8 participants including 2 pilots. The 2 pilot participants will each execute an MRI acquisition session in order to adjust the experimental paradigm Read more about this study
- Who is it for?
- Ages 18 to 30 yearsHealthy volunteers can take part
- Conditions the study is for
- Mental Health
- How many people
- 8 participants
- Where
- 1 siteFrance
- Study dates
- 29 Sep 2025to 29 Sep 2030
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- All sexes
- Healthy volunteers accepted
- Adult
Study population: healthy adult volunteers aged 18 to 30 who have no contraindications to an MRI scan.
Who may be able to join
- The inclusion criteria include
- age between 18 and 30 years,
- right-handedness (assessed using the Edinburgh Handedness Inventory),
- native French speaker, affiliation with the French national health insurance system
- provision of written informed consent prior to participation.
Who cannot join
- contraindications to MRI,
- neurological or psychiatric disorders
- history of traumatic brain injury
- any geographical or psychological condition preventing full compliance with the study protocol.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Study of Individual Neurocognitive Changes Associated With the Training of the Working Memory(SAMPLEX)
8 participants including 2 pilots. The 2 pilot participants will each execute an MRI acquisition session in order to adjust the experimental paradigm
Read the detailed description
The participants will benefit from a comprehensive training program in the Memory of the taught by the computerized CogMed method. This training showed a positive effect for improve the skills in Memory of the working in the healthy subject
- Conditions
- Mental Health
- Medical subject headings
- Psychological Well-Being
What is being measured
The primary outcome is the main question the study is designed to answer.
Working memory performance - Cogmed
Cognitive trajectories will be characterized using performance measures derived from the home-based training.
Measured: 5 week.
Working memory performance - CANTAB
Cognitive trajectories will be characterized using performance measures derived from the Spatial Span (SSP) task from the CANTAB battery, administered under standardized conditions at GHU Paris Psychiatry and Neurosciences.
Measured: 2 week
Multimodal MRI data
Multimodal MRI data - including anatomical, resting-state, working memory (WM) task-based functional, and diffusion-weighted sequences - will be acquired repeatedly over a six-week period during WM training, as well as before and after the training phase.
Measured: 2 week
Secondary outcomes (2)
executive functions performance
To enable complementary analyses of non-trained executive functions (EF), the participant will complete three tasks from the NIH Toolbox Cognitive Battery.
Measured: 1 week
behavioral variables
At baseline, we will collect demographic and cognitive information including age, sex, years of education, and baseline cognitive performance. In addition, we will record a set of covariates related to the participant's state during the scanning session and within the 24 hours preceding each training session.
Measured: 5 week for most variables
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Oct 2026
- Study start29 Sep 2025
- Primary completion29 Sep 2030 (estimated)
- Study completion29 Sep 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Mental HealthStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier St AnneThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Other
- Enrolment
- 8 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier St Anne
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- CACHIA Arnaud, Principal investigator, hospital saint anne of the GHU Paris
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07851051
- Sponsor's protocol ID
- D25-P007
- Acronym
- SAMPLEX
- Status last verified
- Sep 2026
- First submitted
- 19 Jan 2026
- Last updated
- 1 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 1 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Study of Individual Neurocognitive Changes Associated With the Training of the Working Memory(SAMPLEX)
- ClinicalTrials.gov ID
- NCT07851051
- Acronym / sponsor ID
- SAMPLEX / D25-P007
- Conditions
- Mental Health
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 8 participants (estimated)
- Lead sponsor
- Centre Hospitalier St AnneUniversity, hospital or other
- Study start
- 29 Sep 2025 (actual)
- Primary completion
- 29 Sep 2030 (estimated)
- Study completion
- 29 Sep 2030 (estimated)
- First posted
- 1 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
8 participants including 2 pilots. The 2 pilot participants will each execute an MRI acquisition session in order to adjust the experimental paradigm
Detailed description
The participants will benefit from a comprehensive training program in the Memory of the taught by the computerized CogMed method. This training showed a positive effect for improve the skills in Memory of the working in the healthy subject
Study design
- Observational model
- Case only
- Time perspective
- Other
Who may qualify
- Ages
- 18 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- healthy adult volunteers aged 18 to 30 who have no contraindications to an MRI scan.
Key inclusion criteria (5 listed)
- The inclusion criteria include
- age between 18 and 30 years,
- right-handedness (assessed using the Edinburgh Handedness Inventory),
- native French speaker, affiliation with the French national health insurance system
- provision of written informed consent prior to participation.
Key exclusion criteria (4 listed)
- contraindications to MRI,
- neurological or psychiatric disorders
- history of traumatic brain injury
- any geographical or psychological condition preventing full compliance with the study protocol.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Working memory performance - Cogmed
Time frame: 5 week.
Cognitive trajectories will be characterized using performance measures derived from the home-based training.
Working memory performance - CANTAB
Time frame: 2 week
Cognitive trajectories will be characterized using performance measures derived from the Spatial Span (SSP) task from the CANTAB battery, administered under standardized conditions at GHU Paris Psychiatry and Neurosciences.
Multimodal MRI data
Time frame: 2 week
Multimodal MRI data - including anatomical, resting-state, working memory (WM) task-based functional, and diffusion-weighted sequences - will be acquired repeatedly over a six-week period during WM training, as well as before and after the training phase.
2 secondary outcomes
executive functions performance
Time frame: 1 week
behavioral variables
Time frame: 5 week for most variables
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Oct 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
CACHIA Arnaud principal investigator
hospital saint anne of the GHU Paris
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Mental Health, run by Centre Hospitalier St Anne at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 1 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact CACHIA Arnaud (0661519200, arnaud.cachia@u-paris.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Working memory performance - Cogmed (time frame: 5 week.). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Oct 2026.