Post ICU SyndromeTHRIVE@TTSHNCT07854080
Protocol for a Hybrid Implementation-effectiveness Feasibility Study of a Transdisciplinary ICU-to-home Recovery Model
A study testing THRIVE@TTSH follow up program in people with Post ICU Syndrome, run by Tan Tock Seng Hospital.
Trial summary
This is a prospective, single-centre study which will recruit 50 adult ICU survivors over 12 months. Assessments will occur during hospitalisation and at Months 3 and 6 after hospital discharge, with a final phone follow-up at Month 12. There will be volunteer-supported home visits for 6 months post hospital discharge. Read more about this study
- Who is it for?
- Ages 21 years and older
- Conditions the study is for
- Post ICU Syndrome
- What is being tested?
- THRIVE@TTSH follow up program
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- No sites listed yet
- Study dates
- 31 Oct 2026to 31 Dec 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Received invasive mechanical ventilation for ≥ 48 hours;
- Aged ≥ 21 years;
- Premorbidly independent in basic activities of daily living;
- Had decision-making capacity before the acute illness and are expected to regain capacity before acute hospital discharge;
- Have evidence of new or worsening physical, cognitive, mental-health or swallowing impairment compared with their premorbid state; and
- Are ultimately planned for discharge to the community/home setting. Worsening in PICS domains is defined as an increase in CFS score compared with premorbid status, newly acquired swallowing dysfunction, new cognitive impairment after exclusion of delirium, suspected anxiety or depressive symptoms, or clinically important deterioration in physical or functional performance.
- Mental-health screening will not be interpreted as diagnostic criteria for anxiety or depressive disorders.
Who cannot join
- cognitive or psychiatric impairment that precludes meaningful participation in the study;
- are already enrolled in, or expected to enter, a structured follow-up pathway that substantially duplicates the rehabilitation intervention; or
- have treatment primarily directed towards palliation or end-of-life care
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Transition Support and Holistic Recovery Interventions for Vulnerable Ex-ICU Patients @ Tan Tock Seng Hospital (THRIVE@TTSH): Protocol for a Hybrid Implementation-effectiveness Feasibility Study of a Transdisciplinary ICU-to-home Recovery Model
This is a prospective, single-centre study which will recruit 50 adult ICU survivors over 12 months. Assessments will occur during hospitalisation and at Months 3 and 6 after hospital discharge, with a final phone follow-up at Month 12. There will be volunteer-supported home visits for 6 months post hospital discharge.
Read the detailed description
This is a prospective, single-centre hybrid implementation-effectiveness feasibility study which will recruit 50 adult ICU survivors over 12 months. Assessments will occur during hospitalisation and at Months 3 and 6 after hospital discharge, with a final phone follow-up at Month 12. There will be volunteer-supported home visits for 6 months post hospital discharge. The primary feasibility outcome is the proportion of enrolled participants alive at Month 6 who complete outcome assessment.
Secondary implementation outcomes include recruitment, retention, home-visit completion and acceptability. Exploratory outcomes include Post ICU Syndrome (PICS) recovery trajectories, healthcare utilisation and mortality through 12 months post discharge from the acute hospital.
- Conditions
- Post ICU Syndrome
- Being tested
- THRIVE@TTSH follow up program
- Keywords
- post icu syndrome, critical care, implementation study, rehabilitation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
THRIVE@TTSH follow up programOther
- Structured post-ICU screening
- Comprehensive multidomain assessment
- Personalised ICU recovery summary
- Multidisciplinary review and closed-loop care coordination
- Volunteer-supported home follow-up and multidisciplinary meetings
| Study group | Role | What they receive |
|---|---|---|
| Single arm feasibility study | Experimental | Not described Receives: Other: THRIVE@TTSH follow up program |
What is being measured
The primary outcome is the main question the study is designed to answer.
completion of the Month-6 PICS physical assessment
Physical :5 Times Sit-to-Stand Time in seconds required to complete five sit-to-stand repetitions. Values will be summarized at each assessment time point and change over time described.
Measured: From recruitment to 6 months post hospital discharge, or death by any cause, up to 24 months from recruitment
completion of the Month 6 physical domain assessment
Handgrip strength measured in kilograms using a standardized dynamometer procedure. Values will be summarized at each assessment time point and longitudinal change described.
Measured: From recruitment to 6 months post hospital discharge, or death by any cause, up to 24 months from recruitment
completion of Month 6 Cognitive domain assessment
Cognitive function measured using the Mini Mental State examination. Scores will be summarized at each assessment time point and longitudinal change described. MoCA may be used where clinically indicated and will be reported separately rather than treated as equivalent to MMSE.
Measured: From recruitment to 6 months post hospital discharge, or death by any cause, up to 24 months from recruitment Time points: (Hospital discharge, 3, 6 month post hospital discharge)
Completion of Month 6 Mental Domain assessment
Depressive symptoms screened using the Patient Health Questionnaire-9(PHQ-9). Total scores will be summarized at each assessment time point
Measured: From recruitment to 6 months post hospital discharge, or death by any cause, up to 24 months from recruitment
Completion of Month 6 Mental Domain Assessment
Anxiety symptoms screened using the GAD-7. Total scores will be summarized at each assessment time point
Measured: From recruitment to 6 months post hospital discharge, or death by any cause, up toFrom recruitment to 6 months post hospital discharge, or death by any cause, up to 24 months from recruitment
Health related quality of life
Health-related quality of life assessed using the EQ-5D-5L. EQ-5D-5L health-state/index values and EQ visual analogue scale scores will be summarized as applicable at each assessment time point.
Measured: from recruitment to 12 months post hospital discharge, or date of death from any cause (time points: 3,6 and 12 months post hospital discharge), up to 24 months from recruitment
Modified Barthel Index
Functional independence measured using the Modified Barthel Index. Higher scores indicate greater independence in activities of daily living. Scores will be summarized at each assessment time point
Measured: From recruitment to 12 months post hospital discharge, or death by any cause up to 24 months from recruitment
Return to work status
Employment status prior to ICU admission and post hospital discharge will be assessed. Among participants employed before critical illness, the number and percentage who have returned to work will be reported.
Measured: From recruitment to 6 months post hospital discharge, or death by any cause, up to 24 months from recruitment
Secondary outcomes (21)
Feasibility of program
proportion of eligible patients successfully recruited out (screened at ICU discharge)
Measured: From start of screening to 12 months post hospital discharge for the last patient recruited (approximately 24 months from start of study)
Five Times Sit to Stand
Time in seconds required to complete five sit-to-stand repetitions. Values will be summarized at each assessment time point and change over time described.
Measured: From recruitment to 6 months post hospital discharge, or death by any cause, up to 24 months from recruitment (time points :at hospital discharge, 3 and 6 months post hospital discharge
Grip strength
Handgrip strength with dynamometer
Measured: From recruitment to 6 months post hospital discharge or date of death from any cause, up to 24 months from recruitment (Time points: ICU discharge, hospital discharge, 3 and 6 months post hospital discharge)
Modified Barthel Index
Functional independence measured using the Modified Barthel Index. Higher scores indicate greater independence in activities of daily living. Scores will be summarized at each assessment time point and longitudinal change described.
Measured: From recruitment to 6 months post hospital discharge, or death by any cause, up to 24 months from recruitment (Time points: hospital discharge, 3,6, 12 month post hospital discharge
Mini-mental state examination
Cognitive function measured using the MMSE. Scores will be summarized at each assessment time point and longitudinal change described. MoCA may be used where clinically indicated and will be reported separately rather than treated as equivalent to MMSE.
Measured: From recruitment to 6 months post hospital discharge, up to 24 months from recruitment Time points: (Hospital discharge, 3, 6 month post hospital discharge)
Patient health questionnaire -9
Depressive symptoms measured using the PHQ-9. Total scores will be summarized at each assessment time point and longitudinal change described.
Measured: From recruitment to 6 months post hospital discharge, or death by any cause, up to 24 months from recruitment (Time points :Hospital discharge, 3, 6 month post hospital discharge)
General anxiety scale-7
Anxiety symptoms measured using the GAD-7. Total scores will be summarized at each assessment time point and longitudinal change described.
Measured: From recruitment up to 24 months from recruitment (time points: hospital discharge, 3,6 month post hospital discharge)
Retention at 6 months
Number of ICU survivors who have not withdrawn/ lost to follow up compared to original recruited number (excluding deaths)
Measured: From recruitment to 6 months post hospital discharge, or death by any cause, up to 24 months from recruitment
Completion of planned home visits
Monthly home visits x6 are planned per ICU survivor Number of planned home visits declined/ lost to follow up amongst survivors (excluding deaths) 3 and 6 month home visits converted to telehealth/ hospital visits
Measured: 6 months post hospital discharge, up to 24 months from recruitment
UCLA loneliness scale-3
University of California Los Angeles loneliness scale-3
Measured: from recruitment up to 24 months post recruitment (time points 1,4 12 months post hospital discharge)
Caregiver burden
Caregiver burden will be measured using the shortened 9-item Zarit Burden Interview (ZBI-9), with scores summarized over follow-up.
Measured: From recruitment to 6 months post hospital discharge, or patient death by any cause , up to 24 hours post recruitment (Time points :1 and 6 months post hospital discharge)
reasons for non-participation or declining home visits
reasons for non-participation of home visits
Measured: at the point of enrolment into home visits at hospital discharge up to 6 months post hospital discharge, or death from any cause, whichever comes first , up to 24 months from recruitment
Medication or follow-up appointment reconciliation events
number of medication or follow up appointment reconciliation events done during home visits, per home visit
Measured: 6 months post hospital discharge, from recruitment up to 24 months from recruitment
Swallowing status
In- hospital, oral intake and swallowing status assessed using the Functional Oral Intake Scale. EAT-10 questionnaire post hospital discharge; Scores will be summarized descriptively over follow-up.
Measured: From recruitment into study, up 24 months from recruitment, or death by any cause, whichever first (time points: at the Icu discharge, hospital discharge, 2 and 5 months post hospital discharge
Body weight
Contributes to nutritional assessment Body weight measured in kilograms and summarized at each assessment time point and longitudinally.
Measured: From recruitment into study, up to 24 months from recruitment, or death from any cause, whichever comes first (time points: pre ICU, at the Icu discharge, hospital discharge, 2 and 5 months post hospital discharge
arm and leg circumference
arm and leg circumference as a surrogate for nutritional status and muscle bulk.
Excludes patients who have contraindications e.g. loss of limb, abnormal BMI, edema
Measured: From recruitment into study, up to 24months from recruitment or death from any cause, whichever comes first (Time points: at the Icu discharge, hospital discharge, 2 and 5 months post hospital discharge)
Chelsea Critical Care Physical Assessment tool
CPax
Measured: From recruitment into study, up to death from any cause or 24 months from recruitment, whichever comes first.
Montreal Cognitive Assessment Tool
MoCA assessment for patients screened with MMSE and have high suspicion of cognitive impairment
Measured: From recruitment into study, 6 months post hospital discharge, or date of death from any cause, whichever comes first (if applicable)
healthcare utilisation
number of unplanned clinic visits, emergency department visits, unplanned admissions with reference from point of hospital discharge
Measured: 12 months post hospital discharge
mortality
mortality
Measured: From recruitment to 12 months post hospital discharge, up till 24 months from recruitment, or death by any cause, whichever comes first
return to work status
for survivors who were working pre ICU admission, the number who returned to work
Measured: From recruitment until 24 months from recruitment (time points: 3,6 12 months post hospital discharge)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Oct 2026
- Study start31 Oct 2026 (estimated)
- Primary completion30 Jun 2028 (estimated)
- Study completion31 Dec 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Post ICU SyndromeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- This is a prospective, single-centre study using a Type 3 hybrid implementation-effectiveness feasibility design, as described by Curran et al. The study is designed to evaluate whether THRIVE@TTSH can be delivered within routine clinical and community workflows. Implementation outcomes will be informed by Proctor's framework, including feasibility, acceptability and fidelity. RE-AIM (Reach, Effectiveness, Adoption, Implementation and Maintenance) will provide the broader reporting framework; effectiveness outcomes will be exploratory
- Masking
- None (open label)
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Tan Tock Seng Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Lau Yie Hui, Tan Tock Seng Hospital
- Investigators
- Yie Hui Lau, Principal investigator, Tan Tock Seng Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07854080
- Sponsor's protocol ID
- NTF_FY25_T1C1_17
- Acronym
- THRIVE@TTSH
- Status last verified
- Sep 2026
- First submitted
- 21 Sep 2026
- Last updated
- 2 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 2 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Transition Support and Holistic Recovery Interventions for Vulnerable Ex-ICU Patients @ Tan Tock Seng Hospital (THRIVE@TTSH): Protocol for a Hybrid Implementation-effectiveness Feasibility Study of a Transdisciplinary ICU-to-home Recovery Model
- ClinicalTrials.gov ID
- NCT07854080
- Acronym / sponsor ID
- THRIVE@TTSH / NTF_FY25_T1C1_17
- Conditions
- Post ICU Syndrome
- Keywords
- post icu syndrome, critical care, implementation study, rehabilitation
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Tan Tock Seng HospitalUniversity, hospital or other
- Study start
- 31 Oct 2026 (estimated)
- Primary completion
- 30 Jun 2028 (estimated)
- Study completion
- 31 Dec 2028 (estimated)
- First posted
- 2 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is a prospective, single-centre study which will recruit 50 adult ICU survivors over 12 months. Assessments will occur during hospitalisation and at Months 3 and 6 after hospital discharge, with a final phone follow-up at Month 12. There will be volunteer-supported home visits for 6 months post hospital discharge.
Detailed description
This is a prospective, single-centre hybrid implementation-effectiveness feasibility study which will recruit 50 adult ICU survivors over 12 months. Assessments will occur during hospitalisation and at Months 3 and 6 after hospital discharge, with a final phone follow-up at Month 12. There will be volunteer-supported home visits for 6 months post hospital discharge. The primary feasibility outcome is the proportion of enrolled participants alive at Month 6 who complete outcome assessment.
Secondary implementation outcomes include recruitment, retention, home-visit completion and acceptability. Exploratory outcomes include Post ICU Syndrome (PICS) recovery trajectories, healthcare utilisation and mortality through 12 months post discharge from the acute hospital.
Study design
- Primary purpose
- Health services research
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- This is a prospective, single-centre study using a Type 3 hybrid implementation-effectiveness feasibility design, as described by Curran et al. The study is designed to evaluate whether THRIVE@TTSH can be delivered within routine clinical and community workflows. Implementation outcomes will be informed by Proctor's framework, including feasibility, acceptability and fidelity. RE-AIM (Reach, Effectiveness, Adoption, Implementation and Maintenance) will provide the broader reporting framework; effectiveness outcomes will be exploratory
| Arm | Type | Receives |
|---|---|---|
| Single arm feasibility study | Experimental | Other: THRIVE@TTSH follow up program |
Who may qualify
- Ages
- 21 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- Received invasive mechanical ventilation for ≥ 48 hours;
- Aged ≥ 21 years;
- Premorbidly independent in basic activities of daily living;
- Had decision-making capacity before the acute illness and are expected to regain capacity before acute hospital discharge;
- Have evidence of new or worsening physical, cognitive, mental-health or swallowing impairment compared with their premorbid state; and
Key exclusion criteria (3 listed)
- cognitive or psychiatric impairment that precludes meaningful participation in the study;
- are already enrolled in, or expected to enter, a structured follow-up pathway that substantially duplicates the rehabilitation intervention; or
- have treatment primarily directed towards palliation or end-of-life care
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| THRIVE@TTSH follow up program1. Structured post-ICU screening 2. Comprehensive multidomain assessment 3. Personalised ICU recovery summary 4. Multidisciplinary review and closed-loop care coordination 5. Volunteer-supported home follow-up and multidisciplinary meetings | Other | Single arm feasibility study |
Primary outcome
completion of the Month-6 PICS physical assessment
Time frame: From recruitment to 6 months post hospital discharge, or death by any cause, up to 24 months from recruitment
Physical :5 Times Sit-to-Stand Time in seconds required to complete five sit-to-stand repetitions. Values will be summarized at each assessment time point and change over time described.
completion of the Month 6 physical domain assessment
Time frame: From recruitment to 6 months post hospital discharge, or death by any cause, up to 24 months from recruitment
Handgrip strength measured in kilograms using a standardized dynamometer procedure. Values will be summarized at each assessment time point and longitudinal change described.
completion of Month 6 Cognitive domain assessment
Time frame: From recruitment to 6 months post hospital discharge, or death by any cause, up to 24 months from recruitment Time points: (Hospital discharge, 3, 6 month post hospital discharge)
Cognitive function measured using the Mini Mental State examination. Scores will be summarized at each assessment time point and longitudinal change described. MoCA may be used where clinically indicated and will be reported separately rather than treated as equivalent to MMSE.
Completion of Month 6 Mental Domain assessment
Time frame: From recruitment to 6 months post hospital discharge, or death by any cause, up to 24 months from recruitment
Depressive symptoms screened using the Patient Health Questionnaire-9(PHQ-9). Total scores will be summarized at each assessment time point
Completion of Month 6 Mental Domain Assessment
Time frame: From recruitment to 6 months post hospital discharge, or death by any cause, up toFrom recruitment to 6 months post hospital discharge, or death by any cause, up to 24 months from recruitment
Anxiety symptoms screened using the GAD-7. Total scores will be summarized at each assessment time point
Health related quality of life
Time frame: from recruitment to 12 months post hospital discharge, or date of death from any cause (time points: 3,6 and 12 months post hospital discharge), up to 24 months from recruitment
Health-related quality of life assessed using the EQ-5D-5L. EQ-5D-5L health-state/index values and EQ visual analogue scale scores will be summarized as applicable at each assessment time point.
Modified Barthel Index
Time frame: From recruitment to 12 months post hospital discharge, or death by any cause up to 24 months from recruitment
Functional independence measured using the Modified Barthel Index. Higher scores indicate greater independence in activities of daily living. Scores will be summarized at each assessment time point
Return to work status
Time frame: From recruitment to 6 months post hospital discharge, or death by any cause, up to 24 months from recruitment
Employment status prior to ICU admission and post hospital discharge will be assessed. Among participants employed before critical illness, the number and percentage who have returned to work will be reported.
21 secondary outcomes
Feasibility of program
Time frame: From start of screening to 12 months post hospital discharge for the last patient recruited (approximately 24 months from start of study)
Five Times Sit to Stand
Time frame: From recruitment to 6 months post hospital discharge, or death by any cause, up to 24 months from recruitment (time points :at hospital discharge, 3 and 6 months post hospital discharge
Grip strength
Time frame: From recruitment to 6 months post hospital discharge or date of death from any cause, up to 24 months from recruitment (Time points: ICU discharge, hospital discharge, 3 and 6 months post hospital discharge)
Modified Barthel Index
Time frame: From recruitment to 6 months post hospital discharge, or death by any cause, up to 24 months from recruitment (Time points: hospital discharge, 3,6, 12 month post hospital discharge
Mini-mental state examination
Time frame: From recruitment to 6 months post hospital discharge, up to 24 months from recruitment Time points: (Hospital discharge, 3, 6 month post hospital discharge)
Patient health questionnaire -9
Time frame: From recruitment to 6 months post hospital discharge, or death by any cause, up to 24 months from recruitment (Time points :Hospital discharge, 3, 6 month post hospital discharge)
General anxiety scale-7
Time frame: From recruitment up to 24 months from recruitment (time points: hospital discharge, 3,6 month post hospital discharge)
Retention at 6 months
Time frame: From recruitment to 6 months post hospital discharge, or death by any cause, up to 24 months from recruitment
Completion of planned home visits
Time frame: 6 months post hospital discharge, up to 24 months from recruitment
UCLA loneliness scale-3
Time frame: from recruitment up to 24 months post recruitment (time points 1,4 12 months post hospital discharge)
Caregiver burden
Time frame: From recruitment to 6 months post hospital discharge, or patient death by any cause , up to 24 hours post recruitment (Time points :1 and 6 months post hospital discharge)
reasons for non-participation or declining home visits
Time frame: at the point of enrolment into home visits at hospital discharge up to 6 months post hospital discharge, or death from any cause, whichever comes first , up to 24 months from recruitment
Medication or follow-up appointment reconciliation events
Time frame: 6 months post hospital discharge, from recruitment up to 24 months from recruitment
Swallowing status
Time frame: From recruitment into study, up 24 months from recruitment, or death by any cause, whichever first (time points: at the Icu discharge, hospital discharge, 2 and 5 months post hospital discharge
Body weight
Time frame: From recruitment into study, up to 24 months from recruitment, or death from any cause, whichever comes first (time points: pre ICU, at the Icu discharge, hospital discharge, 2 and 5 months post hospital discharge
arm and leg circumference
Time frame: From recruitment into study, up to 24months from recruitment or death from any cause, whichever comes first (Time points: at the Icu discharge, hospital discharge, 2 and 5 months post hospital discharge)
Chelsea Critical Care Physical Assessment tool
Time frame: From recruitment into study, up to death from any cause or 24 months from recruitment, whichever comes first.
Montreal Cognitive Assessment Tool
Time frame: From recruitment into study, 6 months post hospital discharge, or date of death from any cause, whichever comes first (if applicable)
healthcare utilisation
Time frame: 12 months post hospital discharge
mortality
Time frame: From recruitment to 12 months post hospital discharge, up till 24 months from recruitment, or death by any cause, whichever comes first
return to work status
Time frame: From recruitment until 24 months from recruitment (time points: 3,6 12 months post hospital discharge)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Yie Hui Lau principal investigator
Tan Tock Seng Hospital
Questions about this trial
What is this clinical trial studying?
A study testing THRIVE@TTSH follow up program in people with Post ICU Syndrome, run by Tan Tock Seng Hospital.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 2 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Yie Hui Lau (+65 63577771, yie.hui.lau@nhghealth.com.sg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
completion of the Month-6 PICS physical assessment (time frame: From recruitment to 6 months post hospital discharge, or death by any cause, up to 24 months from recruitment). The study lists 8 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Oct 2026; AzTrials last refreshed its copy on 27 Oct 2026.