Apical PeriodontitisNCT07856186
Apical Periodontitis and Glycemic Control in Diabetic and Non-diabetic Egyptian Sub-population
An observational study of Apical Periodontitis, run by Cairo University.
Trial summary
This observational cross-sectional study aims to assess the prevalence of apical periodontitis in diabetic and non-diabetic adult Egyptian patients and to evaluate its association with glycemic control measured by glycated hemoglobin (HbA1c). Read more about this study
- Who is it for?
- Ages 21 years and olderHealthy volunteers can take part
- Conditions the study is for
- Apical Periodontitis
- How many people
- 88 participants
- Where
- No sites listed yet
- Study dates
- 5 Oct 2026to 5 May 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Adult Egyptian male and female patients aged 21 years or older with at least 8 teeth, recruited from outpatient dental clinics at the Faculty of Dentistry, Cairo University and the Endocrine and Diabetes Center, Cairo, Egypt. Participants will be classified into diabetic and non-diabetic groups based on their measured HbA1c levels.
Who may be able to join
- Adult Egyptian males and females
- 21 years or older
- At least 8 teeth present
- Willing to undergo clinical and radiographic examination, HbA1c measurement, -Willing to provide informed consent.
Who cannot join
- Participants younger than 21 years
- fewer than 8 teeth
- Those who refuse clinical or radiographic examination
- Patients with systemic diseases other than diabetes that may affect oral or periapical health.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Prevalence of Apical Periodontitis and it's Association With Glycemic Control in Diabetic and Non-diabetic Egyptian Sub-population: A Cross-sectional Study
This observational cross-sectional study aims to assess the prevalence of apical periodontitis in diabetic and non-diabetic adult Egyptian patients and to evaluate its association with glycemic control measured by glycated hemoglobin (HbA1c). Participants will undergo clinical examination, digital panoramic radiographic assessment, and HbA1c measurement.
Read the detailed description
Apical periodontitis is an inflammatory disease of the periapical tissues that develops as a consequence of endodontic infection. Diabetes mellitus has been associated with an increased prevalence of apical periodontitis, although the available evidence remains limited and inconsistent. In addition, the relationship between glycemic control and apical periodontitis remains unclear, and population-specific data in Egypt are limited.
This observational cross-sectional study will assess the prevalence of apical periodontitis in diabetic and non-diabetic adult Egyptian patients and evaluate the association between glycemic control and apical periodontitis. Participants will be recruited from outpatient dental clinics of the Endocrine and Diabetes Center in Cairo, Egypt, in collaboration with the Department of Endodontics, Faculty of Dentistry, Cairo university.
Eligible participants will be Egyptian males and females aged 21 years or older with at least eight teeth present. Participants will undergo standardized clinical oral examination, digital panoramic radiographic examination, and measurement of glycated hemoglobin (HbA1c). Apical periodontitis will be assessed radiographically based on the presence or absence of periapical radiolucency. Participants will be classified into diabetic and non-diabetic groups according to HbA1c levels.
The primary objective is to assess the prevalence of apical periodontitis in diabetic and non-diabetic patients. The secondary objective is to evaluate the association between HbA1c levels and the presence of apical periodontitis. The planned sample size is 88 participants, with 44 participants in each group.
- Conditions
- Apical Periodontitis
- Medical subject headings
- Periapical Periodontitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Group 1: diabetic participants | Participants with HbA1c ≥6.5% | |
| Group 2: non-diabetic participants | Participants with HbA1c <6.5%. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Prevalence of apical periodontitis
Presence or absence of apical periodontitis assessed by digital panoramic radiographic examination using binary scoring based on the presence of periapical radiolucency.
Measured: During the 6-month study/recruitment period.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Oct 2026
- Study start5 Oct 2026 (estimated)
- Primary completion5 Apr 2027 (estimated)
- Study completion5 May 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Apical PeriodontitisStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 88 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Yara Yousif Abdalla Kairi, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07856186
- Sponsor's protocol ID
- 24.9.2024
- Status last verified
- Sep 2026
- First submitted
- 24 Sep 2026
- Last updated
- 2 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared with individual researchers outside the study team. Study data will be accessible to the Principal Investigator and supervisors and will be protected to maintain participant confidentiality.
Study at a glance
From the registry record, last updated by the sponsor on 2 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Prevalence of Apical Periodontitis and it's Association With Glycemic Control in Diabetic and Non-diabetic Egyptian Sub-population: A Cross-sectional Study
- ClinicalTrials.gov ID
- NCT07856186
- Acronym / sponsor ID
- 24.9.2024
- Conditions
- Apical Periodontitis
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 88 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 5 Oct 2026 (estimated)
- Primary completion
- 5 Apr 2027 (estimated)
- Study completion
- 5 May 2027 (estimated)
- First posted
- 2 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This observational cross-sectional study aims to assess the prevalence of apical periodontitis in diabetic and non-diabetic adult Egyptian patients and to evaluate its association with glycemic control measured by glycated hemoglobin (HbA1c). Participants will undergo clinical examination, digital panoramic radiographic assessment, and HbA1c measurement.
Detailed description
Apical periodontitis is an inflammatory disease of the periapical tissues that develops as a consequence of endodontic infection. Diabetes mellitus has been associated with an increased prevalence of apical periodontitis, although the available evidence remains limited and inconsistent. In addition, the relationship between glycemic control and apical periodontitis remains unclear, and population-specific data in Egypt are limited.
This observational cross-sectional study will assess the prevalence of apical periodontitis in diabetic and non-diabetic adult Egyptian patients and evaluate the association between glycemic control and apical periodontitis. Participants will be recruited from outpatient dental clinics of the Endocrine and Diabetes Center in Cairo, Egypt, in collaboration with the Department of Endodontics, Faculty of Dentistry, Cairo university.
Eligible participants will be Egyptian males and females aged 21 years or older with at least eight teeth present. Participants will undergo standardized clinical oral examination, digital panoramic radiographic examination, and measurement of glycated hemoglobin (HbA1c). Apical periodontitis will be assessed radiographically based on the presence or absence of periapical radiolucency. Participants will be classified into diabetic and non-diabetic groups according to HbA1c levels.
The primary objective is to assess the prevalence of apical periodontitis in diabetic and non-diabetic patients. The secondary objective is to evaluate the association between HbA1c levels and the presence of apical periodontitis. The planned sample size is 88 participants, with 44 participants in each group.
Study design
- Observational model
- Other
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group 1: diabetic participants | – | –Participants with HbA1c ≥6.5% |
| Group 2: non-diabetic participants | – | –Participants with HbA1c <6.5%. |
Who may qualify
- Ages
- 21 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Adult Egyptian male and female patients aged 21 years or older with at least 8 teeth, recruited from outpatient dental clinics at the Faculty of Dentistry, Cairo University and the Endocrine and Diabetes Center, Cairo, Egypt. Participants will be classified into diabetic and non-diabetic groups based on their measured HbA1c levels.
Key inclusion criteria (4 listed)
- Adult Egyptian males and females
- 21 years or older
- At least 8 teeth present
- Willing to undergo clinical and radiographic examination, HbA1c measurement, -Willing to provide informed consent.
Key exclusion criteria (4 listed)
- Participants younger than 21 years
- fewer than 8 teeth
- Those who refuse clinical or radiographic examination
- Patients with systemic diseases other than diabetes that may affect oral or periapical health.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Prevalence of apical periodontitis
Time frame: During the 6-month study/recruitment period.
Presence or absence of apical periodontitis assessed by digital panoramic radiographic examination using binary scoring based on the presence of periapical radiolucency.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Oct 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be shared with individual researchers outside the study team. Study data will be accessible to the Principal Investigator and supervisors and will be protected to maintain participant confidentiality.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
An observational study of Apical Periodontitis, run by Cairo University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 2 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Yara Yousif Kairi (+201555003176, Yara.kairi@dentistry.cu.edu.eg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Prevalence of apical periodontitis (time frame: During the 6-month study/recruitment period.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Oct 2026.