Infertility Assisted Reproductive TechnologyNCT07858227
Association Between Serum Progesterone Levels on Embryo Transfer Day and Clinical Pregnancy in Frozen-thawed Embryo Transfer Cycles Using Hormone Replacement Therapy
An observational study of Infertility Assisted Reproductive Technology, run by Chinese University of Hong Kong.
Trial summary
A retrospective evaluation of routinely collected clinical, embryological, laboratory, and pregnancy outcome data provides an efficient approach to examine the association between serum progesterone on the day of FET and clinical pregnancy in an Asian population. Read more about this study
- Who is it for?
- Any age, women onlyHealthy volunteers can take part
- Conditions the study is for
- Infertility Assisted Reproductive Technology
- What is being tested?
- data collection
- How many people
- 300 participants
- Where
- No sites listed yet
- Study dates
- 15 Oct 2026to 31 Oct 2032
- How long will I take part?
- 1 Day
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- Women only
- Healthy volunteers accepted
- Child, Adult, Older adult
Study population: All eligible HRT-FET cycles performed at the Assisted Reproductive Technology Unit, Department of Obstetrics and Gynaecology
Who may be able to join
- HRT-FET cycles performed during the prespecified retrospective study period
- Women aged 18 to <42 years at the time of embryo transfer
- BMI <30 kg/m²
- Transfer of at least one good-quality embryo
- Serum progesterone measured on the morning of embryo transfer as part of routine care
- Availability of the primary clinical pregnancy outcome in the medical record
Who cannot join
- Severe or uncontrolled endocrine disorders documented at the time of treatment (e.g., thyroid dysfunction or premature ovarian insufficiency)
- Untreated severe uterine factors likely to impair implantation (e.g., severe endometriosis, large or subendometrial fibroids, intrauterine adhesions, or endometrial polyps)
- Missing or implausible key exposure data after source-data verification
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Association Between Serum Progesterone Levels on Embryo Transfer Day and Clinical Pregnancy in Frozen-thawed Embryo Transfer Cycles Using Hormone Replacement Therapy: a Retrospective Cohort Study
A retrospective evaluation of routinely collected clinical, embryological, laboratory, and pregnancy outcome data provides an efficient approach to examine the association between serum progesterone on the day of FET and clinical pregnancy in an Asian population.
- Being tested
- data collection
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
data collectionOther
serum progesterone levels on embryo transfer day and clinical pregnancy
| Study group | Role | What they receive |
|---|---|---|
| Patients with frozen-thawed embryo transfer cycles using hormone replacement therapy | Not described Receives: Other: data collection |
What is being measured
The primary outcome is the main question the study is designed to answer.
Clinical pregnancy rate
To compare the clinical pregnancy rate across prespecified serum progesterone categories on the day of embryo transfer and to estimate the association between progesterone level and clinical pregnancy.
Measured: 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Oct 2026
- Study start15 Oct 2026 (estimated)
- Primary completion31 Oct 2031 (estimated)
- Study completion31 Oct 2032 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Infertility Assisted Reproductive TechnologyStudies of the same condition, open and under way.
- More trials run by Chinese University of Hong KongThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Other
- Enrolment
- 300 participants (estimated)
- Target duration
- 1 Day
Sponsor and investigators
- Lead sponsor
- Chinese University of Hong Kong
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Chung Pui Wah Jacqueline, Chinese University of Hong Kong
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07858227
- Sponsor's protocol ID
- 2026.564
- Status last verified
- Oct 2026
- First submitted
- 30 Sep 2026
- Last updated
- 13 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 13 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Association Between Serum Progesterone Levels on Embryo Transfer Day and Clinical Pregnancy in Frozen-thawed Embryo Transfer Cycles Using Hormone Replacement Therapy: a Retrospective Cohort Study
- ClinicalTrials.gov ID
- NCT07858227
- Acronym / sponsor ID
- 2026.564
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 300 participants (estimated)
- Lead sponsor
- Chinese University of Hong KongUniversity, hospital or other
- Study start
- 15 Oct 2026 (estimated)
- Primary completion
- 31 Oct 2031 (estimated)
- Study completion
- 31 Oct 2032 (estimated)
- First posted
- 5 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
A retrospective evaluation of routinely collected clinical, embryological, laboratory, and pregnancy outcome data provides an efficient approach to examine the association between serum progesterone on the day of FET and clinical pregnancy in an Asian population.
Study design
- Observational model
- Cohort
- Time perspective
- Other
- Target follow-up
- 1 Day
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Patients with frozen-thawed embryo transfer cycles using hormone replacement therapy | – | Other: data collection |
Who may qualify
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
- Study population
- All eligible HRT-FET cycles performed at the Assisted Reproductive Technology Unit, Department of Obstetrics and Gynaecology
Key inclusion criteria (6 listed)
- HRT-FET cycles performed during the prespecified retrospective study period
- Women aged 18 to <42 years at the time of embryo transfer
- BMI <30 kg/m²
- Transfer of at least one good-quality embryo
- Serum progesterone measured on the morning of embryo transfer as part of routine care
Key exclusion criteria (3 listed)
- Severe or uncontrolled endocrine disorders documented at the time of treatment (e.g., thyroid dysfunction or premature ovarian insufficiency)
- Untreated severe uterine factors likely to impair implantation (e.g., severe endometriosis, large or subendometrial fibroids, intrauterine adhesions, or endometrial polyps)
- Missing or implausible key exposure data after source-data verification
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| data collectionserum progesterone levels on embryo transfer day and clinical pregnancy | Other | Patients with frozen-thawed embryo transfer cycles using hormone replacement therapy |
Primary outcome
Clinical pregnancy rate
Time frame: 1 year
To compare the clinical pregnancy rate across prespecified serum progesterone categories on the day of embryo transfer and to estimate the association between progesterone level and clinical pregnancy.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Oct 2026.
- Individual participant dataSharing planned: Undecided
Related trials for Infertility Assisted Reproductive Technology
Active, not recruitingPhase 3
Human Menopausal Gonadotropin Research in Infertility Assessing Cumulative Live Birth With Frozen Embryo Transfer.
Infertility (IVF Patients)
RecruitingObservational study
Safety and Efficacy of Corifollitropin Alfa N02 Injection in Elderly Women Undergoing Assisted Reproductive Technology (ART)
Infertility
Recruiting
225 IU Versus 300 IU Starting FSH Dose in PPOS for Good-Prognosis Women
Infertility (IVF Patients), Infertility Assisted Reproductive Technology
Not yet recruitingObservational study
Low TGF-β and Embryo Implantation in the Context of Assisted Reproductive Technology: Confirmation of a Biomarker Predictive of Success and Characterization of the Immune Microenvironment.
Infertility, Female, Pregnancy Related
RecruitingObservational study
Machine-Learning Prediction of Pregnancy Outcomes After Assisted Reproductive Treatments
IVF Outcomes, Prediction Models
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
An observational study of Infertility Assisted Reproductive Technology, run by Chinese University of Hong Kong.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 13 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Chung PW Jacqueline (35051537, jacquelinechung@cuhk.edu.hk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Clinical pregnancy rate (time frame: 1 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Oct 2026.