Cardiovascular RiskPhase 3AMBIENCENCT07861100
A Research Study to Look at How Well Zenagamtide Works Compared to Placebo in People With Established Atherosclerotic Cardiovascular Disease and Either Overweight or Obesity
A Phase 3 study testing Zenagamtide in people with Cardiovascular Risk and Obesity, run by Novo Nordisk A/S at 769 sites in 26 countries.
Trial summary
This clinical study is being conducted to evaluate the safety and effectiveness of zenagamtide in people with atherosclerotic cardiovascular disease (ASCVD) and excess body weight compared with placebo. Read more about this study
- Who is it for?
- Ages 45 years and older
- Conditions the study is for
- Cardiovascular Risk, Obesity
- What is being tested?
- Zenagamtide
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 8,500 participants
- Where
- 769 sitesin 26 countries
- Study dates
- 26 Oct 2026to 16 Sep 2030
- Phase
- Phase 3
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 45 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Established ASCVD is defined as at least one of the below conditions (a-c):
- Prior myocardial infarction (MI) b. Symptomatic peripheral artery disease (PAD) defined as at least one of the following: i. Intermittent claudication with an ankle-brachial index (ABI) less than (<) 0.85 at rest ii. Lower extremity amputation at or above ankle due to atherosclerotic disease (excluding e.g. trauma or osteomyelitis) c. Cerebrovascular disease defined as the following: i. Prior stroke
- Participants with Type 2 Diabetes (T2D) (at screening) are allowed in the study with the following provisions:
- Treatment should be stable for greater than or equal to (≥) 90 days before screening as assessed by the investigator.
- Glucose lowering agents are permitted according to local label except glucagon-like peptide-1 receptor agonist (GLP-1 RA), glucose-dependent insulinotropic polypeptide (GIP) and amylin analogues; for insulins, only basal insulin is allowed.
Who cannot join
- MI, stroke, unstable angina pectoris, or worsening heart failure (HF) leading to either hospitalization or intravenous loop diuretics within 30 days prior to the day of screening and until randomization.
- Coronary, carotid, or peripheral artery revascularization or percutaneous valve repair or replacement within 30 days prior to the day of screening or planned during the study period and known at screening.
- Chronic heart failure classified at screening.
- Glycaemia-related:
- Recurrent severe hypoglycaemic episodes within the last year as judged by the investigator.
- Known history of hypoglycaemia unawareness as indicated by the investigator according to Clarke's questionnaire question 8.
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- History of type 1 diabetes (T1D).
- Participant with diabetic retinopathy or maculopathy who received treatment with retinal photocoagulation, vitrectomy or anti-Vascular Endothelial Growth Factor (anti-VEGF) within 180 days before screening or who, at the time of screening, are expected to require treatment within 180 days after screening. Diabetic retinopathy or maculopathy must be verified by an eye examination performed within 90 days before screening or in the period between screening and randomization. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination.
- Glycated haemoglobin (HbA1c) greater than (>) 10 percentage (%) (86 millimoles per mole [mmol/mol]) as measured by central laboratory at screening.
- General health and safety:
- Treatment with any GLP-1 RA, GIP RA or amylin analogue for any indication before screening.
Trial locations and contacts
769 sites in 26 countries. Contact the study team or a site near you to ask about taking part.
769 sites in 26 countries
United States155 sites
Javara/Privia Med Grp GA,LLC
Albany, Georgia, 31707
PharmaTex Research
Amarillo, Texas, 79109
Ascension Texas Cardiovascular
Austin, Texas, 78705
Pinnacle Clinical Research
Austin, Texas, 78757
American Health Network of Indiana, LLC_Avon_0
Avon, Indiana, 46123
MedStar Good Samaritan Hosp
Baltimore, Maryland, 21044
Ascension Saint Agnes Heart Ca
Baltimore, Maryland, 21229
Metropolitan Cardiology PA
Beaumont, Texas, 77701
Heritage Valley Medical Group
Beaver, Pennsylvania, 15009
National Heart Institute Cal
Beverly Hills, California, 90211
Uni of Alabama at Birmingham
Birmingham, Alabama, 35294
Grace Research, LLC
Bossier City, Louisiana, 71111
Progressive Clinical Research UT
Bountiful, Utah, 84010
Flourish Research Bowie
Bowie, Maryland, 20715
Bridgeport Hospital
Bridgeport, Connecticut, 06610
Holston Medical Group Pc
Bristol, Tennessee, 37620-7352
West Georgia Cardiology
Carrollton, Georgia, 30117
Clinical Research Professionals
Chesterfield, Missouri, 63005
California Inst Of Renal Res
Chula Vista, California, 91910
Univ of Cincinnati Med Cent
Cincinnati, Ohio, 45267
Innovative Research of W FL
Clearwater, Florida, 33756
Centennial Medical Group
Columbia, Maryland, 21045
Javara Inc. / Privia Medical Group Gulf Coast PLLC
Conroe, Texas, 77384
Cardiovascular Care Center & CRC
Conyers, Georgia, 30012
Hope Clin Res & Wellness
Conyers, Georgia, 30094
Core Clinical Trials
Cordele, Georgia, 31015
South Texas Clinical Research
Corpus Christi, Texas, 78404
West Broadway Clinic
Council Bluffs, Iowa, 51501
Valley Clinical Trials
Covina, California, 91723
Louisiana Heart Center
Covington, Louisiana, 70433
Nature Coast Clin Rsrch_Crystal River
Crystal River, Florida, 34429
Thyroid Endocrinology & Diabetes PA
Dallas, Texas, 75208
Baylor Jack and Jane Hamilton
Dallas, Texas, 75226
Liberty Research Center_Dallas
Dallas, Texas, 75230
Florida Premier Cardiology
Delray Beach, Florida, 33484
Henry Ford Health System
Detroit, Michigan, 48202
Durham Nephrology Associates
Durham, North Carolina, 27704
Eastern Shore Rsrch Inst, LLC
Fairhope, Alabama, 36532
Lillestol Research LLC
Fargo, North Dakota, 58104
Elite Research Center
Flint, Michigan, 48532
Piedmont Research Partners, LLC
Fort Mill, South Carolina, 29707
American Health Network of IN LLC_Franklin
Franklin, Indiana, 46131
Mercy Gilbert Medical Center
Gilbert, Arizona, 85297
Macoupin Research Group
Gillespie, Illinois, 62033
Sun City Clinical Research
Glendale, Arizona, 85304
St. Vincent Hosp-Prevea Health
Green Bay, Wisconsin, 54303
American Health Network of Indiana, LLC_Greenfield
Greenfield, Indiana, 46140
Medication Mgmnt, LLC_Grnsboro
Greensboro, North Carolina, 27405
Carolina Nephrology Clinical Research
Greenville, South Carolina, 29605
Elevate Clinical Research
Gurnee, Illinois, 60031
Forefront Med Res Inst PLLC
Harlingen, Texas, 78550
Chicago Medical Research LLC
Hazel Crest, Illinois, 60429
Encore Medical Research LLC
Hollywood, Florida, 33024
PrimeCare Medical Group
Houston, Texas, 77024
JCCT- Juno NW Houston
Houston, Texas, 77040
Northwest Houston Cardiology, P.A.
Houston, Texas, 77070
Endocrine And Psychiatry Center
Houston, Texas, 77095
Rocky Mountain Diab&Osteo Ctr
Idaho Falls, Idaho, 83404-7596
University of Iowa Prev Inter Ctr
Iowa City, Iowa, 52772
Est Cst Inst for Rsrch,Jksnvil
Jacksonville, Florida, 32216
Jacksonville Ctr Clin Res
Jacksonville, Florida, 32216
NSC Research, Inc
Johns Creek, Georgia, 30024
Clinical Research Consultants
Kansas City, Missouri, 64111
The Alliance for Multispecialty Research LLC AMR
Kansas City, Missouri, 64114
Holston Medical Group
Kingsport, Tennessee, 37660
Clinical Research of Cent FL
Lakeland, Florida, 33805
First Valley Medical Group
Lancaster, California, 93534
Palm Research Center Inc-Vegas
Las Vegas, Nevada, 89128
AMR Clinical
Layton, Utah, 84041
The Research Group of Lexington LLC
Lexington, Kentucky, 40503
Torrance Clin Res Inst, Inc.
Lomita, California, 90717
DCOL Ctr for Clin Res
Longview, Texas, 75605
Pacific Clinical Studies
Los Alamitos, California, 90720
Academic Medical Research Institute
Los Angeles, California, 90022
Norton Clinical Research Group
Louisville, Kentucky, 40217
Texas Inst, Kdny & Endo Disor
Lufkin, Texas, 75904
GA Arrhythmia Cons & Rsch Inst
Macon, Georgia, 31201
K2 Medical Research
Maitland, Florida, 32751
Carient Heart and Vascular
Manassas, Virginia, 20109
Central New York Clinical Research CNYCR
Manlius, New York, 13104
Advanced Med Res Maumee
Maumee, Ohio, 43537
PRX Research
Mesquite, Texas, 75149
Life Spring Research Foundation LLC
Miami, Florida, 33130
Flourish Research - North Miami
Miami, Florida, 33138
Oceane 7 Medical & Research Center, Inc.
Miami, Florida, 33144
San Marcus Res Clin Miami Lakes
Miami Lakes, Florida, 33014
Mobile Heart Specialists
Mobile, Alabama, 36608
Cardiovascular Associates of America
Moline, Illinois, 61265
Chambliss Clinical Trials LLC
Montgomery, Alabama, 36106
Tekton Research Inc
Moore, Oklahoma, 73160
Carteret Medical Group
Morehead City, North Carolina, 28557
Ukpong Cardiology Service
Moultrie, Georgia, 31768
Accellacare US Inc._SC
Mt. Pleasant, South Carolina, 29464
American Health Network of IN LLC
Muncie, Indiana, 47304
Carolina Health Specialists
Myrtle Beach, South Carolina, 29572
Advance Rsch for Hlth Improvement_Naples
Naples, Florida, 34102
MidState Endocrine Associates
Nashville, Tennessee, 37203
Suncoast Clinical Research, Inc.
New Port Richey, Florida, 34652
Mid Hudson Med Res-New Windsor
New Windsor, New York, 12553
NYU School of Medicine
New York, New York, 10016
Capital Area Research LLC
Newport, Pennsylvania, 17074
TPMG Clinical Research
Newport News, Virginia, 23606
Sentara Health Research Center
Norfolk, Virginia, 23507
Lynn Institute of Norman
Norman, Oklahoma, 73072
Valley Clinical Trials, Inc.
Northridge, California, 91325
Genesis Orthopedics & Sports Medicine
Oak Brook, Illinois, 60523
Ocala Cardiovascular Research
Ocala, Florida, 34471
VA NEB - Western IA Health Stm
Omaha, Nebraska, 68105
University of Nebraska Medical Center
Omaha, Nebraska, 68198
Oviedo Medical Research, LLC
Oviedo, Florida, 32765
Cardio Partners Clin Res Inst
Palm Beach Gardens, Florida, 33410
Suncoast Clinical Research, Inc.
Palm Harbor, Florida, 34684
Desert Oasis Hlthcr Med Group
Palm Springs, California, 92262
Javara Inc. / Privia Medical Group Georgia LLC
Peachtree City, Georgia, 30269
Suncoast Research Associates LLC
Pembroke Pines, Florida, 33024
UnityPoint Health-Diabetes Care Center
Peoria, Illinois, 61603
Aria Endocrine Metabolic Assoc
Philadelphia, Pennsylvania, 19114
Seacoast Kidney & Htn Specialists
Portsmouth, New Hampshire, 03801
Dominion Medical Associates
Richmond, Virginia, 23219
Florida Kidney Physicians LLC
Riverview, Florida, 33578
Ascension Texas Cardiovascular
Round Rock, Texas, 78665
Clinical Trials Research_Sacramento
Sacramento, California, 95821
VA Medical Center_Salem
Salem, Virginia, 24153-6404
Clinical Advancement Center
San Antonio, Texas, 78212
Sun Research Institute
San Antonio, Texas, 78215
The IMA Group IMA Clinical Trials of America Inc. CTA
San Antonio, Texas, 78229
Univ Of Texas Hlth Science Cntr
San Antonio, Texas, 78229
VIP Trials
San Antonio, Texas, 78230
Paradigm Clinical Research
San Diego, California, 92108
N America Res Inst - San Dimas
San Dimas, California, 91773
Fomat Medical Research
Santa Maria, California, 93454
Cardiovascular Associates of America
Schaumburg, Illinois, 60173
Honor Health
Scottsdale, Arizona, 85258
Louisiana Heart Center_Slidell
Slidell, Louisiana, 70458
Providence Medical Research Center
Spokane, Washington, 99204
Headlands Research
Springfield, Missouri, 65807
Amicis Centers of Clinical Research
St Louis, Missouri, 63128
Piedmont Healthcare/Research
Statesville, North Carolina, 28625
Simcare Medical Research, LLC
Sugar Land, Texas, 77478
Houston Research Institute
Sugar Land, Texas, 77479
Clinical Research Institute of Arizona
Surprise, Arizona, 85374
Care Access
Tamarac, Florida, 33321
NYC Health + Hospitals/Lincoln
The Bronx, New York, 10451
Northwest Houston Clinical Research, PLLC
Tomball, Texas, 77375
Cotton O'Neil Diab & Endo Ctr
Topeka, Kansas, 66606
Arcturus Healthcare, PLC.
Troy, Michigan, 48098
Atlanta Heart Specialist
Tucker, Georgia, 30084
Crossroads Clinical Res- Texas
Victoria, Texas, 77901
Conquest Research
Vienna, Virginia, 22182
Cardiovascular Associates of America
Wellington, Florida, 33449-8095
Iowa Diab & Endo Res Center
West Des Moines, Iowa, 50266
Kalo Clinical Research
West Valley City, Utah, 84120
Great Lakes Medical Research
Westfield, New York, 14787
Selma Medical Associates
Winchester, Virginia, 22601-3834
Trinity Health Michigan Heart
Ypsilanti, Michigan, 48197
Poland60 sites
angiolog.pl PIOTR LISOWSKI
Bialystok, Podlaskie Voivodeship, 15-668
Kresmed Sp. z o. o.
Bialystok, 15-481
Uniwersytecki Szpital Kliniczny w Bialymstoku
Bialystok, 15-540
American Heart of Poland S.A.
Bielsko-Biala, 43-316
Centrum Medyczne "Hipokrates" s.c. Elżbieta i Grzegorz Grześk
Bydgoszcz, 85-092
American Heart of Poland S.A.
Chrzanów, 32-500
Synexus Polska Sp. z o.o. Oddzial w Czestochowie
Częstochowa, Silesian Voivodeship, 42-202
American Heart of Poland S.A.
Dąbrowa Górnicza, 41-300
Synexus Polska Sp. z o.o. Oddzial w Gdansku
Gdansk, 80-382
Pratia S.A.
Gdynia, 81-338
Uniwersyteckie Centrum Medycyny Morskiej i Tropikalnej
Gdynia, 81-519
Synexus Gdynia
Gdynia, 81-537
Szpital Miejski w Gliwicach Sp. z o.o.
Gliwice, 44-100
Specjalistyczny Gabinet Diabetologiczny Radoslaw Rumianowski
Gorzów Wielkopolski, Lubusz Voivodeship, 66-400
Ameds Clinical Research Sp. z o.o.
Grodzisk Mazowiecki, Masovian Voivodeship, 05-825
Clinical Medical Research Sp. z o.o.
Katowice, 40-156
Care Clinic Sp. z o. o.
Katowice, 40-568
Gyncentrum Sp. z o. o.
Katowice, 40-600
Vita Longa Sp. z o. o.
Katowice, 40-748
American Heart of Poland S.A.
Kędzierzyn-Koźle, 47-200
SCANMED Spółka Akcyjna
Kluczbork, 46-200
Specjalistyczna Praktyka Lekarska Ewa Mirek Bryniarska
Krakow, 30-082
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w Krakowie
Krakow, 30-688
SCANMED Spółka Akcyjna
Krakow, 30-693
Szpital Specjalistyczny im. J.Dietla w Krakowie
Krakow, 31-121
Centrum Medyczne Zdrowa J. Trebacz W. Zajdel Sp. j.
Krakow, 31-216
Med. Cent. Diabet. Endo. Metabol. DIAB-ENDO-MET
Krakow, 31-261
UniCardia & UniMedica & UniEstetica
Krakow, 31-271
Intercard Spolka z ograniczona odpowiedzialnoscia
Krosno, 38-400
Centrum Opieki Zdrowotnej Orkan-Med Stec - Michalska Sp. j.
Ksawerów, 95-054
Synexus Łódź
Lodz, 90-127
Uniwersytecki Szpital Kliniczny nr 2 Uniwersytetu Medycznego w Lodzi
Lodz, 90-549
Wojewódzki Specjalistyczny Szpital im.Wl. Bieganskiego,
Lodz, 91-347
Miedziowe Centrum Zdrowia s.a.
Lubin, 59301
Drelich Grzegorz Centrum Kardiologiczne KARDIO-MED
Lublin, Lublin Voivodeship, 20-518
Zana-Med Medical Group Sp. z o.o.
Lublin, Lublin Voivodeship, 20-601
Clinical Best Solutions Sp. z o.o., Sp. k
Lublin, 20-011
1 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ
Lublin, 20-049
NZOZ Twoja Przychodnia Sp. z o.o.
Lublin, 20-857
Kresmed Sp. z o. o.
Ostrów Mazowiecka, Masovian Voivodeship, 07-300
Jantar Sp. z o.o.
Ostrów Wielkopolski, 63-400
Formed 2 Sp. z o.o.
Oświęcim, 32-600
Provita Centrum Medyczne Sp. z o.o.
Piotrkow Trybunalski, 97-300
Synexus Polska Sp. z o.o. Oddział w Poznaniu
Poznan, 60-702
Uniwersytecki Szpital Kliniczny W Poznaniu
Poznan, 61-848
SCANMED Spółka Akcyjna
Racibórz, 47-400
Samodzielny Publiczny Zaklad Opieki Zdrowotnej Ministerstwa Spraw Wewnetrznych i Administracji w Rzeszowie
Rzeszów, 35-111
Velocity Nova Sp. z o.o.
Skierniewice, Łódź Voivodeship, 96-100
Gabinety od serca Bębenek,Mazurek,Metzgier-Gumiela sp. j.
Torun, 87-100
Narodowy Instytut Kardiologii Stefana Kardynala Wyszynskiego Panstwowy Instytut Badawczy
Warsaw, Masovian Voivodeship, 04-635
Gyncentrum Sp. z o. o.
Warsaw, 00-124
NBR Polska Tomasz Klodawski
Warsaw, 00-710
BalsamMedica Sp. z o.o.
Warsaw, 01-249
Centrum medyczne Justmed Sp. z o.o.
Warsaw, 01-696
Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. prof. dr hab. med. Eleonory Reicher
Warsaw, 02-637
ETG Warszawa Sp. z o.o.
Warsaw, 02-677
Narodowy Instytut Kardiologii Stefana Kardynala Wyszynskiego Panstwowy Instytut Badawczy
Warsaw, 04-628
Etg Zamosc Sp. z o.o.
Zamość, 22-400
NZOZ Centrum Medyczne SERAFIN-MED Halina Serafin
Żarów, 58-130
American Heart of Poland S.A.
Zgierz, 95-100
India56 sites
SN Medical College
Agra, Uttar Pradesh, 282003
EPIC Hospital
Ahmedabad, Gujarat, 380054
Marengo CIMS Hospital
Ahmedabad, Gujarat, 380060
Jawaharlal Nehru Medical College and Hospital
Aligarh, Uttar Pradesh, 202002
Fortis Escorts Hospital, Amritsar
Amritsar, Punjab, 143001
KLES Dr. Prabhakar Kore Hospital & Medical Research Centre
Belagavi, Karnataka, 590010
All India Institute of Medical Sciences (AIIMS), Bhubaneswar
Bhubaneswar, Odisha, 751019
Kamalnayan Bajaj Hospital
Chhatrapati Sambhajinagar, Maharashtra, 431010
Shri Mahant Indiresh Hospital
Dehradun, Uttarakhand, 248001
Amrita Institute of Medical Sciences, Faridabad
Faridabad, Haryana, 121002
Nirmal Hospital Pvt. Ltd.
Gujarat, 395002
Endolife Specialty Hospitals
Guntur, Andhra Pradesh, 522001
Lalitha PVS Institute of Medical Sciences
Guntur, Andhra Pradesh, 522001
Fortis Memorial Research Institute _Gurgaon
Gurugram, Haryana, 122003
Osmania General Hospital_Hyderabad
Hyderabad, Telangana, 500012
ESIC Medical College and Hospital, Hyderabad
Hyderabad, Telangana, 500038
Malla Reddy Narayana Multispeciality Hospital
Hyderabad, Telangana, 500055
Mohak Hi-Tech Speciality Hospital
Indore, Madhya Pradesh, 453555
SMS Hospital
Jaipur, 302004
Eternal Heart Care Centre
Jaipur, 302017
Lps Institute of Cardiology, Gsvm Medical College
Kanpur, Uttar Pradesh, 208002
Krishna Vishwa Vidyapeeth
Karad, Maharashtra, 415539
Lisie Hospital
Kochi, Kerala, 682018
Aster Medcity
Kochi, Kerala, 682027
Excel Endocrine Centre
Kolhāpur, Maharashtra, 416008
IPGME&R and SSKM Hospital
Kolkata, West Bengal, 700020
Apollo Multispeciality Hospital, Kolkata
Kolkata, West Bengal, 700054
Government Medical College, Kozhikode
Kozhikode, Kerala, 673008
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Lucknow, Uttar Pradesh, 226014
Kasturba Medical College and Hospital, Manipal
Manipal, Karnataka, 576014
Lala Lajpat Rai Memorial Medical College
Meerut, Uttar Pradesh, 250004
Fortis Hospital, Mohali
Mohali, Punjab, 160062
Seth GS Medical College & KEM Hospital
Mumbai, Maharashtra, 400012
Mysore Medical College and Research Institute
Mysore, Karnataka, 570001
Arneja Heart & Multispeciality Hospital
Nagpur, Maharashtra, 440010
Nkpsims & Rc , Lata Mangeshkar Hospital , Hingna
Nagpur, Maharashtra, 440019
All India Institute of Medical Sciences (AIIMS), Nagpur
Nagpur, Maharashtra, 441108
Vijan Hospital & Research Centre
Nashik, Maharashtra, 422005
G B Pant Institute of Postgraduate Medical Education and Research
New Delhi, National Capital Territory of Delhi, 110002
Vardhaman Mahavir Medical College & Safdarjung Hospital
New Delhi, National Capital Territory of Delhi, 110029
All India Institute of Medical Sciences (AIIMS)
New Delhi, National Capital Territory of Delhi, 110608
ABVIMS,Dr.RML Hospital
New Delhi, 110001
Sir Ganga Ram Hospital
New Delhi, 110060
NIZAM'S Institute of Medical Sciences
Panjagutta, Hyderabad, 500082
Moti Lal Nehru Medical College
Prayagraj, Uttar Pradesh, 211002
Ace Hospital and Research Centre
Pune, Maharashtra, 411004
Deenanath Mangeshkar Hospital & Research Centre
Pune, Maharashtra, 411004
SMC Heart Institute and IVF Research Centre
Raipur, Chhattisgarh, 492007
BLK-Max Super Speciality Hospital
Rajinder Nagar, New Delhi, 110005
SIDS Hospital and Research Centre
Surat, Gujarat, 395002
SSG Hospital, Baroda
Vadodara, Gujarat, 390001
GMERS Medical college and hospital
Vadodara, 390021
Rhythm Heart Institute - A unit of Synergy Lifecare Pvt
Vadodara, 390022
Galaxy Life Care Services Pvt. Ltd
Varanasi, Uttar Pradesh, 221010
Christian Medical College Hospital, Vellore
Vellore, Tamil Nadu, 632004
Government Siddhartha Medical College & Government General Hospital, Vijayawada
Vijayawada, Andhra Pradesh, 520008
Bulgaria32 sites
Medical center Medconsult Burgas OOD
Burgas, 8000
MHAT Heart and Brain EAD - Burgas, Cardiology
Burgas, 8000
Medical Center New Polyclinic Gabrovo OOD
Gabrovo, 5312
MC I - Harmanli EOOD
Harmanli, 6450
MC Rodopimed EOOD
Kardzhali, 6600
Medical centre Zdrave 1 OOD
Kozloduy, 3320
Medical Centre Hera - Kyustendil EOOD
Kyustendil, 2500
Medical center Medconsult Pleven OOD
Pleven, 5800
AIPSMPC - Dr. Trendafil Tonkov EOOD
Plovdiv, 4000
DCC Sveti Georgi EOOD
Plovdiv, 4002
UMHAT Pulmed OOD - Plovdiv, Department of Cardiology
Plovdiv, 4002
UMHAT Sveti Georgi EAD, Plovdiv, Clinic of Cardiology
Plovdiv, 4002
MHAT Sveta Karidad EAD
Plovdiv, 4004
MC Kardiomaks EOOD
Plovdiv, 4019
AIPSOMCC - Dr. Gonovska EOOD
Plovdiv, 4023
UMHAT Medica - Ruse OOD
Rousse, 7013
MHAT Southwest Hospital OOD, Cardiology Department
Sandanski, 2800
Medical Center Hipokrena EOOD
Sevlievo, 5400
Medical Centre Cardiomed 2020 EOOD
Sliven, 8801
MHAT Dr. Bratan Shukerov
Smolyan, 4700
NMTH Tsar Boris III
Sofia, 1233
MHAT Lozenets EAD, Clinic of Cardiology
Sofia, 1407
MC Gatevi EOOD
Sofia, 1408
Acibadem City Clinic UMHAT EOOD, Cardiology
Sofia, 1415
UMHAT Aleksandrovska EAD, Clinic of Cardiology
Sofia, 1431
USHATE Acad. Ivan Penchev EAD, First Clinic of Endocrinology
Sofia, 1431
Medical center ISUL - Tsaritsa Yoanna EOOD
Sofia, 1527
DCC XX - Sofia EOOD, Cardiology
Sofia, 1618
SHATC - Cardiolife OOD - Varna
Varna, 9009
UMHAT Sveta Marina EAD, Clinic of Internal Diseases
Varna, 9010
UMHAT Sveta Marina EAD, Second Clinic of Cardiology
Varna, 9010
MDHAT Dr. Stephen Cherkezov AD
Veliko Tarnovo, 5000
Czechia32 sites
MEDICUS SERVICES s.r.o.
Brandýs nad Labem, 250 01
Univmed s.r.o.
Brno, 602 00
CC LIFE s.r.o.
Brno, 602 0
Kardiologie Stříbrný s.r.o.
Brno, 60200
Top Moravia Health s.r.o.
Brno, 615 00
Edumed s.r.o.
Broumov, 550 01
Nemocnice České Budějovice a.s.
České Budějovice, 370 01
Kardio LPV ambulance s.r.o.
České Budějovice, 37011
Kardio Chlumec s.r.o.
Chlumec nad Cidlinou, 503 51
MUDr. Ján Hubač, s.r.o.
Chrudim, 537 01
CTC Hodonin s.r.o.
Hodonín, 695 01
DIEN SERVIS s.r.o.
Humpolec, 39601
KardioBušák s.r.o.
Louny, 44001
InterKardioML s.r.o.
Mariánské Lázně, 353 01
PreventaMed s.r.o.
Olomouc, 779 00
Skinkick s.r.o.
Prague, 11000
Všeobecná fakultní nemocnice v Praze
Prague, 120 00
Fakultní Thomayerova nemocnice
Prague, 14000
Kardiologické centrum MUDr. Janky Škrobákové s.r.o.
Prague, 150 00
Fakultni Nemocnice Motol A Homolka
Prague, 150 06
Corintez s.r.o.
Prague, 15800
ResTrial s.r.o.
Prague, 18100
KARDIOINTERN CHYTIL s.r.o.
Přerov, 750 02
Kardio Václavík s.r.o.
Přerov, 75002
MUDr. Jarmila Otrubová
Prostějov, 796 01
Nová kardiologie s.r.o.
Říčany, 25101
Nemocnice Slany
Slaný, 274 01
Internist Care s.r.o.
Smiřice, 503 03
Nemocnice AGEL Třinec-Podlesí a.s.
Třinec, 739 61
Kardiologická ambulance MUDr. Ferkl s.r.o.
Trutnov, 541 01
Clinical Trials Service s.r.o.
Uherské Hradiště, 68601
Cardio Research s.r.o.
Zlín, 76001
Italy32 sites
Ente Ecclesiastico Ospedale Generale Regionale Miulli - Cardiologia e UTIC
Acquaviva delle Fonti, 70021
AOU Consorziale Policlinico Bari - U.O.C. Endocrinologia Universitaria
Bari, Apulia, 70124
ASST Papa Giovanni XXIII - Cardiologia 1
Bergamo, Lombardy, 24127
Unità Operativa Semplice Valorizzazione della Ricerca (UOSVA)
Castellana Grotte (BA), Apulia, 70013
AOU "Renato Dulbecco" - Università Magna Graecia di Catanzaro
Catanzaro, Calabria, 88100
Università degli studi G. D'Annunzio di Chieti - CAST - Centro Ricera Clinica (CRC)
Chieti, Abruzzo, 66100
Ospedale Santissima Annunziata - Dipartimento Cardio Toraco Vascolare
Cosenza, Calabria, 87100
Arcispedale Sant'Anna (Cona) - Dipartimento Interaziendale Cardio-toraco-vascolare
Ferrara, Emilia-Romagna, 44124
Azienda Ospedaliero Universitaria Careggi - SOD Malattie Aterotrombotiche
Florence, Tuscany, 50134
Ospedale Misericordia Grosseto - UOC Cardiologia
Grosseto, Tuscany, 58100
ICOT Istituto Marco Pasquali - UOC Cardiologia
Latina, Lazio, 04100
Ospedale Santa Maria Goretti - UOD Diabetologia
Latina, LT, 04100
AUSL Toscana Nord Ovest - Cittadella della Salute Campo di Marte - Diabetologia Lucca e Valle del Serchio
Lucca, Tuscany, 55100
ULSS3 Serenissima - Ospedale di Mestre
Mestre, Veneto, 30174
Centro Cardiologico Monzino - Unità di Diabetologia, Endocrinologia e Malattie Metaboliche
Milan, Lombardy, 20138
Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico
Milan, 20122
ASST Fatebenefratelli Ospedale Luigi Sacco Medicina Interna
Milan, 20157
AOU Federico II Di Napoli - DAI Endocr. Diab. Andro. e Nutr. - UOC Endocrinologia Diabetologia e Andrologia
Naples, Campania, 80131
Azienda Ospedaliera Dei Colli - Monaldi - UOC Cardiologia
Naples, Campania, 80131
IRCCS Ospedale Sacro Cuore Don Calabria - U.O. Cardiologia
Negrar (VR), Veneto, 37024
Azienda Ospedaliera Universitaria San Luigi Gonzaga - S.C.D.U. Cardiologia
Orbassano, 10043
Azienda Ospedaliera di Padova - UOC Cardiologia
Padova, Veneto, 35128
Azienda Ospedaliera di Padova
Padova, Veneto, 35128
Ospedale Infermi - UOC Cardiologia
Rimini, Emilia-Romagna, 47923
AOU Policlinico Umberto I - Dip. Medicina Interna, Scienze endocrino-metaboliche e malattie infettive
Rome, Lazio, 00161
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Dipartimento di Scienze Cardiovascolari
Rome, Lazio, 00168
Azienda Ospedaliera San Giovanni Addolorata - Dipartimento Cardio Toraco Vascolare
Rome, Lazio, 00184
Azienda Ospedaliero - Universitaria Sant'Andrea - UOC Cardiologia
Rome, Lazio, 00189
AOU San Giovanni Di Dio E Ruggi d'Aragona - Cardiologia - Torre Cardiologica
Salerno, Campania, 84131
IRCCS Multimedica Sesto San Giovanni - Cardiologia
Sesto San Giovanni, Lombardy, 20099
Azienda Ospedaliero Universitaria Senese - Endocrinologia
Siena, Tuscany, 53100
Azienda Sanitaria Ospedaliera Ordine Mauriziano SC Cardiologia
Torino, To, 10128
Argentina29 sites
Kynet Recoleta
Buenos Aires, C1119ACU
CardiaMet
Buenos Aires, C1129ABO
Glenny Corp. S.A
CABA, C1430CKE
Centro de Investigaciones Metabólicas
Capital Federal, Buenos Aires, C1056ABI
IMOBA
City of Buenos Aires, C1056ABH
CICEMO- Consultorio (Av Directorio)
Ciudad Autónoma de Buenos Aires, Buenos Aires, C1424CIQ
Centro Médico Arsema
Ciudad Autónoma de Buenos Aires, Buenos Aires, C1427
Clínica Privada Velez Sarsfield
Córdoba, 5000
Instituto de Investigaciones Clínicas Córdoba
Córdoba, 5000
Sanatorio Duarte Quiros
Córdoba, X5002AOQ
Instituto Médico DAMIC
Córdoba, X5003DCE
Centro Médico Privado San Vicente Diabetes
Córdoba, X5006IKK
Instituto de Cardiología de Corrientes
Corrientes, W3400AMZ
Hospital Interdistrital Evita
Formosa, P3600KGC
CIPADI
Godoy Cruz, M5501ARP
Hospital Español de Mendoza
Godoy Cruz, Mendoza, Mendoza Province, 5501
Instituto Médico Platense
La Plata, Buenos Aires, B1900AVG
Instituto de Investigaciones Clinicas Mar Del Plata
Mar del Plata, Buenos Aires, B7600FZN
Centro de Investigacion de Instituto Medico - CIIM
Río Cuarto, Córdoba Province, X5800
Instituto Especialidades de la Salud Rosario
Rosario, Santa Fe Province, 2000
Instituto de Investigaciones Clínicas Rosario
Rosario, Santa Fe Province, S2000CUD
Fundacion Estudios Clinicos
Rosario, Santa Fe Province, S2000DEJ
Instituto Medico Catamarca
Rosario, Santa Fe Province, S2000
Investigaciones Clinicas Salta - ICSAL
Salta, A4400
Corporación Médica San Martin
San Martín, Buenos Aires, B1650
Centro de Investigación C.I.C.E 9 de Julio - Sanatorio 9 de Julio
San Miguel de Tucumán, Tucumán Province, T4000DPX
Instituto de Investigaciones Clinicas San Nicolás
San Nicolás, B2900
Centro de investigaciones Clinicas del Litoral
Santa Fe, 3000
Instituto de Investigaciones Clinicas Zarate
Zárate, Buenos Aires, B2800
Canada27 sites
Heart Health Institute Research, Inc.
Ajax, L1Z 0B1
CIUSS Hopit de Chicoutimi
Chicoutimi, Quebec, G7H 5H6
Edmonton Cardiology Consultants
Edmonton, Alberta, T5H 2V1
Mazankowski Alberta Heart Institute
Edmonton, Alberta, T6G 2B7
Diex Recherche Joliette
Joliette, Quebec, J6E 6A9
Western University Centre for Studies in Fam Med
London, Ontario, N6G 2M1
Centricity Research Mirabel
Mirabel, Quebec, J7J 2K8
ClinSurge Research - KMH Mississauga
Mississauga, Ontario, L5K 2L3
G.A. Research Associates Ltd.
Moncton, New Brunswick, E1G 1A7
CHUM-Hosp de Univ Montreal
Montreal, Quebec, H2X 0C1
Montreal Heart Institute
Montreal, Quebec, QC H1T 1C8
North York Diagn & Cardiac Ctr
North York, Ontario, M6B 3H7
Kawartha Cardiology Clinical Trials
Peterborough, Ontario, K9J 0B2
CHU de Quebec-Universite-Laval,HDQ
Québec, G1R 2J6
Diex Recherche Trois-Rivieres
Québec, G1V 0A6
Institut universitaire de cardiologie
Québec, G1V 4G5
CARe Clinic Ltd.
Red Deer, Alberta, T4P 1K4
Clinique de pneumologie et du sommeil de Lanaudiere
Saint-Charles-Borromée, Quebec, J6E 2B4
Diex Recherche Sherbrooke
Sherbrooke, Quebec, J1L 0H8
CIUSSS de l'E CHUS_Sherbrooke
Sherbrooke, J1H 5N4
Centre de Médecine Métabolique de Lanaudière
Terrebonne, Quebec, J6X 4P7
Sunnybrook Health Sciences Centre
Toronto, Ontario, M4N 3M5
St. Michael's - Division of Cardiology
Toronto, Ontario, M5B 1W8
Diabetes Heart Research Centre
Toronto, Ontario, M6G 1M2
Colchester Research Group
Truro, Nova Scotia, B2N 1L2
Univ. of British Columbia, Division of Cardiology
Vancouver, British Columbia, V5Z1M9
ARC Biosystems Inc
Vancouver, British Columbia, V6H 2Z2
Spain27 sites
CHUA Coruña_Hosp.Abente y Lago_Medicina Interna
A Coruña, 15006
Hospital del Mar
Barcelona, 08003
H.Quirónsalud Barcelona_Medicina Interna
Barcelona, 08023
Hospital Vall d´Hebrón_Cardiología
Barcelona, 08035
H.Madrid Montepríncipe_CIEC
Boadilla del Monte, 28660
Hospital San Pedro de Álcantara_Cardiología
Cáceres, 10003
Hospital Reina Sofia
Córdoba, 14004
Hospital Univ. Virgen de la Arrixaca
El Palmar, 30120
Hosp. Univ. Virgen de las Nieves_Cardiología
Granada, 18014
H.Universitario Juan Ramón Jiménez_Hemodinámica
Huelva, 21005
Arnau de Villanova_C.Externas Endocrinología
Lleida, 25198
Hospital Univ. La Luz_Cardiología
Madrid, 28003
Hospital Infanta Leonor_Medicina Interna
Madrid, 28031
F. Jiménez Díaz_Nefrología
Madrid, 28040
Hospital Clínico San Carlos
Madrid, 28040
Hospital 12 de Octubre_Medicina Interna
Madrid, 28041
Hospital Universitario La Paz
Madrid, 28046
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, 28222
H. Clinico Univ. Virgen de la Victoria
Málaga, 29010
Hospital Costa del Sol_Cardiología
Marbella, Málaga, 29603
Hospital Univ. Central de Asturias_Endocrinología
Oviedo, 33011
Hospital de Navarra_Medicina Interna
Pamplona, 31008
Hospital Universitario Marqués de Valdecilla
Santander, 39008
Hospital Universitario Virgen del Rocío
Seville, 41013
Hospital General de Valencia_Cardiología
Valencia, 46014
Hospital Universitario Rio Hortega_Medicina Interna
Valladolid, 47012
Hospital Alvaro Cunqueiro de Vigo
Vigo, 36312
Turkey (Türkiye)27 sites
Adana Şehir Eğitim ve Araştırma Hastanesi
Adana, 01060
Sakarya Egitim ve Arastirma Hastanesi-Nefroloji
Adapazarı/Turkiye, 54100
Afyonkarahisar Sağlık Bilimleri Üniversitesi Sağlık Uygulama Ve Araştırma Merkezi- Kardiyoloji
Afyonkarahisar, 03200
Hacettepe Üniversitesi Hastanesi- Kardiyoloji
Ankara, 06230
Gazi Üniversitesi Hastanesi- Nefroloji
Ankara, 06500
Ankara Bilkent Şehir Hastanesi-Kardiyoloji
Ankara, 06800
Çanakkale Onsekiz Mart Üniversitesi Sağlık Araştırma ve Uygulama Hastanesi- Kardiyoloji
Çanakkale/Türkiye, 17020
Eskişehir Osmangazi Üniversitesi Hastanesi- Kardiyoloji
Eskişehir, 26040
Eskişehir Şehir Hastanesi- Kardiyoloji
Eskişehir, 26080
İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Hastanesi- Prof. Dr. Murat Dilmener Yerleşkesi
Istanbul, Bakirkoy, 34153
İstanbul Üniversitesi-Cerrahpaşa Kardiyoloji Enstitüsü
Istanbul, 34098
Mehmet Akif Ersoy Göğüs Kalp ve Damar Cerrahisi EAH
Istanbul, 34303
Dr. Siyami Ersek Göğüs Kalp ve Damar Cerrahisi EAH- Kardiyoloji
Istanbul, 34668
Koşuyolu Yüksek İhtisas EAH- Kardiyoloji
Istanbul, 34718
Erciyes Üniversitesi Hastanesi - Nefroloji
Kayseri, Melikgazi, 38039
Erciyes Üniversitesi Hastanesi- Kardiyoloji
Kayseri, 38039
Kayseri Şehir Hastanesi-Kardiyoloji
Kayseri, 38080
Kocaeli Üniversitesi Araştıma ve Uygulama Hastanesi - Nefroloji
Kocaeli, 41380
Kocaeli Üniversitesi Hastanesi- Kardiyoloji
Kocaeli, 41380
Kütahya Şehir Hastanesi-Kardiyoloji
Kütahya, 43100
İnönü Üniversitesi Turgut Özal Tıp Merkezi - Kardiyoloji
Malatya, 44280
Mersin Şehir Eğitim Araştırma Hastanesi- Kardiyoloji
Mersin, 33240
Mersin Üniversitesi Hastanesi- Kardiyoloji
Mersin, 33343
Antalya Eğitim ve Araştırma Hastanesi- Kardiyoloji
Muratpasa/ Antalya, 07100
Ondokuz Mayıs Üniversitesi Hastanesi- Kardiyoloji
Samsun, 55200
Atatürk Üniversitesi Araştırma Hastanesi-Kardiyoloji
Yakutiye / Erzurum, 25040
Adana Şehir Eğitim ve Araştırma Hastanesi-Dahiliye
Yuregir/Adana, 01060
Greece26 sites
General Hospital of Athens "Elpis" - Cardiology Department
Ampelokipoi/Athens, 11522
Naval Hospital of Athens - Clinic of Cardiology
Athens, 115 21
Laiko General Hospital Of Athens - 1st department of Internal Medicine
Athens, 115 27
'G. Gennimatas' General Hospital of Athens - Cardiology Department
Athens, 11527
Hippokration Hospital
Athens, 11527
Thoracic General Hospital Of Athens I Sotiria - Cardiology Department
Athens, 11527
General Hospital Of Athens Alexandra - Clinical Therapeutics
Athens, 11528
"Hygeia" General Hospital of Athens
Athens, 15123
Metropolitan General Hospital Healthcare Facilities Operation And Management Single Member S.A. - Cardiology Clinic
Athens, 15562
University General Hospital of Athens "Attiko"
Chaidari, Athens, GR-12462
General Hospital Of Chania Agios Georgios - Cardiology Department
Chania, 73300
General Hospital of Chios "Skilitsio" - Cardiology Clinic
Chios, 82100
General Hospital Of Thessaloniki Papageorgiou - 3rd Department of Internal Medicine
Efkarpia, 564 29
General Hospital Of Eleusina Thriasio - Cardiology Clinic
Eleusina, 19018
General Hospital of Athens "LAIKO"
Goudi/Athens, 115 27
General Hospital of Ioannina G. Hatzikosta - Cardiology Clinic
Ioannina, 45001
Kat Attica General Hospital - Cardiology Department
Kifissia, 14561
Eftixios Patsidis Medical S.A - Cardiology Department
Larissa, 41335
Athens Medical Center S.A. (Iatriko Athinon) - Diabetes and Obesity Unit
Marousi, 15125
General Hospital Of Patras Agios Andreas - Cardiology Department
Pátrai, 265 00
Athens Medical Center S.A. (Iatriko Peristeriou) - Diabetes, obesity and cardiometabolic diseases department
Peristeri, 121 31
University General Hospital Of Thessaloniki Ahepa - Α' Internal Medicine Clinic
Thessaloniki, 546 36
"AHEPA" University General Hospital of Thessaloniki
Thessaloniki, 54636
AHEPA General University Hospital
Thessaloniki, 54636
'Ippokrateio' General Hospital of Thessaloniki
Thessaloniki, 54642
Geniko Nosokomeio Thessalonikis George Papanikolaou - Internal Medicine and Diabetes Department
Thessaloniki, 570 10
Japan25 sites
Akaicho Clinic_Internal medicine
Chiba-shi, Chiba, 260-0804
SAKAKIBARA HEART INSTITUTE_Cardiology
Fuchu-shi,Tokyo, 183-0003
St.Mary's Hospital_Cardiology
Fukuoka, 830-8543
Hyogo Prefectural HarimaHimeji General Medical Center_Cardiology
Himeji-shi, Hyogo, 670-8560
Nishinomiya Watanabe Cardiovascular Cerebral Center_Cardiovascular Medicine
Hyōgo, 662-0911
Higashi Takarazuka Satoh Hospital_Cardiology
Hyōgo, 665-0873
Yokohama City University Medical Center_Cardiovascular Center
Kanagawa, 232-0024
Kumamoto University Hospital, Cardiovascular Medicine
Kumamoto-shi, Kumamoto, 860-8556
Japan Red Cross Kyoto Daiichi Hospital_Cardiology
Kyoto-shi, Kyoto, 605-0981
Aizawa Hospital_Cardiovascular Medicine
Matsumoto-shi, Nagano, 390-8510
Ehime Prefectural Central Hospital_Cardiology
Matsuyama-shi, Ehime, 790-0024
Iwate Prefectural Central Hospital_Cardiology
Morioka-shi, Iwate, 020-0066
Kita-Harima Medical Center_Cardiology
Ono-shi Hyogo, 675-1392
Osaka Saiseikai Nakatsu Hospital_Cardiovascular Medicine
Osaka-shi Osaka, 530-0012
Kinugawa Cardiology Clinic_Internal medicine, Cardiology
Osaka-shi, Osaka, 532-0025
Ota Memorial Hospital_Cardiology
Ota-shi, Gunma, 373-8585
NewHeart Watanabe Institute_Cardiology
Suginami-ku, Tokyo, 168-0065
Kagawa Prefectural Central Hospital_Cardiovascular Medicine
Takamatsu-shi, Kagawa, 760-8557
Saino Clinic_Internal Medicine
Tokorozawa-shi,Saitama, 359-1141
Tokyo-Eki Center-building Clinic_Internal Medicine
Tokyo, 103-0027
Fukuwa Clinic_Internal Medicine
Tokyo, 104-0031
Minamino Cardiovascular Hospital_Cardiovascular medicine
Tokyo, 192-0918
Sekino Hospital_Internal Medicine
Toshima-ku,Tokyo, 171-0014
Japanese Red Cross Wakayama Medical Center_Department of Cardiology
Wakayama-shi, Wakayama, 640-8558
Yao Tokushukai General Hospital_Internal medicine
Yao City, Osaka, 581-0011
China24 sites
Peking University First Hospital-Cardiology
Beijing, Beijing Municipality, 100034
Chinese Academy of Medical Sciences Fuwai Hospital-Cardiology
Beijing, Beijing Municipality, 100037
Chinese Academy of Medical Sciences Fuwai Hospital-Endocrinology
Beijing, Beijing Municipality, 100037
Peking University People's Hospital-Endocrinology
Beijing, Beijing Municipality, 100044
China-Japan Union Hospital of Jilin University-Cardiology
Changchun, Jilin, 130033
The First Bethune hospital of Jilin University-Endocrinology
Changchun, Jilin, 130061
Changsha Central Hospital-Cardiovascular Medicine
Changsha, Hunan, 410004
Changzhou No.2 People's Hospital-Cardiology
Changzhou, Jiangsu, 213003
The First People's Hospital of Changzhou-Cardiology
Changzhou, Jiangsu, 213004
The Second Affiliated Hospital of Chongqing Medical University-Cardiology
Chongqing, Chongqing Municipality, 402260
Guangdong Provincial People's Hospital-Cardiovascular
Guangzhou, Guangdong, 510080
Jinan Central Hospital-Cardiovascular
Jinan, Shandong, 250013
Jinan Central Hospital-General Medicine
Jinan, Shandong, 250013
The Affiliated Hospital of Jining Medical University-Cardiology
Jining, Shandong, 272029
The First Affiliated Hospital of Henan University of Science and Technology-Endocrinology
Luoyang, Henan, 471003
The Second Affiliated Hospital of Nanjing Medical University-Endocrinology
Nanjing, Jiangsu, 210011
The People's Hospital of Liaoning Province-Cardiology
Shenyang, Liaoning, 110016
Hebei General Hospital-Cardiology
Shijiazhuang, Hebei, 050051
The First Affiliated Hospital of Soochow University-Cardiology
Suzhou, Jiangsu, 215006
Tianjin Union Medical Center-Cardiology
Tianjin, Tianjin Municipality, 3000000
Tianjin Medical University General Hospital-Endocrinology
Tianjin, Tianjin Municipality, 300052
TEDA International Cardiovascular Hospital-Cardiovascular
Tianjin, Tianjin Municipality, 300457
Shaanxi Provincial People's Hospital-Cardiology
Xi'an, Shaanxi, 710068
The Affiliated Hospital of Jiangsu University-Endocrinology
Zhenjiang, Jiangsu, 212001
Germany24 sites
Uniklinik Aachen - Med. Klinik I
Aachen, 52074
Herz- und Diabeteszentrum NRW - Bad Oeynhausen
Bad Oeynhausen, 32545
Charité - Campus Virchow-Klinikum - Kardiologie, Angiologie und Intensivmedizin (CRU)
Berlin, 13353
Praxis Dr.med. Frank Menzel
Dessau, 06846
Cardiologicum Dresden und Pirna - MVZ "Am Felsenkeller" (Dresden)
Dresden, 01277
Zentrum für klinische Studien Südbrandenburg GmbH
Elsterwerda, 04910
Medizentrum Essen-Borbeck
Essen, 45355
MVZ CCB Frankfurt und Main-Taunus GbR
Frankfurt, 60389
Uniklinik FFM - Nephrologie
Frankfurt A. M., 60596
Universitätsklinikum Freiburg - Medical Center
Freiburg im Breisgau, 79106
Wendisch - Dahl Hamburg - DZHW
Hamburg, 22607
Siteworks GmbH Hannover
Hanover, 30449
Siteworks GmbH Karlsruhe
Karlsruhe, 76137
Zentrum für Klinische Forschung Köln-Dünnwald
Köln-Dünnwald, 51069
Universitätsklinikum Leipzig - Klinik und Poliklinik für Kardiologie
Leipzig, 04103
Uniklinik Schleswig-Holstein - Medizinischen Klinik I am Campus Lübeck
Lübeck, 23538
Cardiopraxis Mainz und Ingelheim
Mainz, 55122
Praxis Reichelsheim
Reichelsheim, 61203
Zentrum für klinische Studien Alexander Segner
Saint Ingbert-Oberwürzbach, 66386
Robert Bosch Gesellschaft für medizinische Forschung mbH (RBMF)
Stuttgart, 70376
Kliniken Südostbayern AG - Klinikum Traunstein
Traunstein, 83278
Praxis für Prävention und Therapie, Drs Jacob
Villingen-Schwenningen, 78048
Gemeinschaftspraxis Dres. Großkopf
Wallerfing, 94574
Universitatsklinikum Würzburg - Zentrum für Herzinsuffizienz
Würzburg, 97078
Malaysia24 sites
Hospital Sultanah Bahiyah
Alor Star, Kedah, 05460
Hospital Ampang
Ampang, Selangor, 68000
Hospital Canselor Tuanku Muhriz UKM
Cheras, Kuala Lumpur, 56000
Gleneagles Hospital Penang
George Town, Pulau Pinang, 10050
Hospital Raja Permaisuri Bainun Ipoh
Ipoh, Perak, 30450
Hospital Serdang
Kajang, Selangor, 43000
Hospital Raja Perempuan Zainab II
Kota Bharu, Kelantan, 15586
Hospital Universiti Sains Malaysia
Kota Bharu, Kelantan, 16150
Sarawak Heart Centre
Kota Samarahan, Sarawak, 94300
National Heart Institute
Kuala Lumpur, 50400
Hospital Tuanku Ampuan Najihah
Kuala Pilah, 72000
Hospital Tengku Ampuan Afzan
Kuantan, Pahang, 25100
University Malaya Medical Centre
Lembah Pantai, Kuala Lumpur, 59100
Hospital Melaka
Malacca, 75400
Hospital Miri
Miri, Sarawak, 98000
Hospital Pakar Sultanah Fatimah
Muar town, Johor, 84000
Sunway Medical Centre Penang
Perai, Pulau Pinang, 13700
Hospital Seberang Jaya
Pulau Pinang, 13700
Hospital Putrajaya
Putrajaya, 62250
Hospital Tuanku Jaafar
Seremban, 70300
Hospital Seri Manjung
Seri Manjung, Perak, 32040
Hospital Shah Alam
Shah Alam, Selangor, 40000
University Technology MARA (UiTM) - Sg Buloh
Sungai Buloh, Selangor, 47000
Hospital Taiping
Taiping, Perak, 34000
South Africa23 sites
IATROS International
Bloemfontein, Free State, 9301
Medi-Clinic Bloemfontein
Bloemfontein, Free State, 9301
Tread Research (Pty)Ltd
Cape Town, Western Cape, 7500
Prof Rayner_Division of Nephrology
Cape Town, Western Cape, 7925
Dr Iftikhar Osman Ebrahim
Centurion, Gauteng, 0157
Dr Pillay's Rooms
Durban, KwaZulu-Natal, 4450
Clinical Projects Research (Pty) Ltd
East London, 5219
Dr T Padayachee
eMkhomazi, KwaZulu-Natal, 4170
Dr Moosa's Rooms
Gauteng, Lenasia, 1827
Soweto Clinical Trial Centre
Johannesburg, Gauteng, 1818
Ubuntu Clinical Research
Johannesburg, Gauteng, 1827
Wits Bara Clinical Trial Site
Johannesburg, Gauteng, 2013
WITS Clinical Research
Johannesburg, Gauteng, 2193
DJW Research
Krugersdorp, Gauteng, 1739
Clinical Research Institute of South Africa
KwaDukuza, KwaZulu-Natal, 4449
Dr Hendrik Snyman's Practice
Mossel Bay, Western Cape, 6500
Paarl Research Centre
Paarl, Cape Town, Western Cape, 7646
Phoenix Pharma
Port Elizabeth, Eastern Cape, 6001
Clinical Trials Network Pretoria
Pretoria, Gauteng, 0084
Clinical Trial Systems (CTC)
Pretoria, Gauteng, 0186
Roodepoort Medicross Clinical Research Centre
Roodepoort, Gauteng, 1724
Clinical Trials Network Helderberg (Pty) Ltd
Somerset West, Western Cape, 7130
Clinical Projects Research
Worcester, Western Cape, 6850
United Kingdom23 sites
Aberdeen Royal Infirmary - Diabetes
Aberdeen, AB25 2ZP
Ashton Medical Group
Ashton-under-Lyne, OL6 6EW
The Health Centre
Bradford on Avon, BA15 1DQ
Royal Sussex County Hospital
Brighton, BN2 1ES
Southmead Hospital - Cardiology Research
Bristol, BS10 5NB
West Walk Surgery
Bristol, BS37 4AX
St. Richard's Hospital_Cardiology
Chichester, West Sussex, PO19 6SE
University Hospital Coventry - WISDEM Centre
Coventry, CV2 2DX
Ninewells Hospital
Dundee, DD1 9SY
Queen Elizabeth University Hospital
Glasgow, G51 4TF
Northwick Park Hospital - Cardiac Research Dept
Harrow, HA1 3UJ
Leicester General Hospital - Leicester Diabetes Centre
Leicester, LE5 4PW
Aintree University Hospital
Liverpool, L9 7AL
The Royal London Hospital
London, E1 1BB
Royal Victoria Infirmary
Newcastle upon Tyne, NE1 4LP
Newquay Health Centre
Newquay, Cornwall, TR7 1RU
Penicuik Medical Practice
Penicuik, EH26 8LF
The Adam Practice
Poole, Dorset, BH16 5PW
Staploe Medical Centre
Soham, CB7 5JD
Moorgreen Hospital
Southampton, SO30 3JB
Breckland Alliance
Thetford, Norfolk, IP24 1JD
Sandwell Health Campus
West Bromwich, West Midlands, B71 4HJ
Marine Lake Medical Practice
West Kirby, Wirral, CH48 5AA
South Korea22 sites
The Catholic University of Korea, Bucheon ST. Mary's Hospital
Bucheon-si, Gyeonggi-do, 14647
Dong-A University Hospital
Busan, 49201
Pusan National University Hospital
Busan, 49241
Kyungpook National University Hospital_Cardiology
Daegu, 41944
Yeungnam Univ. Medical Center
Daegu, 42415
Daegu Catholic Univ. Medical Center
Daegu, 42472
Keimyung University Dongsan Hospital
Daegu, 42601
Chungnam National University Hospital
Daejeon, 35015
Wonju Severance Christian Hospital
Gangwon-do, 26426
Chonnam National University Hospital
Gwangju, 61469
Chung-Ang University Gwangmyeong Hospital
Gyeonggi-do, 14353
Inha University Hospital
Incheon, 22332
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, 13620
Korea University Anam Hospital
Seoul, 02841
Kyung Hee University Hospital at Gangdong
Seoul, 05278
Chung-Ang University Hospital
Seoul, 06973
Ewha Womans University Seoul Hospital
Seoul, 07804
Ajou University Hospital
Suwon, Gyeonggi-do, 16499
The Catholic University of Korea. Uijeongbu St. Mary's Hospital
Uijeongbu-si, Gyeonggi-do, 11765
Ulsan University Hospital
Ulsan, 44033
Pusan National University Yangsan Hospital
Yangsan, Gyeongsangnam-do, 50612
Yongin Severance Hospital
Yŏngin, 16995
Brazil20 sites
Hospital Universitário Walter Cantídio
Bairro Rodolfo Teófilo, Fortaleza, Ceará, 60416-000
Universidade Estadual Paulista Julio de Mesquita Filho- Campus de Botucatu Faculdade de Medicina
Botucatu, São Paulo, 18618-687
Associação Lar São Francisco de Assis na Providência de Deus - Bragança Paulista
Bragança Paulista, São Paulo, 12916-542
Instituto de Pesquisa Clínica de Campinas
Campinas, São Paulo, 13060-080
Sociedade Campineira De Educação E Instrução (SCEI)
Campinas, São Paulo, 13060-803
i9 Pesquisas Clínicas
Campinas, São Paulo, 13092-133
PUCPR - Pontificia Universidade Catolica do Parana
Curitiba, Paraná, 80230-130
Hospital Ruy Azeredo Ltda
Goiânia, Goiás, 74453200
CPHosp Manaus Medicina, Ensino e Pesquisa LTDA
Manaus, Amazonas, 69057-088
Irmandade da Santa Casa de Misericórdia de Marília
Marília, São Paulo, 17515-900
Hospital Maternidade e Pronto Socorro Santa Lúcia
Poços de Caldas, Minas Gerais, 37706-106
Hospital de Clínicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90410000
Núcleo de Pesquisa Clínica do Rio Grande do Sul Ltda.
Porto Alegre, Rio Grande do Sul, 90430-001
CIPES - Centro Internacional de Pesquisa Clínica LTDA
São José dos Campos, São Paulo, 12230-001
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
Sao Jose Rio Preto, 15090-000
CPQuali Pesquisa Clínica Ltda
São Paulo, São Paulo, 01228-000
BR Trials - Ensaios Clínicos e Consultoria Ltda.
São Paulo, São Paulo, 01236-030
Instituto Brasileiro de Controle do CânceNúcleo de Pesquisa e Ensino IBCC / São Camilo
São Paulo, São Paulo, 04014-001
Centro de Pesquisa Clínica do Hospital das Clínicas da Faculdade de Medicina da USP
São Paulo, São Paulo, 05403-000
Instituto do Coração - HCFMUSP
São Paulo, São Paulo, 05403-000
Australia18 sites
Royal Adelaide Hospital - Cardiology Department
Adelaide, South Australia, 5000
Flinders Medical Centre - Cardiology Department
Bedford Park, South Australia, 5042
Charles Perkins Centre
Camperdown, New South Wales, 2050
Canberra Hospital - Clinical Trials Unit
Canberra, Australian Capital Territory, 2605
The Prince Charles Hospital - Cardiology Clinical Research Centre
Chermside, Queensland, 4032
Townsville University Hospital - Cardiology Department
Douglas, Queensland, 4814
Northern Health
Epping, Victoria, 3076
St Vincent's Hospital Melbourne - Endocrinology & Diabetes Department
Fitzroy, Victoria, 3065
Adrian Costa Clinical Trials Centre
Geelong, Victoria, 3220
Austin Health - Cardiology Department
Heidelberg, Victoria, 3084
Advara HeartCare Joondalup
Joondalup, Western Australia, 6027
Nepean Hospital
Kingswood, 2747
Core Research Group
Milton, Queensland, 4064
Rockhampton Hospital
Rockhampton, Queensland, 4700
University of Sunshine Coast - Sippy Downs
Sippy Downs, Queensland, 4556
Sunshine Hospital - Western Centre for Health Research and Education
St Albans, Victoria, 3021
Latrobe Regional Hospital - Research Unit
Traralagon, Victoria, 3844
Illawarra Heart Health Centre
Wollongong, New South Wales, 2500
Mexico18 sites
Centro de Atención al Diabético Actopan (CAD)
Actopan, Hidalgo, 42500
Promotora Medica Aguascalientes SA de CV
Aguascalientes, 20230
ICARO Investigaciones en Medicina
Chihuahua City, 31000
Clinstile S.A. de C.V.
Col Roma Norte, Mexico City, 06700
Cryptex Investigación Clínica, S.A. de C.V.
Cuauhtémoc, Mexico City, 06100
Instituto de Terapeútica Experimental y Clínica (INTEC)
Guadalajara, Jalisco, 44600
Panamerican Clinical Research Mexico S. A de C.V
Guadalajara, Jalisco, 44670
Centro de Investigación Clínica Médica y Farmacológica S.A. de C.V. CINVEC Médica
Guadalajara, Jalisco, 44690
Medical Care and Research S. A de C.V
Mérida, Yucatán, 97070
Centro Médico Nacional Siglo XXI
Mexico City, 06720
Instituto Nacional de Cardiología Ignacio Chávez
Mexico City, 14080
Internal Medicine Clin Trials
Monterrey, Nuevo León, 64020
Servicios de Oncología Médica Integral S.A. de C.V. (ONCARE)
Monterrey, Nuevo León, 66220
Boca Clinical Trials
Puebla City, 72160
Centro de Investigación y Control Metabólico S. C.
San Nicolás de los Garza, Nuevo León, 66465
Instituto Nacional de Ciencias Médicas y Nutrición
Tlalpan, Mexico City, 14080
Sociedad de Metabolismo y Corazón S.C.
Veracruz de Ignacio de La Llave, Veracruz, 91855
Consultorio 1020 Hospital Angeles Xalapa
Xalapa, Veracruz, 91193
Netherlands16 sites
Jeroen Bosch Zkh - Cardiologie
's-Hertogenbosch, 5223 GZ
Noordwest Ziekenhuisgroep - Cardiologie
Alkmaar, 1815 JD
ZGT Almelo - Cardiologie
Almelo, 7609 PP
AmsterdamUMC AMC - Cardiologie
Amsterdam, 1105 AZ
Rode Kruis Zkh Beverwijk - Cardiologie
Beverwijk, 1942 LE
Deventer Ziekenhuis - Cardiologie
Deventer, 7416 SE
Catharina Zkh Eindhoven - Cardiologie
Eindhoven, 5623 EJ
Medisch Spectrum Twente - Cardiologie
Enschede, 7512 KZ
Saxenburgh MC - Cardiologie
Hardenberg, 7772 SE
Zuyderland ziekenhuis - Cardiologie
Heerlen, 6419 PC
Elkerliek Ziekenhuis - Cardiologie
Helmond, 5707 HA
Alrijne Leiderdorp - Cardiologie
Leiderdorp, 2353 GA
Franciscus Gasthuis en Vlietland - Cardiologie
Rotterdam, 3045 PM
Ikazia Ziekenhuis - Cardiologie
Rotterdam, 3083 AN
Zkh Rivierenland Tiel - Cardiologie
Tiel, 4002 WP
Diakonessenhuis Utrecht - Cardiologie
Utrecht, 3582 KE
Israel12 sites
Assuta Ashdod MC - The Institute of Cardiology
Ashdod, 7747629
Shamir MC - Cardiology Department
Beer Yaakov, 7033001
Hillel Yaffe MC - Cardiology Department
Hadera, 3810101
Rambam MC - Heart Failure Unit
Haifa, 3109601
Clalit HMO Holon - Heart Institute
Holon, 5840511
Shaare Zedek MC - Cardiology Department
Jerusalem, 9103102
Hadassah Ein Karam MC - Cardio Department
Jerusalem, 91120
Meir MC - Cardiology department
Kfar Saba, 44281
Rabin MC Beilinson - Heart Failure Unit
Petah Tikva, 49100
Ziv MC - Cardiology Department
Safed, 13100
Sheba MC - Cardiology Clinical Research Unit
Tel HaShomer, 5265601
Poriya Tzafon MC - Cardiology Department
Tiberias, 1528001
France10 sites
CHRU TOURS - HOPITAL TROUSSEAU - Service de Cardiologie
Chambray-lès-Tours, 37170
LES HOPITAUX DE CHARTRES_HOPITAL LOUIS PASTEUR_Service de Cardiologie
Le Coudray, 28630
INSTITUT COEUR POUMON_Service de cardiologie
Lille, 59037
HOPITAL PRIVE JACQUES CARTIER - Service de Cardiologie
Massy, 91300
FONDATION HÔPITAL SAINT JOSEPH_Service de Chirurgie vasculaire et endovasculaire
Paris, 75014
CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUX-HOPITAL HAUT LEVEQUE_Service de Cardiologie
Pessac, 33604
CENTRE HOSPITALIER UNIVERSITAIRE DE POITIERS - Centre Cardio Vasculaire
Poitiers, 86000
Clinique La Croix du Sud_Service de cardiologie
Quint-Fonsegrives, 31130
Hôpital privé de Villeneuve d'Ascq- Service de cardiologie
Villeneuve-d'Ascq, 59650
RESEAU DE SANTE MUTUALISTE_Service d'endocrinologie
Villeurbanne, 69100
Denmark6 sites
Sygehus Sønderjylland, Aabenraa - Afdeling for Hjertesygdomme
Aabenraa, 6200
Aarhus Universitetshospital, Hjertesygdomme
Aarhus N, 8200
Herlev Hospital - Afdeling for Hjertesygdomme, Forskning 1
Herlev, 2730
Regionshospitalet Gødstrup, Hjertesygdomme
Herning, 7400
Hvidovre Hospital Hjertemedicinsk
Hvidovre, 2650
Kolding Sygehus Karkirurgi
Kolding, 6000
About this study
Official title: Zenagamtide Use for the Reduction of Risk of Major Adverse Cardiovascular Events in People With Established Atherosclerotic Cardiovascular Disease and Either Overweight or Obesity
This clinical study is being conducted to evaluate the safety and effectiveness of zenagamtide in people with atherosclerotic cardiovascular disease (ASCVD) and excess body weight compared with placebo. The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have ASCVD and excess body weight. Participants will be randomly assigned by chance to receive either zenagamtide, the investigational treatment being tested, or a placebo, which contains no active medicine. Half of the participants will receive zenagamtide, and treatment assignment will be determined randomly. Zenagamtide is a new investigational medicine that is not yet available for prescription by doctors.
- Conditions
- Cardiovascular Risk, Obesity
- Being tested
- Zenagamtide, Placebo
- Medical subject headings
- Obesity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ZenagamtideDrug
Zenagamtide will be administered subcutaneously.
PlaceboDrug
Placebo will be administered subcutaneously.
| Study group | Role | What they receive |
|---|---|---|
| Zenagamtide | Experimental | Participants will receive zenagamtide subcutaneously (s.c.) in a dose escalating manner once weekly. Receives: Drug: Zenagamtide |
| Placebo | Placebo comparator | Participants will receive placebo matched to zenagamtide s.c. once weekly. Receives: Drug: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Time from randomization to first occurrence of a 4-point (P) composite major adverse cardiovascular events (MACE) endpoint consisting of: Cardiovascular (CV) death, Non-fatal MI, Non-fatal stroke, HF hospitalization or urgent HF visit
Measured in days.
Measured: From baseline (week 0) to up to 203 weeks or longer
Secondary outcomes (5)
Time from randomization to first occurrence of an expanded 5-P composite MACE endpoint consisting of: All-cause death, Non-fatal MI, Non-fatal stroke, HF hospitalization or urgent HF visit, Coronary revascularization
Measured in days.
Measured: From baseline (week 0) to up to 203 weeks or longer
Time from randomization to first occurrence of a 3-P composite MACE endpoint consisting of: CV death, Non-fatal MI, Non-fatal stroke
Measured in days.
Measured: From baseline (week 0) to up to 203 weeks or longer
Change in Estimated Glomerular Filtration Rate (eGFR) (creatinine and cystatin C-based Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] 2021) for participants with baseline eGFR< 60 millilitre per minute per 1.73 square metre (mL/min/1.73 m^2)
Measured as mL/min/1.73 m^2.
Measured: From baseline (week 0) to week 104
Time from randomization to all-cause death
Measured in days.
Measured: From baseline (week 0) to up to 203 weeks or longer
Time from randomization to CV death
Measured in days.
Measured: From baseline (week 0) to up to 203 weeks or longer
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Oct 2026
- Study start26 Oct 2026 (estimated)
- Primary completion16 Sep 2030 (estimated)
- Study completion16 Sep 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cardiovascular RiskStudies of the same condition, open and under way.
- More trials run by Novo Nordisk A/SThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 3
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 8,500 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Novo Nordisk A/S
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Clinical Transparency (dept. 2834), Study director, Novo Nordisk A/S
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07861100
- Sponsor's protocol ID
- NN9490-8037
- Other IDs
- U1111-1335-0048, 2026-525182-53
- Acronym
- AMBIENCE
- Status last verified
- Sep 2026
- First submitted
- 30 Sep 2026
- Last updated
- 6 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
- Individual data sharing
- Yes: According to the Novo Nordisk disclosure commitment on novonordisk-trials.com
Study at a glance
From the registry record, last updated by the sponsor on 6 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Zenagamtide Use for the Reduction of Risk of Major Adverse Cardiovascular Events in People With Established Atherosclerotic Cardiovascular Disease and Either Overweight or Obesity
- ClinicalTrials.gov ID
- NCT07861100
- Acronym / sponsor ID
- AMBIENCE / NN9490-8037
- Conditions
- Cardiovascular Risk, Obesity
- Phase
- Phase 3
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 8,500 participants (estimated)
- Lead sponsor
- Novo Nordisk A/SIndustry (pharma, biotech, devices)
- Study start
- 26 Oct 2026 (estimated)
- Primary completion
- 16 Sep 2030 (estimated)
- Study completion
- 16 Sep 2030 (estimated)
- First posted
- 6 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This clinical study is being conducted to evaluate the safety and effectiveness of zenagamtide in people with atherosclerotic cardiovascular disease (ASCVD) and excess body weight compared with placebo. The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have ASCVD and excess body weight. Participants will be randomly assigned by chance to receive either zenagamtide, the investigational treatment being tested, or a placebo, which contains no active medicine. Half of the participants will receive zenagamtide, and treatment assignment will be determined randomly. Zenagamtide is a new investigational medicine that is not yet available for prescription by doctors.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Zenagamtide | Experimental | Drug: ZenagamtideParticipants will receive zenagamtide subcutaneously (s.c.) in a dose escalating manner once weekly. |
| Placebo | Placebo comparator | Drug: PlaceboParticipants will receive placebo matched to zenagamtide s.c. once weekly. |
Who may qualify
- Ages
- 45 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Established ASCVD is defined as at least one of the below conditions (a-c):
- Participants with Type 2 Diabetes (T2D) (at screening) are allowed in the study with the following provisions:
Key exclusion criteria (11 listed)
- MI, stroke, unstable angina pectoris, or worsening heart failure (HF) leading to either hospitalization or intravenous loop diuretics within 30 days prior to the day of screening and until randomization.
- Coronary, carotid, or peripheral artery revascularization or percutaneous valve repair or replacement within 30 days prior to the day of screening or planned during the study period and known at screening.
- Chronic heart failure classified at screening.
- Glycaemia-related:
- General health and safety:
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ZenagamtideZenagamtide will be administered subcutaneously. | Drug | Zenagamtide |
| PlaceboPlacebo will be administered subcutaneously. | Drug | Placebo |
Primary outcome
Time from randomization to first occurrence of a 4-point (P) composite major adverse cardiovascular events (MACE) endpoint consisting of: Cardiovascular (CV) death, Non-fatal MI, Non-fatal stroke, HF hospitalization or urgent HF visit
Time frame: From baseline (week 0) to up to 203 weeks or longer
Measured in days.
5 secondary outcomes
Time from randomization to first occurrence of an expanded 5-P composite MACE endpoint consisting of: All-cause death, Non-fatal MI, Non-fatal stroke, HF hospitalization or urgent HF visit, Coronary revascularization
Time frame: From baseline (week 0) to up to 203 weeks or longer
Time from randomization to first occurrence of a 3-P composite MACE endpoint consisting of: CV death, Non-fatal MI, Non-fatal stroke
Time frame: From baseline (week 0) to up to 203 weeks or longer
Change in Estimated Glomerular Filtration Rate (eGFR) (creatinine and cystatin C-based Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] 2021) for participants with baseline eGFR< 60 millilitre per minute per 1.73 square metre (mL/min/1.73 m^2)
Time frame: From baseline (week 0) to week 104
Time from randomization to all-cause death
Time frame: From baseline (week 0) to up to 203 weeks or longer
Time from randomization to CV death
Time frame: From baseline (week 0) to up to 203 weeks or longer
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Oct 2026.
- Individual participant dataSharing planned: Yes. According to the Novo Nordisk disclosure commitment on novonordisk-trials.com
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Clinical Transparency (dept. 2834) study director
Novo Nordisk A/S
769 sites in 26 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 3 study testing Zenagamtide in people with Cardiovascular Risk and Obesity, run by Novo Nordisk A/S at 769 sites in 26 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 6 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 769 sites in United States, Poland, India, Bulgaria, Czechia and 21 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Novo Nordisk ((+1) 866-867-7178, clinicaltrials@novonordisk.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Time from randomization to first occurrence of a 4-point (P) composite major adverse cardiovascular events (MACE) endpoint consisting of: Cardiovascular (CV) death, Non-fatal MI, Non-fatal stroke, HF hospitalization or urgent HF visit (time frame: From baseline (week 0) to up to 203 weeks or longer). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Oct 2026.