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Lung NeoplasmsTEPULNCT07861282

Telerehabilitation Exercise Program for Postoperative Recovery in Lung Cancer.

A study testing Therapeutic Exercise-Based Telerehabilitation and Usual Postoperative Care in people with Lung Neoplasms and Thoracic Surgery Lung, run by University of Seville at 1 site in Spain.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
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Trial summary

Lung cancer is one of the leading causes of cancer-related morbidity and mortality worldwide. Thoracic surgery remains the treatment of choice for patients with early-stage disease; however, postoperative recovery is frequently associated with reduced functional capacity, decreased physical activity levels, pulmonary… Read more about this study

Who is it for?
Ages 18 to 80 years
Conditions the study is for
Lung Neoplasms, Thoracic Surgery Lung
What is being tested?
Therapeutic Exercise-Based Telerehabilitation and Usual Postoperative Care
Could I receive a placebo?
No, everyone receives an active treatment
How many people
56 participants
Where
1 siteSpain
Study dates
8 Sep 2026to Nov 2028
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 80 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Adults aged 18 to 80 years.
  • Histologically confirmed primary lung cancer (stage 0 to IIIB).
  • Patients who have undergone thoracic surgery for lung cancer.
  • Medical clearance to participate in an exercise-based rehabilitation program.
  • Ability to understand and communicate verbally.
  • Access to a smartphone and/or computer with internet connection.

Who cannot join

  • Any medical condition or comorbidity that contraindicates participation in an exercise program.
  • Current psychiatric disorder that may interfere with study participation.
  • Inability to provide written informed consent.
  • Previous thoracic surgery.
  • History of another malignancy within the past one year.

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

David Ortega Valle, PT, MSc contact

663616650 ext. +34

davortval@alum.us.es

María Jesús Casuso Holgado, PT, PhD contact

659213135 ext. +34

mcasuso@us.es

Spain1 site, 1 recruiting
  • Hospital Universitario Virgen Macarena

    Seville, Andalusia, 41009

    David Ortega Valle, PT, MSc, 663616650 ext. +34, davortval@alum.us.es

    María Jesús Casuso Holgado, PT, PhD

    Recruiting

Other trials in Spain

About this study

Official title: Impact of a Therapeutic Exercise Program Delivered Through Telerehabilitation on Postoperative Recovery in Patients Diagnosed With Lung Cancer (TEPUL): A Randomized Controlled Clinical Trial.

Lung cancer is one of the leading causes of cancer-related morbidity and mortality worldwide. Thoracic surgery remains the treatment of choice for patients with early-stage disease; however, postoperative recovery is frequently associated with reduced functional capacity, decreased physical activity levels, pulmonary complications, dyspnea, and impaired quality of life. Early physiotherapy interventions are recommended to minimize these adverse outcomes, although access to postoperative rehabilitation services remains limited in many healthcare settings, including the Andalusian Public Health System.

Telerehabilitation has emerged as a promising strategy to improve access to rehabilitation services by delivering therapeutic exercise and clinical follow-up remotely. Previous studies have demonstrated that telerehabilitation is safe, effective, and cost-efficient across different clinical populations. However, evidence regarding its effectiveness in patients recovering from lung cancer surgery remains limited.

Read more

This single-blind randomized controlled trial aims to compare the effects of an eight-week telerehabilitation program based on therapeutic exercise with usual postoperative care in patients with lung cancer undergoing thoracic surgery. Participants allocated to the intervention group will receive 24 therapeutic exercise sessions and 8 online clinical follow-up sessions delivered through the Rehbody platform over an 8-week period. Outcomes will include functional capacity, dyspnea, physical activity level, postoperative pulmonary complications, and health-related quality of life.

The study is designed to address the following research question: In adults with lung cancer undergoing thoracic surgery (Population), does an eight-week therapeutic exercise-based telerehabilitation program (Intervention), compared with usual postoperative care (Comparison), improve postoperative recovery as measured by functional capacity, dyspnea, physical activity level, postoperative pulmonary complications, and quality of life (Outcomes)?

Read the detailed description

Lung cancer remains the leading cause of cancer-related mortality worldwide and continues to impose a substantial burden on healthcare systems. Surgical resection is considered the standard treatment for patients with resectable disease and offers the best opportunity for long-term survival. However, despite advances in surgical techniques and perioperative care, recovery following thoracic surgery is frequently characterized by impaired physical function, reduced exercise capacity, dyspnea, decreased physical activity levels, postoperative pulmonary complications, and deterioration in health-related quality of life.

The physical and functional consequences of lung cancer treatment may persist for months or years after surgery and can negatively affect independence, participation in daily activities, and overall well-being. Postoperative rehabilitation and therapeutic exercise have therefore become important components of comprehensive cancer care. Early physiotherapy interventions aim to prevent postoperative pulmonary complications, facilitate recovery of physical function, reduce symptom burden, and promote a safe return to daily activities. Previous studies have shown that exercise-based rehabilitation following lung resection can improve functional capacity and quality of life while reducing postoperative morbidity.

Despite these recognized benefits, access to structured rehabilitation programs remains limited in many healthcare settings due to geographical, logistical, organizational, and resource-related barriers. This challenge is particularly relevant in publicly funded healthcare systems, where rehabilitation services may not be universally available after hospital discharge. As a result, many patients do not receive adequate follow-up rehabilitation during a critical phase of postoperative recovery.

Telerehabilitation has emerged as a promising alternative model of healthcare delivery that enables rehabilitation services to be provided remotely through digital technologies. This approach has the potential to improve accessibility, continuity of care, adherence to prescribed exercise programs, and patient engagement while reducing travel requirements and healthcare costs. Growing evidence supports the safety, feasibility, and effectiveness of telemedicine and telerehabilitation interventions across a variety of chronic and oncological conditions.

In patients with lung cancer, recent studies have reported encouraging results regarding the use of mobile applications and remotely supervised rehabilitation programs. These interventions have been associated with improved adherence to treatment, enhanced functional recovery, better pulmonary function, increased physical activity levels, reduced symptom burden, and improvements in quality of life. Furthermore, digital rehabilitation strategies may facilitate long-term monitoring and support during the postoperative period, helping patients maintain active participation in their recovery process.

Nevertheless, important knowledge gaps remain. The number of high-quality randomized controlled trials specifically evaluating structured postoperative telerehabilitation programs after lung cancer surgery is still limited. Existing studies have often included small sample sizes, heterogeneous interventions, or mixed cancer populations, making it difficult to establish definitive recommendations regarding the optimal design and clinical effectiveness of telerehabilitation in this population. Additional research is needed to determine whether remotely delivered therapeutic exercise programs can produce clinically meaningful improvements in postoperative recovery and patient-centered outcomes.

The present randomized controlled trial has been designed to address this evidence gap by evaluating the effectiveness of an eight-week telerehabilitation program based on therapeutic exercise in patients undergoing thoracic surgery for lung cancer. Participants allocated to the intervention group will receive a structured and progressive exercise program delivered through a dedicated telerehabilitation platform, combined with regular online clinical follow-up sessions. The intervention incorporates aerobic exercise, muscle strengthening exercises, respiratory muscle training, individualized progression, and continuous monitoring of adherence and symptoms. Participants assigned to the control group will receive the usual postoperative physiotherapy care routinely provided after thoracic surgery.

The study will evaluate the impact of the intervention on key dimensions of postoperative recovery, including functional capacity, dyspnea, physical activity levels, postoperative pulmonary complications, and health-related quality of life. Assessments will be performed before surgery, after completion of the intervention period, and following a short-term follow-up period to explore the maintenance of potential benefits.

The findings of this study may contribute to the development of evidence-based rehabilitation pathways for patients recovering from lung cancer surgery. If effective, this telerehabilitation model could represent an accessible, scalable, and cost-efficient strategy for improving postoperative outcomes and expanding access to rehabilitation services within routine clinical practice.

Being tested
Therapeutic Exercise-Based Telerehabilitation, Usual Postoperative Care
Keywords
Thoracic Surgery, Lung Neoplasms, Telerehabilitation, Dyspnea, Exercise Therapy, Quality of Life, Postoperative Complications
Medical subject headings
Lung Neoplasms, Dyspnea, Postoperative Complications

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Therapeutic Exercise-Based TelerehabilitationBehavioural

    Participants will receive an 8-week telerehabilitation program delivered through the RehBody platform. The intervention includes 24 supervised therapeutic exercise sessions and 8 online clinical follow-up sessions. Exercise sessions incorporate aerobic training, strength exercises, respiratory muscle training, individualized progression, symptom monitoring, and adherence support. Participants will also receive usual postoperative care.

  • Usual Postoperative CareOther

    Participants assigned to the control group will receive usual postoperative care routinely provided after thoracic surgery for lung cancer. This includes early mobilization, progressive ambulation according to individual tolerance, deep breathing exercises, active upper-limb and trunk mobility exercises, cough training with wound protection, and discharge recommendations for home-based recovery. No structured telerehabilitation or supervised exercise program will be provided after hospital discharge.

Study groups in NCT07861282
Study groupRoleWhat they receive
Telerehabilitation + Usual CareActive comparatorNot described
Receives: Behavioral: Therapeutic Exercise-Based Telerehabilitation
Usual CareActive comparatorNot described
Receives: Other: Usual Postoperative Care

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Functional capacity measured by the One-Minute Sit-to-Stand Test (1MSTS)

    Functional capacity will be assessed using the One-Minute Sit-to-Stand Test (1MSTS). Participants will stand up and sit down from a standardized chair as many times as possible within one minute. The total number of completed repetitions will be recorded. There is no fixed maximum value, and higher numbers of repetitions indicate better functional capacity.

    Measured: Baseline (pre-surgery), 8 weeks (post-intervention), and 12 weeks (4-week follow-up).

Secondary outcomes (5)
  1. Dyspnea measured by the Modified Medical Research Council (mMRC) Dyspnea Scale.

    Dyspnea will be assessed using the Modified Medical Research Council (mMRC) Dyspnea Scale, a 5-point ordinal scale. Scores range from 0 to 4 (minimum 0, maximum 4). Higher scores indicate greater breathlessness and functional limitation due to dyspnea (worse outcome).

    Measured: Baseline (pre-surgery), 8 weeks (post-intervention), and 12 weeks (4-week follow-up).

  2. Physical activity level measured by the International Physical Activity Questionnaire - Short Form (IPAQ-SF), MET-minutes/week.

    Physical activity will be assessed using the International Physical Activity Questionnaire - Short Form (IPAQ-SF). Results will be expressed as total MET-minutes/week (metabolic equivalent of task-minutes per week), with a minimum of 0 and no fixed maximum. Higher values indicate a higher level of physical activity (better outcome). Participants will also be categorized as having low, moderate, or high physical activity levels according to the standardized IPAQ scoring protocol.

    Measured: Baseline (pre-surgery), 8 weeks (post-intervention), and 12 weeks (4-week follow-up).

  3. Incidence of postoperative pulmonary complications defined by the European Perioperative Clinical Outcome (EPCO) criteria.

    Postoperative pulmonary complications will be collected from clinical records and defined according to the European Perioperative Clinical Outcome (EPCO) criteria. Complications will be recorded from hospital discharge until the end of the intervention and follow-up period. The outcome will be reported as the number and percentage of participants with at least one postoperative pulmonary complication.

    Measured: From hospital discharge to 12-week follow-up.

  4. Health-related quality of life measured by the EQ-5D-5L descriptive system (index value).

    Health-related quality of life will be assessed using the descriptive system of the EuroQol 5-Dimension 5-Level questionnaire (EQ-5D-5L), which covers five dimensions (mobility, self-care, usual activities, pain/discomfort, anxiety/depression) with five levels each. Responses will be converted into an index value using a country-specific value set. A value of 1 represents full health and 0 represents a state equivalent to dead; negative values indicate states considered worse than dead, and the minimum depends on the value set used. Higher values indicate better health status (better outcome).

    Measured: Baseline (pre-surgery), 8 weeks (post-intervention), and 12 weeks (4-week follow-up).

  5. Self-rated health measured by the EuroQol Visual Analogue Scale (EQ-VAS).

    Self-rated health will be assessed using the EuroQol Visual Analogue Scale (EQ-VAS), on which participants rate their health on the day of assessment. Scores range from 0 (the worst health you can imagine) to 100 (the best health you can imagine). Higher scores indicate better perceived health status (better outcome).

    Measured: Baseline (pre-surgery), 8 weeks (post-intervention), and 12 weeks (4-week follow-up).

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted6 Oct 2026
  2. Study start8 Sep 2026
  3. Primary completionApr 2028 (estimated)
  4. Study completionNov 2028 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Supportive care
Allocation
Randomised
Intervention model
Parallel groups
Model description
Participants will be randomly assigned in a 1:1 ratio to one of two parallel study arms. The experimental group will receive usual postoperative care plus an 8-week telerehabilitation program based on therapeutic exercise, whereas the control group will receive usual postoperative care alone. Outcomes will be assessed at baseline, after the intervention period, and following a 4-week follow-up period.
Masking
Single blind
Who is masked
Outcomes assessor
Enrolment
56 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07861282
Sponsor's protocol ID
ECA-TR-CP-26
Acronym
TEPUL
Status last verified
Oct 2026
First submitted
30 Sep 2026
Last updated
21 Oct 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Questions about this trial

What is this clinical trial studying?

A study testing Therapeutic Exercise-Based Telerehabilitation and Usual Postoperative Care in people with Lung Neoplasms and Thoracic Surgery Lung, run by University of Seville at 1 site in Spain.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 21 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact David Ortega Valle, PT, MSc (663616650 ext. +34, davortval@alum.us.es), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Functional capacity measured by the One-Minute Sit-to-Stand Test (1MSTS) (time frame: Baseline (pre-surgery), 8 weeks (post-intervention), and 12 weeks (4-week follow-up).). It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Oct 2026.

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