Liver Transplantation (LT)NCT07863349
Physical Activity and Quality of Life After Liver Paired Exchange Transplantation
An observational study of Liver Transplantation (LT), run by İlker DEMİR at 1 site in Turkey (Türkiye).
Trial summary
This prospective longitudinal observational study evaluated changes in physical activity, cognitive function, functional exercise capacity, and health-related quality of life in adult recipients following liver paired exchange (LPE) transplantation. Participants were assessed at 3 and 12 months after transplantation. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Liver Transplantation (LT)
- What is being tested?
- Post-Transplant Follow-up Assessments
- How many people
- 68 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Apr 2025to 1 Jul 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult liver transplant recipients who underwent liver paired exchange (LPE) transplantation at the Liver Transplant Institute Hospital of Inonu University, Malatya, Türkiye. Participants were prospectively evaluated at 3 and 12 months after transplantation.
Who may be able to join
- Underwent liver paired exchange (LPE) transplantation
- Aged 18 years or older
- Voluntarily agreed to participate in the study
- Breathing spontaneously
- Able to cooperate and follow instructions
- Hemodynamically stable
- Able to comply with the study assessments
Who cannot join
- Underwent multi-organ transplantation
- Underwent multi-organ transplantation
- Had comorbid conditions that prevented completion of the assessments
- Had orthopedic disorders affecting mobility
- Unable to complete the assessments due to health-related or other reasons
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Inonu University Turgut Ozal Medical Center
Malatya, 44090
About this study
Official title: Investigation of Physical Activity Levels and Quality of Life Following Liver Paired Exchange Transplantation
This prospective longitudinal observational study evaluated changes in physical activity, cognitive function, functional exercise capacity, and health-related quality of life in adult recipients following liver paired exchange (LPE) transplantation. Participants were assessed at 3 and 12 months after transplantation. Physical activity was evaluated using the International Physical Activity Questionnaire-Short Form (IPAQ-SF), cognitive function using the Montreal Cognitive Assessment (MoCA), health-related quality of life using the Short Form-36 (SF-36), and functional exercise capacity using the Six-Minute Walk Test (6MWT). The study aimed to describe changes in these outcomes during the first year following LPE transplantation.
- Conditions
- Liver Transplantation (LT)
- Being tested
- Post-Transplant Follow-up Assessments
- Keywords
- Liver Paired Exchange, Liver Paired Exchange Transplantation, Physical Activity, Quality of Life, Cognitive Function, Functional Exercise Capacity
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Post-Transplant Follow-up AssessmentsOther
Participants who had undergone liver paired exchange transplantation were prospectively followed and evaluated at 3 and 12 months after transplantation. Physical activity, cognitive function, health-related quality of life, and functional exercise capacity were assessed. No therapeutic, surgical, or rehabilitation intervention was assigned as part of the study.
| Study group | Role | What they receive |
|---|---|---|
| Liver Paired Exchange Transplant Recipients | Adult recipients who underwent liver paired exchange (LPE) transplantation were included in this cohort. Participants were evaluated at 3 and 12 months after transplantation. No study-specific intervention was administered. Receives: Other: Post-Transplant Follow-up Assessments |
What is being measured
The primary outcome is the main question the study is designed to answer.
Cognitive Function
Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA). The total MoCA score ranges from 0 to 30, with higher scores indicating better cognitive function.
Measured: At 3 months and 12 months after liver transplantation
Physical Activity Level
Physical activity was assessed using the International Physical Activity Questionnaire-Short Form (IPAQ-SF). The IPAQ-SF assesses walking, moderate-intensity physical activity, vigorous-intensity physical activity, and sitting time during the previous 7 days. Physical activity levels were calculated according to the IPAQ-SF scoring procedure.
Measured: At 3 months and 12 months after liver transplantation
Health-Related Quality of Life
Health-related quality of life was assessed using the Short Form-36 (SF-36). The SF-36 evaluates eight dimensions of health. Scores range from 0 to 100, with higher scores indicating better health-related quality of life.
Measured: At 3 months and 12 months after liver transplantation
Functional Exercise Capacity
Functional exercise capacity was assessed using the Six-Minute Walk Test (6MWT). The distance walked during the test was recorded in meters, with a greater walking distance indicating better functional exercise capacity.
Measured: At 3 months and 12 months after liver transplantation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Oct 2026
- Study start1 Apr 2025
- Primary completion1 Jul 2026
- Study completion1 Jul 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Liver Transplantation (LT)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 68 participants (actual)
Sponsor and investigators
- Lead sponsor
- İlker DEMİR
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, İlker DEMİR, Hasan Kalyoncu University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07863349
- Sponsor's protocol ID
- 2024/6789
- Status last verified
- Oct 2026
- First submitted
- 2 Oct 2026
- Last updated
- 7 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be publicly shared due to participant confidentiality and data protection considerations.
Study at a glance
From the registry record, last updated by the sponsor on 7 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigation of Physical Activity Levels and Quality of Life Following Liver Paired Exchange Transplantation
- ClinicalTrials.gov ID
- NCT07863349
- Acronym / sponsor ID
- 2024/6789
- Conditions
- Liver Transplantation (LT)
- Keywords
- Liver Paired Exchange, Liver Paired Exchange Transplantation, Physical Activity, Quality of Life, Cognitive Function, Functional Exercise Capacity
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 68 participants (actual)
- Lead sponsor
- İlker DEMİRUniversity, hospital or other
- Study start
- 1 Apr 2025 (actual)
- Primary completion
- 1 Jul 2026 (actual)
- Study completion
- 1 Jul 2026 (actual)
- First posted
- 7 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective longitudinal observational study evaluated changes in physical activity, cognitive function, functional exercise capacity, and health-related quality of life in adult recipients following liver paired exchange (LPE) transplantation. Participants were assessed at 3 and 12 months after transplantation. Physical activity was evaluated using the International Physical Activity Questionnaire-Short Form (IPAQ-SF), cognitive function using the Montreal Cognitive Assessment (MoCA), health-related quality of life using the Short Form-36 (SF-36), and functional exercise capacity using the Six-Minute Walk Test (6MWT). The study aimed to describe changes in these outcomes during the first year following LPE transplantation.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Liver Paired Exchange Transplant Recipients | – | Other: Post-Transplant Follow-up AssessmentsAdult recipients who underwent liver paired exchange (LPE) transplantation were included in this cohort. Participants were evaluated at 3 and 12 months after transplantation. No study-specific intervention was administered. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult liver transplant recipients who underwent liver paired exchange (LPE) transplantation at the Liver Transplant Institute Hospital of Inonu University, Malatya, Türkiye. Participants were prospectively evaluated at 3 and 12 months after transplantation.
Key inclusion criteria (7 listed)
- Underwent liver paired exchange (LPE) transplantation
- Aged 18 years or older
- Voluntarily agreed to participate in the study
- Breathing spontaneously
- Able to cooperate and follow instructions
Key exclusion criteria (5 listed)
- Underwent multi-organ transplantation
- Underwent multi-organ transplantation
- Had comorbid conditions that prevented completion of the assessments
- Had orthopedic disorders affecting mobility
- Unable to complete the assessments due to health-related or other reasons
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Post-Transplant Follow-up AssessmentsParticipants who had undergone liver paired exchange transplantation were prospectively followed and evaluated at 3 and 12 months after transplantation. Physical activity, cognitive function, health-related quality of life, and functional exercise capacity were assessed. No therapeutic, surgical, or rehabilitation intervention was assigned as part of the study. | Other | Liver Paired Exchange Transplant Recipients |
Primary outcome
Cognitive Function
Time frame: At 3 months and 12 months after liver transplantation
Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA). The total MoCA score ranges from 0 to 30, with higher scores indicating better cognitive function.
Physical Activity Level
Time frame: At 3 months and 12 months after liver transplantation
Physical activity was assessed using the International Physical Activity Questionnaire-Short Form (IPAQ-SF). The IPAQ-SF assesses walking, moderate-intensity physical activity, vigorous-intensity physical activity, and sitting time during the previous 7 days. Physical activity levels were calculated according to the IPAQ-SF scoring procedure.
Health-Related Quality of Life
Time frame: At 3 months and 12 months after liver transplantation
Health-related quality of life was assessed using the Short Form-36 (SF-36). The SF-36 evaluates eight dimensions of health. Scores range from 0 to 100, with higher scores indicating better health-related quality of life.
Functional Exercise Capacity
Time frame: At 3 months and 12 months after liver transplantation
Functional exercise capacity was assessed using the Six-Minute Walk Test (6MWT). The distance walked during the test was recorded in meters, with a greater walking distance indicating better functional exercise capacity.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Oct 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be publicly shared due to participant confidentiality and data protection considerations.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Liver Transplantation (LT), run by İlker DEMİR at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 7 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cognitive Function (time frame: At 3 months and 12 months after liver transplantation). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Oct 2026.