Maternal Blood Loss During Cesarean DeliveryUAC-DCCNCT07866352
Uterine-Angle Clamping During Delayed Cord Clamping at Cesarean Delivery
A study testing Temporary Uterine-Angle Clamping in people with Maternal Blood Loss During Cesarean Delivery, run by Baskent University at 1 site in Turkey (Türkiye).
Trial summary
This randomized controlled study evaluated whether temporary clamping of the lateral angles of the uterine incision during a standardized 60-second delayed umbilical cord-clamping period reduces maternal blood loss in women undergoing planned term cesarean delivery. Read more about this study
- Who is it for?
- Any age, women only
- Conditions the study is for
- Maternal Blood Loss During Cesarean Delivery
- What is being tested?
- Temporary Uterine-Angle Clamping
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 248 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 21 Sep 2025to 21 Sep 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- Women only
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Singleton pregnancy
- Planned cesarean delivery at 37+0 to 39+6 weeks of gestation
- Cesarean delivery before the onset of labor
Who cannot join
- Active labor
- Induction of labor
- Intrapartum or emergency cesarean delivery
- Placenta previa
- Placental abruption
- Preterm or prelabor rupture of membranes
Show all 14Show fewer
- Preeclampsia
- Chorioamnionitis
- Chronic systemic disease
- Known bleeding or coagulation disorder
- Platelet count <100,000/mm3
- Myoma in the lower uterine segment
- Significant adhesions likely to affect surgery
- Previous cesarean delivery with a uterine incision other than a Kerr incision
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Baskent University Adana Dr. Turgut Noyan Application and Research Center
Adana
About this study
Official title: Temporary Clamping of Uterine Incision Angles During Delayed Cord Clamping to Reduce Maternal Blood Loss at Planned Cesarean Delivery: A Randomized Controlled Trial
This randomized controlled study evaluated whether temporary clamping of the lateral angles of the uterine incision during a standardized 60-second delayed umbilical cord-clamping period reduces maternal blood loss in women undergoing planned term cesarean delivery. Participants were randomized in a 1:1 ratio to uterine-angle clamping or control. Both groups underwent 60-second delayed cord clamping. Maternal blood loss was assessed using calculated estimated blood loss based on preoperative and 24-hour postoperative hematocrit values.
- Being tested
- Temporary Uterine-Angle Clamping
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Temporary Uterine-Angle ClampingProcedure or surgery
Temporary mechanical clamping of both lateral angles of the low transverse uterine incision during the 60-second delayed cord-clamping interval.
| Study group | Role | What they receive |
|---|---|---|
| Uterine-Angle Clamping | Experimental | Immediately after fetal delivery and while the placenta remained in situ, both lateral angles of the uterine incision were temporarily clamped with ovarian clamps. The umbilical cord was clamped and cut 60 seconds after birth. The clamps were removed when closure of the uterine incision was initiated after placental delivery. Receives: Procedure: Temporary Uterine-Angle Clamping |
| Control | No intervention | Participants underwent 60-second delayed umbilical cord clamping without application of clamps to the uterine incision angles. All other aspects of the surgical technique were identical to those used in the intervention group. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Calculated Estimated Blood Loss (cEBL)
Maternal blood loss calculated using the Stafford method from estimated maternal pregnancy blood volume and the proportional change between preoperative and 24-hour postoperative hematocrit.
Measured: within 24 hours after cesarean delivery
Secondary outcomes (9)
Change in Hemoglobin Concentration
Difference between preoperative and 24-hour postoperative hemoglobin concentration.
Measured: Baseline ( preoperative)and 24 hours after cesarean delivery
Change in Hematocrit
Difference between preoperative and 24-hour postoperative hematocrit.
Measured: Baseline ( preoperative ) and 24 hours after cesarean delivery
Calculated Estimated Blood Loss of at Least 500 mL
Proportion of participants with calculated estimated blood loss of at least 500 mL.
Measured: 24 hours after cesarean delivery
Calculated Estimated Blood Loss of at Least 1000 mL
Proportion of participants with calculated estimated blood loss of at least 1000 mL.
Measured: 24 hours after cesarean delivery
Blood Transfusion Requirement
Requirement for maternal blood transfusion.
Measured: From cesarean delivery until hospital discharge, up to 7 days postpartum
Operation Duration
from cesarean delivery through 24 hours postpartum
Measured: During cesarean delivery
Umbilical Artery pH
Umbilical artery pH measured after delivery.
Measured: At delivery
Neonatal Intensive Care Unit Admission
Admission of the neonate to the neonatal intensive care unit.
Measured: from birth until hospital discharge, up to 7 days after birth
Length of Hospital Stay
Maternal length of hospital stay in days.
Measured: From cesarean delivery until hospital discharge, up to 7 days postpartum
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Oct 2026
- Study start21 Sep 2025
- Primary completion21 Sep 2026
- Study completion21 Sep 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Maternal Blood Loss During Cesarean DeliveryStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 248 participants (actual)
Sponsor and investigators
- Lead sponsor
- Baskent University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, MEHMET MURAT ISIKALAN, Baskent University
- Investigators
- Mehmet Murat Isikalan, Principal investigator, Baskent University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07866352
- Sponsor's protocol ID
- KA25-76-UACDCC
- Other IDs
- KA25/76
- Acronym
- UAC-DCC
- Status last verified
- Oct 2026
- First submitted
- 22 Sep 2026
- Last updated
- 8 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 8 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Temporary Clamping of Uterine Incision Angles During Delayed Cord Clamping to Reduce Maternal Blood Loss at Planned Cesarean Delivery: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07866352
- Acronym / sponsor ID
- UAC-DCC / KA25-76-UACDCC
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 248 participants (actual)
- Lead sponsor
- Baskent UniversityUniversity, hospital or other
- Study start
- 21 Sep 2025 (actual)
- Primary completion
- 21 Sep 2026 (actual)
- Study completion
- 21 Sep 2026 (actual)
- First posted
- 8 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled study evaluated whether temporary clamping of the lateral angles of the uterine incision during a standardized 60-second delayed umbilical cord-clamping period reduces maternal blood loss in women undergoing planned term cesarean delivery. Participants were randomized in a 1:1 ratio to uterine-angle clamping or control. Both groups underwent 60-second delayed cord clamping. Maternal blood loss was assessed using calculated estimated blood loss based on preoperative and 24-hour postoperative hematocrit values.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Uterine-Angle Clamping | Experimental | Procedure: Temporary Uterine-Angle ClampingImmediately after fetal delivery and while the placenta remained in situ, both lateral angles of the uterine incision were temporarily clamped with ovarian clamps. The umbilical cord was clamped and cut 60 seconds after birth. The clamps were removed when closure of the uterine incision was initiated after placental delivery. |
| Control | No intervention | –Participants underwent 60-second delayed umbilical cord clamping without application of clamps to the uterine incision angles. All other aspects of the surgical technique were identical to those used in the intervention group. |
Who may qualify
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (3 listed)
- Singleton pregnancy
- Planned cesarean delivery at 37+0 to 39+6 weeks of gestation
- Cesarean delivery before the onset of labor
Key exclusion criteria (14 listed)
- Active labor
- Induction of labor
- Intrapartum or emergency cesarean delivery
- Placenta previa
- Placental abruption
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Temporary Uterine-Angle ClampingTemporary mechanical clamping of both lateral angles of the low transverse uterine incision during the 60-second delayed cord-clamping interval. | Procedure or surgery | Uterine-Angle Clamping |
Primary outcome
Calculated Estimated Blood Loss (cEBL)
Time frame: within 24 hours after cesarean delivery
Maternal blood loss calculated using the Stafford method from estimated maternal pregnancy blood volume and the proportional change between preoperative and 24-hour postoperative hematocrit.
9 secondary outcomes
Change in Hemoglobin Concentration
Time frame: Baseline ( preoperative)and 24 hours after cesarean delivery
Change in Hematocrit
Time frame: Baseline ( preoperative ) and 24 hours after cesarean delivery
Calculated Estimated Blood Loss of at Least 500 mL
Time frame: 24 hours after cesarean delivery
Calculated Estimated Blood Loss of at Least 1000 mL
Time frame: 24 hours after cesarean delivery
Blood Transfusion Requirement
Time frame: From cesarean delivery until hospital discharge, up to 7 days postpartum
Operation Duration
Time frame: During cesarean delivery
Umbilical Artery pH
Time frame: At delivery
Neonatal Intensive Care Unit Admission
Time frame: from birth until hospital discharge, up to 7 days after birth
Length of Hospital Stay
Time frame: From cesarean delivery until hospital discharge, up to 7 days postpartum
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 8 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Mehmet Murat Isikalan principal investigator
Baskent University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Temporary Uterine-Angle Clamping in people with Maternal Blood Loss During Cesarean Delivery, run by Baskent University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 14 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 8 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Calculated Estimated Blood Loss (cEBL) (time frame: within 24 hours after cesarean delivery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 8 Oct 2026.