Guillain-Barre SyndromeNCT07866898
Peripheral Nerve Ultrasound in Children With Guillain-Barré Syndrome
An observational study of Guillain-Barre Syndrome, run by Assiut University.
Trial summary
This prospective observational study aims to evaluate peripheral nerve ultrasound findings, particularly nerve cross-sectional area, in children with Guillain-Barré syndrome. Read more about this study
- Who is it for?
- Ages 1 year to 17 years
- Conditions the study is for
- Guillain-Barre Syndrome
- How many people
- 42 participants
- Where
- No sites listed yet
- Study dates
- 10 Oct 2026to 1 Feb 2028
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 1 year to 17 years
- All sexes
- No healthy volunteers
- Child
Study population: Children aged 1 to 17 years diagnosed with Guillain-Barré syndrome admitted to or evaluated at Assiut University Children's Hospital.
Who may be able to join
- - Age 1 to 17 years
- Diagnosis compatible with Guillain-Barré syndrome according to Brighton criteria
- Written informed consent from parent or legal guardian
Who cannot join
- Previous diagnosis of hereditary peripheral neuropathy
- Chronic inflammatory demyelinating polyneuropathy or another chronic neuropathy
- Previous neuromuscular disease affecting nerve conduction or ultrasound measurements
- Significant peripheral nerve trauma or previous nerve surgery
- Drug-induced neuropathy
- Local anatomical abnormalities or marked edema preventing reliable ultrasound assessment
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Diagnostic Value of Peripheral Nerve Ultrasound in Children With Guillain-Barré Syndrome
This prospective observational study aims to evaluate peripheral nerve ultrasound findings, particularly nerve cross-sectional area, in children with Guillain-Barré syndrome.
Read the detailed description
Guillain-Barré syndrome is an acute immune-mediated neuropathy. High-resolution peripheral nerve ultrasound can measure nerve cross-sectional area and detect structural abnormalities.
This observational study will perform peripheral nerve ultrasound and nerve conduction studies in children aged 1 to 17 years with Guillain-Barré syndrome at baseline and at 3 months.
- Conditions
- Guillain-Barre Syndrome
- Keywords
- Guillain-Barre syndrome, Peripheral nerve ultrasound, Nerve cross-sectional area, Children, Assiut
- Medical subject headings
- Guillain-Barre Syndrome
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Children with Guillain-Barré Syndrome | Children aged 1 to 17 years with Guillain-Barré syndrome undergoing peripheral nerve ultrasound and nerve conduction studies. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Mean nerve cross-sectional area
Mean cross-sectional area of selected peripheral nerves measured by high-resolution ultrasound in mm².
Measured: Baseline
Secondary outcomes (4)
Change in nerve cross-sectional area
Mean change in peripheral nerve cross-sectional area in mm² from baseline to 3 months.
Measured: At 3 months
Mean distal motor latency
Mean distal motor latency measured by nerve conduction study in milliseconds.
Measured: Baseline
Mean compound muscle action potential amplitude
Mean compound muscle action potential amplitude measured by nerve conduction study in millivolts.
Measured: Baseline
GBS Disability Scale Score
Mean Guillain-Barré Syndrome disability scale score (range 0 to 6, higher scores indicate worse disability).
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Oct 2026
- Study start10 Oct 2026 (estimated)
- Primary completion10 Oct 2027 (estimated)
- Study completion1 Feb 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Guillain-Barre SyndromeStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 42 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ahmed Sultan Ahmed Shetawy, Assiut University
- Investigators
- Azza A Eltayeb, prof, Study chair, Pediatrics Department, Assiut University Hospitals
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07866898
- Sponsor's protocol ID
- Nerve-US-GBS-Assiut-2026
- Status last verified
- Oct 2026
- First submitted
- 5 Oct 2026
- Last updated
- 8 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No