Alveolar Bone LossNCT07869082
Biologically Oriented Alveolar Ridge Preservation (BARP) With and Without Advanced Platelet-Rich Fibrin Plus (A-PRF+)
A study testing Socket preservation by deproteinized bovine bone graft and socket preservation by deproteinized bovine bone graft mixed with advanced PRF+ in people with Alveolar Bone Loss, run by Mansoura University at 1 site in Egypt.
Trial summary
Twenty patients were selected from the outpatient clinic of the Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University seeking for extraction of non-restorable maxillary premolar teeth prior to delayed implant placement. Read more about this study
- Who is it for?
- Ages 18 to 50 yearsHealthy volunteers can take part
- Conditions the study is for
- Alveolar Bone Loss
- What is being tested?
- Socket preservation by deproteinized bovine bone graft and socket preservation by deproteinized bovine bone graft mixed with advanced PRF+
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Nov 2025to 8 Sep 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Patient with good oral hygiene.
- Age (18-50) years.
- Presence of non-restorable maxillary premolar teeth due to caries, root resorption, roots fracture, etc.
- No history of parafunctional habits
- Adequate inter arch space
- Patients prepared to comply with the follow-up and maintenance program.
Who cannot join
- Patients with systemic diseases that interfere with dental implant insertion.
- Smokers.
- Pregnancy.
- Immunocompromised patients.
- Presence of acute infection at the tooth to be extracted
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparative Evaluation of Biologically Oriented Alveolar Ridge Preservation (BARP) With and Without Advanced Platelet-Rich Fibrin Plus (A-PRF+) For Delayed Implant Placement in Maxillary Premolars
Twenty patients were selected from the outpatient clinic of the Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University seeking for extraction of non-restorable maxillary premolar teeth prior to delayed implant placement. Patients will be divided into 2 groups:
- Group A: 10 implants were inserted after four months from extraction after socket preservation by putting two collagen sponge layers and in between deproteinized bovine bone.
- Group B: 10 implants were inserted after four months after socket preservation by putting two collagen sponge and in between deproteinized bovine bone with addition of advanced PRF plus layer.
- Closure of the flap was obtained without tension. Implants of all groups were immediately loaded .Some Clinical and Radiographic parameters and Histological and Volumetric evaluation were made at different time intervals along this study.
- Conditions
- Alveolar Bone Loss
- Being tested
- Socket preservation by deproteinized bovine bone graft, socket preservation by deproteinized bovine bone graft mixed with advanced PRF+
- Medical subject headings
- Alveolar Bone Loss
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Socket preservation by deproteinized bovine bone graftProcedure or surgery
After atraumatic extraction, socket preservation by deproteinized bovine bone and collagen sponge was done and implant placement was performed after four months from that.
socket preservation by deproteinized bovine bone graft mixed with advanced PRF+Procedure or surgery
After atraumatic extraction, socket preservation by deproteinized bovine bone mixed with advanced PRF+ and collagen sponge was done and implant placement was performed after four months from that.
| Study group | Role | What they receive |
|---|---|---|
| Deproteinized bovine | Experimental | Deproteinized bovine bone with collagen sponge was used for socket preservation for 10 cases and implant placement was performed after four months. Receives: Procedure: Socket preservation by deproteinized bovine bone graft |
| Deproteinized bovine bone with advanced PRF | Experimental | Deproteinized bovine bone with advanced PRF+ and collagen sponge was used for socket preservation for 10 cases then implant placement was performed after four months. Receives: Procedure: socket preservation by deproteinized bovine bone graft mixed with advanced PRF+ |
What is being measured
The primary outcome is the main question the study is designed to answer.
Implant stability
Implant stability measured using Resonance Frequency Analysis (RFA) with the Osstell Mentor device and SmartPeg. Measurements were recorded in four directions (every 90 degrees) and averaged per implant to provide an ISQ score (scale: 1 to 100, where higher scores indicate greater stability).
Measured: 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Oct 2026
- Study start1 Nov 2025
- Primary completion7 Apr 2026
- Study completion8 Sep 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Alveolar Bone LossStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 20 participants (actual)
Sponsor and investigators
- Lead sponsor
- Mansoura University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07869082
- Sponsor's protocol ID
- MDP.25.09.23
- Status last verified
- Oct 2026
- First submitted
- 4 Oct 2026
- Last updated
- 9 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 9 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Evaluation of Biologically Oriented Alveolar Ridge Preservation (BARP) With and Without Advanced Platelet-Rich Fibrin Plus (A-PRF+) For Delayed Implant Placement in Maxillary Premolars
- ClinicalTrials.gov ID
- NCT07869082
- Acronym / sponsor ID
- MDP.25.09.23
- Conditions
- Alveolar Bone Loss
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 20 participants (actual)
- Lead sponsor
- Mansoura UniversityUniversity, hospital or other
- Study start
- 1 Nov 2025 (actual)
- Primary completion
- 7 Apr 2026 (actual)
- Study completion
- 8 Sep 2026 (actual)
- First posted
- 9 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Twenty patients were selected from the outpatient clinic of the Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Mansoura University seeking for extraction of non-restorable maxillary premolar teeth prior to delayed implant placement. Patients will be divided into 2 groups:
- Group A: 10 implants were inserted after four months from extraction after socket preservation by putting two collagen sponge layers and in between deproteinized bovine bone.
- Group B: 10 implants were inserted after four months after socket preservation by putting two collagen sponge and in between deproteinized bovine bone with addition of advanced PRF plus layer.
- Closure of the flap was obtained without tension. Implants of all groups were immediately loaded .Some Clinical and Radiographic parameters and Histological and Volumetric evaluation were made at different time intervals along this study.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Deproteinized bovine | Experimental | Procedure: Socket preservation by deproteinized bovine bone graftDeproteinized bovine bone with collagen sponge was used for socket preservation for 10 cases and implant placement was performed after four months. |
| Deproteinized bovine bone with advanced PRF | Experimental | Procedure: socket preservation by deproteinized bovine bone graft mixed with advanced PRF+Deproteinized bovine bone with advanced PRF+ and collagen sponge was used for socket preservation for 10 cases then implant placement was performed after four months. |
Who may qualify
- Ages
- 18 to 50 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Patient with good oral hygiene.
- Age (18-50) years.
- Presence of non-restorable maxillary premolar teeth due to caries, root resorption, roots fracture, etc.
- No history of parafunctional habits
- Adequate inter arch space
Key exclusion criteria (5 listed)
- Patients with systemic diseases that interfere with dental implant insertion.
- Smokers.
- Pregnancy.
- Immunocompromised patients.
- Presence of acute infection at the tooth to be extracted
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Socket preservation by deproteinized bovine bone graftAfter atraumatic extraction, socket preservation by deproteinized bovine bone and collagen sponge was done and implant placement was performed after four months from that. | Procedure or surgery | Deproteinized bovine |
| socket preservation by deproteinized bovine bone graft mixed with advanced PRF+After atraumatic extraction, socket preservation by deproteinized bovine bone mixed with advanced PRF+ and collagen sponge was done and implant placement was performed after four months from that. | Procedure or surgery | Deproteinized bovine bone with advanced PRF |
Primary outcome
Implant stability
Time frame: 6 months
Implant stability measured using Resonance Frequency Analysis (RFA) with the Osstell Mentor device and SmartPeg. Measurements were recorded in four directions (every 90 degrees) and averaged per implant to provide an ISQ score (scale: 1 to 100, where higher scores indicate greater stability).
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Oct 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Socket preservation by deproteinized bovine bone graft and socket preservation by deproteinized bovine bone graft mixed with advanced PRF+ in people with Alveolar Bone Loss, run by Mansoura University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 9 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Implant stability (time frame: 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Oct 2026.