Postoperative Cognitive DysfunctionTAU-PETNCT07871487
Tau Pathology in the Brain After Hip or Knee Replacement Surgery
An observational study of Postoperative Cognitive Dysfunction and Alzheimer Disease, run by Uppsala University Hospital at 1 site in Sweden.
Trial summary
The goal of this observational study is to study whether major surgery is linked to changes in the brain that are typical of Alzheimer's disease. The study is a prospective observational study that will be carried out in Uppsala University Hospital. Read more about this study
- Who is it for?
- Ages 55 to 75 years
- Conditions the study is for
- Postoperative Cognitive Dysfunction, Alzheimer Disease, Tauopathies
- What is being tested?
- Hip or Knee Arthroplasty Under Spinal Anesthesia
- Type of treatment
- Injection or infusion, Surgery or procedure
- How many people
- 30 participants
- Where
- 1 siteSweden
- Study dates
- 1 Apr 2029to 1 Apr 2029
- How long will I take part?
- 24 Months
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 55 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adults aged 55 to 75 years with hip or knee osteoarthritis (ASA physical status 1-2), recruited at Uppsala University Hospital, Sweden. The surgical cohort includes patients scheduled for hip or knee arthroplasty under spinal anesthesia. The non-surgical control cohort includes patients from the orthopedic outpatient clinic who are not scheduled for surgery, matched to the surgical cohort by age and sex.
Who may be able to join
- Surgical cohort:
- Age 55 to 75 years
- ASA physical status class 1 or 2
- Scheduled for hip or knee arthroplasty under regional (spinal) anesthesia at Uppsala University Hospital
- Written informed consent
- Non-surgical control cohort:
Show all 11Show fewer
- Age 55 to 75 years
- ASA physical status class 1 or 2
- Hip or knee osteoarthritis, recruited from the orthopedic outpatient clinic at Uppsala University Hospital
- Not scheduled for surgery
- Written informed consent
Who cannot join
- Mini-Mental State Examination (MMSE) score below 23
- History of systemic inflammatory disorder
- Advanced cardiopulmonary disease
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Sweden1 site, 1 recruiting
- Recruiting
Uppsala University Hospital
Uppsala, 751 85
Miklos Lipcsey, Professor, +46-18-6110000, miklos.lipcsey@uu.se
Sana Asif, M.D, PhD, +46186110000, sana.asif@uu.se
About this study
Official title: Surgery and Postoperative Tau Pathology in Humans: A Translational Imaging and Biochemical Study to Explore Surgery-Induced Hallmarks of Alzheimer's Dementia
The goal of this observational study is to study whether major surgery is linked to changes in the brain that are typical of Alzheimer's disease.
The study is a prospective observational study that will be carried out in Uppsala University Hospital. Adults aged 55-75 years who are healthy otherwise American Society of Anesthesiologists (ASA) 1-2 having a hip or knee replacement under spinal anesthesia, and a comparison group of people of the same age and sex with hip or knee arthrosis who are not having surgery will be included.
Read more
The main questions it aims to answer are:
- Does the amount of the protein tau in the brain increase in the two years after surgery?
- Are changes in tau linked to inflammation in the blood and spinal fluid, and to changes in memory and thinking?
Participants will:
- Have brain scans with positron emission tomography (PET) and magnetic resonance imaging (MRI) scans before surgery and 12 and 24 months later
- Give small samples of spinal fluid and blood
- Complete memory and thinking tests at the same time points
Researchers will compare the surgery group with the non-surgery group to see whether surgery is associated with more tau in the brain and with changes in memory and thinking.
Read the detailed description
Background: Postoperative neurocognitive decline is common in older surgical patients and has been associated with an increased risk of later dementia. Experimental studies show that surgery and anesthesia can trigger neuroinflammation, tau phosphorylation and tau aggregation, and clinical studies have shown acute increases in cerebrospinal fluid (CSF) and blood markers of neuronal injury (tau, neurofilament light) after surgery. Whether surgery leads to increased tau pathology in the human brain is unknown.
Aims: To translate preclinical findings of surgery-induced tau pathology to surgical patients by (A) mapping individual brain tau trajectories, cognitive function and biomarkers of neurodegeneration and brain injury during 24 months after surgery compared with matched non-surgical controls, and (B) linking individual patterns of inflammatory and neurodegenerative biomarkers and immune cell phenotypes to tau pathology and neurocognitive outcomes using pattern-recognition analysis.
Design: Prospective, longitudinal observational cohort study at Uppsala University Hospital, Sweden. A surgical cohort (n=20) undergoing elective hip or knee arthroplasty under spinal anesthesia is compared with a non-surgical control cohort (n=10) with hip or knee arthrosis, matched by age and sex. Participants are aged 55-75 years, ASA physical status 1-2, with MMSE score of 23 or higher.
Methods: All assessments are performed at baseline (before surgery), and at 12 and 24 months after surgery, with corresponding time points in the control cohort.
- Tau PET imaging with the second-generation tracer [18F]RO948 on a simultaneous PET-MR camera. Tau burden is quantified as binding potential in automatically delineated cortical regions (FreeSurfer), with cerebellar cortex as reference region.
- Cognitive assessment with the Neuropsychological Test Battery (NTB; composite z-score and the domains memory, psychomotor speed and executive function) and the Clinical Dementia Rating scale (CDR).
- CSF (4 mL) collected by spinal puncture; at baseline this is done in connection with the spinal anesthesia, before injection of the anesthetic.
- Venous blood samples (25 mL) for plasma, serum and immune cell phenotyping by flow cytometry.
- Biomarkers: Neurofilament light chain (NfL), tau and Glial fibrillary acidic protein (GFAP) by Simoa, and broad inflammatory and glial protein panels by proximity extension assay (Olink).
Analysis: Mixed models and multivariate methods (e.g. principal component analysis) will be used to relate individual biomarker and immune cell trajectories to changes in brain tau burden and cognitive outcomes, and to compare the surgical and control cohorts.
- Conditions
- Postoperative Cognitive Dysfunction, Alzheimer Disease, Tauopathies, Neuroinflammation, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
- Being tested
- Hip or Knee Arthroplasty Under Spinal Anesthesia
- Keywords
- Tau PET, [18F]RO948, Postoperative Neurocognitive Disorder, Cerebrospinal Fluid Biomarkers, Spinal Anesthesia, Surgery-Induced Inflammation, Cognitive Decline
- Medical subject headings
- Postoperative Cognitive Complications, Alzheimer Disease, Tauopathies, Neuroinflammatory Diseases, Cognitive Dysfunction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Hip or Knee Arthroplasty Under Spinal AnesthesiaProcedure or surgery
Also called Total hip replacement, Total knee replacement
Elective primary hip or knee arthroplasty performed as part of routine clinical care; the procedure and anesthesia are not assigned by the study, and surgery is the exposure of interest. All patients receive spinal anesthesia, with optional light propofol sedation during surgery. No general anesthesia is used. Before the intrathecal injection, 4 mL of cerebrospinal fluid is collected for research as the baseline sample. Tau PET-MR, cognitive testing and blood sampling are performed before surgery, with repeat PET-MR, cognitive testing, CSF and blood sampling at 12 and 24 months after surgery.
| Study group | Role | What they receive |
|---|---|---|
| Surgical Cohort | Adults aged 55-75 years, ASA physical status 1-2, undergoing elective hip or knee arthroplasty under spinal anesthesia as part of routine care. Tau PET-MR, cognitive testing, CSF and blood sampling before surgery and at 12 and 24 months after surgery, n=20. Receives: Procedure: Hip or Knee Arthroplasty Under Spinal Anesthesia | |
| Non-Surgical Control Cohort | Adults aged 55-75 years, ASA physical status 1-2, with hip or knee arthrosis not scheduled for surgery. Tau PET-MR, cognitive testing, CSF and blood sampling at baseline and at 12 and 24 months, n=10 |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Tau Levels in the Hippocampus on PET Scan
Tau protein levels in the brain will be measured with a PET scan using the tracer [18F]RO948. Brain regions will be outlined automatically on each participant's MRI using allocated software. The cerebellum will be the reference region. The main region of interest is the hippocampus. Tau levels will be reported as binding potential, which has no units; higher values mean more tau. The change from the first scan to the follow-up scan will be compared between the surgery group and the non-surgery group.
Measured: baseline, 12 and 24 months
Change in Brain Tau Burden Measured by [18F]RO948 PET
Tau protein levels in the brain will be measured with a PET scan using the tracer [18F]RO948. Brain regions will be outlined automatically on each participant's MRI using appropriate software. The cerebellum will be the reference region. The main region of interest is the hippocampus. Tau levels will be reported as binding potential, which has no units; higher values mean more tau. The change from the first scan to the follow-up scan will be compared between the surgery group and the non-surgery group.
Measured: 24 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Oct 2026
- Study start1 Apr 2029 (estimated)
- Primary completion1 Apr 2029 (estimated)
- Study completion1 Apr 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (10)Papers the sponsor has linked to this study.
- Other trials for Postoperative Cognitive DysfunctionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 30 participants (estimated)
- Target duration
- 24 Months
Sponsor and investigators
- Lead sponsor
- Uppsala University Hospital
- Sponsor type
- University, hospital or other
- Collaborators
- Karolinska University Hospital, Uppsala University
- Responsible party
- Principal investigator, Miklos Lipcsey, Uppsala University Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07871487
- Sponsor's protocol ID
- Dnr 2024-05719-02
- Other IDs
- Project grant, Project grant, Project grant
- Acronym
- TAU-PET
- Status last verified
- Oct 2026
- First submitted
- 6 Oct 2026
- Last updated
- 15 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared. The data include sensitive health information (brain imaging, cerebrospinal fluid and cognitive data), and sharing is restricted by the EU General Data Protection Regulation (GDPR), Swedish law and the conditions of the ethical approval (Swedish Ethical Review Authority, Dnr 2024-05719-02).
Publications
Bromander S, Anckarsater R, Kristiansson M, Blennow K, Zetterberg H, Anckarsater H, Wass CE. Changes in serum and cerebrospinal fluid cytokines in response to non-neurological surgery: an observational study. J Neuroinflammation. 2012 Oct 24;9:242. doi: 10.1186/1742-2094-9-242.
PubMed 23095517Tang JX, Mardini F, Janik LS, Garrity ST, Li RQ, Bachlani G, Eckenhoff RG, Eckenhoff MF. Modulation of murine Alzheimer pathogenesis and behavior by surgery. Ann Surg. 2013 Mar;257(3):439-48. doi: 10.1097/SLA.0b013e318269d623.
PubMed 22964728Planel E, Bretteville A, Liu L, Virag L, Du AL, Yu WH, Dickson DW, Whittington RA, Duff KE. Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia. FASEB J. 2009 Aug;23(8):2595-604. doi: 10.1096/fj.08-122424. Epub 2009 Mar 11.
PubMed 19279139Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M. Resolving postoperative neuroinflammation and cognitive decline. Ann Neurol. 2011 Dec;70(6):986-995. doi: 10.1002/ana.22664.
PubMed 22190370Forsberg A, Cervenka S, Jonsson Fagerlund M, Rasmussen LS, Zetterberg H, Erlandsson Harris H, Stridh P, Christensson E, Granstrom A, Schening A, Dymmel K, Knave N, Terrando N, Maze M, Borg J, Varrone A, Halldin C, Blennow K, Farde L, Eriksson LI. The immune response of the human brain to abdominal surgery. Ann Neurol. 2017 Apr;81(4):572-582. doi: 10.1002/ana.24909. Epub 2017 Apr 11.
PubMed 28253549Eriksson LI, Lundholm C, Narasimhalu K, Sandin R, Jin YP, Gatz M, Pedersen NL. Hospitalization, surgery, and incident dementia. Alzheimers Dement. 2019 Apr;15(4):534-542. doi: 10.1016/j.jalz.2018.12.005. Epub 2019 Feb 15.
PubMed 30777379Moller JT, Cluitmans P, Rasmussen LS, Houx P, Rasmussen H, Canet J, Rabbitt P, Jolles J, Larsen K, Hanning CD, Langeron O, Johnson T, Lauven PM, Kristensen PA, Biedler A, van Beem H, Fraidakis O, Silverstein JH, Beneken JE, Gravenstein JS. Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction. Lancet. 1998 Mar 21;351(9106):857-61. doi: 10.1016/s0140-6736(97)07382-0.
PubMed 9525362Leslie M. The post-op brain. Science. 2017 Jun 2;356(6341):898-900. doi: 10.1126/science.356.6341.898. No abstract available.
PubMed 28572347Kulmala J, Ngandu T, Kivipelto M. Prevention Matters: Time for Global Action and Effective Implementation. J Alzheimers Dis. 2018;64(s1):S191-S198. doi: 10.3233/JAD-179919.
PubMed 29504541Weiser TG, Regenbogen SE, Thompson KD, Haynes AB, Lipsitz SR, Berry WR, Gawande AA. An estimation of the global volume of surgery: a modelling strategy based on available data. Lancet. 2008 Jul 12;372(9633):139-144. doi: 10.1016/S0140-6736(08)60878-8. Epub 2008 Jun 24.
PubMed 18582931
Study at a glance
From the registry record, last updated by the sponsor on 15 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Surgery and Postoperative Tau Pathology in Humans: A Translational Imaging and Biochemical Study to Explore Surgery-Induced Hallmarks of Alzheimer's Dementia
- ClinicalTrials.gov ID
- NCT07871487
- Acronym / sponsor ID
- TAU-PET / Dnr 2024-05719-02
- Conditions
- Postoperative Cognitive Dysfunction, Alzheimer Disease, Tauopathies, Neuroinflammation, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
- Keywords
- Tau PET, [18F]RO948, Postoperative Neurocognitive Disorder, Cerebrospinal Fluid Biomarkers, Spinal Anesthesia, Surgery-Induced Inflammation, Cognitive Decline
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Uppsala University HospitalUniversity, hospital or other
- Collaborators
- Karolinska University Hospital, Uppsala University
- Study start
- 1 Apr 2029 (estimated)
- Primary completion
- 1 Apr 2029 (estimated)
- Study completion
- 1 Apr 2029 (estimated)
- First posted
- 13 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this observational study is to study whether major surgery is linked to changes in the brain that are typical of Alzheimer's disease.
The study is a prospective observational study that will be carried out in Uppsala University Hospital. Adults aged 55-75 years who are healthy otherwise American Society of Anesthesiologists (ASA) 1-2 having a hip or knee replacement under spinal anesthesia, and a comparison group of people of the same age and sex with hip or knee arthrosis who are not having surgery will be included.
The main questions it aims to answer are:
- Does the amount of the protein tau in the brain increase in the two years after surgery?
- Are changes in tau linked to inflammation in the blood and spinal fluid, and to changes in memory and thinking?
Participants will:
- Have brain scans with positron emission tomography (PET) and magnetic resonance imaging (MRI) scans before surgery and 12 and 24 months later
- Give small samples of spinal fluid and blood
- Complete memory and thinking tests at the same time points
Researchers will compare the surgery group with the non-surgery group to see whether surgery is associated with more tau in the brain and with changes in memory and thinking.
Detailed description
Background: Postoperative neurocognitive decline is common in older surgical patients and has been associated with an increased risk of later dementia. Experimental studies show that surgery and anesthesia can trigger neuroinflammation, tau phosphorylation and tau aggregation, and clinical studies have shown acute increases in cerebrospinal fluid (CSF) and blood markers of neuronal injury (tau, neurofilament light) after surgery. Whether surgery leads to increased tau pathology in the human brain is unknown.
Aims: To translate preclinical findings of surgery-induced tau pathology to surgical patients by (A) mapping individual brain tau trajectories, cognitive function and biomarkers of neurodegeneration and brain injury during 24 months after surgery compared with matched non-surgical controls, and (B) linking individual patterns of inflammatory and neurodegenerative biomarkers and immune cell phenotypes to tau pathology and neurocognitive outcomes using pattern-recognition analysis.
Design: Prospective, longitudinal observational cohort study at Uppsala University Hospital, Sweden. A surgical cohort (n=20) undergoing elective hip or knee arthroplasty under spinal anesthesia is compared with a non-surgical control cohort (n=10) with hip or knee arthrosis, matched by age and sex. Participants are aged 55-75 years, ASA physical status 1-2, with MMSE score of 23 or higher.
Methods: All assessments are performed at baseline (before surgery), and at 12 and 24 months after surgery, with corresponding time points in the control cohort.
- Tau PET imaging with the second-generation tracer [18F]RO948 on a simultaneous PET-MR camera. Tau burden is quantified as binding potential in automatically delineated cortical regions (FreeSurfer), with cerebellar cortex as reference region.
- Cognitive assessment with the Neuropsychological Test Battery (NTB; composite z-score and the domains memory, psychomotor speed and executive function) and the Clinical Dementia Rating scale (CDR).
- CSF (4 mL) collected by spinal puncture; at baseline this is done in connection with the spinal anesthesia, before injection of the anesthetic.
- Venous blood samples (25 mL) for plasma, serum and immune cell phenotyping by flow cytometry.
- Biomarkers: Neurofilament light chain (NfL), tau and Glial fibrillary acidic protein (GFAP) by Simoa, and broad inflammatory and glial protein panels by proximity extension assay (Olink).
Analysis: Mixed models and multivariate methods (e.g. principal component analysis) will be used to relate individual biomarker and immune cell trajectories to changes in brain tau burden and cognitive outcomes, and to compare the surgical and control cohorts.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Target follow-up
- 24 Months
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Surgical Cohort | – | Procedure: Hip or Knee Arthroplasty Under Spinal AnesthesiaAdults aged 55-75 years, ASA physical status 1-2, undergoing elective hip or knee arthroplasty under spinal anesthesia as part of routine care. Tau PET-MR, cognitive testing, CSF and blood sampling before surgery and at 12 and 24 months after surgery, n=20. |
| Non-Surgical Control Cohort | – | –Adults aged 55-75 years, ASA physical status 1-2, with hip or knee arthrosis not scheduled for surgery. Tau PET-MR, cognitive testing, CSF and blood sampling at baseline and at 12 and 24 months, n=10 |
Who may qualify
- Ages
- 55 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adults aged 55 to 75 years with hip or knee osteoarthritis (ASA physical status 1-2), recruited at Uppsala University Hospital, Sweden. The surgical cohort includes patients scheduled for hip or knee arthroplasty under spinal anesthesia. The non-surgical control cohort includes patients from the orthopedic outpatient clinic who are not scheduled for surgery, matched to the surgical cohort by age and sex.
Key inclusion criteria (11 listed)
- Age 55 to 75 years
- ASA physical status class 1 or 2
- Scheduled for hip or knee arthroplasty under regional (spinal) anesthesia at Uppsala University Hospital
- Written informed consent
- Age 55 to 75 years
Key exclusion criteria (3 listed)
- Mini-Mental State Examination (MMSE) score below 23
- History of systemic inflammatory disorder
- Advanced cardiopulmonary disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Hip or Knee Arthroplasty Under Spinal AnesthesiaAlso: Total hip replacement, Total knee replacementElective primary hip or knee arthroplasty performed as part of routine clinical care; the procedure and anesthesia are not assigned by the study, and surgery is the exposure of interest. All patients receive spinal anesthesia, with optional light propofol sedation during surgery. No general anesthesia is used. Before the intrathecal injection, 4 mL of cerebrospinal fluid is collected for research as the baseline sample. Tau PET-MR, cognitive testing and blood sampling are performed before surgery, with repeat PET-MR, cognitive testing, CSF and blood sampling at 12 and 24 months after surgery. | Procedure or surgery | Surgical Cohort |
Primary outcome
Change in Tau Levels in the Hippocampus on PET Scan
Time frame: baseline, 12 and 24 months
Tau protein levels in the brain will be measured with a PET scan using the tracer [18F]RO948. Brain regions will be outlined automatically on each participant's MRI using allocated software. The cerebellum will be the reference region. The main region of interest is the hippocampus. Tau levels will be reported as binding potential, which has no units; higher values mean more tau. The change from the first scan to the follow-up scan will be compared between the surgery group and the non-surgery group.
Change in Brain Tau Burden Measured by [18F]RO948 PET
Time frame: 24 months
Tau protein levels in the brain will be measured with a PET scan using the tracer [18F]RO948. Brain regions will be outlined automatically on each participant's MRI using appropriate software. The cerebellum will be the reference region. The main region of interest is the hippocampus. Tau levels will be reported as binding potential, which has no units; higher values mean more tau. The change from the first scan to the follow-up scan will be compared between the surgery group and the non-surgery group.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Oct 2026.
- Background: PubMed 23095517Bromander S, Anckarsater R, Kristiansson M, Blennow K, Zetterberg H, Anckarsater H, Wass CE. Changes in serum and cerebrospinal fluid cytokines in response to non-neurological surgery: an observational study. J Neuroinflammation. 2012 Oct 24;9:242. doi: 10.1186/1742-2094-9-242.
- Background: PubMed 22964728Tang JX, Mardini F, Janik LS, Garrity ST, Li RQ, Bachlani G, Eckenhoff RG, Eckenhoff MF. Modulation of murine Alzheimer pathogenesis and behavior by surgery. Ann Surg. 2013 Mar;257(3):439-48. doi: 10.1097/SLA.0b013e318269d623.
- Background: PubMed 19279139Planel E, Bretteville A, Liu L, Virag L, Du AL, Yu WH, Dickson DW, Whittington RA, Duff KE. Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia. FASEB J. 2009 Aug;23(8):2595-604. doi: 10.1096/fj.08-122424. Epub 2009 Mar 11.
- Background: PubMed 22190370Terrando N, Eriksson LI, Ryu JK, Yang T, Monaco C, Feldmann M, Jonsson Fagerlund M, Charo IF, Akassoglou K, Maze M. Resolving postoperative neuroinflammation and cognitive decline. Ann Neurol. 2011 Dec;70(6):986-995. doi: 10.1002/ana.22664.
- Background: PubMed 28253549Forsberg A, Cervenka S, Jonsson Fagerlund M, Rasmussen LS, Zetterberg H, Erlandsson Harris H, Stridh P, Christensson E, Granstrom A, Schening A, Dymmel K, Knave N, Terrando N, Maze M, Borg J, Varrone A, Halldin C, Blennow K, Farde L, Eriksson LI. The immune response of the human brain to abdominal surgery. Ann Neurol. 2017 Apr;81(4):572-582. doi: 10.1002/ana.24909. Epub 2017 Apr 11.
- Background: PubMed 30777379Eriksson LI, Lundholm C, Narasimhalu K, Sandin R, Jin YP, Gatz M, Pedersen NL. Hospitalization, surgery, and incident dementia. Alzheimers Dement. 2019 Apr;15(4):534-542. doi: 10.1016/j.jalz.2018.12.005. Epub 2019 Feb 15.
- Background: PubMed 9525362Moller JT, Cluitmans P, Rasmussen LS, Houx P, Rasmussen H, Canet J, Rabbitt P, Jolles J, Larsen K, Hanning CD, Langeron O, Johnson T, Lauven PM, Kristensen PA, Biedler A, van Beem H, Fraidakis O, Silverstein JH, Beneken JE, Gravenstein JS. Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction. Lancet. 1998 Mar 21;351(9106):857-61. doi: 10.1016/s0140-6736(97)07382-0.
- Background: PubMed 28572347Leslie M. The post-op brain. Science. 2017 Jun 2;356(6341):898-900. doi: 10.1126/science.356.6341.898. No abstract available.
- Background: PubMed 29504541Kulmala J, Ngandu T, Kivipelto M. Prevention Matters: Time for Global Action and Effective Implementation. J Alzheimers Dis. 2018;64(s1):S191-S198. doi: 10.3233/JAD-179919.
- Background: PubMed 18582931Weiser TG, Regenbogen SE, Thompson KD, Haynes AB, Lipsitz SR, Berry WR, Gawande AA. An estimation of the global volume of surgery: a modelling strategy based on available data. Lancet. 2008 Jul 12;372(9633):139-144. doi: 10.1016/S0140-6736(08)60878-8. Epub 2008 Jun 24.
- Related InfoLink provided by the sponsor.
- Individual participant dataSharing planned: No. Individual participant data will not be shared. The data include sensitive health information (brain imaging, cerebrospinal fluid and cognitive data), and sharing is restricted by the EU General Data Protection Regulation (GDPR), Swedish law and the conditions of the ethical approval (Swedish Ethical Review Authority, Dnr 2024-05719-02).
Related trials for Postoperative Cognitive Dysfunction
Not yet recruiting
Prediction and Prevention of Postoperative Mortality and Morbidity
Dementia, Postoperative Delirium (POD)
Active, not recruitingObservational study
Association of POCD With Circulating Biomarkers in Patients Undergoing TUR of Bladder Tumor
Cognitive Decline, Urinary Bladder Cancer
Active, not recruitingObservational study
The Effect of Single Lung Ventilation Duration and Intraoperative Brain Oxygenation on Cognitive Function and Postoperative Pain in Geriatric Patients
Thoracic Anesthesia, Geriatric Anesthesia
Not yet recruitingPhase 4
Effects of Remimazolam on Postoperative Cognitive Dysfunction and Neuroinflammatory Biomarkers in Patients Undergoing Aortic Arch Surgery
Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch
Enrolling by invitationPhase 4
Effects of Ciprofol on Perioperative Neurocognitive Function in Elderly Patients Undergoing Daytime Surgery
PND, POCD - Postoperative Cognitive Dysfunction
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Postoperative Cognitive Dysfunction and Alzheimer Disease, run by Uppsala University Hospital at 1 site in Sweden.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 11 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 15 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Sweden. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Miklos Lipcsey, Professor (+46186110000, miklos.lipcsey@uu.se), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Tau Levels in the Hippocampus on PET Scan (time frame: baseline, 12 and 24 months). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07871487, which also lists 10 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Oct 2026.