Pre DiabetesNCT07873437
The Effect of Nutrient Sequencing in Healthy Adults
A study testing Finger Prick- Blood Glucose, Whole Blood Draw and Diet History Questionnaire in people with Pre Diabetes, run by Cornell University at 1 site in United States.
Trial summary
There is emerging evidence that the order in which food is consumed in a meal, known as the "nutrient sequence", can have protective health effects against obesity and metabolic disease. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Pre Diabetes
- What is being tested?
- Finger Prick- Blood Glucose, Whole Blood Draw and Diet History Questionnaire
- Type of treatment
- Surgery or procedure, Lifestyle or therapy programme
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 40 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Sep 2026to 1 Oct 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Weight classification as lean or overweight (BMI: 18.5- 29.9)
- Age range of 18-35 years old
Who cannot join
- Self-reported Type I or II diabetes
- Thyroid dysfunction
- Bleeding disorders (e.g., Hemophilia A/B, Von Willebrand Disease, or known thrombocytopenia)
- Use of prescription blood thinners or anticoagulants (e.g., warfarin, heparin, etc.)
- History of difficulty with blood collection, lab draws, or with prior IV insertion (e.g., 'small veins,' 'hard stick,' etc.)
- Smoking, recreational drug use, weight loss medications, vaccine administration within last two weeks as these conditions will influence whole body metabolism and compromise dietary response.
Trial locations and contacts
1 site in 1 country.
About this study
There is emerging evidence that the order in which food is consumed in a meal, known as the "nutrient sequence", can have protective health effects against obesity and metabolic disease. These studies show that consuming food sources rich in protein before consuming carbohydrates will significantly lower blood glucose levels equivalent to many glucose-lowering medications. This nutrition intervention can have tremendous therapeutic potential in individuals who are pre-diabetic and prevent the onset of obesity. Surprisingly, however, there are no studies to date that have comprehensively tested this efficacy in young health adults. This research proposal will define the response of nutrient sequencing in young healthy individuals to determine if this intervention can improve metabolic profiles such as normalizing blood glucose levels to healthy parameters in order to prevent obesity and type 2 diabetes. We will 1) test if the metabolic benefits of Nutrient Sequencing can extend across different populations in NY state, and 2) define the mechanism of the metabolic response to nutrient sequencing interventions by capturing participant circulating blood proteome and metabolome.
- Conditions
- Pre Diabetes
- Being tested
- Finger Prick- Blood Glucose, Whole Blood Draw, Diet History Questionnaire, Physical Activity Assessment
- Medical subject headings
- Glucose Intolerance
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Finger Prick- Blood GlucoseProcedure or surgery
Measurement of Blood glucose via finger prick
Whole Blood DrawProcedure or surgery
Collection of whole blood for plasma and serum measurements
Diet History QuestionnaireBehavioural
Assessment of dietary frequency patterns via DHQ III
Physical Activity AssessmentBehavioural
Assessment of habitual physical activity via IPAQ survey
| Study group | Role | What they receive |
|---|---|---|
| Control Diet | Placebo comparator | Control Diet: turkey sausage, white bread toast with strawberry jelly, and orange juice consumed in a mixed format within 30min. Receives: Procedure: Finger Prick- Blood Glucose; Procedure: Whole Blood Draw; Behavioral: Diet History Questionnaire; Behavioral: Physical Activity Assessment |
| Nutrient Sequencing | Experimental | Nutrient Sequencing Diet: turkey sausage, white bread toast with strawberry jelly, water. Participants will consume the turkey sausage first and then 10 minutes after they will consume the toast with jelly and orange juice in 20 minutes (Total time = 30 minutes) Receives: Procedure: Finger Prick- Blood Glucose; Procedure: Whole Blood Draw; Behavioral: Diet History Questionnaire; Behavioral: Physical Activity Assessment |
What is being measured
The primary outcome is the main question the study is designed to answer.
Blood Glucose
Measured: Collected via finger prick (5 collection points- Timepoints 0, 30, 60, 90, and 120mins) for both Visit 1 at baseline and Visit 2 which occurs 1 week later after the washout period.
Secondary outcomes (4)
Body Fat Percentage
Measured: Collected during Visit 1at baseline via bioelectrical impedance analysis (BIA).
Blood Insulin Levels
Measured: Blood collection (3 time point each- Timepoints 0, 30, and 120 mins) during Visit 1 at baseline and Visit 2 after a 1 week washout period. Blood insulin levels will be measured two weeks after Visit 2.
Leptin Blood Measurement
Measured: Blood collection (3 time point each- Timepoints 0, 30, and 120 mins) during Visit 1 at baseline and Visit 2 after a 1 week washout period. Blood leptin levels will be measured two weeks after Visit 2.
Healthy Eating Index
Measured: Collected during Visit 1 at baseline using the DHQIII diet frequency questionnaire.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Oct 2026
- Study start1 Sep 2026
- Primary completion1 Oct 2028 (estimated)
- Study completion1 Oct 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Pre DiabetesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 40 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cornell University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07873437
- Sponsor's protocol ID
- 0148937
- Status last verified
- Sep 2026
- First submitted
- 16 Sep 2026
- Last updated
- 14 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 14 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Nutrient Sequencing in Healthy Adults
- ClinicalTrials.gov ID
- NCT07873437
- Acronym / sponsor ID
- 0148937
- Conditions
- Pre Diabetes
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 40 participants (estimated)
- Lead sponsor
- Cornell UniversityUniversity, hospital or other
- Study start
- 1 Sep 2026 (actual)
- Primary completion
- 1 Oct 2028 (estimated)
- Study completion
- 1 Oct 2028 (estimated)
- First posted
- 14 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
There is emerging evidence that the order in which food is consumed in a meal, known as the "nutrient sequence", can have protective health effects against obesity and metabolic disease. These studies show that consuming food sources rich in protein before consuming carbohydrates will significantly lower blood glucose levels equivalent to many glucose-lowering medications. This nutrition intervention can have tremendous therapeutic potential in individuals who are pre-diabetic and prevent the onset of obesity. Surprisingly, however, there are no studies to date that have comprehensively tested this efficacy in young health adults. This research proposal will define the response of nutrient sequencing in young healthy individuals to determine if this intervention can improve metabolic profiles such as normalizing blood glucose levels to healthy parameters in order to prevent obesity and type 2 diabetes. We will 1) test if the metabolic benefits of Nutrient Sequencing can extend across different populations in NY state, and 2) define the mechanism of the metabolic response to nutrient sequencing interventions by capturing participant circulating blood proteome and metabolome.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Control Diet | Placebo comparator | Procedure: Finger Prick- Blood Glucose, Procedure: Whole Blood Draw, Behavioral: Diet History Questionnaire, Behavioral: Physical Activity AssessmentControl Diet: turkey sausage, white bread toast with strawberry jelly, and orange juice consumed in a mixed format within 30min. |
| Nutrient Sequencing | Experimental | Procedure: Finger Prick- Blood Glucose, Procedure: Whole Blood Draw, Behavioral: Diet History Questionnaire, Behavioral: Physical Activity AssessmentNutrient Sequencing Diet: turkey sausage, white bread toast with strawberry jelly, water. Participants will consume the turkey sausage first and then 10 minutes after they will consume the toast with jelly and orange juice in 20 minutes (Total time = 30 minutes) |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Weight classification as lean or overweight (BMI: 18.5- 29.9)
- Age range of 18-35 years old
Key exclusion criteria (6 listed)
- Self-reported Type I or II diabetes
- Thyroid dysfunction
- Bleeding disorders (e.g., Hemophilia A/B, Von Willebrand Disease, or known thrombocytopenia)
- Use of prescription blood thinners or anticoagulants (e.g., warfarin, heparin, etc.)
- History of difficulty with blood collection, lab draws, or with prior IV insertion (e.g., 'small veins,' 'hard stick,' etc.)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Finger Prick- Blood GlucoseMeasurement of Blood glucose via finger prick | Procedure or surgery | Control Diet, Nutrient Sequencing |
| Whole Blood DrawCollection of whole blood for plasma and serum measurements | Procedure or surgery | Control Diet, Nutrient Sequencing |
| Diet History QuestionnaireAssessment of dietary frequency patterns via DHQ III | Behavioural | Control Diet, Nutrient Sequencing |
| Physical Activity AssessmentAssessment of habitual physical activity via IPAQ survey | Behavioural | Control Diet, Nutrient Sequencing |
Primary outcome
Blood Glucose
Time frame: Collected via finger prick (5 collection points- Timepoints 0, 30, 60, 90, and 120mins) for both Visit 1 at baseline and Visit 2 which occurs 1 week later after the washout period.
4 secondary outcomes
Body Fat Percentage
Time frame: Collected during Visit 1at baseline via bioelectrical impedance analysis (BIA).
Blood Insulin Levels
Time frame: Blood collection (3 time point each- Timepoints 0, 30, and 120 mins) during Visit 1 at baseline and Visit 2 after a 1 week washout period. Blood insulin levels will be measured two weeks after Visit 2.
Leptin Blood Measurement
Time frame: Blood collection (3 time point each- Timepoints 0, 30, and 120 mins) during Visit 1 at baseline and Visit 2 after a 1 week washout period. Blood leptin levels will be measured two weeks after Visit 2.
Healthy Eating Index
Time frame: Collected during Visit 1 at baseline using the DHQIII diet frequency questionnaire.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 14 Oct 2026.
- Individual participant dataSharing planned: Yes
Related trials for Pre Diabetes
Recruiting
Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic Adults
Hyperglycaemia (Non Diabetic), Prediabetes
RecruitingObservational study
Food-i-Sense Analytics: Integrating AI Into Continuous Glucose Monitoring Data Analysis for Precision Nutrition.
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Artificial Intelligence Mobile Application
RecruitingPhase 3
A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity
Overweight, Prediabetic State
RecruitingObservational study
Estimated Risk of Preeclampsia in the First Trimester and Its Association With Subclinical Atherosclerosis and Cardiovascular Risk in Women With Type 1 Diabetes
Type 1 Diabetes, Preeclampsia
Enrolling by invitationEarly Phase 1
Truway Diagnostic Tools in Primary Care
Chronic Disease, Type 2 Diabetes Mellitus (T2DM), Obesity, Overweight
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Finger Prick- Blood Glucose, Whole Blood Draw and Diet History Questionnaire in people with Pre Diabetes, run by Cornell University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 14 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Blood Glucose (time frame: Collected via finger prick (5 collection points- Timepoints 0, 30, 60, 90, and 120mins) for both Visit 1 at baseline and Visit 2 which occurs 1 week later after the washout period.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 14 Oct 2026.