Chronic Lung DiseasesPRESIDENCT07874139
Prospective Study on Antimicrobial RESIstance in Chronic Pulmonary DiseasE
An observational study of Chronic Lung Diseases, run by Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico at 68 sites in 33 countries.
Trial summary
This observational, multicentric prospective study aims to understand the prevalence and burden of antimicrobial resistance (AMR) in people with chronic lung diseases (CLD) across the globe, understanding also geographical variability and the risk factors for acquiring AMR. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Chronic Lung Diseases
- How many people
- 683 participants
- Where
- 68 sitesin 33 countries
- Study dates
- 31 Mar 2025to Nov 2029
- How long will I take part?
- 5 Years
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: The study will include patients of all ages with all kinds of chronic lung disease who underwent testing of at least one respiratory sample in the previous 12 months who attend a respiratory outpatient clinic or are hospitalized during the yearly two two-weeks recruitment windows.
Who may be able to join
- Patients of all ages with any chronic lung disease who, for clinical practice, underwent testingof at least one respiratory biological sample (sputum culture; bronchoaspirate; bronchoalveolar lavage; nasal swab; throat swab) within the 12 months prior to the visit.
- Patients attending an outpatient clinic or hospitalized during the study period
Who cannot join
- Patients who have not signed the informed consent form
- Absence of data in the patient record
Trial locations and contacts
68 sites in 33 countries. Contact the study team or a site near you to ask about taking part.
68 sites in 33 countries
United Kingdom15 sites, 15 recruiting
- Recruiting
Antrim Area Hospital
Antrim
Paul Minnis
- Recruiting
Ysbyty Gwynedd
Bangor
Wendy Scrase
- Recruiting
Blackpool Victoria Hospital
Blackpool
Mohamed Etumi
- Recruiting
Ysbyty Glan Clwyd
Bodelwyddan
Jessica Briody-Hughes
- Recruiting
Royal Sussex County Hospital
Brighton
Katie Hurt
- Recruiting
St Richard's University Hospital
Chichester
Bethia Bradley
- Recruiting
University Hospital Coventry
Coventry
Beatriz Lara Gallego
- Recruiting
Ulster Hospital
Dundonald
Jennifer Elder
- Recruiting
NHS Fife Queen Margaret Hospital
Dunfermline
Alison Cassels
- Recruiting
Liverpool Heart and Chest Hospital
Liverpool
Freddy Frost
- Recruiting
Imperial College Healthcare NHS Trust
London
Lydia Finney
- Recruiting
Royal Brompton & Harefield NHS Trust
London
Anand Shah
- Recruiting
Musgrove Park Hospital
Taunton
Joanna Tilley
- Recruiting
Torbay and South Devon Foundation Trust
Torquay
Bianca Hulance
- Recruiting
Wrexham Maelor Hospital
Wrexham
Louise Ransom
Italy7 sites, 6 recruiting
- Recruiting
Policlinico S Orsola - Malpighi
Bologna
Vittoria Comellini
- Recruiting
ULSS3 Serenissima Ospedale di Dolo
Dolo
Manuele Nizzetto
- Recruiting
AOU Policlinico Universitario G Martino
Messina
Sara Manti
- Active, not recruiting
ASST Santi Paolo e Carlo
Milan
- Recruiting
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano
Milan
Andrea Gramegna, +39 0255032020, Andrea.gramegna@policlinico.mi.it
Andrea Gramegna
- Recruiting
IRCCS Humanitas Research Hospital
Milan
Mattia Nigro
- Recruiting
IRCCS San Gerardo dei Tintori
Monza
Paola Faverio
Spain6 sites, 6 recruiting
- Recruiting
Hospital del Mar Research Institute
Barcelona
Esther Barreiro
- Recruiting
Hospital san Joan de Deu de Martorell
Barcelona
Annie Navarro
- Recruiting
Hospital Universitario de Getafe
Getafe
Beatriz Raboso Moreno
- Recruiting
Hospital La Princesa
Madrid
Rosa Maria Giron Moreno
- Recruiting
Hospital Regional Universitario de Malaga
Málaga
Casilda Olveira Fuster
- Recruiting
Hospital Recoletas Salud Campo Grande
Valladolid
Francisco Muniz Gonzalez
Belgium5 sites, 5 recruiting
- Recruiting
Antwerp University Hospital
Antwerp
Katrien Eger
- Recruiting
CHU St Pierre
Brussels
Maria Gabrovska
- Recruiting
AZ Maria Middelares
Ghent
Sarah Loof
- Recruiting
Ghent University Hospital
Ghent
Eva VanBraekel
- Recruiting
University Hospital Leuven
Leuven
Natalie Lorent
India4 sites, 4 recruiting
- Recruiting
GCS Medical College Hospital and Research Centre
Ahmedabad
Jatin Nagar
- Recruiting
AIIMS (All India Institute of Medical Science)
Dehli
Animesh Ray
- Recruiting
Aster Medcity
Kochi
Praveen Valsalan
- Recruiting
Calcutta Medical Research Institute
Kolkata
Raja Dhar
Egypt2 sites, 2 recruiting
- Recruiting
Assiut University Hospital
Asyut
Arafa Abdoelhassan
- Recruiting
Al Hussein University Hospital
Cairo
Ahmed Kabil
Germany2 sites, 2 recruiting
- Recruiting
Charité - Universitatmedizin Berlin
Berlin
Stephanie Thee
- Recruiting
University Clinic Marburg
Marburg
Bernd Schmeck
Turkey (Türkiye)2 sites, 2 recruiting
- Recruiting
Ankara Ataturk Sanatorium Education and Research Hospital
Ankara
Ulku Yilmaz
- Recruiting
Marmara University Faculty of Medicine
Istanbul
Bulent Karadag
United States1 site, 1 recruiting
- Recruiting
University of Michigan
Ann Arbor, Michigan, 48109
Shijing Jia
Albania1 site, 1 recruiting
- Recruiting
Catholic University Our Lady of Good Counsel
Tirana
Malvina Hoxha
Australia1 site, 1 recruiting
- Recruiting
Frankston Hospital
Frankston
Emem Ukor
Brazil1 site, 1 recruiting
- Recruiting
Santa Casa de Belo Horizonte
Minas Gerais
Debora Estrella
Canada1 site, 1 recruiting
- Recruiting
Foothills Medical Centre
Calgary
Christina Thornton
China1 site, 1 recruiting
- Recruiting
Hangzhou Red Cross Hospital
Hangzhou
Chuhui Ru
Croatia1 site, 1 recruiting
- Recruiting
Dubrava University Hospital
Zagreb
Divo Ljubicic
Czechia1 site, 1 recruiting
- Recruiting
2nd Faculty of Medicine, Charles University and Motol University Hospital
Prague
Pavel Drevinek
Denmark1 site, 1 recruiting
- Recruiting
Zealand University Hospital - Roskilde and Naestved
Copenhagen
Markus Fally
France1 site, 1 recruiting
- Recruiting
Centre Hospitalier Universitaire de Reims
Reims
Thomas Guillard
Greece1 site, 1 recruiting
- Recruiting
General Hospital "Papanikolaou"
Thessaloniki
Stavros Tryfon
Hong Kong1 site, 1 recruiting
- Recruiting
The University of Hong Kong, Pok Fu Lam
Hong Kong
Kwok Wang Chun
Nepal1 site, 1 recruiting
- Recruiting
Kathmandu Medical College
Kathmandu
Navin Mishra
Nigeria1 site, 1 recruiting
- Recruiting
Nigeria Centre for Disease Control and Prevention
Abuja
Adekunle Adeoti
North Macedonia1 site, 1 recruiting
- Recruiting
General Hospital 8th September
Skopje
Daniela Buklioska Ilievska
Pakistan1 site, 1 recruiting
- Recruiting
Aga Khan University
Karachi
Muhammad Irfan
Poland1 site, 1 recruiting
- Recruiting
Instytut Gruzlicy i Chorob Pluc
Warsaw
Henryk Mazurek
Portugal1 site, 1 recruiting
- Recruiting
Hospital de Santa Maria, Centro Ospitalar Lisboa Norte EPE
Lisbon
Pilar Azevedo
Serbia1 site, 1 recruiting
- Recruiting
University Clinical Centre Nis
Niš
Desa Nastasijevic Borovac
Slovenia1 site, 1 recruiting
- Recruiting
University Clinic of Respiratory and Allergic Diseases
Golnik
Irena Sarc
South Korea1 site, 1 recruiting
- Recruiting
Hallym University Kangnam Sacred Heart Hospital
Seoul
Hayoung Choi
Sri Lanka1 site, 1 recruiting
- Recruiting
Faculty of Medicine, University of Colombo
Colombo
Vipula Bataduwaraachchi
Tunisia1 site, 1 recruiting
- Recruiting
Internal Security Forces Hospital La Marsa
Tunis
Hela Cherif
Ukraine1 site, 1 recruiting
- Recruiting
St Paraskeva Medical Centre
Lviv
Andriy Serediuk
United Arab Emirates1 site, 1 recruiting
- Recruiting
Cleveland Clinic
Abu Dhabi
Irfan Shafiq
About this study
Official title: PRESIDE: Prospective Study on Antimicrobial RESIstance in Chronic Pulmonary DiseasE
This observational, multicentric prospective study aims to understand the prevalence and burden of antimicrobial resistance (AMR) in people with chronic lung diseases (CLD) across the globe, understanding also geographical variability and the risk factors for acquiring AMR.
The primary objective is to understand the prevalence and burden of AMR in CLD both at a local and gloval level.
Secondary objectives include: 1) understanding susceptibilities models of high priority pathogens in people with CLD; 2) understanding geographic variability in the prevalence of AMR in CLD; 3) analysing risk factors for AMR in CLD Participants will be recruited
Read the detailed description
This is an observational prospective, non-pharmacological, multicentre, international, non-profit study. Data will be collected at all participating centres during two separate two-week periods every year over the course of five consecutive years. Patients with underlying chronic lung diseases in an inpatient or outpatient setting with at least one respiratory sample collected over the prior 12 months will be included. The diagnostic criteria will follow standard clinical procedures. The data will be pseudonymized before being entered into the electronic case report form (eCRF) prepared with RedCap. After signing the informed consent, clinical, demographic, and microbiological variables will be collected. To facilitate the collection of some demographic and clinical variables, a questionnaire will be administered at recruitment.
All procedures whose data will be collected for this protocol fall within normal clinical practice and are in accordance with the standard operating procedures in place at the centre. No procedures, diagnostic tests, or interventions outside the usual clinical practice will be performed for this protocol.
- Conditions
- Chronic Lung Diseases
- Keywords
- AMR, antimicrobial resistance, chronic lung disease, chronic respiratory disease, chronic pulmonary disease, chronic respiratory conditions, high-priority pathogens
What is being measured
The primary outcome is the main question the study is designed to answer.
Prevalence of antimicrobial resistance in chronic lung diseases
Prevalence and burden of antimicrobial resistance in chronic lung diseases at both local and global levels.
Measured: Five years from the beginning of the study.
Secondary outcomes (3)
The antimicrobial susceptibility profile of high-priority resistant pathogens
The antimicrobial susceptibility profile of high-priority resistant pathogens in chronic lung diseases.
Measured: Five years from the beginning of the study.
The geographical variation in the prevalence of antimicrobial resistance
The geographical variation in the prevalence of antimicrobial resistance and antimicrobial susceptibility profiles
Measured: Five years from the beginning of the study
The risk factors for antimicrobial resistance in chronic lung diseases.
The risk factors for antimicrobial resistance in chronic lung diseases.
Measured: Five years from the beginning of the study
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Oct 2026
- Study start31 Mar 2025
- Primary completionNov 2029 (estimated)
- Study completionNov 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Chronic Lung DiseasesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 683 participants (estimated)
- Target duration
- 5 Years
Sponsor and investigators
- Lead sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
- Sponsor type
- University, hospital or other
- Collaborators
- European Respiratory Society, Royal Brompton & Harefield NHS Foundation Trust, Imperial College London
- Responsible party
- Sponsor
- Investigators
- Andrea Gramegna, Principal investigator, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07874139
- Sponsor's protocol ID
- SF 260528
- Acronym
- PRESIDE
- Status last verified
- Oct 2026
- First submitted
- 8 Oct 2026
- Last updated
- 14 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No