Carpel Tunnel SyndromeNCT07875751
Effectiveness of Sensorimotor Proprioceptive Stimulation Combined With Conventional Physical Therapy on Symptoms, Sensory Function, Proprioception, and Hand Function in Patients With Mild-to-Moderate Carpal Tunnel Syndrome
A study testing sensorimotor proprioceptive stimulation and conventional physical therapy in people with Carpel Tunnel Syndrome, run by Delta University for Science and Technology at 1 site in Egypt.
Trial summary
This randomized controlled trial will evaluate whether adding sensorimotor proprioceptive stimulation to conventional physiotherapy improves symptoms and hand function in patients with mild-to-moderate carpal tunnel syndrome. Read more about this study
- Who is it for?
- Ages 30 to 50 years
- Conditions the study is for
- Carpel Tunnel Syndrome
- What is being tested?
- sensorimotor proprioceptive stimulation and conventional physical therapy
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteEgypt
- Study dates
- 5 Oct 2026to 1 Feb 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 50 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Are adults aged 30-50 years.
- Have clinically diagnosed mild-to-moderate carpal tunnel syndrome.
- Report pain, numbness, tingling, or nocturnal symptoms in the median-nerve distribution.
- Have symptoms lasting at least 4 weeks.
- Have electrodiagnostic findings consistent with mild-to-moderate median-nerve compression at the wrist.
- Can understand and follow study instructions.
- Can attend treatment and assessment sessions.
- Provide written informed consent.
Who cannot join
- Severe carpal tunnel syndrome requiring immediate surgery.
- Previous carpal tunnel release or wrist surgery.
- Cervical radiculopathy, brachial plexopathy, or another peripheral neuropathy.
- Diabetes, rheumatoid arthritis, thyroid disease, or other systemic conditions affecting nerve function, unless medically stable and permitted by the protocol.
- Wrist fracture, arthritis, tendon injury, or other upper-limb musculoskeletal disorders.
- Pregnancy.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site
Nile Physio Clinic
Al Mansurah
Ibrahim Abu Ella, PhD, 0201008442281, ibrahimneuron@gmail.com
About this study
Official title: Effectiveness of Sensorimotor Proprioceptive Stimulation Combined With Conventional Physical Therapy on Symptoms, Sensory Function, Proprioception, and Hand Function in Patients With Mild-to-Moderate Carpal Tunnel Syndrome: A Randomized Controlled Trial
This randomized controlled trial will evaluate whether adding sensorimotor proprioceptive stimulation to conventional physiotherapy improves symptoms and hand function in patients with mild-to-moderate carpal tunnel syndrome. The primary outcome is change in the Boston Symptom Severity Scale, while secondary outcomes include functional status, pain, paresthesia, nerve conduction, median-nerve morphology, proprioception, and hand strength.
Read the detailed description
This randomized controlled trial will investigate whether adding sensorimotor proprioceptive stimulation to conventional physical therapy improves symptoms, sensory function, proprioception, and hand function in adults with mild-to-moderate carpal tunnel syndrome.
Participants will be randomly assigned to either an experimental group receiving sensorimotor proprioceptive stimulation plus conventional physical therapy or a control group receiving conventional physical therapy alone. The intervention will target sensory awareness, wrist and hand joint-position control, median-nerve function, coordination, and functional hand use.
Experimental Intervention
The experimental group will receive a structured program involving:
Wrist and hand joint-position-reproduction exercises.
Visual and nonvisual proprioceptive training.
Controlled wrist, thumb, and finger movements.
Tendon-gliding and median-nerve-gliding exercises.
Graded tactile and sensory stimulation.
Grip, pinch, and fine-motor coordination activities.
Progressive closed-chain or weight-bearing exercises, when tolerated.
Home exercises performed according to a standardized program.
Exercises will progress from simple, visually guided movements to more challenging tasks performed with reduced visual feedback and increased functional demand. The therapist will monitor symptom aggravation, numbness, pain, fatigue, and movement accuracy throughout treatment.
- Conditions
- Carpel Tunnel Syndrome
- Being tested
- sensorimotor proprioceptive stimulation, conventional physical therapy
- Keywords
- proprioception, sensorimotor, conventional, CTS
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
sensorimotor proprioceptive stimulationOther
Participants will receive sensorimotor proprioceptive stimulation combined with conventional physical therapy. The program will include joint-position training, tactile sensory stimulation, wrist and hand coordination exercises, tendon and median-nerve gliding, grip and pinch activities, and progressive functional hand exercises.
conventional physical therapyOther
Participants will receive conventional physical therapy alone, including education, ergonomic advice, wrist and hand range-of-motion exercises, tendon-gliding exercises, strengthening exercises, and a standardized home-exercise program.
| Study group | Role | What they receive |
|---|---|---|
| study group | Experimental | Not described Receives: Other: sensorimotor proprioceptive stimulation |
| control group | Active comparator | Not described Receives: Other: conventional physical therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Boston Carpal Tunnel Questionnaire Symptom Severity Scale
The Boston Carpal Tunnel Questionnaire Symptom Severity Scale consists of 11 items assessing pain, numbness, tingling, weakness, nocturnal symptoms, and difficulty grasping objects. Each item is scored from 1 to 5. The total score will be calculated as the mean of the 11 item scores:
Mean SSS score = sum of the 11 item scores ÷ 11
The final score ranges from 1 to 5, with higher scores indicating greater symptom severity.
Measured: baseline
Secondary outcomes (4)
Pain Intensity
Pain intensity will be assessed using a visual analogue scale. Participants will mark their pain intensity on a continuous 10-cm line, where 0 cm represents no pain and 10 cm represents the worst possible pain. The distance from 0 cm to the participant's mark will be recorded.Unit of Measure:
Centimeters (cm)
Measured: baseline
Median sensory nerve-conduction velocity (m/s)
Median sensory nerve-conduction velocity will be measured using standard nerve-conduction studies by stimulating the median nerve at a predefined site and recording the sensory nerve action potential from the selected digit. Conduction velocity will be calculated as the distance between the stimulation and recording sites divided by the relevant conduction time. Unit of Measure:
Meters per second (m/s)
Measured: baseline
Unit of Measure Degrees (°)
Unit of Measure Degrees (°)will be assessed using a joint-position-reproduction test. Participants will reproduce a predefined target wrist position without visual feedback. The absolute angular error will be calculated as the absolute difference between the target angle and the reproduced angle. Errors from the predefined trials will be averaged to obtain one participant-level outcome value. A smaller error indicates better proprioceptive accuracy. Unit of Measure Degrees (°)
Measured: baseline
Median-Nerve cross sectional area (mm²)
The median nerve will be examined using diagnostic ultrasound. The primary measurement will be the cross-sectional area of the median nerve at the carpal tunnel, usually measured at the tunnel inlet unit of measure Square millimeters (mm²)
Measured: baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Oct 2026
- Study start5 Oct 2026 (estimated)
- Primary completion30 Jan 2027 (estimated)
- Study completion1 Feb 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Carpel Tunnel SyndromeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Delta University for Science and Technology
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Ibrahim Ahmed Ibrahim Abu Ella, Delta University for Science and Technology
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07875751
- Sponsor's protocol ID
- CTS30
- Status last verified
- Oct 2026
- First submitted
- 3 Oct 2026
- Last updated
- 15 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: confidentiality
Study at a glance
From the registry record, last updated by the sponsor on 15 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effectiveness of Sensorimotor Proprioceptive Stimulation Combined With Conventional Physical Therapy on Symptoms, Sensory Function, Proprioception, and Hand Function in Patients With Mild-to-Moderate Carpal Tunnel Syndrome: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07875751
- Acronym / sponsor ID
- CTS30
- Conditions
- Carpel Tunnel Syndrome
- Keywords
- proprioception, sensorimotor, conventional, CTS
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Delta University for Science and TechnologyUniversity, hospital or other
- Study start
- 5 Oct 2026 (estimated)
- Primary completion
- 30 Jan 2027 (estimated)
- Study completion
- 1 Feb 2027 (estimated)
- First posted
- 15 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial will evaluate whether adding sensorimotor proprioceptive stimulation to conventional physiotherapy improves symptoms and hand function in patients with mild-to-moderate carpal tunnel syndrome. The primary outcome is change in the Boston Symptom Severity Scale, while secondary outcomes include functional status, pain, paresthesia, nerve conduction, median-nerve morphology, proprioception, and hand strength.
Detailed description
This randomized controlled trial will investigate whether adding sensorimotor proprioceptive stimulation to conventional physical therapy improves symptoms, sensory function, proprioception, and hand function in adults with mild-to-moderate carpal tunnel syndrome.
Participants will be randomly assigned to either an experimental group receiving sensorimotor proprioceptive stimulation plus conventional physical therapy or a control group receiving conventional physical therapy alone. The intervention will target sensory awareness, wrist and hand joint-position control, median-nerve function, coordination, and functional hand use.
Experimental Intervention
The experimental group will receive a structured program involving:
Wrist and hand joint-position-reproduction exercises.
Visual and nonvisual proprioceptive training.
Controlled wrist, thumb, and finger movements.
Tendon-gliding and median-nerve-gliding exercises.
Graded tactile and sensory stimulation.
Grip, pinch, and fine-motor coordination activities.
Progressive closed-chain or weight-bearing exercises, when tolerated.
Home exercises performed according to a standardized program.
Exercises will progress from simple, visually guided movements to more challenging tasks performed with reduced visual feedback and increased functional demand. The therapist will monitor symptom aggravation, numbness, pain, fatigue, and movement accuracy throughout treatment.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| study group | Experimental | Other: sensorimotor proprioceptive stimulation |
| control group | Active comparator | Other: conventional physical therapy |
Who may qualify
- Ages
- 30 to 50 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (8 listed)
- Are adults aged 30-50 years.
- Have clinically diagnosed mild-to-moderate carpal tunnel syndrome.
- Report pain, numbness, tingling, or nocturnal symptoms in the median-nerve distribution.
- Have symptoms lasting at least 4 weeks.
- Have electrodiagnostic findings consistent with mild-to-moderate median-nerve compression at the wrist.
Key exclusion criteria (6 listed)
- Severe carpal tunnel syndrome requiring immediate surgery.
- Previous carpal tunnel release or wrist surgery.
- Cervical radiculopathy, brachial plexopathy, or another peripheral neuropathy.
- Diabetes, rheumatoid arthritis, thyroid disease, or other systemic conditions affecting nerve function, unless medically stable and permitted by the protocol.
- Wrist fracture, arthritis, tendon injury, or other upper-limb musculoskeletal disorders.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| sensorimotor proprioceptive stimulationParticipants will receive sensorimotor proprioceptive stimulation combined with conventional physical therapy. The program will include joint-position training, tactile sensory stimulation, wrist and hand coordination exercises, tendon and median-nerve gliding, grip and pinch activities, and progressive functional hand exercises. | Other | study group |
| conventional physical therapyParticipants will receive conventional physical therapy alone, including education, ergonomic advice, wrist and hand range-of-motion exercises, tendon-gliding exercises, strengthening exercises, and a standardized home-exercise program. | Other | control group |
Primary outcome
Boston Carpal Tunnel Questionnaire Symptom Severity Scale
Time frame: baseline
The Boston Carpal Tunnel Questionnaire Symptom Severity Scale consists of 11 items assessing pain, numbness, tingling, weakness, nocturnal symptoms, and difficulty grasping objects. Each item is scored from 1 to 5. The total score will be calculated as the mean of the 11 item scores: Mean SSS score = sum of the 11 item scores ÷ 11 The final score ranges from 1 to 5, with higher scores indicating greater symptom severity.
4 secondary outcomes
Pain Intensity
Time frame: baseline
Median sensory nerve-conduction velocity (m/s)
Time frame: baseline
Unit of Measure Degrees (°)
Time frame: baseline
Median-Nerve cross sectional area (mm²)
Time frame: baseline
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Oct 2026.
- Individual participant dataSharing planned: No. confidentiality
Related trials for Carpel Tunnel Syndrome
Active, not recruiting
Pregabalin Phonophoresis for Carpal Tunnel Syndrome Pain
Carpal Tunnel Syndrome (CTS)
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing sensorimotor proprioceptive stimulation and conventional physical therapy in people with Carpel Tunnel Syndrome, run by Delta University for Science and Technology at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 15 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ibrahim Abu Ella, PhD (020108442281, ibrahimneuron@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Boston Carpal Tunnel Questionnaire Symptom Severity Scale (time frame: baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Oct 2026.